Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination.

abstract：:Following uncontrolled proliferation, a subset of primary tumour cells acquires additional traits/mutations to trigger phenotypic changes that enhance migration and are hypothesized to be the initiators of metastasis. This study reveals an adaptive mechanism that harnesses synergistic paracrine signalling via IL-6/8, ...

journal_title：Nature communications

authors： Jayatilaka H,Tyle P,Chen JJ,Kwak M,Ju J,Kim HJ,Lee JSH,Wu PH,Gilkes DM,Fan R,Wirtz D

更新日期：2017-05-26 00:00:00

abstract：:The development of efficient reactions for the one-pot construction of bicyclic ring systems bearing two quaternary carbon centres at their bridgehead positions represents a significant challenge to synthetic chemistry. The development of new methods capable of overcoming this challenge is highly desirable, because th...

journal_title：Nature communications

authors： Long R,Huang J,Shao W,Liu S,Lan Y,Gong J,Yang Z

更新日期：2014-12-08 00:00:00

abstract：:Long-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking. Here, we evaluate immune and gene expression profiles in 35 Guinean EBOV_S from the last West African outbreak, a median of 23 months (IQR [18-25]) after discharge from treatment center. Compared with healthy donors, EBOV_S exhi...

journal_title：Nature communications

authors： Wiedemann A,Foucat E,Hocini H,Lefebvre C,Hejblum BP,Durand M,Krüger M,Keita AK,Ayouba A,Mély S,Fernandez JC,Touré A,Fourati S,Lévy-Marchal C,Raoul H,Delaporte E,Koivogui L,Thiébaut R,Lacabaratz C,Lévy Y,PostEboGui

更新日期：2020-07-24 00:00:00

abstract：:Apicomplexans are obligate intracellular parasites that scavenge essential nutrients from their hosts via transporter proteins on their plasma membrane. The identities of the transporters that mediate amino acid uptake into apicomplexans are unknown. Here we demonstrate that members of an apicomplexan-specific protein...

journal_title：Nature communications

authors： Rajendran E,Hapuarachchi SV,Miller CM,Fairweather SJ,Cai Y,Smith NC,Cockburn IA,Bröer S,Kirk K,van Dooren GG

更新日期：2017-02-16 00:00:00

abstract：:Epithelial barrier function is maintained by coordination of cell proliferation and cell loss, whereas barrier dysfunction can lead to disease and organismal death. JNK signalling is a conserved stress signalling pathway activated by bacterial infection and tissue damage, often leading to apoptotic cell death and comp...

journal_title：Nature communications

authors： Zhou J,Edgar BA,Boutros M

更新日期：2017-03-08 00:00:00

abstract：:Laboratory spectroscopy of atomic hydrogen in a magnetic flux density of 10(5) T (1 gigagauss), the maximum observed on high-field magnetic white dwarfs, is impossible because practically available fields are about a thousand times less. In this regime, the cyclotron and binding energies become equal. Here we demonstr...

journal_title：Nature communications

authors： Murdin BN,Li J,Pang ML,Bowyer ET,Litvinenko KL,Clowes SK,Engelkamp H,Pidgeon CR,Galbraith I,Abrosimov NV,Riemann H,Pavlov SG,Hübers HW,Murdin PG

更新日期：2013-01-01 00:00:00

abstract：:Naturally heat-resistant coral populations hold significant potential for facilitating coral reef survival under rapid climate change. However, it remains poorly understood whether they can acclimatize to ocean warming when superimposed on their already thermally-extreme habitats. Furthermore, it is unknown whether th...

journal_title：Nature communications

authors： Schoepf V,Carrion SA,Pfeifer SM,Naugle M,Dugal L,Bruyn J,McCulloch MT

更新日期：2019-09-17 00:00:00

abstract：:The dynamics of many natural and artificial systems are well described as random walks on a network: the stochastic behaviour of molecules, traffic patterns on the internet, fluctuations in stock prices and so on. The vast literature on random walks provides many tools for computing properties such as steady-state pro...

journal_title：Nature communications

authors： Perkins TJ,Foxall E,Glass L,Edwards R

更新日期：2014-10-14 00:00:00

abstract：:Cell-to-cell variability (noise) is an important feature of gene expression that impacts cell fitness and development. The regulatory mechanism of this variability is not fully understood. Here we investigate the effect on gene expression noise in divergent gene pairs (DGPs). We generated reporters driven by divergent...

journal_title：Nature communications

authors： Yan C,Wu S,Pocetti C,Bai L

更新日期：2016-03-24 00:00:00

abstract：:Plant metacaspases mediate programmed cell death in development, biotic and abiotic stresses, damage-induced immune response, and resistance to pathogen attack. Most metacaspases require Ca2+ for their activation and substrate processing. However, the Ca2+-dependent activation mechanism remains elusive. Here we report...

journal_title：Nature communications

authors： Zhu P,Yu XH,Wang C,Zhang Q,Liu W,McSweeney S,Shanklin J,Lam E,Liu Q

更新日期：2020-05-07 00:00:00

abstract：:Gramicidin A (gA) is the simplest known natural channel, and important progress in improving conduction activity has previously been obtained with modified natural gAs. However, simple artificial systems mimicking the gA functions are unknown. Here we show that gA can be mimicked using a simple synthetic triazole or '...

journal_title：Nature communications

authors： Barboiu M,Le Duc Y,Gilles A,Cazade PA,Michau M,Marie Legrand Y,van der Lee A,Coasne B,Parvizi P,Post J,Fyles T

更新日期：2014-06-26 00:00:00

abstract：:Plasma dynamics critically depends on density and temperature, thus well-controlled experimental realizations are essential benchmarks for theoretical models. The formation of an ultracold plasma can be triggered by ionizing a tunable number of atoms in a micrometer-sized volume of a 87Rb Bose-Einstein condensate (BEC...

journal_title：Nature communications

authors： Kroker T,Großmann M,Sengstock K,Drescher M,Wessels-Staarmann P,Simonet J

更新日期：2021-01-26 00:00:00

abstract：:G-protein-coupled receptor (GPCR) expression is extensively studied in bulk cDNA, but heterogeneity and functional patterning of GPCR expression in individual vascular cells is poorly understood. Here, we perform a microfluidic-based single-cell GPCR expression analysis in primary smooth muscle cells (SMC) and endothe...

journal_title：Nature communications

authors： Kaur H,Carvalho J,Looso M,Singh P,Chennupati R,Preussner J,Günther S,Albarrán-Juárez J,Tischner D,Classen S,Offermanns S,Wettschureck N

更新日期：2017-06-16 00:00:00

abstract：:The coupled translocation of transfer RNA and messenger RNA through the ribosome entails large-scale structural rearrangements, including step-wise movements of the tRNAs. Recent structural work has visualized intermediates of translocation induced by elongation factor G (EF-G) with tRNAs trapped in chimeric states wi...

journal_title：Nature communications

authors： Adio S,Senyushkina T,Peske F,Fischer N,Wintermeyer W,Rodnina MV

更新日期：2015-06-15 00:00:00

abstract：:Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers....

journal_title：Nature communications

authors： Seki R,Li C,Fang Q,Hayashi S,Egawa S,Hu J,Xu L,Pan H,Kondo M,Sato T,Matsubara H,Kamiyama N,Kitajima K,Saito D,Liu Y,Gilbert MT,Zhou Q,Xu X,Shiroishi T,Irie N,Tamura K,Zhang G

更新日期：2017-02-06 00:00:00

abstract：:Insight into crumpling or compaction of one-dimensional objects is important for understanding biopolymer packaging and designing innovative technological devices. By compacting various types of wires in rigid confinements and characterizing the morphology of the resulting crumpled structures, here, we report how fric...

journal_title：Nature communications

authors： Shaebani MR,Najafi J,Farnudi A,Bonn D,Habibi M

更新日期：2017-06-06 00:00:00

abstract：:Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent cardiovascular disease (CVD) and treat brain diseases alone or in combination with docosahexaenoic acid (DHA). However, the impact of EPA and DHA supplementation on normal cognitive function and the molecular targets of EPA and DHA are...

journal_title：Nature communications

authors： Liu JH,Wang Q,You QL,Li ZL,Hu NY,Wang Y,Jin ZL,Li SJ,Li XW,Yang JM,Zhu XH,Dai YF,Xu JP,Bai XC,Gao TM

更新日期：2020-10-29 00:00:00

abstract：:Members of the transient receptor potential (TRP) ion channels conduct cations into cells. They mediate functions ranging from neuronally mediated hot and cold sensation to intracellular organellar and primary ciliary signaling. Here we report a cryo-electron microscopy (cryo-EM) structure of TRPC4 in its unliganded (...

journal_title：Nature communications

authors： Duan J,Li J,Zeng B,Chen GL,Peng X,Zhang Y,Wang J,Clapham DE,Li Z,Zhang J

更新日期：2018-08-06 00:00:00

abstract：:Neurodegenerative lesions induce sprouting of new collaterals from surviving axons, but the extent to which this form of axonal remodelling alters brain functional structure remains unclear. To understand how collateral sprouting proceeds in the adult brain, we imaged post-lesion sprouting of cerebellar climbing fibre...

journal_title：Nature communications

authors： Dhar M,Brenner JM,Sakimura K,Kano M,Nishiyama H

更新日期：2016-09-21 00:00:00

abstract：:Spinal cord injury (SCI) often causes severe and permanent disabilities due to the regenerative failure of severed axons. Here we report significant locomotor recovery of both hindlimbs after a complete spinal cord crush. This is achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hy...

journal_title：Nature communications

authors： Leibinger M,Zeitler C,Gobrecht P,Andreadaki A,Gisselmann G,Fischer D

更新日期：2021-01-15 00:00:00

abstract：:Rapid growth in size and complexity of biological data sets has led to the 'Big Data to Knowledge' challenge. We develop advanced data integration methods for multi-level analysis of genomic, transcriptomic, ribosomal profiling, proteomic and fluxomic data. First, we show that pairwise integration of primary omics dat...

journal_title：Nature communications

authors： Ebrahim A,Brunk E,Tan J,O'Brien EJ,Kim D,Szubin R,Lerman JA,Lechner A,Sastry A,Bordbar A,Feist AM,Palsson BO

更新日期：2016-10-26 00:00:00

abstract：:In two-dimensional (2D) lattices, the electronic levels are unevenly spaced, and the density of states (DOS) displays a logarithmic divergence known as the Van Hove singularity (VHS). This is the case in particular for the layered cuprate superconductors. The scanning tunnelling microscope (STM) probes the DOS, and is...

journal_title：Nature communications

authors： Piriou A,Jenkins N,Berthod C,Maggio-Aprile I,Fischer O

更新日期：2011-01-01 00:00:00

abstract：:Capturing and controlling plasmons at buried interfaces with nanometre and femtosecond resolution has yet to be achieved and is critical for next generation plasmonic devices. Here we use light to excite plasmonic interference patterns at a buried metal-dielectric interface in a nanostructured thin film. Plasmons are ...

journal_title：Nature communications

authors： Lummen TTA,Lamb RJ,Berruto G,LaGrange T,Dal Negro L,García de Abajo FJ,McGrouther D,Barwick B,Carbone F

更新日期：2016-10-11 00:00:00

abstract：:Clustering of the T-cell receptor (TCR) is thought to initiate downstream signalling. However, the detection of protein clustering with high spatial and temporal resolution remains challenging. Here we establish a Förster resonance energy transfer (FRET) sensor, named CliF, which reports intermolecular associations of...

journal_title：Nature communications

authors： Ma Y,Pandzic E,Nicovich PR,Yamamoto Y,Kwiatek J,Pageon SV,Benda A,Rossy J,Gaus K

更新日期：2017-04-28 00:00:00

abstract：:The interaction of lipids and proteins plays an important role in plasma membrane bioactivity, and much can be learned from their diffusion characteristics. Here we present the combination of super-resolution STED microscopy with scanning fluorescence correlation spectroscopy (scanning STED-FCS, sSTED-FCS) to characte...

journal_title：Nature communications

authors： Honigmann A,Mueller V,Ta H,Schoenle A,Sezgin E,Hell SW,Eggeling C

更新日期：2014-11-20 00:00:00

abstract：:Self-repairable materials strive to emulate curable and resilient biological tissue; however, their performance is currently insufficient for commercialization purposes because mending and toughening are mutually exclusive. Herein, we report a carbonate-type thermoplastic polyurethane elastomer that self-heals at 35 °...

journal_title：Nature communications

authors： Eom Y,Kim SM,Lee M,Jeon H,Park J,Lee ES,Hwang SY,Park J,Oh DX

更新日期：2021-01-27 00:00:00

abstract：:Polyborylated organic compounds have been emerging as versatile building blocks in chemical synthesis. Here we report a selective cobalt-catalyzed deoxygenative 1,1,3-triborylation reaction of allylic ethers with pinacolborane to prepare 1,1,3-triborylalkane compounds. With naturally abundant and/or synthetic cinnamic...

journal_title：Nature communications

authors： Teo WJ,Yang X,Poon YY,Ge S

更新日期：2020-10-15 00:00:00

abstract：:The discovery of two-dimensional (2D) magnetism combined with van der Waals (vdW) heterostructure engineering offers unprecedented opportunities for creating artificial magnetic structures with non-trivial magnetic textures. Further progress hinges on deep understanding of electronic and magnetic properties of 2D magn...

journal_title：Nature communications

authors： Qiu Z,Holwill M,Olsen T,Lyu P,Li J,Fang H,Yang H,Kashchenko M,Novoselov KS,Lu J

更新日期：2021-01-04 00:00:00

abstract：:The miR-200 family members have been implicated in stress responses and ovarian tumorigenesis. Here, we find that miR-200c/141 transcription is intimately linked to the transcription of the proximal upstream gene PTPN6 (SHP1) in all physiological conditions tested. PTPN6 and miR-200c/141 are transcriptionally co-regul...

journal_title：Nature communications

authors： Batista L,Bourachot B,Mateescu B,Reyal F,Mechta-Grigoriou F

更新日期：2016-01-04 00:00:00

abstract：:With favourable error thresholds and requiring only nearest-neighbour interactions on a lattice, the surface code is an error-correcting code that has garnered considerable attention. At the heart of this code is the ability to perform a low-weight parity measurement of local code qubits. Here we demonstrate high-fide...

journal_title：Nature communications

authors： Chow JM,Gambetta JM,Magesan E,Abraham DW,Cross AW,Johnson BR,Masluk NA,Ryan CA,Smolin JA,Srinivasan SJ,Steffen M

更新日期：2014-06-24 00:00:00