Abstract:
:OPCML, a tumor suppressor gene, is frequently silenced epigenetically in ovarian and other cancers. Here we report, by analysis of databases of tumor sequences, the observation of OPCML somatic missense mutations from various tumor types and the impact of these mutations on OPCML function, by solving the X-ray crystal structure of this glycoprotein to 2.65 Å resolution. OPCML consists of an extended arrangement of three immunoglobulin-like domains and homodimerizes via a network of contacts between membrane-distal domains. We report the generation of a panel of OPCML variants with representative clinical mutations and demonstrate clear phenotypic effects in vitro and in vivo including changes to anchorage-independent growth, interaction with activated cognate receptor tyrosine kinases, cellular migration, invasion in vitro and tumor growth in vivo. Our results suggest that clinically occurring somatic missense mutations in OPCML have the potential to contribute to tumorigenesis in a variety of cancers.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Birtley JR,Alomary M,Zanini E,Antony J,Maben Z,Weaver GC,Von Arx C,Mura M,Marinho AT,Lu H,Morecroft EVN,Karali E,Chayen NE,Tate EW,Jurewicz M,Stern LJ,Recchi C,Gabra Hdoi
10.1038/s41467-019-10966-8subject
Has Abstractpub_date
2019-07-17 00:00:00pages
3134issue
1issn
2041-1723pii
10.1038/s41467-019-10966-8journal_volume
10pub_type
杂志文章abstract::Quasicrystals, materials with aperiodic long-range order, have been found in intermetallics, soft materials such as colloids and supermolecules, and also in two-dimensional monolayer films. Here we present the first example of three-dimensional growth of a single-element quasicrystalline film. Using a hitherto unexplo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3715
更新日期:2013-01-01 00:00:00
abstract::Topologically nontrivial materials host protected edge states associated with the bulk band inversion through the bulk-edge correspondence. Manipulating such edge states is highly desired for developing new functions and devices practically using their dissipation-less nature and spin-momentum locking. Here we introdu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16290-w
更新日期:2020-05-18 00:00:00
abstract::Human-machine interfaces have benefited from the advent of wireless sensor networks and the internet of things, but rely on wearable/attachable electronics exhibiting stretchability, biocompatibility, and transmittance. Limited by weight and volume, wearable devices should be energy efficient and even self-powered. He...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03954-x
更新日期:2018-05-04 00:00:00
abstract::In chronic lymphocytic leukemia (CLL), the non-hematopoietic stromal microenvironment plays a critical role in promoting tumor cell recruitment, activation, survival, and expansion. However, the nature of the stromal cells and molecular pathways involved remain largely unknown. Here, we demonstrate that leukemic B lym...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04150-7
更新日期:2018-05-03 00:00:00
abstract::Fourier ring correlation (FRC) has recently gained popularity among fluorescence microscopists as a straightforward and objective method to measure the effective image resolution. While the knowledge of the numeric resolution value is helpful in e.g., interpreting imaging results, much more practical use can be made o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11024-z
更新日期:2019-07-15 00:00:00
abstract::Activation of the NLRP3 inflammasome and subsequent maturation of IL-1β have been implicated in acute lung injury (ALI), resulting in inflammation and fibrosis. We investigated the role of vimentin, a type III intermediate filament, in this process using three well-characterized murine models of ALI known to require N...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7574
更新日期:2015-03-12 00:00:00
abstract::Roifman Syndrome is a rare congenital disorder characterized by growth retardation, cognitive delay, spondyloepiphyseal dysplasia and antibody deficiency. Here we utilize whole-genome sequencing of Roifman Syndrome patients to reveal compound heterozygous rare variants that disrupt highly conserved positions of the RN...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9718
更新日期:2015-11-02 00:00:00
abstract::When a thin film of active, nematic microtubules and kinesin motor clusters is confined on the surface of a vesicle, four +1/2 topological defects oscillate in a periodic manner between tetrahedral and planar arrangements. Here a theoretical description of nematics, coupled to the relevant hydrodynamic equations, is p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13483
更新日期:2016-11-21 00:00:00
abstract::Cytokinesis mediates the physical separation of dividing cells and, in 3D epithelia, provides a spatial landmark for lumen formation. Here, we unravel an unexpected role in cytokinesis for proteins of the intraflagellar transport (IFT) machinery, initially characterized for their ciliary role and their link to polycys...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01479-3
更新日期:2017-12-04 00:00:00
abstract::The lack of microbial genomes and isolates from the deep seabed means that very little is known about the ecology of this vast habitat. Here, we investigate energy and carbon acquisition strategies of microbial communities from three deep seabed petroleum seeps (3 km water depth) in the Eastern Gulf of Mexico. Shotgun...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09747-0
更新日期:2019-04-18 00:00:00
abstract::The charge density wave in the high-temperature superconductor YBa2Cu3O7-x (YBCO) has two different ordering tendencies differentiated by their c-axis correlations. These correspond to ferro- (F-CDW) and antiferro- (AF-CDW) couplings between CDWs in neighbouring CuO2 bilayers. This discovery has prompted several funda...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14536-1
更新日期:2020-02-20 00:00:00
abstract::The shift from maternal to embryonic control is a critical developmental milestone in preimplantation development. Widespread transcriptomic and epigenetic remodeling facilitate this transition from terminally differentiated gametes to totipotent blastomeres, but the identity of transcription factors (TF) and genomic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18508-3
更新日期:2020-09-17 00:00:00
abstract::The ultrafast dynamics of hot carriers in graphene are key to both understanding of fundamental carrier-carrier interactions and carrier-phonon relaxation processes in two-dimensional materials, and understanding of the physics underlying novel high-speed electronic and optoelectronic devices. Many recent experiments ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11617
更新日期:2016-05-25 00:00:00
abstract::Interfacial issues commonly exist in solid-state batteries, and the microstructural complexity combines with the chemical heterogeneity to govern the local interfacial chemistry. The conventional wisdom suggests that "point-to-point" ion diffusion at the interface determines the ion transport kinetics. Here, we show t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19528-9
更新日期:2020-11-11 00:00:00
abstract::The non-deterministic nature of photon sources is a key limitation for single-photon quantum processors. Spatial multiplexing overcomes this by enhancing the heralded single-photon yield without enhancing the output noise. Here the intrinsic statistical limit of an individual source is surpassed by spatially multiplex...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3582
更新日期:2013-01-01 00:00:00
abstract::Aviation emissions of nitrogen oxides (NOx) alter the composition of the atmosphere, perturbing the greenhouse gases ozone and methane, resulting in positive and negative radiative forcing effects, respectively. In 1981, the International Civil Aviation Organization adopted a first certification standard for the regul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20771-3
更新日期:2021-01-25 00:00:00
abstract::Acid catalysis by hydronium ions is ubiquitous in aqueous-phase organic reactions. Here we show that hydronium ion catalysis, exemplified by intramolecular dehydration of cyclohexanol, is markedly influenced by steric constraints, yielding turnover rates that increase by up to two orders of magnitude in tight confines...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15442
更新日期:2017-05-25 00:00:00
abstract::Chromatin looping allows enhancer-bound regulatory factors to influence transcription. Large domains, referred to as topologically associated domains, participate in genome organization. However, the mechanisms underlining interactions within these domains, which control gene expression, are not fully understood. Here...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10318-6
更新日期:2019-05-24 00:00:00
abstract::Nonreciprocal microwave devices are ubiquitous in radar and radio communication and indispensable in the readout chains of superconducting quantum circuits. Since they commonly rely on ferrite materials requiring large magnetic fields that make them bulky and lossy, there has been significant interest in magnetic-fiel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00447-1
更新日期:2017-09-19 00:00:00
abstract::Potassium ion channels utilize a highly selective filter to rapidly transport K+ ions across cellular membranes. This selectivity filter is composed of four binding sites which display almost equal electron density in crystal structures with high potassium ion concentrations. This electron density can be interpreted t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06957-w
更新日期:2018-10-31 00:00:00
abstract::Inbreeding typically reduces fitness. Related partners may fail to reproduce and any inbred offspring may die early or fail to reproduce themselves. Here we show that inbreeding causes early death in the zebra finch Taeniopygia guttata, and among inbred individuals of the same inbreeding coefficient (F), those that di...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1870
更新日期:2012-05-29 00:00:00
abstract::Scattering-type scanning near-field optical microscopy (s-SNOM) allows spectroscopic imaging with spatial resolution below the diffraction limit. With suitable light sources, s-SNOM is instrumental in numerous discoveries at the nanoscale. So far, the light sources have been limited to continuous wave or high-repetiti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13212
更新日期:2016-10-17 00:00:00
abstract::Auxin is a key coordinative signal required for many aspects of plant development and its levels are controlled by auxin metabolism and intercellular auxin transport. Here we find that a member of PIN auxin transporter family, PIN8 is expressed in male gametophyte of Arabidopsis thaliana and has a crucial role in poll...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1941
更新日期:2012-07-03 00:00:00
abstract::Storage of anthropogenic CO2 in geological formations relies on a caprock as the primary seal preventing buoyant super-critical CO2 escaping. Although natural CO2 reservoirs demonstrate that CO2 may be stored safely for millions of years, uncertainty remains in predicting how caprocks will react with CO2-bearing brine...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12268
更新日期:2016-07-28 00:00:00
abstract::Hollow-core fibre (HCF) is a powerful technology platform offering breakthrough performance improvements in sensing, communications, higher-power pulse delivery and other applications. Free from the usual constraints on what materials can guide light, it promises qualitatively new and ideal operating regimes: precisio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6085
更新日期:2014-10-28 00:00:00
abstract::Ultra-small, magic-sized metal nanoclusters represent an important new class of materials with properties between molecules and particles. However, their small size challenges the conventional methods for structure characterization. Here we present the structure of ultra-stable Au144(SR)60 magic-sized nanoclusters obt...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11859
更新日期:2016-06-14 00:00:00
abstract::The identification of fractionalized excitations, such as Majorana quasi-particles, would be a striking signal of the realization of exotic quantum states of matter. While the paramount demonstration of such excitations would be a probe of their non-Abelian statistics via controlled braiding operations, alternative pr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12280
更新日期:2016-08-02 00:00:00
abstract::Manganese based layered oxides have received increasing attention as cathode materials for sodium ion batteries due to their high theoretical capacities and good sodium ion conductivities. However, the Jahn-Teller distortion arising from the manganese (III) centers destabilizes the host structure and deteriorates the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07646-4
更新日期:2019-01-07 00:00:00
abstract::DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive. Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influence of the DNA sequences flanking the target CpG site on DNMT1...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17531-8
更新日期:2020-07-24 00:00:00
abstract::The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2318
更新日期:2012-01-01 00:00:00