Efficient direct solar-to-hydrogen conversion by in situ interface transformation of a tandem structure.

abstract：:Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant Zeb1 expression. Here, we show that Zeb1 depletion suppresses stemne...

journal_title：Nature communications

authors： Jiang H,Zhou C,Zhang Z,Wang Q,Wei H,Shi W,Li J,Wang Z,Ou Y,Wang W,Wang H,Zhang Q,Sun W,Sun P,Yang S

更新日期：2020-10-12 00:00:00

abstract：:The Middle Eocene Climatic Optimum (MECO) represents a ~500-kyr period of global warming ~40 million years ago and is associated with a rise in atmospheric CO2 concentrations, but the cause of this CO2 rise remains enigmatic. Here we show, based on osmium isotope ratios (187Os/188Os) of marine sediments and published ...

journal_title：Nature communications

authors： van der Ploeg R,Selby D,Cramwinckel MJ,Li Y,Bohaty SM,Middelburg JJ,Sluijs A

更新日期：2018-07-23 00:00:00

abstract：:CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of this neural circuit co...

journal_title：Nature communications

authors： Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC

更新日期：2016-02-04 00:00:00

abstract：:Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell subset, with a unique expression profile including chemokine receptors consistent with migration to target tissues, is expanded in SLE patients,...

journal_title：Nature communications

authors： Wang S,Wang J,Kumar V,Karnell JL,Naiman B,Gross PS,Rahman S,Zerrouki K,Hanna R,Morehouse C,Holoweckyj N,Liu H,Autoimmunity Molecular Medicine Team.,Manna Z,Goldbach-Mansky R,Hasni S,Siegel R,Sanjuan M,Streicher K,Ca

更新日期：2018-05-01 00:00:00

abstract：:Innovations in soft material synthesis and fabrication technologies have led to the development of integrated soft electronic devices. Such soft devices offer opportunities to interact with biological cells, mimicking their soft environment. However, existing fabrication technologies cannot create the submicron-scale,...

journal_title：Nature communications

authors： Kim MG,Brown DK,Brand O

更新日期：2020-02-21 00:00:00

abstract：:Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. ...

journal_title：Nature communications

authors： Garcia-Gomez A,Li T,de la Calle-Fabregat C,Rodríguez-Ubreva J,Ciudad L,Català-Moll F,Godoy-Tena G,Martín-Sánchez M,San-Segundo L,Muntión S,Morales X,Ortiz-de-Solórzano C,Oyarzabal J,San José-Enériz E,Esteller M,Agirre X,P

更新日期：2021-01-18 00:00:00

abstract：:Expansion of Hevea brasiliensis rubber plantations is a resurgent driver of deforestation, carbon emissions, and biodiversity loss in Southeast Asia. Southeast Asian rubber extent is massive, equivalent to 67% of oil palm, with rapid further expansion predicted. Results-based carbon finance could dis-incentivise fores...

journal_title：Nature communications

authors： Warren-Thomas EM,Edwards DP,Bebber DP,Chhang P,Diment AN,Evans TD,Lambrick FH,Maxwell JF,Nut M,O'Kelly HJ,Theilade I,Dolman PM

更新日期：2018-03-02 00:00:00

abstract：:The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine essential for the virulence of many disease causing Gram-negative bacteria. At the core of the injectisome structure is the needle complex, a continuous channel formed by the highly oligomerized inner and outer membrane hollow rin...

journal_title：Nature communications

authors： Hu J,Worrall LJ,Hong C,Vuckovic M,Atkinson CE,Caveney N,Yu Z,Strynadka NCJ

更新日期：2018-09-21 00:00:00

abstract：:Dopamine regulates reward, cognition, and locomotor functions. By mediating rapid reuptake of extracellular dopamine, the dopamine transporter is critical for spatiotemporal control of dopaminergic neurotransmission. Here, we use super-resolution imaging to show that the dopamine transporter is dynamically sequestrate...

journal_title：Nature communications

authors： Rahbek-Clemmensen T,Lycas MD,Erlendsson S,Eriksen J,Apuschkin M,Vilhardt F,Jørgensen TN,Hansen FH,Gether U

更新日期：2017-09-29 00:00:00

abstract：:Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection with E. coli suppress...

journal_title：Nature communications

authors： Straub T,Freudenberg MA,Schleicher U,Bogdan C,Gasteiger G,Pircher H

更新日期：2018-10-08 00:00:00

abstract：:We show how the kinetics of a fast and irreversible chemical reaction in a nanocrystalline material at high temperature can be studied using nanosecond electron pulses in an electron microscope. Infrared laser pulses first heat a nanocrystalline oxide layer on a carbon film, then single nanosecond electron pulses allo...

journal_title：Nature communications

authors： Sinha SK,Khammari A,Picher M,Roulland F,Viart N,LaGrange T,Banhart F

更新日期：2019-08-13 00:00:00

abstract：:The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy req...

journal_title：Nature communications

authors： Rothe S,Andreyev AN,Antalic S,Borschevsky A,Capponi L,Cocolios TE,De Witte H,Eliav E,Fedorov DV,Fedosseev VN,Fink DA,Fritzsche S,Ghys L,Huyse M,Imai N,Kaldor U,Kudryavtsev Y,Köster U,Lane JF,Lassen J,Liberati V,

更新日期：2013-01-01 00:00:00

abstract：:The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 strains in animal models. However, NAb responses are relatively weak and narrow in specificity. Displaying antigens in a multivalent fashion on n...

journal_title：Nature communications

authors： Brouwer PJM,Antanasijevic A,Berndsen Z,Yasmeen A,Fiala B,Bijl TPL,Bontjer I,Bale JB,Sheffler W,Allen JD,Schorcht A,Burger JA,Camacho M,Ellis D,Cottrell CA,Behrens AJ,Catalano M,Del Moral-Sánchez I,Ketas TJ,LaBranche

更新日期：2019-09-19 00:00:00

abstract：:Tyrosine sulfation, a well-characterized post-translation modification in eukaryotes, has not previously been reported in prokaryotes. Here, we demonstrate that the RaxST protein from the Gram-negative bacterium, Xanthomonas oryzae pv. oryzae, is a tyrosine sulfotransferase. We used a newly developed sulfotransferase ...

journal_title：Nature communications

authors： Han SW,Lee SW,Bahar O,Schwessinger B,Robinson MR,Shaw JB,Madsen JA,Brodbelt JS,Ronald PC

更新日期：2012-01-01 00:00:00

abstract：:Pseudo-topotactic conversion of carbon nanotubes into one-dimensional carbon nanowires is a challenging but feasible path to obtain desired diameters and morphologies. Here, a previously predicted but experimentally unobserved carbon allotrope, T-carbon, has been produced from pseudo-topotactic conversion of a multi-w...

journal_title：Nature communications

authors： Zhang J,Wang R,Zhu X,Pan A,Han C,Li X,Dan Zhao,Ma C,Wang W,Su H,Niu C

更新日期：2017-09-25 00:00:00

abstract：:Van der Waals materials exhibit intriguing structural, electronic, and photonic properties. Electron energy loss spectroscopy within scanning transmission electron microscopy allows for nanoscale mapping of such properties. However, its detection is typically limited to energy losses in the eV range-too large for prob...

journal_title：Nature communications

authors： Govyadinov AA,Konečná A,Chuvilin A,Vélez S,Dolado I,Nikitin AY,Lopatin S,Casanova F,Hueso LE,Aizpurua J,Hillenbrand R

更新日期：2017-07-21 00:00:00

abstract：:Although a hydrophobic microtexture at a solid surface most often reflects rain owing to the presence of entrapped air within the texture, it is much more challenging to repel hot water. As it contacts a colder material, hot water generates condensation within the cavities at the solid surface, which eventually builds...

journal_title：Nature communications

authors： Mouterde T,Lecointre P,Lehoucq G,Checco A,Clanet C,Quéré D

更新日期：2019-03-29 00:00:00

abstract：:Thymocyte-expressed, positive selection-associated 1 (Tespa1) is important in T cell receptor (TCR)-driven thymocyte development. Downstream of the TCR, Tespa1 is a crucial component of the linker for activation of T cells (LAT) signalosome, facilitating calcium signalling and subsequent MAPK activation. However, it i...

journal_title：Nature communications

authors： Liang J,Lyu J,Zhao M,Li D,Zheng M,Fang Y,Zhao F,Lou J,Guo C,Wang L,Wang D,Liu W,Lu L

更新日期：2017-06-09 00:00:00

abstract：:One of the hallmark experiments of quantum transport is the observation of the quantized resistance in a point contact in GaAs/AlGaAs heterostructures. Being formed with split gate technology, these structures represent in an ideal manner equilibrium reservoirs which are connected only through a few electron mode chan...

journal_title：Nature communications

authors： Thierschmann H,Mulazimoglu E,Manca N,Goswami S,Klapwijk TM,Caviglia AD

更新日期：2018-06-11 00:00:00

abstract：:In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation of cone function is a major therapeutic goal. However, cone loss is thought to occur as a secondary event resulting from degeneration of rod photoreceptors. Here we report a genome editing approach in which adeno-associated virus...

journal_title：Nature communications

authors： Yu W,Mookherjee S,Chaitankar V,Hiriyanna S,Kim JW,Brooks M,Ataeijannati Y,Sun X,Dong L,Li T,Swaroop A,Wu Z

更新日期：2017-03-14 00:00:00

abstract：:Recent developments in stem cell biology have enabled the study of cell fate decisions in early human development that are impossible to study in vivo. However, understanding how development varies across individuals and, in particular, the influence of common genetic variants during this process has not been characte...

journal_title：Nature communications

authors： Cuomo ASE,Seaton DD,McCarthy DJ,Martinez I,Bonder MJ,Garcia-Bernardo J,Amatya S,Madrigal P,Isaacson A,Buettner F,Knights A,Natarajan KN,HipSci Consortium.,Vallier L,Marioni JC,Chhatriwala M,Stegle O

更新日期：2020-02-10 00:00:00

abstract：:Seismological findings show a complex scenario of plume upwellings from a deep thermo-chemical anomaly (superplume) beneath the East African Rift System (EARS). It is unclear if these geophysical observations represent a true picture of the superplume and its influence on magmatism along the EARS. Thus, it is essentia...

journal_title：Nature communications

authors： O'Connor JM,Jokat W,Regelous M,Kuiper KF,Miggins DP,Koppers AAP

更新日期：2019-12-02 00:00:00

abstract：:The continued development of novel drugs, proteins, and advanced materials strongly rely on our ability to self-assemble molecules in solids with the most suitable structure (polymorph) in order to exhibit desired functionalities. The search for new polymorphs remains a scientific challenge, that is at the core of cry...

journal_title：Nature communications

authors： Potticary J,Terry LR,Bell C,Papanikolopoulos AN,Christianen PC,Engelkamp H,Collins AM,Fontanesi C,Kociok-Köhn G,Crampin S,Da Como E,Hall SR

更新日期：2016-05-10 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome that elevates the risk of hepatocellular carcinoma (HCC). Although alteration of lipid metabolism has been increasingly recognized as a hallmark of cancer cells, the deregulated metabolic modulation of HCC cells in the NAF...

journal_title：Nature communications

authors： Tian Y,Yang B,Qiu W,Hao Y,Zhang Z,Yang B,Li N,Cheng S,Lin Z,Rui YC,Cheung OKW,Yang W,Wu WKK,Cheung YS,Lai PBS,Luo J,Sung JJY,Chen R,Wang HY,Cheng ASL,Yang P

更新日期：2019-07-29 00:00:00

abstract：:Disassembly of apoptotic cells into smaller fragments (a form of extracellular vesicle called apoptotic bodies) can facilitate removal of apoptotic debris and intercellular communication. However, the mechanism underpinning this process is unclear. While observing monocytes undergoing apoptosis by time-lapse microscop...

journal_title：Nature communications

authors： Atkin-Smith GK,Tixeira R,Paone S,Mathivanan S,Collins C,Liem M,Goodall KJ,Ravichandran KS,Hulett MD,Poon IK

更新日期：2015-06-15 00:00:00

abstract：:Organic conjugated polymers demonstrate great potential in transistors, solar cells and light-emitting diodes, whose performances are fundamentally governed by charge transport. However, the morphology-property relationships and the underpinning charge transport mechanisms remain unclear. Particularly, whether the non...

journal_title：Nature communications

authors： Wang J,Niu J,Shao B,Yang G,Lu C,Li M,Zhou Z,Chuai X,Chen J,Lu N,Huang B,Wang Y,Li L,Liu M

更新日期：2021-01-04 00:00:00

abstract：:Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs expressing fibroblast activation protein alpha (FAP) and haem oxygenase-1 (HO-1), which are also fou...

journal_title：Nature communications

authors： Muliaditan T,Caron J,Okesola M,Opzoomer JW,Kosti P,Georgouli M,Gordon P,Lall S,Kuzeva DM,Pedro L,Shields JD,Gillett CE,Diebold SS,Sanz-Moreno V,Ng T,Hoste E,Arnold JN

更新日期：2018-07-27 00:00:00

abstract：:Rheb is a small GTP-binding protein and its GTPase activity is activated by the complex of Tsc1 and Tsc2 whose mutations cause tuberous sclerosis complex (TSC). We previously reported that cultured TSC neurons showed impaired spine synapse morphogenesis in an mTORC1-independent manner. Here we show that the PDZ protei...

journal_title：Nature communications

authors： Sugiura H,Yasuda S,Katsurabayashi S,Kawano H,Endo K,Takasaki K,Iwasaki K,Ichikawa M,Kobayashi T,Hino O,Yamagata K

更新日期：2015-04-16 00:00:00

abstract：:It has been suggested that deficient protein trafficking to the cell membrane is the dominant mechanism associated with type 2 Long QT syndrome (LQT2) caused by Kv11.1 potassium channel missense mutations, and that for many mutations the trafficking defect can be corrected pharmacologically. However, this inference wa...

journal_title：Nature communications

authors： Anderson CL,Kuzmicki CE,Childs RR,Hintz CJ,Delisle BP,January CT

更新日期：2014-11-24 00:00:00

abstract：:Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown...

journal_title：Nature communications

authors： Kim DH,Park ES,Lee AR,Park S,Park YK,Ahn SH,Kang HS,Won JH,Ha YN,Jae B,Kim DS,Chung WC,Song MJ,Kim KH,Park SH,Kim SH,Kim KH

更新日期：2018-08-16 00:00:00