Abstract:
:In the original version of this Article, the title of the legend to Fig. 7 incorrectly read 'Knockdown of B55α increases breast cancer metastasis' instead of 'Knockdown of B55α decreases breast cancer metastasis'. This has now been corrected in both the PDF and HTML versions of the Article.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Zhang L,Zhou H,Li X,Vartuli RL,Rowse M,Xing Y,Rudra P,Ghosh D,Zhao R,Ford HLdoi
10.1038/s41467-018-06265-3subject
Has Abstractpub_date
2018-09-17 00:00:00pages
3830issue
1issn
2041-1723pii
10.1038/s41467-018-06265-3journal_volume
9pub_type
杂志文章,已发布勘误abstract::The hierarchical relationships between various stem and progenitor cell subpopulations driving mammary gland morphogenesis and homoeostasis are poorly understood. Conditional inactivation experiments previously demonstrated that expression of the zinc finger transcriptional repressor Blimp1/PRDM1 is essential for the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01971-w
更新日期:2017-11-20 00:00:00
abstract::The temperature-jump technique, in which the sample is rapidly heated by a powerful laser pulse, has been widely used to probe the fast dynamics of folding of proteins and nucleic acids. However, the existing temperature-jump setups tend to involve sophisticated and expensive instrumentation, while providing only mode...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6737
更新日期:2014-12-17 00:00:00
abstract::Precise manipulation and control of coherent lattice oscillations via nanostructuring and phonon-wave interference has the potential to significantly impact a broad array of technologies and research areas. Resolving the dynamics of individual phonons in defect-laden materials presents an enormous challenge, however, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11230
更新日期:2016-04-15 00:00:00
abstract::Insight into crumpling or compaction of one-dimensional objects is important for understanding biopolymer packaging and designing innovative technological devices. By compacting various types of wires in rigid confinements and characterizing the morphology of the resulting crumpled structures, here, we report how fric...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15568
更新日期:2017-06-06 00:00:00
abstract::In most applications of nanoporous materials the pore structure is as important as the chemical composition as a determinant of performance. For example, one can alter performance in applications like carbon capture or methane storage by orders of magnitude by only modifying the pore structure. For these applications ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15396
更新日期:2017-05-23 00:00:00
abstract::Single-cell RNA-sequencing (scRNA-Seq) is a compelling approach to directly and simultaneously measure cellular composition and state, which can otherwise only be estimated by applying deconvolution methods to bulk RNA-Seq estimates. However, it has not yet become a widely used tool in population-scale analyses, due t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19365-w
更新日期:2020-10-30 00:00:00
abstract::The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR st...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6383
更新日期:2014-11-21 00:00:00
abstract::High harmonics generated by counter-rotating laser fields at the fundamental and second harmonic frequencies have raised important interest as a table-top source of circularly polarized ultrashort extreme-ultraviolet light. However, this emission has not yet been fully characterized: in particular it was assumed to be...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07151-8
更新日期:2018-11-09 00:00:00
abstract::Semiconductur nano- and micropillars represent a promising platform for hybrid nanodevices. Their ability to couple to a broad variety of nanomechanical, acoustic, charge, spin, excitonic, polaritonic, or electromagnetic excitations is utilized in fields as diverse as force sensing or optoelectronics. In order to full...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13309-9
更新日期:2019-11-20 00:00:00
abstract::Mutant Huntingtin (mtHtt) causes neurodegeneration in Huntington's disease (HD) by evoking defects in the mitochondria, but the underlying mechanisms remains elusive. Our proteomic analysis identifies valosin-containing protein (VCP) as an mtHtt-binding protein on the mitochondria. Here we show that VCP is selectively...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12646
更新日期:2016-08-26 00:00:00
abstract::Farnesoid X receptor (FXR) has important roles in maintaining bile acid and cholesterol homeostasis. Here we report that the antiparasitic drug ivermectin is a ligand for nuclear FXR. We identify ivermectin using a high-throughput compound library screening and show that it induces the transcriptional activity of the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2924
更新日期:2013-01-01 00:00:00
abstract::Although multiphoton-pumped lasing from a solution of chromophores is important in the emerging fields of nonlinear optofluidics and bio-photonics, conventionally used organic dyes are often rendered unsuitable because of relatively small multiphoton absorption cross-sections and low photostability. Here, we demonstra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9513
更新日期:2015-09-30 00:00:00
abstract::Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, electrolyte abnormalities and metabolic waste accumulation- manifesting as acute kidney injury (A...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15638-6
更新日期:2020-04-21 00:00:00
abstract::Current mitigation efforts and existing future commitments are inadequate to accomplish the Paris Agreement temperature goals. In light of this, research and debate are intensifying on the possibilities of additionally employing proposed climate geoengineering technologies, either through atmospheric carbon dioxide re...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-018-05938-3
更新日期:2018-09-13 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-13138-w
更新日期:2019-11-22 00:00:00
abstract::Human estrogen receptor alpha (hERα) is a hormone-responsive nuclear receptor (NR) involved in cell growth and survival that contains both a DNA-binding domain (DBD) and a ligand-binding domain (LBD). Functionally relevant inter-domain interactions between the DBD and LBD have been observed in several other NRs, but f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06034-2
更新日期:2018-08-30 00:00:00
abstract::No method exists to measure large-scale translation of genes in uncultured organisms in microbiomes. To overcome this limitation, we develop MetaRibo-Seq, a method for simultaneous ribosome profiling of tens to hundreds of organisms in microbiome samples. MetaRibo-Seq was benchmarked against gold-standard Ribo-Seq in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17081-z
更新日期:2020-06-29 00:00:00
abstract::Determining nanoscale protein distribution via Photoactivated Localization Microscopy (PALM) mandates precise knowledge of the applied fluorophore's blinking properties to counteract overcounting artifacts that distort the resulting biomolecular distributions. Here, we present a readily applicable methodology to deter...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18726-9
更新日期:2020-10-05 00:00:00
abstract::Microcephaly is a cortical malformation disorder characterized by an abnormally small brain. Recent studies have revealed severe cases of microcephaly resulting from human mutations in the NDE1 gene, which is involved in the regulation of cytoplasmic dynein. Here using in utero electroporation of NDE1 short hairpin RN...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12551
更新日期:2016-08-24 00:00:00
abstract::Thermal conductivity of two-dimensional (2D) materials is of interest for energy storage, nanoelectronics and optoelectronics. Here, we report that the thermal conductivity of molybdenum disulfide can be modified by electrochemical intercalation. We observe distinct behaviour for thin films with vertically aligned bas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13211
更新日期:2016-10-21 00:00:00
abstract::In patients with damage to the primary visual cortex (V1), residual vision can guide goal-directed movements to targets in the blind field without awareness. This phenomenon has been termed blindsight, and its neural mechanisms are controversial. There should be visual pathways to the higher visual cortices bypassing ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08058-0
更新日期:2019-01-11 00:00:00
abstract::Insulin-like growth factor 1 (IGF-1) is a critical regulator of many physiological functions, ranging from longevity to immunity. However, little is known about the role of IGF-1 in natural killer cell development and function. Here, we identify an essential role for IGF-1 in the positive regulation of human natural k...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2484
更新日期:2013-01-01 00:00:00
abstract::Liquid sensors composed of ionic liquids are rising as alternatives to solid semiconductors for flexible and self-healing electronics. However, the fluidic nature may give rise to leakage problems in cases of accidental damages. Here, we proposed a liquid sensor based on a binary ionic liquid system, in which a flowin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08433-5
更新日期:2019-02-01 00:00:00
abstract::The gyrotropic rotation around the equilibrium position constitutes the fundamental excitation of magnetic vortices in nanostructures. The frequency of this mode varies with material and sample geometry, but is independent of the vortex handedness and its core direction. Here, we demonstrate that this degeneracy is li...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7409
更新日期:2015-03-03 00:00:00
abstract::Low-damping magnetic materials have been widely used in microwave and spintronic applications because of their low energy loss and high sensitivity. While the Gilbert damping constant can reach 10-4 to 10-5 in some insulating ferromagnets, metallic ferromagnets generally have larger damping due to magnon scattering by...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00332-x
更新日期:2017-08-10 00:00:00
abstract::Genetic ablation of endothelial focal adhesion kinase (FAK) can inhibit pathological angiogenesis, suggesting that loss of endothelial FAK is sufficient to reduce neovascularization. Here we show that reduced stromal FAK expression in FAK-heterozygous mice unexpectedly enhances both B16F0 and CMT19T tumour growth and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3020
更新日期:2013-01-01 00:00:00
abstract::It has been speculated that the partial pressure of carbon dioxide (pCO2) in shelf waters may lag the rise in atmospheric CO2. Here, we show that this is the case across many shelf regions, implying a tendency for enhanced shelf uptake of atmospheric CO2. This result is based on analysis of long-term trends in the air...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02738-z
更新日期:2018-01-31 00:00:00
abstract::In response to brain injury, microglia rapidly extend processes that isolate lesion sites and protect the brain from further injury. Here we report that microglia carrying a pathogenic mutation in the Parkinson's disease (PD)-associated gene, G2019S-LRRK2 (GS-Tg microglia), show retarded ADP-induced motility and delay...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9255
更新日期:2015-09-14 00:00:00
abstract::Recent efforts to evaluate the contribution of neonicotinoid insecticides to worldwide pollinator declines have focused on honey bees and the chronic levels of exposure experienced when foraging on crops grown from neonicotinoid-treated seeds. However, few studies address non-crop plants as a potential route of pollin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11629
更新日期:2016-05-31 00:00:00
abstract::Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4309
更新日期:2014-01-01 00:00:00