Abstract:
:Toward the development of surface-sensitive analytical techniques for biosensors and diagnostic biochip assays, a local integration of low-concentration target materials into the sensing region of interest is essential to improve the sensitivity and reliability of the devices. As a result, the dynamic process of sorting and accurate positioning the nanoparticulate biomolecules within pre-defined micro/nanostructures is critical, however, it remains a huge hurdle for the realization of practical surface-sensitive biosensors and biochips. A scalable, massive, and non-destructive trapping methodology based on dielectrophoretic forces is highly demanded for assembling nanoparticles and biosensing tools. Herein, we propose a vertical nanogap architecture with an electrode-insulator-electrode stack structure, facilitating the generation of strong dielectrophoretic forces at low voltages, to precisely capture and spatiotemporally manipulate nanoparticles and molecular assemblies, including lipid vesicles and amyloid-beta protofibrils/oligomers. Our vertical nanogap platform, allowing low-voltage nanoparticle captures on optical metasurface designs, provides new opportunities for constructing advanced surface-sensitive optoelectronic sensors.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Yu ES,Lee H,Lee SM,Kim J,Kim T,Lee J,Kim C,Seo M,Kim JH,Byun YT,Park SC,Lee SY,Lee SD,Ryu YSdoi
10.1038/s41467-020-16630-wsubject
Has Abstractpub_date
2020-06-04 00:00:00pages
2804issue
1issn
2041-1723pii
10.1038/s41467-020-16630-wjournal_volume
11pub_type
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