Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny.

abstract：:Foxg constitutes a regulatory loop with Fgf8 and plays an important role in the development of anterior placodes and the telencephalon in vertebrate embryos. Ascidians, which belong to Tunicata, the sister group of vertebrates, develop a primitive placode-like structure at the anterior boundary of the neural plate, bu...

journal_title：Nature communications

authors： Liu B,Satou Y

更新日期：2019-10-29 00:00:00

abstract：:Human social networks are overwhelmingly homophilous: individuals tend to befriend others who are similar to them in terms of a range of physical attributes (e.g., age, gender). Do similarities among friends reflect deeper similarities in how we perceive, interpret, and respond to the world? To test whether friendship...

journal_title：Nature communications

authors： Parkinson C,Kleinbaum AM,Wheatley T

更新日期：2018-01-30 00:00:00

abstract：:Human ether-a-go-go-related gene (hERG) potassium channels determine cardiac action potential and contraction duration. Human uterine contractions are underpinned by an action potential that also possesses an initial spike followed by prolonged depolarization. Here we show that hERG channel proteins (α-conducting and ...

journal_title：Nature communications

authors： Parkington HC,Stevenson J,Tonta MA,Paul J,Butler T,Maiti K,Chan EC,Sheehan PM,Brennecke SP,Coleman HA,Smith R

更新日期：2014-06-17 00:00:00

abstract：:Multiple lithium-ion transport pathways and local phase changes upon lithiation in silver hollandite are revealed via in situ microscopy including electron diffraction, imaging and spectroscopy, coupled with density functional theory and phase field calculations. We report unexpected inter-nanorod lithium-ion transpor...

journal_title：Nature communications

authors： Xu F,Wu L,Meng Q,Kaltak M,Huang J,Durham JL,Fernandez-Serra M,Sun L,Marschilok AC,Takeuchi ES,Takeuchi KJ,Hybertsen MS,Zhu Y

更新日期：2017-05-24 00:00:00

abstract：:Intracranial aneurysm is a common life-threatening disease. Computed tomography angiography is recommended as the standard diagnosis tool; yet, interpretation can be time-consuming and challenging. We present a specific deep-learning-based model trained on 1,177 digital subtraction angiography verified bone-removal co...

journal_title：Nature communications

authors： Shi Z,Miao C,Schoepf UJ,Savage RH,Dargis DM,Pan C,Chai X,Li XL,Xia S,Zhang X,Gu Y,Zhang Y,Hu B,Xu W,Zhou C,Luo S,Wang H,Mao L,Liang K,Wen L,Zhou L,Yu Y,Lu GM,Zhang LJ

更新日期：2020-11-30 00:00:00

abstract：:Central insulin is thought to act at the neural interface between metabolic and hedonic drives to eat. Here, using pharmacological fMRI, we show that intranasal insulin (INI) changes the value of food cues through modulation of mesolimbic pathways. Overnight fasted participants rated the palatability of food pictures ...

journal_title：Nature communications

authors： Tiedemann LJ,Schmid SM,Hettel J,Giesen K,Francke P,Büchel C,Brassen S

更新日期：2017-07-18 00:00:00

abstract：:The liquid and glass states of metal-organic frameworks (MOFs) have recently become of interest due to the potential for liquid-phase separations and ion transport, alongside the fundamental nature of the latter as a new, fourth category of melt-quenched glass. Here we show that the MOF liquid state can be blended wit...

journal_title：Nature communications

authors： Longley L,Collins SM,Zhou C,Smales GJ,Norman SE,Brownbill NJ,Ashling CW,Chater PA,Tovey R,Schönlieb CB,Headen TF,Terrill NJ,Yue Y,Smith AJ,Blanc F,Keen DA,Midgley PA,Bennett TD

更新日期：2018-06-15 00:00:00

abstract：:Gfi1b is a transcriptional repressor expressed in hematopoietic stem cells (HSCs) and megakaryocytes (MKs). Gfi1b deficiency leads to expansion of both cell types and abrogates the ability of MKs to respond to integrin. Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtB...

journal_title：Nature communications

authors： Shooshtarizadeh P,Helness A,Vadnais C,Brouwer N,Beauchemin H,Chen R,Bagci H,Staal FJT,Coté JF,Möröy T

更新日期：2019-03-20 00:00:00

abstract：:Animal propulsors such as wings and fins bend during motion and these bending patterns are believed to contribute to the high efficiency of animal movements compared with those of man-made designs. However, efforts to implement flexible designs have been met with contradictory performance results. Consequently, there ...

journal_title：Nature communications

authors： Lucas KN,Johnson N,Beaulieu WT,Cathcart E,Tirrell G,Colin SP,Gemmell BJ,Dabiri JO,Costello JH

更新日期：2014-01-01 00:00:00

abstract：:Solitary chemosensory cells (SCCs) are epithelial sentinels that utilize bitter Tas2r receptors and coupled taste transduction elements to detect pathogenic bacterial metabolites, triggering host defenses to control the infection. Here we report that SCCs are present in mouse gingival junctional epithelium, where they...

journal_title：Nature communications

authors： Zheng X,Tizzano M,Redding K,He J,Peng X,Jiang P,Xu X,Zhou X,Margolskee RF

更新日期：2019-10-03 00:00:00

abstract：:DNA can form diverse higher-order structures, whose details are greatly dependent on nucleotide sequence. G-rich sequences containing four or more repeats of three guanines are expected to form G-quadruplexes. Here we show that DNA sequences with GGGAGCG repeats found in the regulatory region of the PLEKHG3 gene are c...

journal_title：Nature communications

authors： Kocman V,Plavec J

更新日期：2014-12-15 00:00:00

abstract：:Although the amyloid β-protein (Aβ) is believed to play an initiating role in Alzheimer's disease (AD), the molecular characteristics of the key pathogenic Aβ forms are not well understood. As a result, it has proved difficult to identify optimal agents that target disease-relevant forms of Aβ. Here, we combined the u...

journal_title：Nature communications

authors： Jin M,O'Nuallain B,Hong W,Boyd J,Lagomarsino VN,O'Malley TT,Liu W,Vanderburg CR,Frosch MP,Young-Pearse T,Selkoe DJ,Walsh DM

更新日期：2018-07-11 00:00:00

abstract：:Culture (behaviour based on socially transmitted information) is present in diverse animal species, yet how it interacts with genetic evolution remains largely unexplored. Here, we review the evidence for gene-culture coevolution in animals, especially birds, cetaceans and primates. We describe how culture can relax o...

journal_title：Nature communications

authors： Whitehead H,Laland KN,Rendell L,Thorogood R,Whiten A

更新日期：2019-06-03 00:00:00

abstract：:A central paradigm in conservation biology is that population bottlenecks reduce genetic diversity and population viability. In an era of biodiversity loss and climate change, understanding the determinants and consequences of bottlenecks is therefore an important challenge. However, as most studies focus on single sp...

journal_title：Nature communications

authors： Stoffel MA,Humble E,Paijmans AJ,Acevedo-Whitehouse K,Chilvers BL,Dickerson B,Galimberti F,Gemmell NJ,Goldsworthy SD,Nichols HJ,Krüger O,Negro S,Osborne A,Pastor T,Robertson BC,Sanvito S,Schultz JK,Shafer ABA,Wolf JBW

更新日期：2018-11-16 00:00:00

abstract：:Selected groups of peptides, including those that are presented by major histocompatibility complex (MHC) proteins, have been proposed to transmit information to the olfactory system of vertebrates via their ability to stimulate chemosensory neurons. However, the lack of knowledge about such peptides in natural source...

journal_title：Nature communications

authors： Sturm T,Leinders-Zufall T,Maček B,Walzer M,Jung S,Pömmerl B,Stevanović S,Zufall F,Overath P,Rammensee HG

更新日期：2013-01-01 00:00:00

abstract：:Long duration gamma-ray bursts (GRBs), the brightest events since the Big Bang itself, are believed to originate in an ultra-relativistic jet breaking out from a massive stellar envelope. Despite decades of study, there is still no consensus on their emission mechanism. One unresolved question is the origin of the tig...

journal_title：Nature communications

authors： Ito H,Matsumoto J,Nagataki S,Warren DC,Barkov MV,Yonetoku D

更新日期：2019-04-03 00:00:00

abstract：:Perovskite light emitting diodes suffer from poor operational stability, exhibiting a rapid decay of external quantum efficiency within minutes to hours after turn-on. To address this issue, we explore surface treatment of perovskite films with phenylalkylammonium iodide molecules of varying alkyl chain lengths. Combi...

journal_title：Nature communications

authors： Guo Y,Apergi S,Li N,Chen M,Yin C,Yuan Z,Gao F,Xie F,Brocks G,Tao S,Zhao N

更新日期：2021-01-28 00:00:00

abstract：:Mineralisation of calcium phosphates in bone has been proposed to proceed via an initial amorphous precursor phase which transforms into nanocrystalline, carbonated hydroxyapatite. While calcium phosphates have been under intense investigation, the exact steps during the crystallisation of spherical amorphous particle...

journal_title：Nature communications

authors： Lotsari A,Rajasekharan AK,Halvarsson M,Andersson M

更新日期：2018-10-09 00:00:00

abstract：:Visual brain areas exhibit tuning characteristics well suited for image statistics present in our natural environment. However, visual sensation is an active process, and if there are any brain areas that ought to be particularly in tune with natural scene statistics, it would be sensory-motor areas critical for guidi...

journal_title：Nature communications

authors： Chen CY,Sonnenberg L,Weller S,Witschel T,Hafed ZM

更新日期：2018-07-20 00:00:00

abstract：:Somatic mutations in the RNase IIIb domain of DICER1 arise in cancer and disrupt the cleavage of 5' pre-miRNA arms. Here, we characterize an unstudied, recurrent, mutation (S1344L) in the DICER1 RNase IIIa domain in tumors from The Cancer Genome Atlas (TCGA) project and MSK-IMPACT profiling. RNase IIIa/b hotspots are ...

journal_title：Nature communications

authors： Vedanayagam J,Chatila WK,Aksoy BA,Majumdar S,Skanderup AJ,Demir E,Schultz N,Sander C,Lai EC

更新日期：2019-08-15 00:00:00

abstract：:ATP-dependent chromatin remodelling enzymes (remodellers) regulate DNA accessibility in eukaryotic genomes. Many remodellers reposition (slide) nucleosomes, however, how DNA is propagated around the histone octamer during this process is unclear. Here we examine the real-time coordination of remodeller-induced DNA mov...

journal_title：Nature communications

authors： Sabantsev A,Levendosky RF,Zhuang X,Bowman GD,Deindl S

更新日期：2019-04-12 00:00:00

abstract：:Application of coherent light-matter interactions has recently been extended to the ultrafast control of magnetization. An important but unrealized technique is the manipulation of magnetization vector motion to make it follow an arbitrarily designed multidimensional trajectory. Here we demonstrate a full manipulation...

journal_title：Nature communications

authors： Kanda N,Higuchi T,Shimizu H,Konishi K,Yoshioka K,Kuwata-Gonokami M

更新日期：2011-06-21 00:00:00

abstract：:Woody (lignocellulosic) plant biomass is an abundant renewable feedstock, rich in polysaccharides that are bound into an insoluble fiber composite with lignin. Marine crustacean woodborers of the genus Limnoria are among the few animals that can survive on a diet of this recalcitrant material without relying on gut re...

journal_title：Nature communications

authors： Besser K,Malyon GP,Eborall WS,Paro da Cunha G,Filgueiras JG,Dowle A,Cruz Garcia L,Page SJ,Dupree R,Kern M,Gomez LD,Li Y,Elias L,Sabbadin F,Mohamad SE,Pesante G,Steele-King C,Ribeiro de Azevedo E,Polikarpov I,Dupree

更新日期：2018-12-03 00:00:00

abstract：:Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV...

journal_title：Nature communications

authors： Pérez-Guzmán EX,Pantoja P,Serrano-Collazo C,Hassert MA,Ortiz-Rosa A,Rodríguez IV,Giavedoni L,Hodara V,Parodi L,Cruz L,Arana T,White LJ,Martínez MI,Weiskopf D,Brien JD,de Silva A,Pinto AK,Sariol CA

更新日期：2019-09-20 00:00:00

abstract：:Organic light-emitting diodes utilizing thermally activated delayed fluorescence is a potential solution for achieving stable blue devices. Sky-blue devices (CIEy < 0.4) with high stability and high external quantum efficiency (>15%) at 1000 cd m-2 based on either delayed fluorescence or phosphorescence are still limi...

journal_title：Nature communications

authors： Chan CY,Tanaka M,Nakanotani H,Adachi C

更新日期：2018-11-28 00:00:00

abstract：:Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we study the complete spectrum of mtDNA changes, including deletions, copy-number variation and point ...

journal_title：Nature communications

authors： Dölle C,Flønes I,Nido GS,Miletic H,Osuagwu N,Kristoffersen S,Lilleng PK,Larsen JP,Tysnes OB,Haugarvoll K,Bindoff LA,Tzoulis C

更新日期：2016-11-22 00:00:00

abstract：:Choroidal neovascularization (CNV) is the major cause of vision loss in wet age-related macular degeneration (AMD). Current therapies require repeated intravitreal injections, which are painful and can cause infection, bleeding, and retinal detachment. Here we develop nanoparticles (NP-[CPP]) that can be administered ...

journal_title：Nature communications

authors： Wang Y,Liu CH,Ji T,Mehta M,Wang W,Marino E,Chen J,Kohane DS

更新日期：2019-02-18 00:00:00

abstract：:The cell adhesion molecule Neuroligin2 (NL2) is localized selectively at GABAergic synapses, where it interacts with the scaffolding protein gephyrin in the post-synaptic density. However, the role of this interaction for formation and plasticity of GABAergic synapses is unclear. Here, we demonstrate that endogenous N...

journal_title：Nature communications

authors： Antonelli R,Pizzarelli R,Pedroni A,Fritschy JM,Del Sal G,Cherubini E,Zacchi P

更新日期：2014-10-09 00:00:00

abstract：:Advances in large-area graphene synthesis via chemical vapour deposition on metals like copper were instrumental in the demonstration of graphene-based novel, wafer-scale electronic circuits and proof-of-concept applications such as flexible touch panels. Here, we show that graphene grown by chemical vapour deposition...

journal_title：Nature communications

authors： Balakrishnan J,Koon GK,Avsar A,Ho Y,Lee JH,Jaiswal M,Baeck SJ,Ahn JH,Ferreira A,Cazalilla MA,Castro Neto AH,Özyilmaz B

更新日期：2014-09-01 00:00:00

abstract：:Despite centuries of research, much about the barbarian migrations that took place between the fourth and sixth centuries in Europe remains hotly debated. To better understand this key era that marks the dawn of modern European societies, we obtained ancient genomic DNA from 63 samples from two cemeteries (from Hungar...

journal_title：Nature communications

authors： Amorim CEG,Vai S,Posth C,Modi A,Koncz I,Hakenbeck S,La Rocca MC,Mende B,Bobo D,Pohl W,Baricco LP,Bedini E,Francalacci P,Giostra C,Vida T,Winger D,von Freeden U,Ghirotto S,Lari M,Barbujani G,Krause J,Caramelli D

更新日期：2018-09-11 00:00:00