Abstract:
:During plant radial growth typically seen in trees, procambial and cambial cells act as meristematic cells in the vascular system to self-proliferate and differentiate into xylem cells. These two processes are regulated by a signalling pathway composed of a peptide ligand and its receptor; tracheary element differentiation inhibitory factor (TDIF) and TDIF RECEPTOR (TDR). Here we show that glycogen synthase kinase 3 proteins (GSK3s) are crucial downstream components of the TDIF signalling pathway suppressing xylem differentiation from procambial cells. TDR interacts with GSK3s at the plasma membrane and activates GSK3s in a TDIF-dependent fashion. Consistently, a specific inhibitor of plant GSK3s strongly induces xylem cell differentiation through BRI1-EMS SUPPRESSOR 1 (BES1), a well-known target transcription factor of GSK3s. Our findings provide insight into the regulation of cell fate determination in meristem maintenance.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Kondo Y,Ito T,Nakagami H,Hirakawa Y,Saito M,Tamaki T,Shirasu K,Fukuda Hdoi
10.1038/ncomms4504subject
Has Abstractpub_date
2014-03-24 00:00:00pages
3504issn
2041-1723pii
ncomms4504journal_volume
5pub_type
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