Microfluidic multipoles theory and applications.

abstract：:The ability to suppress unwanted emotional memories is crucial for human mental health. Through consolidation over time, emotional memories often become resistant to change. However, how consolidation impacts the effectiveness of emotional memory suppression is still unknown. Using event-related fMRI while concurrentl...

journal_title：Nature communications

authors： Liu Y,Lin W,Liu C,Luo Y,Wu J,Bayley PJ,Qin S

更新日期：2016-11-29 00:00:00

abstract：:The ~70 km-diameter Yarrabubba impact structure in Western Australia is regarded as among Earth's oldest, but has hitherto lacked precise age constraints. Here we present U-Pb ages for impact-driven shock-recrystallised accessory minerals. Shock-recrystallised monazite yields a precise impact age of 2229 ± 5 Ma, coeva...

journal_title：Nature communications

authors： Erickson TM,Kirkland CL,Timms NE,Cavosie AJ,Davison TM

更新日期：2020-01-21 00:00:00

abstract：:The endoplasmic reticulum-mitochondria encounter structure (ERMES) connects the mitochondrial outer membrane with the ER. Multiple functions have been linked to ERMES, including maintenance of mitochondrial morphology, protein assembly and phospholipid homeostasis. Since the mitochondrial distribution and morphology p...

journal_title：Nature communications

authors： Ellenrieder L,Opaliński Ł,Becker L,Krüger V,Mirus O,Straub SP,Ebell K,Flinner N,Stiller SB,Guiard B,Meisinger C,Wiedemann N,Schleiff E,Wagner R,Pfanner N,Becker T

更新日期：2016-10-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Lee CH,Kang TH,Godon O,Watanabe M,Delidakis G,Gillis CM,Sterlin D,Hardy D,Cogné M,Macdonald LE,Murphy AJ,Tu N,Lee J,McDaniel JR,Makowski E,Tessier PM,Meyer AS,Bruhns P,Georgiou G

更新日期：2019-11-26 00:00:00

abstract：:Optic atrophy 1 (OPA1) is a mitochondrial inner membrane protein that has an important role in mitochondrial fusion and structural integrity. Dysfunctional OPA1 mutations cause atrophy of the optic nerve leading to blindness. Here, we show that OPA1 has an important role in the innate immune system. Using conditional ...

journal_title：Nature communications

authors： Amini P,Stojkov D,Felser A,Jackson CB,Courage C,Schaller A,Gelman L,Soriano ME,Nuoffer JM,Scorrano L,Benarafa C,Yousefi S,Simon HU

更新日期：2018-07-27 00:00:00

abstract：:Despite over a century of interest, the function of zebra stripes has never been examined systematically. Here we match variation in striping of equid species and subspecies to geographic range overlap of environmental variables in multifactor models controlling for phylogeny to simultaneously test the five major expl...

journal_title：Nature communications

authors： Caro T,Izzo A,Reiner RC Jr,Walker H,Stankowich T

更新日期：2014-04-01 00:00:00

abstract：:Adult neural stem cells (NSCs) reside in a specialized microenvironment, the subventricular zone (SVZ), which provides them with unique signaling cues to control their basic properties and prevent their exhaustion. While the signaling mechanisms that regulate NSC lineage progression are well characterized, the molecul...

journal_title：Nature communications

authors： Chavali M,Klingener M,Kokkosis AG,Garkun Y,Felong S,Maffei A,Aguirre A

更新日期：2018-01-02 00:00:00

abstract：:Connection of tubules into larger networks is the key process for the development of circulatory systems. In Drosophila development, tip cells of the tracheal system lead the migration of each branch and connect tubules by adhering to each other and simultaneously changing into a torus-shape. We show that as adhesion ...

journal_title：Nature communications

authors： Kato K,Dong B,Wada H,Tanaka-Matakatsu M,Yagi Y,Hayashi S

更新日期：2016-04-12 00:00:00

abstract：:Optimising the supported modes of atom or ion dispersal onto substrates, to synchronously integrate high reactivity and robust stability in catalytic conversion, is an important yet challenging area of research. Here, theoretical calculations first show that three-coordinated copper (Cu) sites have higher activity tha...

journal_title：Nature communications

authors： Huang C,Dong J,Sun W,Xue Z,Ma J,Zheng L,Liu C,Li X,Zhou K,Qiao X,Song Q,Ma W,Zhang L,Lin Z,Wang T

更新日期：2019-06-25 00:00:00

abstract：:Currently, there is no comprehensive framework to evaluate the evolutionary forces acting on genomic regions associated with human complex traits and contextualize the relationship between evolution and molecular function. Here, we develop an approach to test for signatures of diverse evolutionary forces on trait-asso...

journal_title：Nature communications

authors： LaBella AL,Abraham A,Pichkar Y,Fong SL,Zhang G,Muglia LJ,Abbot P,Rokas A,Capra JA

更新日期：2020-07-24 00:00:00

abstract：:Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptors. Receptors with t...

journal_title：Nature communications

authors： Cai W,Sakaguchi M,Kleinridders A,Gonzalez-Del Pino G,Dreyfuss JM,O'Neill BT,Ramirez AK,Pan H,Winnay JN,Boucher J,Eck MJ,Kahn CR

更新日期：2017-03-27 00:00:00

abstract：:Regulatory T (Treg) cells derived from the thymus (tTreg) and periphery (pTreg) have central and distinct functions in immunosuppression, but mechanisms for the generation and activation of Treg subsets in vivo are unclear. Here, we show that mechanistic target of rapamycin (mTOR) unexpectedly supports the homeostasis...

journal_title：Nature communications

authors： Chapman NM,Zeng H,Nguyen TM,Wang Y,Vogel P,Dhungana Y,Liu X,Neale G,Locasale JW,Chi H

更新日期：2018-05-29 00:00:00

abstract：:The Cas9 endonuclease can be targeted to genomic sequences by programming the sequence of an associated single guide RNA (sgRNA). For unknown reasons, the activity of these Cas9-sgRNA combinations varies widely at different genomic loci and in different cell types. Thus, disrupting genes in polyploid cell lines or whe...

journal_title：Nature communications

authors： Richardson CD,Ray GJ,Bray NL,Corn JE

更新日期：2016-08-17 00:00:00

abstract：:Electric fields can transform materials with respect to their structure and properties, enabling various applications ranging from batteries to spintronics. Recently electrolytic gating, which can generate large electric fields and voltage-driven ion transfer, has been identified as a powerful means to achieve electri...

journal_title：Nature communications

authors： Yi D,Wang Y,van ʼt Erve OMJ,Xu L,Yuan H,Veit MJ,Balakrishnan PP,Choi Y,N'Diaye AT,Shafer P,Arenholz E,Grutter A,Xu H,Yu P,Jonker BT,Suzuki Y

更新日期：2020-02-14 00:00:00

abstract：:Estimates of recent biodiversity change remain inconsistent, debated, and infrequently assessed for their functional implications. Here, we report that spatial scale and type of biodiversity measurement influence evidence of temporal biodiversity change. We show a pervasive scale dependence of temporal trends in taxon...

journal_title：Nature communications

authors： Jarzyna MA,Jetz W

更新日期：2018-07-02 00:00:00

abstract：:Eastern Beringia is one of the few Western Arctic regions where full Holocene climate reconstructions are possible. However, most full Holocene reconstructions in Eastern Beringia are based either on pollen or midges, which show conflicting early Holocene summer temperature histories. This discrepancy precludes unders...

journal_title：Nature communications

authors： Porter TJ,Schoenemann SW,Davies LJ,Steig EJ,Bandara S,Froese DG

更新日期：2019-04-09 00:00:00

abstract：:Six CO2 fixation pathways are known to operate in photoautotrophic and chemoautotrophic microorganisms. Here, we describe chemolithoautotrophic growth of the sulphate-reducing bacterium Desulfovibrio desulfuricans (strain G11) with hydrogen and sulphate as energy substrates. Genomic, transcriptomic, proteomic and meta...

journal_title：Nature communications

authors： Sánchez-Andrea I,Guedes IA,Hornung B,Boeren S,Lawson CE,Sousa DZ,Bar-Even A,Claassens NJ,Stams AJM

更新日期：2020-10-09 00:00:00

abstract：:Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understandin...

journal_title：Nature communications

authors： Zhu Z,Zhang S,Liu H,Shen H,Lin X,Yang F,Zhou YJ,Jin G,Ye M,Zou H,Zhao ZK

更新日期：2012-01-01 00:00:00

abstract：:Selected groups of peptides, including those that are presented by major histocompatibility complex (MHC) proteins, have been proposed to transmit information to the olfactory system of vertebrates via their ability to stimulate chemosensory neurons. However, the lack of knowledge about such peptides in natural source...

journal_title：Nature communications

authors： Sturm T,Leinders-Zufall T,Maček B,Walzer M,Jung S,Pömmerl B,Stevanović S,Zufall F,Overath P,Rammensee HG

更新日期：2013-01-01 00:00:00

abstract：:Hybrid organic-inorganic perovskites have attractive optoelectronic properties including exceptional solar cell performance. The improved properties of perovskites have been attributed to polaronic effects involving stabilization of localized charge character by structural deformations and polarizations. Here we exami...

journal_title：Nature communications

authors： Park M,Neukirch AJ,Reyes-Lillo SE,Lai M,Ellis SR,Dietze D,Neaton JB,Yang P,Tretiak S,Mathies RA

更新日期：2018-06-28 00:00:00

abstract：:Symmetry-breaking phase transitions are an example of non-equilibrium processes that require real-time treatment, a major challenge in strongly coupled systems without long-lived quasiparticles. Holographic duality provides such an approach by mapping strongly coupled field theories in D dimensions into weakly coupled...

journal_title：Nature communications

authors： Sonner J,Del Campo A,Zurek WH

更新日期：2015-06-23 00:00:00

abstract：:Synthetic lethality is a promising concept in cancer research, potentially opening new possibilities for the development of more effective and selective treatments. Here, we present a computational method to predict and exploit synthetic lethality in cancer metabolism. Our approach relies on the concept of genetic min...

journal_title：Nature communications

authors： Apaolaza I,San José-Eneriz E,Tobalina L,Miranda E,Garate L,Agirre X,Prósper F,Planes FJ

更新日期：2017-09-06 00:00:00

abstract：:Our ability to uncover complex network structure and dynamics from data is fundamental to understanding and controlling collective dynamics in complex systems. Despite recent progress in this area, reconstructing networks with stochastic dynamical processes from limited time series remains to be an outstanding problem...

journal_title：Nature communications

authors： Shen Z,Wang WX,Fan Y,Di Z,Lai YC

更新日期：2014-07-11 00:00:00

abstract：:Rhinovirus (RV) infections are major triggers of acute exacerbations of severe respiratory diseases such as pre-school wheeze, asthma and chronic obstructive pulmonary disease (COPD). The occurrence of numerous RV types is a major challenge for the identification of the culprit virus types and for the improvement of v...

journal_title：Nature communications

authors： Niespodziana K,Stenberg-Hammar K,Megremis S,Cabauatan CR,Napora-Wijata K,Vacal PC,Gallerano D,Lupinek C,Ebner D,Schlederer T,Harwanegg C,Söderhäll C,van Hage M,Hedlin G,Papadopoulos NG,Valenta R

更新日期：2018-06-18 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion conformation has been described. Here we report alternative strategies ...

journal_title：Nature communications

authors： Krarup A,Truan D,Furmanova-Hollenstein P,Bogaert L,Bouchier P,Bisschop IJM,Widjojoatmodjo MN,Zahn R,Schuitemaker H,McLellan JS,Langedijk JPM

更新日期：2015-09-03 00:00:00

abstract：:Standard units of measurement are required for the quantitative description of nature; however, few standard units have been established for genomics to date. Here, we have developed a synthetic DNA ladder that defines a quantitative standard unit that can measure DNA sequence abundance within a next-generation sequen...

journal_title：Nature communications

authors： Reis ALM,Deveson IW,Wong T,Madala BS,Barker C,Blackburn J,Marcellin E,Mercer TR

更新日期：2020-07-17 00:00:00

abstract：:Human mesenchymal stromal cells (hMSCs) are a promising source for engineered cell-based therapies in which genetic engineering could enhance therapeutic efficacy and install novel cellular functions. Here, we describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutagenesis and integrat...

journal_title：Nature communications

authors： Srifa W,Kosaric N,Amorin A,Jadi O,Park Y,Mantri S,Camarena J,Gurtner GC,Porteus M

更新日期：2020-05-18 00:00:00

abstract：:Hydrogen spillover phenomenon is well-documented in hydrogenation catalysis but still highly disputed in hydrogen storage. Until now, the existence of hydrogen spillover through metal-organic frameworks (MOFs) remains a topic of ongoing debate and how far the split hydrogen atoms diffuse in such materials is unknown. ...

journal_title：Nature communications

authors： Zhan G,Zeng HC

更新日期：2018-09-17 00:00:00

abstract：:In humans, males have lower recombination rates than females over the majority of the genome, but the opposite is usually true near the telomeres. These broad-scale differences have been known for decades, yet little is known about differences at the fine scale. By combining data sets, we have collected recombination ...

journal_title：Nature communications

authors： Bhérer C,Campbell CL,Auton A

更新日期：2017-04-25 00:00:00

abstract：:The formation of the HIV-1 core is the final step in the viral maturation pathway, resulting in the formation of infectious virus. Most current models for HIV-1 core formation suggest that, upon proteolytic cleavage from the immature Gag, capsid (CA) dissociates into the viral interior before reforming into the core. ...

journal_title：Nature communications

authors： Frank GA,Narayan K,Bess JW Jr,Del Prete GQ,Wu X,Moran A,Hartnell LM,Earl LA,Lifson JD,Subramaniam S

更新日期：2015-01-08 00:00:00