Abstract:
:Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accurate models to predict mass transport within them. In this work, we introduce the complete solutions to mass transport in multipolar microfluidics based on the iterative conformal mapping of 2D advection-diffusion around a simple edge into dipoles and multipolar geometries, revealing a rich landscape of transport modes. The models are validated experimentally with a library of 3D printed devices and found in excellent agreement. Following a theory-guided design approach, we further ideate and fabricate two classes of spatiotemporally reconfigurable multipolar devices that are used for processing surfaces with time-varying reagent streams, and to realize a multistep automated immunoassay. Overall, the results set the foundations for exploring, developing, and applying open-space microfluidic multipoles.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Goyette PA,Boulais É,Normandeau F,Laberge G,Juncker D,Gervais Tdoi
10.1038/s41467-019-09740-7subject
Has Abstractpub_date
2019-04-16 00:00:00pages
1781issue
1issn
2041-1723pii
10.1038/s41467-019-09740-7journal_volume
10pub_type
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