当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.

IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.

Abstract：

:Cytokinesis mediates the physical separation of dividing cells and, in 3D epithelia, provides a spatial landmark for lumen formation. Here, we unravel an unexpected role in cytokinesis for proteins of the intraflagellar transport (IFT) machinery, initially characterized for their ciliary role and their link to polycystic kidney disease. Using 2D and 3D cultures of renal cells, we show that IFT proteins are required to correctly shape the central spindle, to control symmetric cleavage furrow ingression and to ensure central lumen positioning. Mechanistically, IFT88 directly interacts with the kinesin MKLP2 and is essential for the correct relocalization of the Aurora B/MKLP2 complex to the central spindle. IFT88 is thus required for proper centralspindlin distribution and central spindle microtubule organization. Overall, this work unravels a novel non-ciliary mechanism for IFT proteins at the central spindle, which could contribute to kidney cyst formation by affecting lumen positioning.

journal_name

Nat Commun

journal_title

Nature communications

authors

Taulet N,Vitre B,Anguille C,Douanier A,Rocancourt M,Taschner M,Lorentzen E,Echard A,Delaval B

doi

10.1038/s41467-017-01479-3

subject

Has Abstract

pub_date

2017-12-04 00:00:00

pages

1928

issue

1

issn

2041-1723

pii

10.1038/s41467-017-01479-3

journal_volume

8

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Preserving π-conjugation in covalently functionalized carbon nanotubes for optoelectronic applications.

    abstract：:Covalent functionalization tailors carbon nanotubes for a wide range of applications in varying environments. Its strength and stability of attachment come at the price of degrading the carbon nanotubes sp2 network and destroying the tubes electronic and optoelectronic features. Here we present a non-destructive, cova...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14281

    authors： Setaro A,Adeli M,Glaeske M,Przyrembel D,Bisswanger T,Gordeev G,Maschietto F,Faghani A,Paulus B,Weinelt M,Arenal R,Haag R,Reich S

    更新日期：2017-01-30 00:00:00

  • Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.

    abstract：:Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs expressing fibroblast activation protein alpha (FAP) and haem oxygenase-1 (HO-1), which are also fou...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05346-7

    authors： Muliaditan T,Caron J,Okesola M,Opzoomer JW,Kosti P,Georgouli M,Gordon P,Lall S,Kuzeva DM,Pedro L,Shields JD,Gillett CE,Diebold SS,Sanz-Moreno V,Ng T,Hoste E,Arnold JN

    更新日期：2018-07-27 00:00:00

  • Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO4 recognition and ADP-ribosylation.

    abstract：:Tpt1 is an essential agent of fungal tRNA splicing that removes the 2'-PO4 at the splice junction generated by fungal tRNA ligase. Tpt1 catalyzes a unique two-step reaction whereby the 2'-PO4 attacks NAD+ to form an RNA-2'-phospho-ADP-ribosyl intermediate that undergoes transesterification to yield 2'-OH RNA and ADP-r...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-08211-9

    authors： Banerjee A,Munir A,Abdullahu L,Damha MJ,Goldgur Y,Shuman S

    更新日期：2019-01-15 00:00:00

  • Uranium transport in acidic brines under reducing conditions.

    abstract：:The behavior of uranium in environments, ranging from those of natural systems responsible for the formation of uranium deposits to those of nuclear reactors providing 11% of the world's electricity, is governed by processes involving high-temperature aqueous solutions. It has been well documented that uranium is mobi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03564-7

    authors： Timofeev A,Migdisov AA,Williams-Jones AE,Roback R,Nelson AT,Xu H

    更新日期：2018-04-16 00:00:00

  • A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions.

    abstract：:Clustered regularly-interspaced palindromic repeats (CRISPR)-based genetic screens using single-guide-RNA (sgRNA) libraries have proven powerful to identify genetic regulators. Applying CRISPR screens to interrogate functional elements in noncoding regions requires generating sgRNA libraries that are densely covering,...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11178

    authors： Cheng J,Roden CA,Pan W,Zhu S,Baccei A,Pan X,Jiang T,Kluger Y,Weissman SM,Guo S,Flavell RA,Ding Y,Lu J

    更新日期：2016-03-30 00:00:00

  • Optical soliton molecular complexes in a passively mode-locked fibre laser.

    abstract：:Ultrashort optical pulses propagating in a dissipative nonlinear system can interact and bind stably, forming optical soliton molecules. Soliton molecules in ultrafast lasers are under intense research focus and present striking analogies with their matter molecules counterparts. The recent development of real-time sp...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08755-4

    authors： Wang ZQ,Nithyanandan K,Coillet A,Tchofo-Dinda P,Grelu P

    更新日期：2019-02-19 00:00:00

  • RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients.

    abstract：:Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). RORγt, the key Thelper17 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including invariant natural killer T (iNKT) and γδ-T cells, but their contributio...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07911-6

    authors： Venken K,Jacques P,Mortier C,Labadia ME,Decruy T,Coudenys J,Hoyt K,Wayne AL,Hughes R,Turner M,Van Gassen S,Martens L,Smith D,Harcken C,Wahle J,Wang CT,Verheugen E,Schryvers N,Varkas G,Cypers H,Wittoek R,Piette Y

    更新日期：2019-01-02 00:00:00

  • Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation.

    abstract：:The extent to which the impact of regulatory genetic variants may depend on other factors, such as the expression levels of upstream transcription factors, remains poorly understood. Here we report a framework in which regulatory variants are first aggregated into sets, and using these as estimates of the total cis-ge...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13762-6

    authors： Wragg D,Liu Q,Lin Z,Riggio V,Pugh CA,Beveridge AJ,Brown H,Hume DA,Harris SE,Deary IJ,Tenesa A,Prendergast JGD

    更新日期：2020-01-17 00:00:00

  • Geologically-inspired strong bulk ceramics made with water at room temperature.

    abstract：:Dense ceramic materials can form in nature under mild temperatures in water. By contrast, man-made ceramics often require sintering temperatures in excess of 1,400 °C for densification. Chemical strategies inspired by biomineralization processes have been demonstrated but remain limited to the fabrication of thin film...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14655

    authors： Bouville F,Studart AR

    更新日期：2017-03-06 00:00:00

  • Distinct CCK-positive SFO neurons are involved in persistent or transient suppression of water intake.

    abstract：:The control of water-intake behavior is critical for life because an excessive water intake induces pathological conditions, such as hyponatremia or water intoxication. However, the brain mechanisms controlling water intake currently remain unclear. We previously reported that thirst-driving neurons (water neurons) in...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19191-0

    authors： Matsuda T,Hiyama TY,Kobayashi K,Kobayashi K,Noda M

    更新日期：2020-11-10 00:00:00

  • Electrophysiological dynamics of antagonistic brain networks reflect attentional fluctuations.

    abstract：:Neuroimaging evidence suggests that the default mode network (DMN) exhibits antagonistic activity with dorsal attention (DAN) and salience (SN) networks. Here we use human intracranial electroencephalography to investigate the behavioral relevance of fine-grained dynamics within and between these networks. The three n...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-14166-2

    authors： Kucyi A,Daitch A,Raccah O,Zhao B,Zhang C,Esterman M,Zeineh M,Halpern CH,Zhang K,Zhang J,Parvizi J

    更新日期：2020-01-16 00:00:00

  • Field-induced spin-density wave beyond hidden order in URu2Si2.

    abstract：:URu2Si2 is one of the most enigmatic strongly correlated electron systems and offers a fertile testing ground for new concepts in condensed matter science. In spite of >30 years of intense research, no consensus on the order parameter of its low-temperature hidden-order phase exists. A strong magnetic field transforms...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13075

    authors： Knafo W,Duc F,Bourdarot F,Kuwahara K,Nojiri H,Aoki D,Billette J,Frings P,Tonon X,Lelièvre-Berna E,Flouquet J,Regnault LP

    更新日期：2016-10-20 00:00:00

  • A synthetic microbial biosensor for high-throughput screening of lactam biocatalysts.

    abstract：:Biocatalytic cyclization is highly desirable for efficient synthesis of biologically derived chemical substances, such as the commodity chemicals ε-caprolactam and δ-valerolactam. To identify biocatalysts in lactam biosynthesis, we develop a caprolactam-detecting genetic enzyme screening system (CL-GESS). The Alcalige...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07488-0

    authors： Yeom SJ,Kim M,Kwon KK,Fu Y,Rha E,Park SH,Lee H,Kim H,Lee DH,Kim DM,Lee SG

    更新日期：2018-11-29 00:00:00

  • Global heat and salt transports by eddy movement.

    abstract：:Oceanic mesoscale eddies contribute important horizontal heat and salt transports on a global scale. Here we show that eddy transports are mainly due to individual eddy movements. Theoretical and observational analyses indicate that cyclonic and anticyclonic eddies move westwards, and they also move polewards and equa...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4294

    authors： Dong C,McWilliams JC,Liu Y,Chen D

    更新日期：2014-01-01 00:00:00

  • A polymer tandem solar cell with 10.6% power conversion efficiency.

    abstract：:An effective way to improve polymer solar cell efficiency is to use a tandem structure, as a broader part of the spectrum of solar radiation is used and the thermalization loss of photon energy is minimized. In the past, the lack of high-performance low-bandgap polymers was the major limiting factor for achieving high...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2411

    authors： You J,Dou L,Yoshimura K,Kato T,Ohya K,Moriarty T,Emery K,Chen CC,Gao J,Li G,Yang Y

    更新日期：2013-01-01 00:00:00

  • TET2 directs mammary luminal cell differentiation and endocrine response.

    abstract：:Epigenetic regulation plays an important role in governing stem cell fate and tumorigenesis. Lost expression of a key DNA demethylation enzyme TET2 is associated with human cancers and has been linked to stem cell traits in vitro; however, whether and how TET2 regulates mammary stem cell fate and mammary tumorigenesis...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18129-w

    authors： Kim MR,Wu MJ,Zhang Y,Yang JY,Chang CJ

    更新日期：2020-09-15 00:00:00

  • KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.

    abstract：:Ciliary membrane composition is controlled by transition zone (TZ) proteins such as RPGRIP1, RPGRIPL and NPHP4, which are vital for balanced coordination of diverse signalling systems like the Sonic hedgehog (Shh) pathway. Activation of this pathway involves Shh-induced ciliary accumulation of Smoothened (SMO), which ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14177

    authors： Schou KB,Mogensen JB,Morthorst SK,Nielsen BS,Aleliunaite A,Serra-Marques A,Fürstenberg N,Saunier S,Bizet AA,Veland IR,Akhmanova A,Christensen ST,Pedersen LB

    更新日期：2017-01-30 00:00:00

  • Author Correction: Infralimbic cortex is required for learning alternatives to prelimbic promoted associations through reciprocal connectivity.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-019-11205-w

    authors： Mukherjee A,Caroni P

    更新日期：2019-07-12 00:00:00

  • CMOS-based carbon nanotube pass-transistor logic integrated circuits.

    abstract：:Field-effect transistors based on carbon nanotubes have been shown to be faster and less energy consuming than their silicon counterparts. However, ensuring these advantages are maintained for integrated circuits is a challenge. Here we demonstrate that a significant reduction in the use of field-effect transistors ca...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1682

    authors： Ding L,Zhang Z,Liang S,Pei T,Wang S,Li Y,Zhou W,Liu J,Peng LM

    更新日期：2012-02-14 00:00:00

  • Middle Eocene greenhouse warming facilitated by diminished weathering feedback.

    abstract：:The Middle Eocene Climatic Optimum (MECO) represents a ~500-kyr period of global warming ~40 million years ago and is associated with a rise in atmospheric CO2 concentrations, but the cause of this CO2 rise remains enigmatic. Here we show, based on osmium isotope ratios (187Os/188Os) of marine sediments and published ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05104-9

    authors： van der Ploeg R,Selby D,Cramwinckel MJ,Li Y,Bohaty SM,Middelburg JJ,Sluijs A

    更新日期：2018-07-23 00:00:00

  • Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides.

    abstract：:Mechanical injury to connective tissue causes changes in collagen structure and material behaviour, but the role and mechanisms of molecular damage have not been established. In the case of mechanical subfailure damage, no apparent macroscale damage can be detected, yet this damage initiates and potentiates in patholo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14913

    authors： Zitnay JL,Li Y,Qin Z,San BH,Depalle B,Reese SP,Buehler MJ,Yu SM,Weiss JA

    更新日期：2017-03-22 00:00:00

  • Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling.

    abstract：:Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed somatic cells is mostly unknown. Here we show that Eed deficiency in chondrocytes causes s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12047

    authors： Mirzamohammadi F,Papaioannou G,Inloes JB,Rankin EB,Xie H,Schipani E,Orkin SH,Kobayashi T

    更新日期：2016-06-22 00:00:00

  • Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat.

    abstract：:Cold- and β3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of e...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12152

    authors： Seki T,Hosaka K,Lim S,Fischer C,Honek J,Yang Y,Andersson P,Nakamura M,Näslund E,Ylä-Herttuala S,Sun M,Iwamoto H,Li X,Liu Y,Samani NJ,Cao Y

    更新日期：2016-08-05 00:00:00

  • Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning.

    abstract：:Highly specific Cas9 nucleases derived from SpCas9 are valuable tools for genome editing, but their wide applications are hampered by a lack of knowledge governing guide RNA (gRNA) activity. Here, we perform a genome-scale screen to measure gRNA activity for two highly specific SpCas9 variants (eSpCas9(1.1) and SpCas9...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12281-8

    authors： Wang D,Zhang C,Wang B,Li B,Wang Q,Liu D,Wang H,Zhou Y,Shi L,Lan F,Wang Y

    更新日期：2019-09-19 00:00:00

  • Blending of animal colour patterns by hybridization.

    abstract：:Biologists have long been fascinated by the amazing diversity of animal colour patterns. Despite much interest, the underlying evolutionary and developmental mechanisms contributing to their rich variety remain largely unknown, especially the vivid and complex colour patterns seen in vertebrates. Here, we show that co...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1071

    authors： Miyazawa S,Okamoto M,Kondo S

    更新日期：2010-09-07 00:00:00

  • Nitric oxide-dependent anaerobic ammonium oxidation.

    abstract：:Nitric oxide (NO) has important functions in biology and atmospheric chemistry as a toxin, signaling molecule, ozone depleting agent and the precursor of the greenhouse gas nitrous oxide (N2O). Although NO is a potent oxidant, and was available on Earth earlier than oxygen, it is unclear whether NO can be used by micr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09268-w

    authors： Hu Z,Wessels HJCT,van Alen T,Jetten MSM,Kartal B

    更新日期：2019-03-20 00:00:00

  • How ligand binds to the type 1 insulin-like growth factor receptor.

    abstract：:Human type 1 insulin-like growth factor receptor is a homodimeric receptor tyrosine kinase that signals into pathways directing normal cellular growth, differentiation and proliferation, with aberrant signalling implicated in cancer. Insulin-like growth factor binding is understood to relax conformational restraints w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03219-7

    authors： Xu Y,Kong GK,Menting JG,Margetts MB,Delaine CA,Jenkin LM,Kiselyov VV,De Meyts P,Forbes BE,Lawrence MC

    更新日期：2018-02-26 00:00:00

  • A correlated nickelate synaptic transistor.

    abstract：:Inspired by biological neural systems, neuromorphic devices may open up new computing paradigms to explore cognition, learning and limits of parallel computation. Here we report the demonstration of a synaptic transistor with SmNiO₃, a correlated electron system with insulator-metal transition temperature at 130°C in ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3676

    authors： Shi J,Ha SD,Zhou Y,Schoofs F,Ramanathan S

    更新日期：2013-01-01 00:00:00

  • Publisher Correction: Nitric oxide-dependent anaerobic ammonium oxidation.

    abstract：:The original HTML version of this Article had an incorrect Published online date of 20 March 2019; it should have been 18 March 2019. This has been corrected in the HTML version of the Article. The PDF version was correct from the time of publication. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-019-09797-4

    authors： Hu Z,Wessels HJCT,van Alen T,Jetten MSM,Kartal B

    更新日期：2019-04-18 00:00:00

  • A general method for controlling and resolving rotational orientation of molecules in molecule-surface collisions.

    abstract：:The outcome of molecule-surface collisions can be modified by pre-aligning the molecule; however, experiments accomplishing this are rare because of the difficulty of preparing molecules in aligned quantum states. Here we present a general solution to this problem based on magnetic manipulation of the rotational magne...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15357

    authors： Godsi O,Corem G,Alkoby Y,Cantin JT,Krems RV,Somers MF,Meyer J,Kroes GJ,Maniv T,Alexandrowicz G

    更新日期：2017-05-08 00:00:00