Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons.

abstract：:Organizers are regions of the embryo that can both induce new fates and impart pattern on other regions. So far, surprisingly few organizers have been discovered, considering the number of patterned tissue types generated during development. This may be because their discovery has relied on transplantation and ablatio...

journal_title：Nature communications

authors： Anderson C,Khan MAF,Wong F,Solovieva T,Oliveira NMM,Baldock RA,Tickle C,Burt DW,Stern CD

更新日期：2016-08-25 00:00:00

abstract：:Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given the frequency of immune related adverse events and increasing use of ICB, predictors of response to CTLA-4 and/or PD-1 blockade represent unmet clinical needs. Using a systems biology-...

journal_title：Nature communications

authors： Jacquelot N,Roberti MP,Enot DP,Rusakiewicz S,Ternès N,Jegou S,Woods DM,Sodré AL,Hansen M,Meirow Y,Sade-Feldman M,Burra A,Kwek SS,Flament C,Messaoudene M,Duong CPM,Chen L,Kwon BS,Anderson AC,Kuchroo VK,Weide B,Au

更新日期：2017-09-19 00:00:00

abstract：:The actin-like protein MreB has been proposed to coordinate the synthesis of the cell wall to determine cell shape in bacteria. MreB is preferentially localized to areas of the cell with specific curved geometries, avoiding the cell poles. It remains unclear whether MreB's curvature preference is regulated by addition...

journal_title：Nature communications

authors： Bratton BP,Shaevitz JW,Gitai Z,Morgenstein RM

更新日期：2018-07-18 00:00:00

abstract：:The immunosuppressive microenvironment that is shaped by hepatic metastatic pancreatic ductal adenocarcinoma (PDAC) is essential for tumor cell evasion of immune destruction. Neutrophils are important components of the metastatic tumor microenvironment and exhibit heterogeneity. However, the specific phenotypes, funct...

journal_title：Nature communications

authors： Wang X,Hu LP,Qin WT,Yang Q,Chen DY,Li Q,Zhou KX,Huang PQ,Xu CJ,Li J,Yao LL,Wang YH,Tian GA,Yang JY,Yang MW,Liu DJ,Sun YW,Jiang SH,Zhang XL,Zhang ZG

更新日期：2021-01-08 00:00:00

abstract：:Innate immune chemoreceptors of the formyl peptide receptor (Fpr) family are expressed by vomeronasal sensory neurons (VSNs) in the accessory olfactory system. Their biological function and coding mechanisms remain unknown. We show that mouse Fpr3 (Fpr-rs1) recognizes the core peptide motif f-MKKFRW that is predominan...

journal_title：Nature communications

authors： Bufe B,Teuchert Y,Schmid A,Pyrski M,Pérez-Gómez A,Eisenbeis J,Timm T,Ishii T,Lochnit G,Bischoff M,Mombaerts P,Leinders-Zufall T,Zufall F

更新日期：2019-10-25 00:00:00

abstract：:The emergence of artificial intelligence (AI) and its progressively wider impact on many sectors requires an assessment of its effect on the achievement of the Sustainable Development Goals. Using a consensus-based expert elicitation process, we find that AI can enable the accomplishment of 134 targets across all the ...

journal_title：Nature communications

authors： Vinuesa R,Azizpour H,Leite I,Balaam M,Dignum V,Domisch S,Felländer A,Langhans SD,Tegmark M,Fuso Nerini F

更新日期：2020-01-13 00:00:00

abstract：:Accurate pathogenicity prediction of missense variants is critically important in genetic studies and clinical diagnosis. Previously published prediction methods have facilitated the interpretation of missense variants but have limited performance. Here, we describe MVP (Missense Variant Pathogenicity prediction), a n...

journal_title：Nature communications

authors： Qi H,Zhang H,Zhao Y,Chen C,Long JJ,Chung WK,Guan Y,Shen Y

更新日期：2021-01-21 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these tumours have altered metabolic requirements, making them highly reliant on a number of adaptations including a non-canonical glutamine (Gln) metabolic pathway and...

journal_title：Nature communications

authors： Biancur DE,Paulo JA,Małachowska B,Quiles Del Rey M,Sousa CM,Wang X,Sohn ASW,Chu GC,Gygi SP,Harper JW,Fendler W,Mancias JD,Kimmelman AC

更新日期：2017-07-03 00:00:00

abstract：:Current machine learning classifiers have successfully been applied to whole-genome sequencing data to identify genetic determinants of antimicrobial resistance (AMR), but they lack causal interpretation. Here we present a metabolic model-based machine learning classifier, named Metabolic Allele Classifier (MAC), that...

journal_title：Nature communications

authors： Kavvas ES,Yang L,Monk JM,Heckmann D,Palsson BO

更新日期：2020-05-22 00:00:00

abstract：:A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20006-5. ...

journal_title：Nature communications

authors： Escalera-Zamudio M,Golden M,Gutiérrez B,Thézé J,Keown JR,Carrique L,Bowden TA,Pybus OG

更新日期：2020-11-23 00:00:00

abstract：:The shift from maternal to embryonic control is a critical developmental milestone in preimplantation development. Widespread transcriptomic and epigenetic remodeling facilitate this transition from terminally differentiated gametes to totipotent blastomeres, but the identity of transcription factors (TF) and genomic ...

journal_title：Nature communications

authors： Halstead MM,Ma X,Zhou C,Schultz RM,Ross PJ

更新日期：2020-09-17 00:00:00

abstract：:Heterogeneous catalysis is an enabling technology that utilises transition metal nanoparticles (NPs) supported on oxides to promote chemical reactions. Structural mismatch at the NP-support interface generates lattice strain that could affect catalytic properties. However, detailed knowledge about strain in supported ...

journal_title：Nature communications

authors： Nilsson Pingel T,Jørgensen M,Yankovich AB,Grönbeck H,Olsson E

更新日期：2018-07-13 00:00:00

abstract：:Biologists have long been fascinated by the amazing diversity of animal colour patterns. Despite much interest, the underlying evolutionary and developmental mechanisms contributing to their rich variety remain largely unknown, especially the vivid and complex colour patterns seen in vertebrates. Here, we show that co...

journal_title：Nature communications

authors： Miyazawa S,Okamoto M,Kondo S

更新日期：2010-09-07 00:00:00

abstract：:Traumatic spinal cord injury results in severe and irreversible loss of function. The injury triggers a complex cascade of inflammatory and pathological processes, culminating in formation of a scar. While traditionally referred to as a glial scar, the spinal injury scar in fact comprises multiple cellular and extrace...

journal_title：Nature communications

authors： Bradbury EJ,Burnside ER

更新日期：2019-08-28 00:00:00

abstract：:Covalently locking interacting proteins in situ is an attractive strategy for addressing the challenge of identifying weak and transient protein interactions, yet it is demanding to execute chemical reactions in live systems in a biocompatible, specific, and autonomous manner. Harnessing proximity-enabled reactivity o...

journal_title：Nature communications

authors： Yang B,Tang S,Ma C,Li ST,Shao GC,Dang B,DeGrado WF,Dong MQ,Wang PG,Ding S,Wang L

更新日期：2017-12-21 00:00:00

abstract：:Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing strain. We demonstrate that TeA is synthesize...

journal_title：Nature communications

authors： Yun CS,Motoyama T,Osada H

更新日期：2015-10-27 00:00:00

abstract：:Crustal fluids exist near fault zones, but their relation to the processes that generate earthquakes, including slow-slip events, is unclear. Fault-zone fluids are characterized by low electrical resistivity. Here we investigate the time-dependent crustal resistivity in the rupture area of the 1999 Mw 7.6 Izmit earthq...

journal_title：Nature communications

authors： Honkura Y,Oshiman N,Matsushima M,Barış S,Kemal Tunçer M,Bülent Tank S,Celik C,Ciftçi ET

更新日期：2013-01-01 00:00:00

abstract：:The Mycobacterium tuberculosis (Mtb) electron transport chain (ETC) has received significant attention as a drug target, however its vulnerability may be affected by its flexibility in response to disruption. Here we determine the effect of the ETC inhibitors bedaquiline, Q203 and clofazimine on the Mtb ETC, and the v...

journal_title：Nature communications

authors： Lamprecht DA,Finin PM,Rahman MA,Cumming BM,Russell SL,Jonnala SR,Adamson JH,Steyn AJ

更新日期：2016-08-10 00:00:00

abstract：:Rosemary extracts containing the phenolic diterpenes carnosic acid and its derivative carnosol are approved food additives used in an increasingly wide range of products to enhance shelf-life, thanks to their high anti-oxidant activity. We describe here the elucidation of the complete biosynthetic pathway of carnosic ...

journal_title：Nature communications

authors： Scheler U,Brandt W,Porzel A,Rothe K,Manzano D,Božić D,Papaefthimiou D,Balcke GU,Henning A,Lohse S,Marillonnet S,Kanellis AK,Ferrer A,Tissier A

更新日期：2016-10-05 00:00:00

abstract：:Toward the development of surface-sensitive analytical techniques for biosensors and diagnostic biochip assays, a local integration of low-concentration target materials into the sensing region of interest is essential to improve the sensitivity and reliability of the devices. As a result, the dynamic process of sorti...

journal_title：Nature communications

authors： Yu ES,Lee H,Lee SM,Kim J,Kim T,Lee J,Kim C,Seo M,Kim JH,Byun YT,Park SC,Lee SY,Lee SD,Ryu YS

更新日期：2020-06-04 00:00:00

abstract：:Intestinal intraepithelial T cells contribute to the regulation of inflammatory responses in the intestine; however, the molecular basis for their development and maintenance is unknown. The aryl hydrocarbon receptor complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT) and senses environmental fact...

journal_title：Nature communications

authors： Nakajima K,Maekawa Y,Kataoka K,Ishifune C,Nishida J,Arimochi H,Kitamura A,Yoshimoto T,Tomita S,Nagahiro S,Yasutomo K

更新日期：2013-01-01 00:00:00

abstract：:Circadian rhythms are a nearly universal feature of living organisms and affect almost every biological process. Our innate preference for mornings or evenings is determined by the phase of our circadian rhythms. We conduct a genome-wide association analysis of self-reported morningness, followed by analyses of biolog...

journal_title：Nature communications

authors： Hu Y,Shmygelska A,Tran D,Eriksson N,Tung JY,Hinds DA

更新日期：2016-02-02 00:00:00

abstract：:Diversity-oriented synthesis (DOS) can provide a collection of diverse and complex drug-like small molecules, which is critical in the development of new chemical probes for biological research of undruggable targets. However, the design and synthesis of small-molecule libraries with improved biological relevance as w...

journal_title：Nature communications

authors： Kim J,Jung J,Koo J,Cho W,Lee WS,Kim C,Park W,Park SB

更新日期：2016-10-24 00:00:00

abstract：:Lysosomes are the major degradative compartments within cells, harbouring a wide variety of hydrolytic enzymes within their lumen. Release of lysosomal hydrolases from lysosomes into the cell cytoplasm results in cell death. Here we report that damaged lysosomes undergo autophagic turnover. Using a light-induced lysos...

journal_title：Nature communications

authors： Hung YH,Chen LM,Yang JY,Yang WY

更新日期：2013-01-01 00:00:00

abstract：:Developing single-site catalysts featuring maximum atom utilization efficiency is urgently desired to improve oxidation-reduction efficiency and cycling capability of lithium-oxygen batteries. Here, we report a green method to synthesize isolated cobalt atoms embedded ultrathin nitrogen-rich carbon as a dual-catalyst ...

journal_title：Nature communications

authors： Wang P,Ren Y,Wang R,Zhang P,Ding M,Li C,Zhao D,Qian Z,Zhang Z,Zhang L,Yin L

更新日期：2020-03-27 00:00:00

abstract：:Post-translational protein modification by tyrosine sulfation has an important role in extracellular protein-protein interactions. The protein tyrosine sulfation reaction is catalysed by the Golgi enzyme called the tyrosylprotein sulfotransferase. To date, no crystal structure is available for tyrosylprotein sulfotran...

journal_title：Nature communications

authors： Teramoto T,Fujikawa Y,Kawaguchi Y,Kurogi K,Soejima M,Adachi R,Nakanishi Y,Mishiro-Sato E,Liu MC,Sakakibara Y,Suiko M,Kimura M,Kakuta Y

更新日期：2013-01-01 00:00:00

abstract：:Transport of nanoscale energy in the form of excitons is at the core of photosynthesis and the operation of a wide range of nanostructured optoelectronic devices such as solar cells, light-emitting diodes and excitonic transistors. Of particular importance is the relationship between exciton transport and nanoscale di...

journal_title：Nature communications

authors： Akselrod GM,Deotare PB,Thompson NJ,Lee J,Tisdale WA,Baldo MA,Menon VM,Bulović V

更新日期：2014-04-16 00:00:00

abstract：:To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported to date. Here we completely sequence the genome of the filastere...

journal_title：Nature communications

authors： Suga H,Chen Z,de Mendoza A,Sebé-Pedrós A,Brown MW,Kramer E,Carr M,Kerner P,Vervoort M,Sánchez-Pons N,Torruella G,Derelle R,Manning G,Lang BF,Russ C,Haas BJ,Roger AJ,Nusbaum C,Ruiz-Trillo I

更新日期：2013-01-01 00:00:00

abstract：:Bacterial autotransporters comprise a 12-stranded membrane-embedded β-barrel domain, which must be folded in a process that entraps segments of an N-terminal passenger domain. This first stage of autotransporter folding determines whether subsequent translocation can deliver the N-terminal domain to its functional for...

journal_title：Nature communications

authors： Leyton DL,Johnson MD,Thapa R,Huysmans GH,Dunstan RA,Celik N,Shen HH,Loo D,Belousoff MJ,Purcell AW,Henderson IR,Beddoe T,Rossjohn J,Martin LL,Strugnell RA,Lithgow T

更新日期：2014-06-26 00:00:00

abstract：:Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting stratified associa...

journal_title：Nature communications

authors： Arnold M,Nho K,Kueider-Paisley A,Massaro T,Huynh K,Brauner B,MahmoudianDehkordi S,Louie G,Moseley MA,Thompson JW,John-Williams LS,Tenenbaum JD,Blach C,Chang R,Brinton RD,Baillie R,Han X,Trojanowski JQ,Shaw LM,Martin

更新日期：2020-03-02 00:00:00