Abstract:
:In vivo liposomes, like other types of nanoparticles, acquire a totally new 'biological identity' due to the formation of a biomolecular coating known as the protein corona that depends on and modifies the liposomes' synthetic identity. The liposome-protein corona is a dynamic interface that regulates the interaction of liposomes with the physiological environment. Here we show that the biological identity of liposomes is clearly linked to their sequestration from peripheral blood mononuclear cells (PBMCs) of healthy donors that ultimately leads to removal from the bloodstream. Pre-coating liposomes with an artificial corona made of human plasma proteins drastically reduces capture by circulating leukocytes in whole blood and may be an effective strategy to enable prolonged circulation in vivo. We conclude with a critical assessment of the key concepts of liposome technology that need to be reviewed for its definitive clinical translation.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Giulimondi F,Digiacomo L,Pozzi D,Palchetti S,Vulpis E,Capriotti AL,Chiozzi RZ,Laganà A,Amenitsch H,Masuelli L,Peruzzi G,Mahmoudi M,Screpanti I,Zingoni A,Caracciolo Gdoi
10.1038/s41467-019-11642-7subject
Has Abstractpub_date
2019-08-15 00:00:00pages
3686issue
1issn
2041-1723pii
10.1038/s41467-019-11642-7journal_volume
10pub_type
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