Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells.

abstract：:Stimulation of TNFR1 by TNFα can promote three distinct alternative mechanisms of cell death: necroptosis, RIPK1-independent and -dependent apoptosis. How cells decide which way to die is unclear. Here, we report that TNFα-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulati...

journal_title：Nature communications

authors： Geng J,Ito Y,Shi L,Amin P,Chu J,Ouchida AT,Mookhtiar AK,Zhao H,Xu D,Shan B,Najafov A,Gao G,Akira S,Yuan J

更新日期：2017-08-25 00:00:00

abstract：:Metal-organic frameworks (MOFs) are well known for their tunable structure and porosity. Many studies have shown they are promising for various important applications, for which their performance can be further enhanced by encapsulating functional species, such as luminescent guest molecules, within the frameworks. Al...

journal_title：Nature communications

authors： Sun CY,Wang XL,Zhang X,Qin C,Li P,Su ZM,Zhu DX,Shan GG,Shao KZ,Wu H,Li J

更新日期：2013-01-01 00:00:00

abstract：:Cold- and β3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of e...

journal_title：Nature communications

authors： Seki T,Hosaka K,Lim S,Fischer C,Honek J,Yang Y,Andersson P,Nakamura M,Näslund E,Ylä-Herttuala S,Sun M,Iwamoto H,Li X,Liu Y,Samani NJ,Cao Y

更新日期：2016-08-05 00:00:00

abstract：:As the desire to explore opaque materials is ordinarily frustrated by multiple scattering of waves, attention has focused on the transmission matrix of the wave field. This matrix gives the fullest account of transmission and conductance and enables the control of the transmitted flux; however, it cannot address the f...

journal_title：Nature communications

authors： Davy M,Shi Z,Park J,Tian C,Genack AZ

更新日期：2015-04-20 00:00:00

abstract：:Arabinosyltransferase B (EmbB) belongs to a family of membrane-bound glycosyltransferases that build the lipidated polysaccharides of the mycobacterial cell envelope, and are targets of anti-tuberculosis drug ethambutol. We present the 3.3 Å resolution single-particle cryo-electron microscopy structure of Mycobacteriu...

journal_title：Nature communications

authors： Tan YZ,Rodrigues J,Keener JE,Zheng RB,Brunton R,Kloss B,Giacometti SI,Rosário AL,Zhang L,Niederweis M,Clarke OB,Lowary TL,Marty MT,Archer M,Potter CS,Carragher B,Mancia F

更新日期：2020-07-07 00:00:00

abstract：:Layered materials embrace rich intercalation reactions to accommodate high concentrations of foreign species within their structures, and find many applications spanning from energy storage, ion exchange to secondary batteries. Light alkali metals are generally most easily intercalated due to their light mass, high ch...

journal_title：Nature communications

authors： Yajima T,Koshiko M,Zhang Y,Oguchi T,Yu W,Kato D,Kobayashi Y,Orikasa Y,Yamamoto T,Uchimoto Y,Green MA,Kageyama H

更新日期：2016-12-14 00:00:00

abstract：:The European steppes and their biota have been hypothesized to be either young remnants of the Pleistocene steppe belt or, alternatively, to represent relicts of long-term persisting populations; both scenarios directly bear on nature conservation priorities. Here, we evaluate the conservation value of threatened disj...

journal_title：Nature communications

authors： Kirschner P,Záveská E,Gamisch A,Hilpold A,Trucchi E,Paun O,Sanmartín I,Schlick-Steiner BC,Frajman B,Arthofer W,STEPPE Consortium.,Steiner FM,Schönswetter P

更新日期：2020-04-23 00:00:00

abstract：:The most explosive basaltic scoria cone eruption yet documented (>20 km high plumes) occurred at Sunset Crater (Arizona) ca. 1085 AD by undetermined eruptive mechanisms. We present melt inclusion analysis, including bubble contents by Raman spectroscopy, yielding high total CO2 (approaching 6000 ppm) and S (~2000 ppm)...

journal_title：Nature communications

authors： Allison CM,Roggensack K,Clarke AB

更新日期：2021-01-11 00:00:00

abstract：:Both anti-PD1/PD-L1 therapy and oncolytic virotherapy have demonstrated promise, yet have exhibited efficacy in only a small fraction of cancer patients. Here we hypothesized that an oncolytic poxvirus would attract T cells into the tumour, and induce PD-L1 expression in cancer and immune cells, leading to more suscep...

journal_title：Nature communications

authors： Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL

更新日期：2017-03-27 00:00:00

abstract：:The low-energy electronic excitations in graphene are described by massless Dirac fermions that have a linear dispersion relation. Taking advantage of this 'optics-like' electron dynamics, generic optical elements like lenses and wave guides have been proposed for electrons in graphene. Tuning of these elements relies...

journal_title：Nature communications

authors： Rickhaus P,Maurand R,Liu MH,Weiss M,Richter K,Schönenberger C

更新日期：2013-01-01 00:00:00

abstract：:Multilayer hexagonal boron nitride (h-BN) is highly desirable as a dielectric substrate for the fabrication of two-dimensional (2D) electronic and optoelectronic devices. However, the controllable synthesis of multilayer h-BN in large areas is still limited in terms of crystallinity, thickness and stacking order. Here...

journal_title：Nature communications

authors： Shi Z,Wang X,Li Q,Yang P,Lu G,Jiang R,Wang H,Zhang C,Cong C,Liu Z,Wu T,Wang H,Yu Q,Xie X

更新日期：2020-02-12 00:00:00

abstract：:The Greenland and Antarctic Ice Sheets cover ~ 10% of global land surface, but are rarely considered as active components of the global iron cycle. The ocean waters around both ice sheets harbour highly productive coastal ecosystems, many of which are iron limited. Measurements of iron concentrations in subglacial run...

journal_title：Nature communications

authors： Hawkings JR,Wadham JL,Tranter M,Raiswell R,Benning LG,Statham PJ,Tedstone A,Nienow P,Lee K,Telling J

更新日期：2014-05-21 00:00:00

abstract：:Recent studies demonstrated a dramatically increased risk of leukemia in patients with a rare genetic disorder, Xeroderma Pigmentosum group C (XP-C), characterized by constitutive deficiency of global genome nucleotide excision repair (GG-NER). The genetic mechanisms of non-skin cancers in XP-C patients remain unexplo...

journal_title：Nature communications

authors： Yurchenko AA,Padioleau I,Matkarimov BT,Soulier J,Sarasin A,Nikolaev S

更新日期：2020-11-17 00:00:00

abstract：:Neurons can activate pathways that destroy the whole cell via apoptosis or selectively degenerate only the axon (pruning). Both apoptosis and axon degeneration require Bax and caspases. Here we demonstrate that despite this overlap, the pathways mediating axon degeneration during apoptosis versus axon pruning are dist...

journal_title：Nature communications

authors： Cusack CL,Swahari V,Hampton Henley W,Michael Ramsey J,Deshmukh M

更新日期：2013-01-01 00:00:00

abstract：:The recent levelling of global mean temperatures after the late 1990s, the so-called global warming hiatus or slowdown, ignited a surge of scientific interest into natural global mean surface temperature variability, observed temperature biases, and climate communication, but many questions remain about how these find...

journal_title：Nature communications

authors： Johnson NC,Xie SP,Kosaka Y,Li X

更新日期：2018-04-30 00:00:00

abstract：:It is difficult to achieve minimally invasive injectable cell delivery while maintaining high cell retention and animal survival for in vivo stem cell therapy of myocardial infarction. Here we show that pluripotent stem cell aggregates pre-differentiated into the early cardiac lineage and encapsulated in a biocompatib...

journal_title：Nature communications

authors： Zhao S,Xu Z,Wang H,Reese BE,Gushchina LV,Jiang M,Agarwal P,Xu J,Zhang M,Shen R,Liu Z,Weisleder N,He X

更新日期：2016-10-27 00:00:00

abstract：:OPCML, a tumor suppressor gene, is frequently silenced epigenetically in ovarian and other cancers. Here we report, by analysis of databases of tumor sequences, the observation of OPCML somatic missense mutations from various tumor types and the impact of these mutations on OPCML function, by solving the X-ray crystal...

journal_title：Nature communications

authors： Birtley JR,Alomary M,Zanini E,Antony J,Maben Z,Weaver GC,Von Arx C,Mura M,Marinho AT,Lu H,Morecroft EVN,Karali E,Chayen NE,Tate EW,Jurewicz M,Stern LJ,Recchi C,Gabra H

更新日期：2019-07-17 00:00:00

abstract：:Reversible acetylation of α-tubulin is an evolutionarily conserved modification in microtubule networks. Despite its prevalence, the physiological function and regulation of microtubule acetylation remain poorly understood. Here we report that macrophages challenged by bacterial lipopolysaccharides (LPS) undergo exten...

journal_title：Nature communications

authors： Wang B,Rao YH,Inoue M,Hao R,Lai CH,Chen D,McDonald SL,Choi MC,Wang Q,Shinohara ML,Yao TP

更新日期：2014-03-17 00:00:00

abstract：:Semiconducting two-dimensional transition metal dichalcogenides are emerging as top candidates for post-silicon electronics. While most of them exhibit isotropic behaviour, lowering the lattice symmetry could induce anisotropic properties, which are both scientifically interesting and potentially useful. Here we prese...

journal_title：Nature communications

authors： Liu E,Fu Y,Wang Y,Feng Y,Liu H,Wan X,Zhou W,Wang B,Shao L,Ho CH,Huang YS,Cao Z,Wang L,Li A,Zeng J,Song F,Wang X,Shi Y,Yuan H,Hwang HY,Cui Y,Miao F,Xing D

更新日期：2015-05-07 00:00:00

abstract：:How sleep influences brain plasticity is not known. In particular, why certain electroencephalographic (EEG) rhythms are linked to memory consolidation is poorly understood. Calcium activity in dendrites is known to be necessary for structural plasticity changes, but this has never been carefully examined during sleep...

journal_title：Nature communications

authors： Seibt J,Richard CJ,Sigl-Glöckner J,Takahashi N,Kaplan DI,Doron G,de Limoges D,Bocklisch C,Larkum ME

更新日期：2017-09-25 00:00:00

abstract：:Arterial networks enlarge in response to increase in tissue metabolism to facilitate flow and nutrient delivery. Typically, the transition of a growing artery with a small diameter into a large caliber artery with a sizeable diameter occurs upon the blood flow driven change in number and shape of endothelial cells lin...

journal_title：Nature communications

authors： Klems A,van Rijssel J,Ramms AS,Wild R,Hammer J,Merkel M,Derenbach L,Préau L,Hinkel R,Suarez-Martinez I,Schulte-Merker S,Vidal R,Sauer S,Kivelä R,Alitalo K,Kupatt C,van Buul JD,le Noble F

更新日期：2020-10-21 00:00:00

abstract：:Microbial fermentation of lignocellulosic biomass to produce industrial chemicals is exacerbated by the recalcitrant network of lignin, cellulose and hemicelluloses comprising the plant secondary cell wall. In this study, we show that transgenic poplar (Populus trichocarpa) lines can be solubilized without any pretrea...

journal_title：Nature communications

authors： Straub CT,Khatibi PA,Wang JP,Conway JM,Williams-Rhaesa AM,Peszlen IM,Chiang VL,Adams MWW,Kelly RM

更新日期：2019-08-07 00:00:00

abstract：:Accurate estimates of the BOLD hemodynamic response function (HRF) are crucial for the interpretation and analysis of event-related functional MRI data. To date, however, there have been no comprehensive measurements of the HRF in white matter (WM) despite increasing evidence that BOLD signals in WM change after a sti...

journal_title：Nature communications

authors： Li M,Newton AT,Anderson AW,Ding Z,Gore JC

更新日期：2019-03-08 00:00:00

abstract：:Although the changes in melting behaviour on the nanoscale have long attracted the interest of researchers, the mechanism by which nanoparticles melt remains an open problem. We report the direct observation, at atomic resolution, of surface melting in individual size-selected Au clusters (2-5 nm diameter) supported o...

journal_title：Nature communications

authors： Foster DM,Pavloudis T,Kioseoglou J,Palmer RE

更新日期：2019-06-13 00:00:00

abstract：:The emergence of antimicrobial-resistant bacteria is an increasingly serious threat to global health, necessitating the development of innovative antimicrobials. Here we report the development of a series of CRISPR-Cas13a-based antibacterial nucleocapsids, termed CapsidCas13a(s), capable of sequence-specific killing o...

journal_title：Nature communications

authors： Kiga K,Tan XE,Ibarra-Chávez R,Watanabe S,Aiba Y,Sato'o Y,Li FY,Sasahara T,Cui B,Kawauchi M,Boonsiri T,Thitiananpakorn K,Taki Y,Azam AH,Suzuki M,Penadés JR,Cui L

更新日期：2020-06-10 00:00:00

abstract：:Angiogenesis is a necessary process for solid tumor growth. Cellular markers for endothelial cell proliferation are potential targets for identifying the vasculature of tumors in homeostasis. Here we customize the behaviors of engineered cells to recognize Apj, a surface marker of the neovascular endothelium, using sy...

journal_title：Nature communications

authors： Wang Z,Wang F,Zhong J,Zhu T,Zheng Y,Zhao T,Xie Q,Ma F,Li R,Tang Q,Xu F,Tian X,Zhu J

更新日期：2020-05-01 00:00:00

abstract：:The identification of fractionalized excitations, such as Majorana quasi-particles, would be a striking signal of the realization of exotic quantum states of matter. While the paramount demonstration of such excitations would be a probe of their non-Abelian statistics via controlled braiding operations, alternative pr...

journal_title：Nature communications

authors： Laflamme C,Budich JC,Zoller P,Dalmonte M

更新日期：2016-08-02 00:00:00

abstract：:Understanding marine environmental change and associated biological turnover across the Palaeocene-Eocene Thermal Maximum (PETM; ~56 Ma)-the most pronounced Cenozoic short-term global warming event-is important because of the potential role of the ocean in atmospheric CO2 drawdown, yet proxies for tracing marine produ...

journal_title：Nature communications

authors： Chang L,Harrison RJ,Zeng F,Berndt TA,Roberts AP,Heslop D,Zhao X

更新日期：2018-10-01 00:00:00

abstract：:Enzymatic digestion for protein sequencing usually requires much time, and does not always result in high sequence coverage. Here we report the use of aqueous microdroplets to accelerate enzymatic reactions and, in particular, to improve protein sequencing. When a room temperature aqueous solution containing 10 µM myo...

journal_title：Nature communications

authors： Zhong X,Chen H,Zare RN

更新日期：2020-02-26 00:00:00

abstract：:Ferroelectric materials exhibit a phase transition to a paraelectric state driven by temperature - called the Curie transition. In conventional ferroelectrics, the Curie transition is caused by a change in crystal symmetry, while the material itself remains a continuous three-dimensional solid crystal. However, ferroe...

journal_title：Nature communications

authors： Hafner J,Benaglia S,Richheimer F,Teuschel M,Maier FJ,Werner A,Wood S,Platz D,Schneider M,Hradil K,Castro FA,Garcia R,Schmid U

更新日期：2021-01-08 00:00:00