Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles.

abstract：:Numerous examples of biosynthetic gene clusters (BGCs), including for compounds of agricultural and medicinal importance, have now been discovered in plant genomes. However, little is known about how these complex traits are assembled and diversified. Here, we examine a large number of variants within and between spec...

journal_title：Nature communications

authors： Liu Z,Cheema J,Vigouroux M,Hill L,Reed J,Paajanen P,Yant L,Osbourn A

更新日期：2020-10-23 00:00:00

abstract：:Increasing incidence of inflammatory bowel disorders demands a better understanding of the molecular mechanisms underlying its multifactorial aetiology. Here we demonstrate that mice deficient for REGγ, a proteasome activator, show significantly attenuated intestinal inflammation and colitis-associated cancer in dextr...

journal_title：Nature communications

authors： Xu J,Zhou L,Ji L,Chen F,Fortmann K,Zhang K,Liu Q,Li K,Wang W,Wang H,Xie W,Wang Q,Liu J,Zheng B,Zhang P,Huang S,Shi T,Zhang B,Dang Y,Chen J,O'Malley BW,Moses RE,Wang P,Li L,Xiao J,Hoffmann A,Li X

更新日期：2016-02-22 00:00:00

abstract：:Scleractinian corals' microbial symbionts influence host health, yet how coral microbiomes assembled over evolution is not well understood. We survey bacterial and archaeal communities in phylogenetically diverse Australian corals representing more than 425 million years of diversification. We show that coral microbio...

journal_title：Nature communications

authors： Pollock FJ,McMinds R,Smith S,Bourne DG,Willis BL,Medina M,Thurber RV,Zaneveld JR

更新日期：2018-11-22 00:00:00

abstract：:A superconducting state is characterized by the gap in the electronic density of states, which vanishes at the superconducting transition temperature T(c). It was discovered that in high-temperature superconductors, a noticeable depression in the density of states, the pseudogap, still remains even at temperatures abo...

journal_title：Nature communications

authors： Sacépé B,Chapelier C,Baturina TI,Vinokur VM,Baklanov MR,Sanquer M

更新日期：2010-01-01 00:00:00

abstract：:RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated RNA silencing regulates both intrinsic energy production and consumption and di...

journal_title：Nature communications

authors： Zhang C,Seo J,Murakami K,Salem ESB,Bernhard E,Borra VJ,Choi K,Yuan CL,Chan CC,Chen X,Huang T,Weirauch MT,Divanovic S,Qi NR,Thomas HE,Mercer CA,Siomi H,Nakamura T

更新日期：2018-09-10 00:00:00

abstract：:Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. Despite these well-established roles, such information has yet to be exploited for drug design. Here we show by nuclear magnetic resonance spectroscopy that inhibito...

journal_title：Nature communications

authors： Lee CJ,Liang X,Wu Q,Najeeb J,Zhao J,Gopalaswamy R,Titecat M,Sebbane F,Lemaitre N,Toone EJ,Zhou P

更新日期：2016-02-25 00:00:00

abstract：:A major conundrum in climate science is how to account for dependence between climate models. This complicates interpretation of probabilistic projections derived from such models. Here we show that this problem can be addressed using a novel method to test multiple non-exclusive hypotheses, and to make predictions un...

journal_title：Nature communications

authors： Olson R,An SI,Fan Y,Chang W,Evans JP,Lee JY

更新日期：2019-07-09 00:00:00

abstract：:Marine reserves are viewed as flagship tools to protect exploited species and to contribute to the effective management of coastal fisheries. Yet, the extent to which marine reserves are globally interconnected and able to effectively seed areas, where fisheries are most critical for food and livelihood security is la...

journal_title：Nature communications

authors： Andrello M,Guilhaumon F,Albouy C,Parravicini V,Scholtens J,Verley P,Barange M,Sumaila UR,Manel S,Mouillot D

更新日期：2017-07-10 00:00:00

abstract：:Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). RORγt, the key Thelper17 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including invariant natural killer T (iNKT) and γδ-T cells, but their contributio...

journal_title：Nature communications

authors： Venken K,Jacques P,Mortier C,Labadia ME,Decruy T,Coudenys J,Hoyt K,Wayne AL,Hughes R,Turner M,Van Gassen S,Martens L,Smith D,Harcken C,Wahle J,Wang CT,Verheugen E,Schryvers N,Varkas G,Cypers H,Wittoek R,Piette Y

更新日期：2019-01-02 00:00:00

abstract：:Many bacteria can exchange genetic material through horizontal gene transfer (HGT) mediated by plasmids and plasmid-borne transposable elements. Here, we study the population structure and dynamics of over 10,000 bacterial plasmids, by quantifying their genetic similarities and reconstructing a network based on their ...

journal_title：Nature communications

authors： Acman M,van Dorp L,Santini JM,Balloux F

更新日期：2020-05-15 00:00:00

abstract：:Identification of the complete set of translated genes of viruses is important to understand viral replication and pathogenesis as well as for therapeutic approaches to control viral infection. Here, we use chemical proteomics, integrating bio-orthogonal non-canonical amino acid tagging and high-resolution mass spectr...

journal_title：Nature communications

authors： Kato A,Adachi S,Kawano S,Takeshima K,Watanabe M,Kitazume S,Sato R,Kusano H,Koyanagi N,Maruzuru Y,Arii J,Hatta T,Natsume T,Kawaguchi Y

更新日期：2020-09-29 00:00:00

abstract：:Nonlinear spectroscopies are utilized extensively for selective measurements of chemical dynamics in the optical, infrared, and radio-frequency regimes. The development of these techniques for extreme ultraviolet (XUV) light sources facilitates measurements of electronic dynamics on attosecond timescales. Here, we elu...

journal_title：Nature communications

authors： Fidler AP,Camp SJ,Warrick ER,Bloch E,Marroux HJB,Neumark DM,Schafer KJ,Gaarde MB,Leone SR

更新日期：2019-03-27 00:00:00

abstract：:Marine particles transport organic matter through the water column to the sediment where the organic matter can be buried. This pathway is one of the few natural removal mechanisms of CO2 from the atmosphere over geological time. Picophytoplankton, major primary producers in the ocean, have until recently been thought...

journal_title：Nature communications

authors： Tang T,Kisslinger K,Lee C

更新日期：2014-06-12 00:00:00

abstract：:The degradation of intrinsic properties of graphene during the transfer process constitutes a major challenge in graphene device fabrication, stimulating the need for direct growth of graphene on dielectric substrates. Previous attempts of metal-induced transformation of diamond and silicon carbide into graphene suffe...

journal_title：Nature communications

authors： Berman D,Deshmukh SA,Narayanan B,Sankaranarayanan SK,Yan Z,Balandin AA,Zinovev A,Rosenmann D,Sumant AV

更新日期：2016-07-04 00:00:00

abstract：:Upgrading C1 chemicals (for example, CO, CO/H2, MeOH and CO2) with C-C bond formation is essential for the synthesis of bulk chemicals. In general, these industrially important processes (for example, Fischer Tropsch) proceed at drastic reaction conditions (>250 °C; high pressure) and suffer from low selectivity, whic...

journal_title：Nature communications

authors： Dong K,Elangovan S,Sang R,Spannenberg A,Jackstell R,Junge K,Li Y,Beller M

更新日期：2016-07-05 00:00:00

abstract：:The extraction of a clear and simple footprint of the structure of large, weighted and directed networks is a general problem that has relevance for many applications. An important example is seen in origin-destination matrices, which contain the complete information on commuting flows, but are difficult to analyze an...

journal_title：Nature communications

authors： Louail T,Lenormand M,Picornell M,García Cantú O,Herranz R,Frias-Martinez E,Ramasco JJ,Barthelemy M

更新日期：2015-01-21 00:00:00

abstract：:Frequency tuning within the auditory papilla of most non-mammalian species is electrical, deriving from ion-channel resonance within their sensory hair cells. In contrast, tuning within the mammalian cochlea is mechanical, stemming from active mechanisms within outer hair cells that amplify the basilar membrane travel...

journal_title：Nature communications

authors： Xia A,Liu X,Raphael PD,Applegate BE,Oghalai JS

更新日期：2016-10-31 00:00:00

abstract：:The dominant dipolar component of the Earth's magnetic field has been steadily weakening for at least the last 170 years. Prior to these direct measurements, archaeomagnetic records show short periods of significantly elevated geomagnetic intensity. These striking phenomena are not captured by current field models and...

journal_title：Nature communications

authors： de Groot LV,Biggin AJ,Dekkers MJ,Langereis CG,Herrero-Bervera E

更新日期：2013-01-01 00:00:00

abstract：:Owing to their pathogenical role and unique ability to exist both as soluble proteins and transmembrane complexes, pore-forming toxins (PFTs) have been a focus of microbiologists and structural biologists for decades. PFTs are generally secreted as water-soluble monomers and subsequently bind the membrane of target ce...

journal_title：Nature communications

authors： Iacovache I,De Carlo S,Cirauqui N,Dal Peraro M,van der Goot FG,Zuber B

更新日期：2016-07-13 00:00:00

abstract：:Majority of disease-modifying therapeutic targets are restricted to the intracellular space and are therefore not druggable using existing biologic modalities. The ability to efficiently deliver macromolecules inside target cells or tissues would greatly expand the current landscape of therapeutic targets for future g...

journal_title：Nature communications

authors： Wang Q,Yu J,Kadungure T,Beyene J,Zhang H,Lu Q

更新日期：2018-03-06 00:00:00

abstract：:Whispering-gallery-mode resonators have been extensively used in conjunction with different materials for the development of a variety of photonic devices. Among the latter, hybrid structures, consisting of dielectric microspheres and colloidal core/shell semiconductor nanocrystals as gain media, have attracted intere...

journal_title：Nature communications

authors： Grivas C,Li C,Andreakou P,Wang P,Ding M,Brambilla G,Manna L,Lagoudakis P

更新日期：2013-01-01 00:00:00

abstract：:The change of global-mean precipitation under global warming and interannual variability is predominantly controlled by the change of atmospheric longwave radiative cooling. Here we show that tightening of the ascending branch of the Hadley Circulation coupled with a decrease in tropical high cloud fraction is key in ...

journal_title：Nature communications

authors： Su H,Jiang JH,Neelin JD,Shen TJ,Zhai C,Yue Q,Wang Z,Huang L,Choi YS,Stephens GL,Yung YL

更新日期：2017-06-07 00:00:00

abstract：:Because maintenance of non-scalable cellular components--membranes and chromosomes--requires an increasing fraction of energy as cell size decreases, miniaturization comes at a considerable energetic cost for a phytoplanktonic cell. Consequently, if eukaryotes can use their superior energetic resources to acquire nutr...

journal_title：Nature communications

authors： Zubkov MV

更新日期：2014-04-29 00:00:00

abstract：:Crystallization by particle attachment is impacting our understanding of natural mineralization processes and holds promise for novel materials design. When particles assemble in crystallographic alignment, expulsion of the intervening solvent and particle coalescence are enabled by near-perfect co-alignment via inter...

journal_title：Nature communications

authors： Zhang X,Shen Z,Liu J,Kerisit SN,Bowden ME,Sushko ML,De Yoreo JJ,Rosso KM

更新日期：2017-10-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Ma X,Liang H,Cui X,Liu Y,Lu H,Ning W,Poon NY,Ho B,Zhou K

更新日期：2019-08-21 00:00:00

abstract：:Although environmental selection and spatial separation have been shown to shape the distribution and abundance of marine microorganisms, the effects of advection (physical transport) have not been directly tested. Here we examine 25 samples covering all major water masses of the Southern Ocean to determine the effect...

journal_title：Nature communications

authors： Wilkins D,van Sebille E,Rintoul SR,Lauro FM,Cavicchioli R

更新日期：2013-01-01 00:00:00

abstract：:Glucagon promotes hepatic gluconeogenesis and maintains whole-body glucose levels during fasting. The regulatory factors that are involved in fasting glucagon response are not well understood. Here we report a role of p52, a key activator of the noncanonical nuclear factor-kappaB signaling, in hepatic glucagon respons...

journal_title：Nature communications

authors： Zhang WS,Pan A,Zhang X,Ying A,Ma G,Liu BL,Qi LW,Liu Q,Li P

更新日期：2019-09-20 00:00:00

abstract：:DNA strands of well-defined sequence are valuable in synthetic biology and nanostructure assembly. Drawing inspiration from solid-phase synthesis, here we describe a DNA assembly method that uses time, or order of addition, as a parameter to define structural complexity. DNA building blocks are sequentially added with...

journal_title：Nature communications

authors： Hamblin GD,Rahbani JF,Sleiman HF

更新日期：2015-05-05 00:00:00

abstract：:The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to the structural and functional complexity of the heart. It is unclear whether newly generated myocytes originate from cardiac stem/progenitor cells or from pre-existing cardiomyocytes that re-enter the cell cycle. Here, we...

journal_title：Nature communications

authors： Sereti KI,Nguyen NB,Kamran P,Zhao P,Ranjbarvaziri S,Park S,Sabri S,Engel JL,Sung K,Kulkarni RP,Ding Y,Hsiai TK,Plath K,Ernst J,Sahoo D,Mikkola HKA,Iruela-Arispe ML,Ardehali R

更新日期：2018-02-21 00:00:00

abstract：:Understanding human mobility is crucial for applications such as forecasting epidemic spreading, planning transport infrastructure and urbanism in general. While, traditionally, mobility information has been collected via surveys, the pervasive adoption of mobile technologies has brought a wealth of (real time) data. ...

journal_title：Nature communications

authors： Mazzoli M,Molas A,Bassolas A,Lenormand M,Colet P,Ramasco JJ

更新日期：2019-08-29 00:00:00