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Src-transformed cells hijack mitosis to extrude from the epithelium.

Abstract：

:At the initial stage of carcinogenesis single mutated cells appear within an epithelium. Mammalian in vitro experiments show that potentially cancerous cells undergo live apical extrusion from normal monolayers. However, the mechanism underlying this process in vivo remains poorly understood. Mosaic expression of the oncogene vSrc in a simple epithelium of the early zebrafish embryo results in extrusion of transformed cells. Here we find that during extrusion components of the cytokinetic ring are recruited to adherens junctions of transformed cells, forming a misoriented pseudo-cytokinetic ring. As the ring constricts, it separates the basal from the apical part of the cell releasing both from the epithelium. This process requires cell cycle progression and occurs immediately after vSrc-transformed cell enters mitosis. To achieve extrusion, vSrc coordinates cell cycle progression, junctional integrity, cell survival and apicobasal polarity. Without vSrc, modulating these cellular processes reconstitutes vSrc-like extrusion, confirming their sufficiency for this process.

journal_name

Nat Commun

journal_title

Nature communications

authors

Anton KA,Kajita M,Narumi R,Fujita Y,Tada M

doi

10.1038/s41467-018-07163-4

subject

Has Abstract

pub_date

2018-11-08 00:00:00

pages

4695

issue

1

issn

2041-1723

pii

10.1038/s41467-018-07163-4

journal_volume

9

pub_type

杂志文章

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