Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system.

abstract：:One of the fundamental design paradigms in organic photovoltaic device engineering is based on the idea that charge separation is an extrinsically driven process requiring an interface for exciton fission. This idea has driven an enormous materials science engineering effort focused on construction of domain sizes com...

journal_title：Nature communications

authors： Labastide JA,Thompson HB,Marques SR,Colella NS,Briseno AL,Barnes MD

更新日期：2016-02-25 00:00:00

abstract：:Single-cell RNA-sequencing (scRNA-Seq) is a compelling approach to directly and simultaneously measure cellular composition and state, which can otherwise only be estimated by applying deconvolution methods to bulk RNA-Seq estimates. However, it has not yet become a widely used tool in population-scale analyses, due t...

journal_title：Nature communications

authors： Mandric I,Schwarz T,Majumdar A,Hou K,Briscoe L,Perez R,Subramaniam M,Hafemeister C,Satija R,Ye CJ,Pasaniuc B,Halperin E

更新日期：2020-10-30 00:00:00

abstract：:Tissue injury and the healing response lead to the release of endogenous danger signals including Toll-like receptor (TLR) and interleukin-1 receptor, type 1 (IL-1R1) ligands, which modulate the immune microenvironment. Because TLRs and IL-1R1 have been shown to influence the repair process of various tissues, we expl...

journal_title：Nature communications

authors： Martino MM,Maruyama K,Kuhn GA,Satoh T,Takeuchi O,Müller R,Akira S

更新日期：2016-03-22 00:00:00

abstract：:Photosynthesis is nature's route to convert intermittent solar irradiation into storable energy, while its use for an industrial energy supply is impaired by low efficiency. Artificial photosynthesis provides a promising alternative for efficient robust carbon-neutral renewable energy generation. The approach of direc...

journal_title：Nature communications

authors： May MM,Lewerenz HJ,Lackner D,Dimroth F,Hannappel T

更新日期：2015-09-15 00:00:00

abstract：:Alkali metal vapors enable access to single electron systems, suitable for demonstrating fundamental light-matter interactions and promising for quantum logic operations, storage and sensing. However, progress is hampered by the need for robust and repeatable control over the atomic vapor density and over the associat...

journal_title：Nature communications

authors： Rusimova KR,Slavov D,Pradaux-Caggiano F,Collins JT,Gordeev SN,Carbery DR,Wadsworth WJ,Mosley PJ,Valev VK

更新日期：2019-05-24 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can cause both juvenile and late onset ALS. We generated and characterized induced pluripotent stem cells (iPSCs) from ALS patients with dif...

journal_title：Nature communications

authors： Guo W,Naujock M,Fumagalli L,Vandoorne T,Baatsen P,Boon R,Ordovás L,Patel A,Welters M,Vanwelden T,Geens N,Tricot T,Benoy V,Steyaert J,Lefebvre-Omar C,Boesmans W,Jarpe M,Sterneckert J,Wegner F,Petri S,Bohl D,Vande

更新日期：2017-10-11 00:00:00

abstract：:A central question in stem cell biology is the relationship between stem cells and their niche. Although previous reports have uncovered how signaling molecules released by niche cells support stem cell function, the role of the extra-cellular matrix (ECM) within the niche is unclear. Here, we show that upon activatio...

journal_title：Nature communications

authors： Rayagiri SS,Ranaldi D,Raven A,Mohamad Azhar NIF,Lefebvre O,Zammit PS,Borycki AG

更新日期：2018-03-14 00:00:00

abstract：:Metal ions at the active site of an enzyme act as cofactors, and their dynamic fluctuations can potentially influence enzyme activity. Here, we use λ-exonuclease as a model enzyme with two Mg2+ binding sites and probe activity at various concentrations of magnesium by single-molecule-FRET. We find that while MgA2+ and...

journal_title：Nature communications

authors： Hwang W,Yoo J,Lee Y,Park S,Hoang PL,Cho H,Yu J,Hoa Vo TM,Shin M,Jin MS,Park D,Hyeon C,Lee G

更新日期：2018-10-23 00:00:00

abstract：:The insulin/IGF-1 signalling (IIS) pathway plays an important role in the regulation of larval diapause, the long-lived growth arrest state called dauer arrest, in Caenorhabditis elegans. In this nematode, 40 insulin-like peptides (ILPs) have been identified as putative ligands of the IIS pathway; however, it remains ...

journal_title：Nature communications

authors： Matsunaga Y,Honda Y,Honda S,Iwasaki T,Qadota H,Benian GM,Kawano T

更新日期：2016-02-03 00:00:00

abstract：:Selection rules are of vital importance in determining the basic optical properties of atoms, molecules and semiconductors. They provide general insights into the symmetry of the system and the nature of relevant electronic states. A two-dimensional electron gas in a magnetic field is a model system where optical tran...

journal_title：Nature communications

authors： Ju L,Wang L,Li X,Moon S,Ozerov M,Lu Z,Taniguchi T,Watanabe K,Mueller E,Zhang F,Smirnov D,Rana F,McEuen PL

更新日期：2020-06-10 00:00:00

abstract：:The RNA exosome provides eukaryotic cells with an essential 3'-5' exoribonucleolytic activity, which processes or eliminates many classes of RNAs. Its nine-subunit core (Exo9) is structurally related to prokaryotic phosphorolytic exoribonucleases. Yet, yeast and animal Exo9s have lost the primordial phosphorolytic cap...

journal_title：Nature communications

authors： Sikorska N,Zuber H,Gobert A,Lange H,Gagliardi D

更新日期：2017-12-18 00:00:00

abstract：:Methanol is a biotechnologically promising substitute for food and feed substrates since it can be produced renewably from electricity, water and CO2. Although progress has been made towards establishing Escherichia coli as a platform organism for methanol conversion via the energy efficient ribulose monophosphate (Ru...

journal_title：Nature communications

authors： Keller P,Noor E,Meyer F,Reiter MA,Anastassov S,Kiefer P,Vorholt JA

更新日期：2020-10-26 00:00:00

abstract：:Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. The value of CR as a tool to understand human ageing relies on translatability of CR's effects in primates. Here we show tha...

journal_title：Nature communications

authors： Colman RJ,Beasley TM,Kemnitz JW,Johnson SC,Weindruch R,Anderson RM

更新日期：2014-04-01 00:00:00

abstract：:Interfacial issues commonly exist in solid-state batteries, and the microstructural complexity combines with the chemical heterogeneity to govern the local interfacial chemistry. The conventional wisdom suggests that "point-to-point" ion diffusion at the interface determines the ion transport kinetics. Here, we show t...

journal_title：Nature communications

authors： Lou S,Liu Q,Zhang F,Liu Q,Yu Z,Mu T,Zhao Y,Borovilas J,Chen Y,Ge M,Xiao X,Lee WK,Yin G,Yang Y,Sun X,Wang J

更新日期：2020-11-11 00:00:00

abstract：:Covalent organic frameworks (COFs) have served as a family of porous crystalline molecules for various promising applications. However, controllable synthesis of COFs with uniform morphology is paramount yet still remains quite challenging. Herein, we report self-templated synthesis of uniform and unique hollow sphere...

journal_title：Nature communications

authors： Liu YY,Li XC,Wang S,Cheng T,Yang H,Liu C,Gong Y,Lai WY,Huang W

更新日期：2020-11-03 00:00:00

abstract：:The Fc region of HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) is required for suppressing viraemia, through mechanisms which remain poorly understood. Here, we identify bNAbs that exert antibody-dependent cellular cytotoxicity (ADCC) in cell culture and kill HIV-1-infected lymphocytes through natural kil...

journal_title：Nature communications

authors： Bruel T,Guivel-Benhassine F,Amraoui S,Malbec M,Richard L,Bourdic K,Donahue DA,Lorin V,Casartelli N,Noël N,Lambotte O,Mouquet H,Schwartz O

更新日期：2016-03-03 00:00:00

abstract：:The low-energy electronic excitations in graphene are described by massless Dirac fermions that have a linear dispersion relation. Taking advantage of this 'optics-like' electron dynamics, generic optical elements like lenses and wave guides have been proposed for electrons in graphene. Tuning of these elements relies...

journal_title：Nature communications

authors： Rickhaus P,Maurand R,Liu MH,Weiss M,Richter K,Schönenberger C

更新日期：2013-01-01 00:00:00

abstract：:Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and mitogen-activated protein kinase pathw...

journal_title：Nature communications

authors： Yeh I,Lang UE,Durieux E,Tee MK,Jorapur A,Shain AH,Haddad V,Pissaloux D,Chen X,Cerroni L,Judson RL,LeBoit PE,McCalmont TH,Bastian BC,de la Fouchardière A

更新日期：2017-09-21 00:00:00

abstract：:Successive cold winters of severely low temperatures in recent years have had critical social and economic impacts on the mid-latitude continents in the Northern Hemisphere. Although these cold winters are thought to be partly driven by dramatic losses of Arctic sea-ice, the mechanism that links sea-ice loss to cold w...

journal_title：Nature communications

authors： Kim BM,Son SW,Min SK,Jeong JH,Kim SJ,Zhang X,Shim T,Yoon JH

更新日期：2014-09-02 00:00:00

abstract：:The mega-diversity of herbivorous insects is attributed to their co-evolutionary associations with plants. Despite abundant studies on insect-plant interactions, we do not know whether host-plant shifts have impacted both genomic adaptation and species diversification over geological times. We show that the antagonist...

journal_title：Nature communications

authors： Allio R,Nabholz B,Wanke S,Chomicki G,Pérez-Escobar OA,Cotton AM,Clamens AL,Kergoat GJ,Sperling FAH,Condamine FL

更新日期：2021-01-13 00:00:00

abstract：:Magnetic skyrmions are localized, topologically protected spin structures that have been proposed for storing or processing information due to their intriguing dynamical and transport properties. Important in terms of applications is the recent discovery of interface stabilized skyrmions as evidenced in ultra-thin tra...

journal_title：Nature communications

authors： Dupé B,Bihlmayer G,Böttcher M,Blügel S,Heinze S

更新日期：2016-06-03 00:00:00

abstract：:The mammary gland undergoes cycles of growth and regeneration throughout reproductive life, a process that requires mammary stem cells (MaSCs). Whilst recent genetic fate-mapping studies using lineage-specific promoters have provided valuable insights into the mammary epithelial hierarchy, the true differentiation pot...

journal_title：Nature communications

authors： Davis FM,Lloyd-Lewis B,Harris OB,Kozar S,Winton DJ,Muresan L,Watson CJ

更新日期：2016-10-25 00:00:00

abstract：:Both anti-PD1/PD-L1 therapy and oncolytic virotherapy have demonstrated promise, yet have exhibited efficacy in only a small fraction of cancer patients. Here we hypothesized that an oncolytic poxvirus would attract T cells into the tumour, and induce PD-L1 expression in cancer and immune cells, leading to more suscep...

journal_title：Nature communications

authors： Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL

更新日期：2017-03-27 00:00:00

abstract：:Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a plasticity in L5 auditory cortex (ACtx) neurons that innervate the inferior colliculus (IC), thalamus, lateral amygdala and striatum. We track daily ch...

journal_title：Nature communications

authors： Asokan MM,Williamson RS,Hancock KE,Polley DB

更新日期：2018-06-25 00:00:00

abstract：:Owing to the significant difference in the numbers of simulated and experimentally feasible zeolite structures, several alternative strategies have been developed for zeolite synthesis. Despite their rationality and originality, most of these techniques are based on trial-and-error, which makes it difficult to predict...

journal_title：Nature communications

authors： Kasneryk V,Shamzhy M,Zhou J,Yue Q,Mazur M,Mayoral A,Luo Z,Morris RE,Čejka J,Opanasenko M

更新日期：2019-11-12 00:00:00

abstract：:The significant degradation that fossilized biomolecules may experience during burial makes it challenging to assess the biogenicity of organic microstructures in ancient rocks. Here we investigate the molecular signatures of 1.88 Ga Gunflint organic microfossils as a function of their diagenetic history. Synchrotron-...

journal_title：Nature communications

authors： Alleon J,Bernard S,Le Guillou C,Marin-Carbonne J,Pont S,Beyssac O,McKeegan KD,Robert F

更新日期：2016-06-17 00:00:00

abstract：:Rapid growth in size and complexity of biological data sets has led to the 'Big Data to Knowledge' challenge. We develop advanced data integration methods for multi-level analysis of genomic, transcriptomic, ribosomal profiling, proteomic and fluxomic data. First, we show that pairwise integration of primary omics dat...

journal_title：Nature communications

authors： Ebrahim A,Brunk E,Tan J,O'Brien EJ,Kim D,Szubin R,Lerman JA,Lechner A,Sastry A,Bordbar A,Feist AM,Palsson BO

更新日期：2016-10-26 00:00:00

abstract：:Mitochondrial Ca(2+) uptake through the recently discovered Mitochondrial Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1). However, the physiological and pathological role of MICU1 remains unclear. Here we show that MICU1 is vital for adaptation to postnatal life and for ...

journal_title：Nature communications

authors： Antony AN,Paillard M,Moffat C,Juskeviciute E,Correnti J,Bolon B,Rubin E,Csordás G,Seifert EL,Hoek JB,Hajnóczky G

更新日期：2016-03-09 00:00:00

abstract：:The performance of conjugated polymer devices is largely dictated by charge transport processes. However, it is difficult to obtain a clear relationship between conjugated polymer structures and charge transport properties, due to the complexity of the structure and the dispersive nature of charge transport in conjuga...

journal_title：Nature communications

authors： Jiang Y,McNeill J

更新日期：2018-10-17 00:00:00

abstract：:The survival of viruses partly relies on their ability to self-assemble inside host cells. Although coarse-grained simulations have identified different pathways leading to assembled virions from their components, experimental evidence is severely lacking. Here, we use time-resolved small-angle X-ray scattering to unc...

journal_title：Nature communications

authors： Chevreuil M,Law-Hine D,Chen J,Bressanelli S,Combet S,Constantin D,Degrouard J,Möller J,Zeghal M,Tresset G

更新日期：2018-08-06 00:00:00