Membrane tension controls the assembly of curvature-generating proteins.

abstract：:The Mid-Cayman spreading centre is an ultraslow-spreading ridge in the Caribbean Sea. Its extreme depth and geographic isolation from other mid-ocean ridges offer insights into the effects of pressure on hydrothermal venting, and the biogeography of vent fauna. Here we report the discovery of two hydrothermal vent fie...

journal_title：Nature communications

authors： Connelly DP,Copley JT,Murton BJ,Stansfield K,Tyler PA,German CR,Van Dover CL,Amon D,Furlong M,Grindlay N,Hayman N,Hühnerbach V,Judge M,Le Bas T,McPhail S,Meier A,Nakamura K,Nye V,Pebody M,Pedersen RB,Plouviez S,

更新日期：2012-01-10 00:00:00

abstract：:Ring expansion provides a powerful way of introducing a heteroatom substituent into a carbocyclic framework. However, such reactions are often limited by the tendency of a given substrate to afford only one of the two rearrangement products or fail to achieve high selectivity at all. These limitations are particularly...

journal_title：Nature communications

authors： Charaschanya M,Aubé J

更新日期：2018-03-05 00:00:00

abstract：:Decision-making is often accompanied by a degree of confidence on whether a choice is correct. Decision uncertainty, or lack in confidence, may lead to change-of-mind. Studies have identified the behavioural characteristics associated with decision confidence or change-of-mind, and their neural correlates. Although se...

journal_title：Nature communications

authors： Atiya NAA,Rañó I,Prasad G,Wong-Lin K

更新日期：2019-05-23 00:00:00

abstract：:The responses of atmospheric variability to Tibetan Plateau (TP) snow cover (TPSC) at seasonal, interannual and decadal time scales have been extensively investigated. However, the atmospheric response to faster subseasonal variability of TPSC has been largely ignored. Here, we show that the subseasonal variability of...

journal_title：Nature communications

authors： Li W,Guo W,Qiu B,Xue Y,Hsu PC,Wei J

更新日期：2018-10-12 00:00:00

abstract：:Development of efficient catalysts for selective electroreduction of CO2 to high-value products is essential for the deployment of carbon utilization technologies. Here we present a scalable method for preparing Cu electrocatalysts that favor CO2 conversion to C2+ products with faradaic efficiencies up to 72%. Grazing...

journal_title：Nature communications

authors： Kim T,Palmore GTR

更新日期：2020-07-17 00:00:00

abstract：:In eukaryotes, adventitious oxidation of erythrose-4-phosphate, an intermediate of the pentose phosphate pathway (PPP), generates 4-phosphoerythronate (4PE), which inhibits 6-phosphogluconate dehydrogenase. 4PE is detoxified by metabolite-proofreading phosphatases such as yeast Pho13. Here, we report that a similar fu...

journal_title：Nature communications

authors： Sachla AJ,Helmann JD

更新日期：2019-04-04 00:00:00

abstract：:Transcription activator-like effectors (TALEs) are important Xanthomonas virulence factors that bind DNA via a unique tandem 34-amino-acid repeat domain to induce expression of plant genes. So far, TALE repeats are described to bind as a consecutive array to a consecutive DNA sequence, in which each repeat independent...

journal_title：Nature communications

authors： Richter A,Streubel J,Blücher C,Szurek B,Reschke M,Grau J,Boch J

更新日期：2014-03-11 00:00:00

abstract：:Development of sensitive local probes of magnon dynamics is essential to further understand the physical processes that govern magnon generation, propagation, scattering, and relaxation. Quantum spin sensors like the NV center in diamond have long spin lifetimes and their relaxation can be used to sense magnetic field...

journal_title：Nature communications

authors： McCullian BA,Thabt AM,Gray BA,Melendez AL,Wolf MS,Safonov VL,Pelekhov DV,Bhallamudi VP,Page MR,Hammel PC

更新日期：2020-10-16 00:00:00

abstract：:Synthetic lethality is a promising concept in cancer research, potentially opening new possibilities for the development of more effective and selective treatments. Here, we present a computational method to predict and exploit synthetic lethality in cancer metabolism. Our approach relies on the concept of genetic min...

journal_title：Nature communications

authors： Apaolaza I,San José-Eneriz E,Tobalina L,Miranda E,Garate L,Agirre X,Prósper F,Planes FJ

更新日期：2017-09-06 00:00:00

abstract：:Previous studies have demonstrated that aneuploidy in human embryos is surprisingly frequent with 50-80% of cleavage-stage human embryos carrying an abnormal chromosome number. Here we combine non-invasive time-lapse imaging with karyotypic reconstruction of all blastomeres in four-cell human embryos to address the hy...

journal_title：Nature communications

authors： Chavez SL,Loewke KE,Han J,Moussavi F,Colls P,Munne S,Behr B,Reijo Pera RA

更新日期：2012-01-01 00:00:00

abstract：:The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastable phenotypic variants (persisters), some of which represent ste...

journal_title：Nature communications

authors： Pisco AO,Brock A,Zhou J,Moor A,Mojtahedi M,Jackson D,Huang S

更新日期：2013-01-01 00:00:00

abstract：:Ductal occlusion has been postulated to precipitate focal pancreatic inflammation, while the nature of the primary occluding agents has remained elusive. Neutrophils make use of histone citrullination by peptidyl arginine deiminase-4 (PADI4) in contact to particulate agents to extrude decondensed chromatin as neutroph...

journal_title：Nature communications

authors： Leppkes M,Maueröder C,Hirth S,Nowecki S,Günther C,Billmeier U,Paulus S,Biermann M,Munoz LE,Hoffmann M,Wildner D,Croxford AL,Waisman A,Mowen K,Jenne DE,Krenn V,Mayerle J,Lerch MM,Schett G,Wirtz S,Neurath MF,Herrm

更新日期：2016-03-11 00:00:00

abstract：:Contextual influences on choice are ubiquitous in ecological settings. Current evidence suggests that subjective values are normalized with respect to the distribution of potentially available rewards. However, how this context-sensitivity is realised in the brain remains unknown. To address this, here we examine func...

journal_title：Nature communications

authors： Rigoli F,Friston KJ,Dolan RJ

更新日期：2016-08-18 00:00:00

abstract：:Yeast lacks dedicated photoreceptors; however, blue light still causes pronounced oscillations of the transcription factor Msn2 into and out of the nucleus. Here we show that this poorly understood phenomenon is initiated by a peroxisomal oxidase, which converts light into a hydrogen peroxide (H2O2) signal that is sen...

journal_title：Nature communications

authors： Bodvard K,Peeters K,Roger F,Romanov N,Igbaria A,Welkenhuysen N,Palais G,Reiter W,Toledano MB,Käll M,Molin M

更新日期：2017-03-24 00:00:00

abstract：:Fluctuations in glacier motion are very common and are thought to be controlled by subglacial hydrology and till deformation. There are few instrumented studies that have monitored seasonal changes. We use the innovative Glacsweb subglacial in situ wireless probes, combined with dGPS and custom geophone data from an I...

journal_title：Nature communications

authors： Hart JK,Martinez K,Basford PJ,Clayton AI,Robson BA,Young DS

更新日期：2019-04-08 00:00:00

abstract：:Ice-shelf channels are long curvilinear tracts of thin ice found on Antarctic ice shelves. Many of them originate near the grounding line, but their formation mechanisms remain poorly understood. Here we use ice-penetrating radar data from Roi Baudouin Ice Shelf, East Antarctica, to infer that the morphology of severa...

journal_title：Nature communications

authors： Drews R,Pattyn F,Hewitt IJ,Ng FSL,Berger S,Matsuoka K,Helm V,Bergeot N,Favier L,Neckel N

更新日期：2017-05-09 00:00:00

abstract：:Purkinje cells (PCs) in Crus 1 represent whisker movement via linear changes in firing rate, but the circuit mechanisms underlying this coding scheme are unknown. Here we examine the role of upstream inputs to PCs-excitatory granule cells (GCs) and inhibitory molecular layer interneurons-in processing of whisking sign...

journal_title：Nature communications

authors： Chen S,Augustine GJ,Chadderton P

更新日期：2017-08-10 00:00:00

abstract：:The Greenland and Antarctic Ice Sheets cover ~ 10% of global land surface, but are rarely considered as active components of the global iron cycle. The ocean waters around both ice sheets harbour highly productive coastal ecosystems, many of which are iron limited. Measurements of iron concentrations in subglacial run...

journal_title：Nature communications

authors： Hawkings JR,Wadham JL,Tranter M,Raiswell R,Benning LG,Statham PJ,Tedstone A,Nienow P,Lee K,Telling J

更新日期：2014-05-21 00:00:00

abstract：:Large igneous province subduction is a rare process on Earth. A modern example is the subduction of the oceanic Hikurangi Plateau beneath the southern Kermadec arc, offshore New Zealand. This segment of the arc has the largest total lava volume erupted and the highest volcano density of the entire Kermadec arc. Here w...

journal_title：Nature communications

authors： Timm C,Davy B,Haase K,Hoernle KA,Graham IJ,de Ronde CE,Woodhead J,Bassett D,Hauff F,Mortimer N,Seebeck HC,Wysoczanski RJ,Caratori-Tontini F,Gamble JA

更新日期：2014-09-17 00:00:00

abstract：:Optical super-resolution microscopy allows nanoscale imaging of protein molecules in intact biological tissues. However, it is still challenging to perform large volume super-resolution imaging for entire animal organs. Here we develop a single-wavelength Bessel lightsheet method, optimized for refractive-index matchi...

journal_title：Nature communications

authors： Chu LA,Lu CH,Yang SM,Liu YT,Feng KL,Tsai YC,Chang WK,Wang WC,Chang SW,Chen P,Lee TK,Hwu YK,Chiang AS,Chen BC

更新日期：2019-10-18 00:00:00

abstract：:Turning graphene magnetic is a promising challenge to make it an active material for spintronics. Predictions state that graphene structures with specific shapes can spontaneously develop magnetism driven by Coulomb repulsion of π-electrons, but its experimental verification is demanding. Here, we report on the observ...

journal_title：Nature communications

authors： Li J,Sanz S,Corso M,Choi DJ,Peña D,Frederiksen T,Pascual JI

更新日期：2019-01-14 00:00:00

abstract：:Estimates of recent biodiversity change remain inconsistent, debated, and infrequently assessed for their functional implications. Here, we report that spatial scale and type of biodiversity measurement influence evidence of temporal biodiversity change. We show a pervasive scale dependence of temporal trends in taxon...

journal_title：Nature communications

authors： Jarzyna MA,Jetz W

更新日期：2018-07-02 00:00:00

abstract：:Culturing microorganisms is a critical step in understanding and utilizing microbial life. Here we map the landscape of existing culture media by extracting natural-language media recipes into a Known Media Database (KOMODO), which includes >18,000 strain-media combinations, >3300 media variants and compound concentra...

journal_title：Nature communications

authors： Oberhardt MA,Zarecki R,Gronow S,Lang E,Klenk HP,Gophna U,Ruppin E

更新日期：2015-10-13 00:00:00

abstract：:The discovery of charge- and spin-density-wave (CDW/SDW) orders in superconducting cuprates has altered our perspective on the nature of high-temperature superconductivity (SC). However, it has proven difficult to fully elucidate the relationship between the density wave orders and SC. Here, using resonant soft X-ray ...

journal_title：Nature communications

authors： Wen JJ,Huang H,Lee SJ,Jang H,Knight J,Lee YS,Fujita M,Suzuki KM,Asano S,Kivelson SA,Kao CC,Lee JS

更新日期：2019-07-22 00:00:00

abstract：:Protein aggregation plays a key role in neurodegenerative disease, giving rise to small oligomers that may become cytotoxic to cells. The fundamental microscopic reactions taking place during aggregation, and their rate constants, have been difficult to determine due to lack of suitable methods to identify and follow ...

journal_title：Nature communications

authors： Shammas SL,Garcia GA,Kumar S,Kjaergaard M,Horrocks MH,Shivji N,Mandelkow E,Knowles TP,Mandelkow E,Klenerman D

更新日期：2015-04-30 00:00:00

abstract：:The prokaryotic chemotaxis system is arguably the best-understood signaling pathway in biology. In all previously described species, chemoreceptors organize into a hexagonal (P6 symmetry) extended array. Here, we report an alternative symmetry (P2) of the chemotaxis apparatus that emerges from a strict linear organiza...

journal_title：Nature communications

authors： Muok AR,Ortega DR,Kurniyati K,Yang W,Maschmann ZA,Sidi Mabrouk A,Li C,Crane BR,Briegel A

更新日期：2020-11-13 00:00:00

abstract：:Akin to single-site homogeneous catalysis, a long sought-after goal is to achieve reaction site precision in heterogeneous catalysis for chemical control over patterns of activity, selectivity and stability. Herein, we report on metal phosphides as a class of material capable of realizing these attributes and unlock t...

journal_title：Nature communications

authors： Xu YF,Duchesne PN,Wang L,Tavasoli A,Jelle AA,Xia M,Liao JF,Kuang DB,Ozin GA

更新日期：2020-10-13 00:00:00

abstract：:Choroidal neovascularization (CNV) is a major cause of visual impairment in patients suffering from wet age-related macular degeneration (AMD), particularly when refractory to intraocular anti-VEGF injections. Here we report that treatment with the oral mineralocorticoid receptor (MR) antagonist spironolactone reduces...

journal_title：Nature communications

authors： Zhao M,Mantel I,Gelize E,Li X,Xie X,Arboleda A,Seminel M,Levy-Boukris R,Dernigoghossian M,Prunotto A,Andrieu-Soler C,Rivolta C,Canonica J,Naud MC,Lechner S,Farman N,Bravo-Osuna I,Herrero-Vanrell R,Jaisser F,Behar-Co

更新日期：2019-01-21 00:00:00

abstract：:Iron (Fe) is essential for life, but in excess can cause oxidative cytotoxicity through the generation of Fe-catalyzed reactive oxygen species. It is yet unknown which genes and mechanisms can provide Fe-toxicity tolerance. Here, we identify S-nitrosoglutathione-reductase (GSNOR) variants underlying a major quantitati...

journal_title：Nature communications

authors： Li B,Sun L,Huang J,Göschl C,Shi W,Chory J,Busch W

更新日期：2019-08-29 00:00:00

abstract：:Developing physical models of complex dynamic systems showing emergent behaviour is key to informing on persistence and replication in biology, how living matter emerges from chemistry, and how to design systems with new properties. Herein we report a fully synthetic small molecule system in which a surfactant replica...

journal_title：Nature communications

authors： Colomer I,Morrow SM,Fletcher SP

更新日期：2018-06-08 00:00:00