Abstract:
:Single spins in the solid state offer a unique opportunity to store and manipulate quantum information, and to perform quantum-enhanced sensing of local fields and charges. Optical control of these systems using techniques developed in atomic physics has yet to exploit all the advantages of the solid state. Here we demonstrate voltage tunability of the spin energy-levels in a single quantum dot by modifying how spins sense magnetic field. We find that the in-plane g-factor varies discontinuously for electrons, as more holes are loaded onto the dot. In contrast, the in-plane hole g-factor varies continuously. The device can change the sign of the in-plane g-factor of a single hole, at which point an avoided crossing is observed in the two spin eigenstates. This is exactly what is required for universal control of a single spin with a single electrical gate.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Bennett AJ,Pooley MA,Cao Y,Sköld N,Farrer I,Ritchie DA,Shields AJdoi
10.1038/ncomms2519subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1522issn
2041-1723pii
ncomms2519journal_volume
4pub_type
杂志文章abstract::Plasma accelerators driven by particle beams are a very promising future accelerator technology as they can sustain high accelerating fields over long distances with high energy efficiency. They rely on the excitation of a plasma wave in the wake of a drive beam. To generate the plasma, a neutral gas can be field-ioni...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11898
更新日期:2016-06-17 00:00:00
abstract::The fusion of genome engineering and adoptive cellular therapy holds immense promise for the treatment of genetic disease and cancer. Multiplex genome engineering using targeted nucleases can be used to increase the efficacy and broaden the application of such therapies but carries safety risks associated with uninten...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13007-6
更新日期:2019-11-19 00:00:00
abstract::How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11444-x
更新日期:2019-08-08 00:00:00
abstract::The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here we show...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11013-2
更新日期:2019-07-24 00:00:00
abstract::Previous studies have demonstrated that aneuploidy in human embryos is surprisingly frequent with 50-80% of cleavage-stage human embryos carrying an abnormal chromosome number. Here we combine non-invasive time-lapse imaging with karyotypic reconstruction of all blastomeres in four-cell human embryos to address the hy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2249
更新日期:2012-01-01 00:00:00
abstract::When immersed into water, most solids develop a surface charge, which is neutralized by an accumulation of dissolved counterions at the interface. Although the density distribution of counterions perpendicular to the interface obeys well-established theories, little is known about counterions' lateral organization at ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5400
更新日期:2014-07-16 00:00:00
abstract::Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accur...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09740-7
更新日期:2019-04-16 00:00:00
abstract::Application of coherent light-matter interactions has recently been extended to the ultrafast control of magnetization. An important but unrealized technique is the manipulation of magnetization vector motion to make it follow an arbitrarily designed multidimensional trajectory. Here we demonstrate a full manipulation...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1366
更新日期:2011-06-21 00:00:00
abstract::Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer. Although the control of Gli transcription factors by SuFu is critical in Hh signalling, our understanding of the mechanism regulating this key e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03339-0
更新日期:2018-03-07 00:00:00
abstract::Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate that the Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), which has been implicated in inflammation, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9995
更新日期:2015-12-21 00:00:00
abstract::Soil bacterial diversity varies across biomes with potential impacts on soil ecological functioning. Here, we incorporate key factors that affect soil bacterial abundance and diversity across spatial scales into a mechanistic modeling framework considering soil type, carbon inputs and climate towards predicting soil b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13966-w
更新日期:2020-01-08 00:00:00
abstract::The diversity of life and its organization in networks of interacting species has been a long-standing theoretical puzzle for ecologists. Ever since May's provocative paper challenging whether 'large complex systems [are] stable' various hypotheses have been proposed to explain when stability should be the rule, not t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12457
更新日期:2016-08-24 00:00:00
abstract::Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for reward and motivation, has been implicated in the pathophysiology of depression; however, the afferent source of this increased glutamate tone is not known. The NAc receives glutamatergic inputs from the medial prefrontal cortex ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8062
更新日期:2015-05-08 00:00:00
abstract::Molecules containing multiple bonds between atoms-most often in the form of olefins-are ubiquitous in nature, commerce, and science, and as such have a huge impact on everyday life. Given their prominence, over the last few decades, frequent attempts have been made to perturb the structure and reactivity of multiply-b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02998-3
更新日期:2018-03-22 00:00:00
abstract::The NLRP3 inflammasome is the most characterized inflammasome activated by cellular infection or stress, which is responsible for the maturation of proinflammatory cytokines IL-1β and IL-18. The precise molecular mechanism for negative regulation of NLRP3 inflammasome activation needs to be further defined. Here we id...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3075
更新日期:2013-01-01 00:00:00
abstract::As a key variance partitioning tool, linear mixed models (LMMs) using genome-based restricted maximum likelihood (GREML) allow both fixed and random effects. Classic LMMs assume independence between random effects, which can be violated, causing bias. Here we introduce a generalized GREML, named CORE GREML, that expli...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18085-5
更新日期:2020-08-21 00:00:00
abstract::The prediction of implant behavior in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. Simulated body fluids (SBFs) have been proposed and widely used to evaluate the bone-bonding ability of implant materials. In view of its limitations, we report here a rapid in vitro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09673-1
更新日期:2019-05-02 00:00:00
abstract::CRISPR/Cas9 has demonstrated a high-efficiency in site-specific gene targeting. However, potential off-target effects of the Cas9 nuclease represent a major safety concern for any therapeutic application. Here, we knock out the Tafazzin gene by CRISPR/Cas9 in human-induced pluripotent stem cells with 54% efficiency. W...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6507
更新日期:2014-11-26 00:00:00
abstract::Quantum dots (QDs) are an excellent single-photon source that can be combined with a spin quantum memory. Many quantum technologies require increased control over the characteristics of emitted photons. A powerful approach is to trigger coherent Raman photons from QDs with a Λ energy-level system, such as the spin sin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02552-7
更新日期:2018-01-09 00:00:00
abstract::IL-17+ CD4+ T (Th17) cells contribute to the pathogenesis of several human inflammatory diseases. Here we demonstrate that TNF inhibitor (TNFi) drugs induce the anti-inflammatory cytokine IL-10 in CD4+ T cells including IL-17+ CD4+ T cells. TNFi-mediated induction of IL-10 in IL-17+ CD4+ T cells is Treg-/Foxp3-indepen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4199
更新日期:2014-01-01 00:00:00
abstract::Cyclin-dependent kinases 4 and 6 (CDK4/6) in complex with D-type cyclins promote cell cycle entry. Most human cancers contain overactive CDK4/6-cyclin D, and CDK4/6-specific inhibitors are promising anti-cancer therapeutics. Here, we investigate the critical functions of CDK4/6-cyclin D kinases, starting from an unbia...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6906
更新日期:2015-01-06 00:00:00
abstract::Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed osteoblastic bone formation is mostly unknown. Here, we show that increased osteoclastic miR-214-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10872
更新日期:2016-03-07 00:00:00
abstract::The 'phonon-glass electron-crystal' concept has triggered most of the progress that has been achieved in inorganic thermoelectrics in the past two decades. Organic thermoelectric materials, unlike their inorganic counterparts, exhibit molecular diversity, flexible mechanical properties and easy fabrication, and are mo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19537-8
更新日期:2020-11-10 00:00:00
abstract::In the original version of this Article, the title of the legend to Fig. 7 incorrectly read 'Knockdown of B55α increases breast cancer metastasis' instead of 'Knockdown of B55α decreases breast cancer metastasis'. This has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-06265-3
更新日期:2018-09-17 00:00:00
abstract::A common analysis of single-cell sequencing data includes clustering of cells and identifying differentially expressed genes (DEGs). How cell clusters are defined has important consequences for downstream analyses and the interpretation of results, but is often not straightforward. To address this difficulty, we prese...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17900-3
更新日期:2020-08-28 00:00:00
abstract::Bryostatin is in clinical trials for Alzheimer's disease, cancer, and HIV/AIDS eradication. It binds to protein kinase C competitively with diacylglycerol, the endogenous protein kinase C regulator, and plant-derived phorbol esters, but each ligand induces different activities. Determination of the structural origin f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-016-0015-8
更新日期:2017-02-23 00:00:00
abstract::Metagenomic sequencing has greatly improved our ability to profile the composition of environmental and host-associated microbial communities. However, the dependency of most methods on reference genomes, which are currently unavailable for a substantial fraction of microbial species, introduces estimation biases. We ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08844-4
更新日期:2019-03-04 00:00:00
abstract::Intramolecular photostabilization via triple-state quenching was recently revived as a tool to impart synthetic organic fluorophores with 'self-healing' properties. To date, utilization of such fluorophore derivatives is rare due to their elaborate multi-step synthesis. Here we present a general strategy to covalently...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10144
更新日期:2016-01-11 00:00:00
abstract::Identification of the optimal quantum metrological protocols in realistic many particle quantum models is in general a challenge that cannot be efficiently addressed by the state-of-the-art numerical and analytical methods. Here we provide a comprehensive framework exploiting matrix product operators (MPO) type tensor...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13735-9
更新日期:2020-01-14 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-13458-x
更新日期:2019-11-26 00:00:00