Coupled microbial bloom and oxygenation decline recorded by magnetofossils during the Palaeocene-Eocene Thermal Maximum.

abstract：:The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge. Here, we integrate measures of how essential a gene is to supporting life, as inferred from viability and phenotyping screens performed on knockout mice by the In...

journal_title：Nature communications

authors： Cacheiro P,Muñoz-Fuentes V,Murray SA,Dickinson ME,Bucan M,Nutter LMJ,Peterson KA,Haselimashhadi H,Flenniken AM,Morgan H,Westerberg H,Konopka T,Hsu CW,Christiansen A,Lanza DG,Beaudet AL,Heaney JD,Fuchs H,Gailus-Durner

更新日期：2020-01-31 00:00:00

abstract：:A planar slab of negative-index material works as a superlens with sub-diffraction-limited resolution, as propagating waves are focused and, moreover, evanescent waves are reconstructed in the image plane. Here we demonstrate a superlens for electric evanescent fields with low losses using perovskites in the mid-infra...

journal_title：Nature communications

authors： Kehr SC,Liu YM,Martin LW,Yu P,Gajek M,Yang SY,Yang CH,Wenzel MT,Jacob R,von Ribbeck HG,Helm M,Zhang X,Eng LM,Ramesh R

更新日期：2011-01-01 00:00:00

abstract：:Eukaryotic cyclic nucleotide-modulated (CNM) ion channels perform various physiological roles by opening in response to cyclic nucleotides binding to a specialized cyclic nucleotide-binding domain. Despite progress in structure-function analysis, the conformational rearrangements underlying the gating of these channel...

journal_title：Nature communications

authors： Rangl M,Miyagi A,Kowal J,Stahlberg H,Nimigean CM,Scheuring S

更新日期：2016-09-20 00:00:00

abstract：:The history of the Earth has been marked by major ecological transitions, driven by metabolic innovation, that radically reshaped the composition of the oceans and atmosphere. The nature and magnitude of the earliest transitions, hundreds of million years before photosynthesis evolved, remain poorly understood. Using ...

journal_title：Nature communications

authors： Sauterey B,Charnay B,Affholder A,Mazevet S,Ferrière R

更新日期：2020-06-01 00:00:00

abstract：:Circadian clocks generate reliable ~24-h rhythms despite being based on stochastic biochemical reactions. The circadian clock in Synechococcus elongatus uses a post-translational oscillator that cycles deterministically in a test tube. Because the volume of a single bacterial cell is much smaller than a macroscopic re...

journal_title：Nature communications

authors： Chew J,Leypunskiy E,Lin J,Murugan A,Rust MJ

更新日期：2018-08-01 00:00:00

abstract：:Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we show that hPSC-KCs self-organize into kidney organoids that functionally recapitulate tissue-specif...

journal_title：Nature communications

authors： Freedman BS,Brooks CR,Lam AQ,Fu H,Morizane R,Agrawal V,Saad AF,Li MK,Hughes MR,Werff RV,Peters DT,Lu J,Baccei A,Siedlecki AM,Valerius MT,Musunuru K,McNagny KM,Steinman TI,Zhou J,Lerou PH,Bonventre JV

更新日期：2015-10-23 00:00:00

abstract：:Coalescence is an essential phenomenon that governs the equilibrium behaviour in a variety of systems from intercellular transport to planetary formation. In this report, we study coalescence pathways of circularly shaped two-dimensional colloidal membranes, which are one rod-length-thick liquid-like monolayers of ali...

journal_title：Nature communications

authors： Zakhary MJ,Gibaud T,Kaplan CN,Barry E,Oldenbourg R,Meyer RB,Dogic Z

更新日期：2014-01-01 00:00:00

abstract：:Ligand-induced receptor dimerization has traditionally been viewed as the key event in transmembrane signalling by epidermal growth factor receptors (EGFRs). Here we show that the Caenorhabditis elegans EGFR orthologue LET-23 is constitutively dimeric, yet responds to its ligand LIN-3 without changing oligomerization ...

journal_title：Nature communications

authors： Freed DM,Alvarado D,Lemmon MA

更新日期：2015-06-10 00:00:00

abstract：:The Spitzenkörper (SPK) constitutes a collection of secretory vesicles and polarity-related proteins intimately associated with polarized growth of fungal hyphae. Many SPK-localized proteins are known, but their assembly and dynamics remain poorly understood. Here, we identify protein-protein interaction cascades lead...

journal_title：Nature communications

authors： Zheng P,Nguyen TA,Wong JY,Lee M,Nguyen TA,Fan JS,Yang D,Jedd G

更新日期：2020-06-05 00:00:00

abstract：:Topological quantum matter can be realized by subjecting engineered systems to time-periodic modulations. In analogy with static systems, periodically driven quantum matter can be topologically classified by topological invariants, whose non-zero value guarantees the presence of robust edge modes. In the high-frequenc...

journal_title：Nature communications

authors： Mukherjee S,Spracklen A,Valiente M,Andersson E,Öhberg P,Goldman N,Thomson RR

更新日期：2017-01-04 00:00:00

abstract：:The interface between LaAlO(3) and SrTiO(3) possesses a range of intriguing properties, notably a proposed connection between the surface state of the LaAlO(3) and the conductivity buried in the SrTiO(3). Here we study the effect of the surface adsorption of a variety of common laboratory solvents on the conductivity ...

journal_title：Nature communications

authors： Xie Y,Hikita Y,Bell C,Hwang HY

更新日期：2011-10-11 00:00:00

abstract：:The original version of this Article contained errors in Fig. 2, Fig. 3a-c and Supplementary Fig. 2. In Fig. 2g and Supplementary Fig. 2, the band structure plot calculated from density function theory (DFT) had a missing band of mainly z2 character that starts at about - 0.25 eV at the Y point and disperses downwards...

journal_title：Nature communications

authors： Li H,Zhou X,Nummy T,Zhang J,Pardo V,Pickett WE,Mitchell JF,Dessau DS

更新日期：2018-05-11 00:00:00

abstract：:Long-term depression (LTD) underlies learning and memory in various brain regions. Although postsynaptic AMPA receptor trafficking mediates LTD, its underlying molecular mechanisms remain largely unclear. Here we show that stargazin, a transmembrane AMPA receptor regulatory protein, forms a ternary complex with adapto...

journal_title：Nature communications

authors： Matsuda S,Kakegawa W,Budisantoso T,Nomura T,Kohda K,Yuzaki M

更新日期：2013-01-01 00:00:00

abstract：:The competition between bimolecular nucleophilic substitution and base-induced elimination is of fundamental importance for the synthesis of pure samples in organic chemistry. Many factors that influence this competition have been identified over the years, but the underlying atomistic dynamics have remained difficult...

journal_title：Nature communications

authors： Carrascosa E,Meyer J,Zhang J,Stei M,Michaelsen T,Hase WL,Yang L,Wester R

更新日期：2017-06-21 00:00:00

abstract：:Cyclic nucleotide-binding (CNB) domains allosterically regulate the activity of proteins with diverse functions, but the mechanisms that enable the cyclic nucleotide-binding signal to regulate distant domains are not well understood. Here we use optical tweezers and molecular dynamics to dissect changes in folding ene...

journal_title：Nature communications

authors： Hao Y,England JP,Bellucci L,Paci E,Hodges HC,Taylor SS,Maillard RA

更新日期：2019-09-04 00:00:00

abstract：:Farnesoid X receptor (FXR) has important roles in maintaining bile acid and cholesterol homeostasis. Here we report that the antiparasitic drug ivermectin is a ligand for nuclear FXR. We identify ivermectin using a high-throughput compound library screening and show that it induces the transcriptional activity of the ...

journal_title：Nature communications

authors： Jin L,Feng X,Rong H,Pan Z,Inaba Y,Qiu L,Zheng W,Lin S,Wang R,Wang Z,Wang S,Liu H,Li S,Xie W,Li Y

更新日期：2013-01-01 00:00:00

abstract：:Face recognition is highly proficient in humans and other social primates; it emerges in infancy, but the development of the neural mechanisms supporting this behaviour is largely unknown. We use blood-volume functional MRI to monitor longitudinally the responsiveness to faces, scrambled faces, and objects in macaque ...

journal_title：Nature communications

authors： Livingstone MS,Vincent JL,Arcaro MJ,Srihasam K,Schade PF,Savage T

更新日期：2017-03-31 00:00:00

abstract：:Human activity has caused dramatic population declines in many wild species. The resulting bottlenecks have a profound impact on the genetic makeup of a species with unknown consequences for health. A key genetic factor for species survival is the evolution of deleterious mutation load, but how bottleneck strength and...

journal_title：Nature communications

authors： Grossen C,Guillaume F,Keller LF,Croll D

更新日期：2020-02-21 00:00:00

abstract：:Supersymmetry is a conjectured symmetry between bosons and fermions aiming at solving fundamental questions in string and quantum field theory. Its subsequent application to quantum mechanics led to a ground-breaking analysis and design machinery, later fruitfully extrapolated to photonics. In all cases, the algebraic...

journal_title：Nature communications

authors： García-Meca C,Ortiz AM,Sáez RL

更新日期：2020-02-10 00:00:00

abstract：:Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, although the reason for such vulnerability remains poorly understood. In this work, we develop a microfluidic chip formed by HGPS-S...

journal_title：Nature communications

authors： Pitrez PR,Estronca L,Monteiro LM,Colell G,Vazão H,Santinha D,Harhouri K,Thornton D,Navarro C,Egesipe AL,Carvalho T,Dos Santos RL,Lévy N,Smith JC,de Magalhães JP,Ori A,Bernardo A,De Sandre-Giovannoli A,Nissan X,Rosel

更新日期：2020-08-17 00:00:00

abstract：:The bundle of stereocilia on inner ear hair cells responds to subnanometer deflections produced by sound or head movement. Stereocilia are interconnected by a variety of links and also carry an electron-dense surface coat. The coat may contribute to stereocilia adhesion or protect from stereocilia fusion, but its mole...

journal_title：Nature communications

authors： Wu X,Ivanchenko MV,Al Jandal H,Cicconet M,Indzhykulian AA,Corey DP

更新日期：2019-08-23 00:00:00

abstract：:The RNA-binding protein Roquin is required to prevent autoimmunity. Roquin controls T-helper cell activation and differentiation by limiting the induced expression of costimulatory receptors such as tumor necrosis factor receptor superfamily 4 (Tnfrs4 or Ox40). A constitutive decay element (CDE) with a characteristic ...

journal_title：Nature communications

authors： Janowski R,Heinz GA,Schlundt A,Wommelsdorf N,Brenner S,Gruber AR,Blank M,Buch T,Buhmann R,Zavolan M,Niessing D,Heissmeyer V,Sattler M

更新日期：2016-03-24 00:00:00

abstract：:Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers. While we previously identified KRAS mutations as molecular culprits of MPE formation, the underlying mechanism remained unknown. Here, we determine that non-canonical IKKα-RelB pathway activation of KRAS-mutant tumor cells mediat...

journal_title：Nature communications

authors： Marazioti A,Lilis I,Vreka M,Apostolopoulou H,Kalogeropoulou A,Giopanou I,Giotopoulou GA,Krontira AC,Iliopoulou M,Kanellakis NI,Agalioti T,Giannou AD,Jones-Paris C,Iwakura Y,Kardamakis D,Blackwell TS,Taraviras S,Spella M

更新日期：2018-02-14 00:00:00

abstract：:Tropical south-western Pacific temperatures are of vital importance to the Great Barrier Reef (GBR), but the role of sea surface temperatures (SSTs) in the growth of the GBR since the Last Glacial Maximum remains largely unknown. Here we present records of Sr/Ca and δ(18)O for Last Glacial Maximum and deglacial corals...

journal_title：Nature communications

authors： Felis T,McGregor HV,Linsley BK,Tudhope AW,Gagan MK,Suzuki A,Inoue M,Thomas AL,Esat TM,Thompson WG,Tiwari M,Potts DC,Mudelsee M,Yokoyama Y,Webster JM

更新日期：2014-06-17 00:00:00

abstract：:Insects that use ephemeral resources must rapidly digest nutrients and simultaneously protect them from competitors. Here we use burying beetles (Nicrophorus vespilloides), which feed their offspring on vertebrate carrion, to investigate the digestive and defensive basis of carrion utilization. We characterize gene ex...

journal_title：Nature communications

authors： Vogel H,Shukla SP,Engl T,Weiss B,Fischer R,Steiger S,Heckel DG,Kaltenpoth M,Vilcinskas A

更新日期：2017-05-09 00:00:00

abstract：:The bio-integrated electronics industry is booming and becoming more integrated with biological tissues. To successfully integrate with the soft tissues of the body (eg. skin), the material must possess many of the same properties including compliance, toughness, elasticity, and tear resistance. In this work, we prepa...

journal_title：Nature communications

authors： Chen S,Sun L,Zhou X,Guo Y,Song J,Qian S,Liu Z,Guan Q,Meade Jeffries E,Liu W,Wang Y,He C,You Z

更新日期：2020-02-27 00:00:00

abstract：:Graphene nanoscrolls are Archimedean-type spirals formed by rolling single-layer graphene sheets. Their unique structure makes them conceptually interesting and understanding their formation gives important information on the manipulation and characteristics of various carbon nanostructures. Here we report a 100% effi...

journal_title：Nature communications

authors： Sharifi T,Gracia-Espino E,Barzegar HR,Jia X,Nitze F,Hu G,Nordblad P,Tai CW,Wågberg T

更新日期：2013-01-01 00:00:00

abstract：:Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how these affect the transcriptome and which changes are linked to transformation or progression, we apply genome-wide expression-methylation quantitative trait loci (emQTL) analysis between DNA methylation and gene expression. On a w...

journal_title：Nature communications

authors： Fleischer T,Tekpli X,Mathelier A,Wang S,Nebdal D,Dhakal HP,Sahlberg KK,Schlichting E,Oslo Breast Cancer Research Consortium (OSBREAC).,Børresen-Dale AL,Borgen E,Naume B,Eskeland R,Frigessi A,Tost J,Hurtado A,Kristensen VN

更新日期：2017-11-09 00:00:00

abstract：:Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease patients. Here, to ...

journal_title：Nature communications

authors： Matic S,Jiang M,Nicholls TJ,Uhler JP,Dirksen-Schwanenland C,Polosa PL,Simard ML,Li X,Atanassov I,Rackham O,Filipovska A,Stewart JB,Falkenberg M,Larsson NG,Milenkovic D

更新日期：2018-03-23 00:00:00

abstract：:A challenge for neuroscience is to understand the conscious and unconscious processes underlying construction of willed actions. We investigated the neural substrate of human motor awareness during awake brain surgery. In a first experiment, awake patients performed a voluntary hand motor task and verbally monitored t...

journal_title：Nature communications

authors： Fornia L,Puglisi G,Leonetti A,Bello L,Berti A,Cerri G,Garbarini F

更新日期：2020-02-04 00:00:00