Non-Darwinian dynamics in therapy-induced cancer drug resistance.

abstract：:Wnt signaling is critical for directing epithelial gland development within the uterine lining to ensure successful gestation in adults. Wnt-dependent, Lgr5-expressing stem/progenitor cells are essential for the development of glandular epithelia in the intestine and stomach, but their existence in the developing repr...

journal_title：Nature communications

authors： Seishima R,Leung C,Yada S,Murad KBA,Tan LT,Hajamohideen A,Tan SH,Itoh H,Murakami K,Ishida Y,Nakamizo S,Yoshikawa Y,Wong E,Barker N

更新日期：2019-11-26 00:00:00

abstract：:Targeted insertion of transgenes at pre-determined plant genomic safe harbors provides a desirable alternative to insertions at random sites achieved through conventional methods. Most existing cases of targeted gene insertion in plants have either relied on the presence of a selectable marker gene in the insertion ca...

journal_title：Nature communications

authors： Dong OX,Yu S,Jain R,Zhang N,Duong PQ,Butler C,Li Y,Lipzen A,Martin JA,Barry KW,Schmutz J,Tian L,Ronald PC

更新日期：2020-03-04 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. ...

journal_title：Nature communications

authors： Trembinski DJ,Bink DI,Theodorou K,Sommer J,Fischer A,van Bergen A,Kuo CC,Costa IG,Schürmann C,Leisegang MS,Brandes RP,Alekseeva T,Brill B,Wietelmann A,Johnson CN,Spring-Connell A,Kaulich M,Werfel S,Engelhardt S,Hirt

更新日期：2020-04-27 00:00:00

abstract：:Oriented assemblies of functional nanoparticles, with the aid of external physical and chemical driving forces, have been prepared on two-dimensional solid substrates. It is challengeable, however, to achieve three-dimensional assembly directly in solution, owing to thermal fluctuations and free diffusion. Here we des...

journal_title：Nature communications

authors： Kim K,Han HS,Choi I,Lee C,Hong S,Suh SH,Lee LP,Kang T

更新日期：2013-01-01 00:00:00

abstract：:All motile organisms use spatially distributed chemical features of their surroundings to guide their behaviors, but the neural mechanisms underlying such behaviors in mammals have been difficult to study, largely due to the technical challenges of controlling chemical concentrations in space and time during behaviora...

journal_title：Nature communications

authors： Radvansky BA,Dombeck DA

更新日期：2018-02-26 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Hermoso-Mendizabal A,Hyafil A,Rueda-Orozco PE,Jaramillo S,Robbe D,de la Rocha J

更新日期：2020-07-07 00:00:00

abstract：:The quantum noise of the vacuum limits the achievable sensitivity of quantum sensors. In non-classical measurement schemes the noise can be reduced to overcome this limitation. However, schemes based on squeezed or Schrödinger cat states require alignment of the relative phase between the measured interaction and the ...

journal_title：Nature communications

authors： Wolf F,Shi C,Heip JC,Gessner M,Pezzè L,Smerzi A,Schulte M,Hammerer K,Schmidt PO

更新日期：2019-07-02 00:00:00

abstract：:Many of the largest known viruses belong to the PRD1-adeno structural lineage characterised by conserved pseudo-hexameric capsomers composed of three copies of a single major capsid protein (MCP). Here, by high-resolution cryo-EM analysis, we show that a class of archaeal viruses possess hetero-hexameric MCPs which mi...

journal_title：Nature communications

authors： De Colibus L,Roine E,Walter TS,Ilca SL,Wang X,Wang N,Roseman AM,Bamford D,Huiskonen JT,Stuart DI

更新日期：2019-03-29 00:00:00

abstract：:Using asymmetric catalysis to simultaneously form carbon-carbon bonds and generate single isomer products is strategically important. Suzuki-Miyaura cross-coupling is widely used in the academic and industrial sectors to synthesize drugs, agrochemicals and biologically active and advanced materials. However, widely ap...

journal_title：Nature communications

authors： Schäfer P,Palacin T,Sidera M,Fletcher SP

更新日期：2017-06-13 00:00:00

abstract：:In vivo liposomes, like other types of nanoparticles, acquire a totally new 'biological identity' due to the formation of a biomolecular coating known as the protein corona that depends on and modifies the liposomes' synthetic identity. The liposome-protein corona is a dynamic interface that regulates the interaction ...

journal_title：Nature communications

authors： Giulimondi F,Digiacomo L,Pozzi D,Palchetti S,Vulpis E,Capriotti AL,Chiozzi RZ,Laganà A,Amenitsch H,Masuelli L,Peruzzi G,Mahmoudi M,Screpanti I,Zingoni A,Caracciolo G

更新日期：2019-08-15 00:00:00

abstract：:At the initial stage of carcinogenesis single mutated cells appear within an epithelium. Mammalian in vitro experiments show that potentially cancerous cells undergo live apical extrusion from normal monolayers. However, the mechanism underlying this process in vivo remains poorly understood. Mosaic expression of the ...

journal_title：Nature communications

authors： Anton KA,Kajita M,Narumi R,Fujita Y,Tada M

更新日期：2018-11-08 00:00:00

abstract：:Optical tracking is often combined with conventional flat panel solar cells to maximize electrical power generation over the course of a day. However, conventional trackers are complex and often require costly and cumbersome structural components to support system weight. Here we use kirigami (the art of paper cutting...

journal_title：Nature communications

authors： Lamoureux A,Lee K,Shlian M,Forrest SR,Shtein M

更新日期：2015-09-08 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Hart Y,Goldberg H,Striem-Amit E,Mayo AE,Noy L,Alon U

更新日期：2020-02-24 00:00:00

abstract：:Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating muscle metabolism, are important to this communication. Here we identify apolipoprotein J (ApoJ) as a novel hepatokine targeting muscle glucose metabolism and insu...

journal_title：Nature communications

authors： Seo JA,Kang MC,Yang WM,Hwang WM,Kim SS,Hong SH,Heo JI,Vijyakumar A,Pereira de Moura L,Uner A,Huang H,Lee SH,Lima IS,Park KS,Kim MS,Dagon Y,Willnow TE,Aroda V,Ciaraldi TP,Henry RR,Kim YB

更新日期：2020-04-24 00:00:00

abstract：:The nutritional environment to which animals are exposed in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life. Here, we demonstrate that the fibroblast growth factor-21 gene (Fgf21) is subject to peroxisome proliferator-activated receptor (PPAR) α-dependent DNA de...

journal_title：Nature communications

authors： Yuan X,Tsujimoto K,Hashimoto K,Kawahori K,Hanzawa N,Hamaguchi M,Seki T,Nawa M,Ehara T,Kitamura Y,Hatada I,Konishi M,Itoh N,Nakagawa Y,Shimano H,Takai-Igarashi T,Kamei Y,Ogawa Y

更新日期：2018-02-12 00:00:00

abstract：:The Spitzenkörper (SPK) constitutes a collection of secretory vesicles and polarity-related proteins intimately associated with polarized growth of fungal hyphae. Many SPK-localized proteins are known, but their assembly and dynamics remain poorly understood. Here, we identify protein-protein interaction cascades lead...

journal_title：Nature communications

authors： Zheng P,Nguyen TA,Wong JY,Lee M,Nguyen TA,Fan JS,Yang D,Jedd G

更新日期：2020-06-05 00:00:00

abstract：:Recently, ferroelectric tunnel junctions have attracted much attention due to their potential applications in non-destructive readout non-volatile memories. Using a semiconductor electrode has been proven effective to enhance the tunnelling electroresistance in ferroelectric tunnel junctions. Here we report a systemat...

journal_title：Nature communications

authors： Xi Z,Ruan J,Li C,Zheng C,Wen Z,Dai J,Li A,Wu D

更新日期：2017-05-17 00:00:00

abstract：:Methanol is a biotechnologically promising substitute for food and feed substrates since it can be produced renewably from electricity, water and CO2. Although progress has been made towards establishing Escherichia coli as a platform organism for methanol conversion via the energy efficient ribulose monophosphate (Ru...

journal_title：Nature communications

authors： Keller P,Noor E,Meyer F,Reiter MA,Anastassov S,Kiefer P,Vorholt JA

更新日期：2020-10-26 00:00:00

abstract：:Recent discovery of the half quantized thermal Hall conductivity in [Formula: see text]-RuCl[Formula: see text], a candidate material for the Kitaev spin liquid, suggests the presence of a highly entangled quantum state in external magnetic fields. This field induced phase appears between the low field zig-zag magneti...

journal_title：Nature communications

authors： Lee HY,Kaneko R,Chern LE,Okubo T,Yamaji Y,Kawashima N,Kim YB

更新日期：2020-04-02 00:00:00

abstract：:Consolidation stabilizes memory traces after initial encoding. Rodent studies suggest that memory consolidation depends on replay of stimulus-specific activity patterns during fast hippocampal "ripple" oscillations. Here, we measured replay in intracranial electroencephalography recordings in human epilepsy patients, ...

journal_title：Nature communications

authors： Zhang H,Fell J,Axmacher N

更新日期：2018-10-05 00:00:00

abstract：:Bacterial vaginosis is a condition associated with adverse reproductive outcomes and characterized by a shift from a Lactobacillus-dominant vaginal microbiota to a polymicrobial microbiota, consistently colonized by strains of Gardnerella vaginalis. Metronidazole is the first-line treatment; however, treatment failure...

journal_title：Nature communications

authors： Lee CY,Cheu RK,Lemke MM,Gustin AT,France MT,Hampel B,Thurman AR,Doncel GF,Ravel J,Klatt NR,Arnold KB

更新日期：2020-12-01 00:00:00

abstract：:Evasion of the host phagocyte response by Staphylococcus aureus is crucial to successful infection with the pathogen. γ-haemolysin AB and CB (HlgAB, HlgCB) are bicomponent pore-forming toxins present in almost all human S. aureus isolates. Cellular tropism and contribution of the toxins to S. aureus pathophysiology ar...

journal_title：Nature communications

authors： Spaan AN,Vrieling M,Wallet P,Badiou C,Reyes-Robles T,Ohneck EA,Benito Y,de Haas CJ,Day CJ,Jennings MP,Lina G,Vandenesch F,van Kessel KP,Torres VJ,van Strijp JA,Henry T

更新日期：2014-11-11 00:00:00

abstract：:The cell cytosol is crowded with high concentrations of many different biomacromolecules, which is difficult to mimic in bottom-up synthetic cell research and limits the functionality of existing protocellular platforms. There is thus a clear need for a general, biocompatible, and accessible tool to more accurately em...

journal_title：Nature communications

authors： Altenburg WJ,Yewdall NA,Vervoort DFM,van Stevendaal MHME,Mason AF,van Hest JCM

更新日期：2020-12-08 00:00:00

abstract：:Insects have presented human society with some of its greatest development challenges by spreading diseases, consuming crops and damaging infrastructure. Despite the massive human and financial toll of invasive insects, cost estimates of their impacts remain sporadic, spatially incomplete and of questionable quality. ...

journal_title：Nature communications

authors： Bradshaw CJ,Leroy B,Bellard C,Roiz D,Albert C,Fournier A,Barbet-Massin M,Salles JM,Simard F,Courchamp F

更新日期：2016-10-04 00:00:00

abstract：:The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes breast cancer cell proliferation, survival, migration and tumour growth. Here we show that, in breast cancer cells, KLF5 is stabilized by the deubiquitinase (DUB) BAP1. With a genome-wide siRNA library screen of DUBs, we identif...

journal_title：Nature communications

authors： Qin J,Zhou Z,Chen W,Wang C,Zhang H,Ge G,Shao M,You D,Fan Z,Xia H,Liu R,Chen C

更新日期：2015-09-30 00:00:00

abstract：:Combining vapour sensors into arrays is an accepted compromise to mitigate poor selectivity of conventional sensors. Here we show individual nanofabricated sensors that not only selectively detect separate vapours in pristine conditions but also quantify these vapours in mixtures, and when blended with a variable mois...

journal_title：Nature communications

authors： Potyrailo RA,Bonam RK,Hartley JG,Starkey TA,Vukusic P,Vasudev M,Bunning T,Naik RR,Tang Z,Palacios MA,Larsen M,Le Tarte LA,Grande JC,Zhong S,Deng T

更新日期：2015-09-01 00:00:00

abstract：:Carbon and hydrogen are fundamental components of organic molecules and a fascinating plethora of functions can be generated using these two elements. Yet, realizing attractive electronic structures only by using carbon and hydrogen remains challenging. Herein, we report the synthesis and properties of the C70 fragmen...

journal_title：Nature communications

authors： Tanaka Y,Fukui N,Shinokubo H

更新日期：2020-08-03 00:00:00

abstract：:Mutations in the gene coding for membrane-bound fatty aldehyde dehydrogenase (FALDH) lead to toxic accumulation of lipid species and development of the Sjögren-Larsson Syndrome (SLS), a rare disorder characterized by skin defects and mental retardation. Here, we present the crystallographic structure of human FALDH, t...

journal_title：Nature communications

authors： Keller MA,Zander U,Fuchs JE,Kreutz C,Watschinger K,Mueller T,Golderer G,Liedl KR,Ralser M,Kräutler B,Werner ER,Marquez JA

更新日期：2014-07-22 00:00:00

abstract：:The ubiquitin proteasome system (UPS) has emerged as a drug target for diverse diseases characterized by altered proteostasis, but pharmacological agents that enhance UPS activity have been challenging to establish. Here we report the Deg-On system, a genetic inverter that translates proteasomal degradation of the tra...

journal_title：Nature communications

authors： Zhao W,Bonem M,McWhite C,Silberg JJ,Segatori L

更新日期：2014-04-08 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Michaelis KA,Norgard MA,Zhu X,Levasseur PR,Sivagnanam S,Liudahl SM,Burfeind KG,Olson B,Pelz KR,Ramos DMA,Maurer HC,Olive KP,Coussens LM,Morgan TK,Marks DL

更新日期：2019-11-15 00:00:00