Coupled microbial bloom and oxygenation decline recorded by magnetofossils during the Palaeocene-Eocene Thermal Maximum.


:Understanding marine environmental change and associated biological turnover across the Palaeocene-Eocene Thermal Maximum (PETM; ~56 Ma)-the most pronounced Cenozoic short-term global warming event-is important because of the potential role of the ocean in atmospheric CO2 drawdown, yet proxies for tracing marine productivity and oxygenation across the PETM are limited and results remain controversial. Here we show that a high-resolution record of South Atlantic Ocean bottom water oxygenation can be extracted from exceptionally preserved magnetofossils-the bioinorganic magnetite nanocrystals produced by magnetotactic bacteria (MTB) using a new multiscale environmental magnetic approach. Our results suggest that a transient MTB bloom occurred due to increased nutrient supply. Bottom water oxygenation decreased gradually from the onset to the peak PETM. These observations provide a record of microbial response to the PETM and establish the value of magnetofossils as palaeoenvironmental indicators.


Nat Commun


Nature communications


Chang L,Harrison RJ,Zeng F,Berndt TA,Roberts AP,Heslop D,Zhao X




Has Abstract


2018-10-01 00:00:00












  • An in-silico approach to predict and exploit synthetic lethality in cancer metabolism.

    abstract::Synthetic lethality is a promising concept in cancer research, potentially opening new possibilities for the development of more effective and selective treatments. Here, we present a computational method to predict and exploit synthetic lethality in cancer metabolism. Our approach relies on the concept of genetic min...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Apaolaza I,San José-Eneriz E,Tobalina L,Miranda E,Garate L,Agirre X,Prósper F,Planes FJ

    更新日期:2017-09-06 00:00:00

  • FAM111A protects replication forks from protein obstacles via its trypsin-like domain.

    abstract::Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or the proteasome in a replication-coupled manner; however, additional proteolytic mechanisms...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Kojima Y,Machida Y,Palani S,Caulfield TR,Radisky ES,Kaufmann SH,Machida YJ

    更新日期:2020-03-12 00:00:00

  • Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.

    abstract::In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS, possibly suggesting a unique oncogenic activity mediated by KRAS-specific interaction partners, which might be targeted. Here, we determine the spec...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Adhikari H,Counter CM

    更新日期:2018-09-07 00:00:00

  • MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.

    abstract::The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and show a distinct distribution of MNK1 and MNK2 in germinal ce...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Landon AL,Muniandy PA,Shetty AC,Lehrmann E,Volpon L,Houng S,Zhang Y,Dai B,Peroutka R,Mazan-Mamczarz K,Steinhardt J,Mahurkar A,Becker KG,Borden KL,Gartenhaus RB

    更新日期:2014-11-18 00:00:00

  • Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling.

    abstract::Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed somatic cells is mostly unknown. Here we show that Eed deficiency in chondrocytes causes s...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Mirzamohammadi F,Papaioannou G,Inloes JB,Rankin EB,Xie H,Schipani E,Orkin SH,Kobayashi T

    更新日期:2016-06-22 00:00:00

  • Employing antineutrino detectors to safeguard future nuclear reactors from diversions.

    abstract::The Non-Proliferation Treaty and other non-proliferation agreements are in place worldwide to ensure that nuclear material and facilities are used only for peaceful purposes. Antineutrino detectors, sensitive to reactor power and fuel changes, can complement the tools already at the disposal of international agencies ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Stewart C,Abou-Jaoude A,Erickson A

    更新日期:2019-08-06 00:00:00

  • The Arabidopsis transcription factor bZIP11 activates auxin-mediated transcription by recruiting the histone acetylation machinery.

    abstract::In higher plants, the hormone auxin orchestrates a diverse array of developmental and environmental responses mainly exerted via transcriptional control. In its absence, auxin-mediated transcription is postulated to be repressed by histone deacetylases, which convert chromatin into a highly packed inactive state. Here...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Weiste C,Dröge-Laser W

    更新日期:2014-05-27 00:00:00

  • A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism.

    abstract::Protein expression evolves under greater evolutionary constraint than mRNA levels, and translation efficiency represents a primary determinant of protein levels during stimuli adaptation. This raises the question as to the translatome remodelers that titrate protein output from mRNA populations. Here, we uncover a net...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Ho JJD,Balukoff NC,Theodoridis PR,Wang M,Krieger JR,Schatz JH,Lee S

    更新日期:2020-05-29 00:00:00

  • Strong confinement-induced engineering of the g factor and lifetime of conduction electron spins in Ge quantum wells.

    abstract::Control of electron spin coherence via external fields is fundamental in spintronics. Its implementation demands a host material that accommodates the desirable but contrasting requirements of spin robustness against relaxation mechanisms and sizeable coupling between spin and orbital motion of the carriers. Here, we ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Giorgioni A,Paleari S,Cecchi S,Vitiello E,Grilli E,Isella G,Jantsch W,Fanciulli M,Pezzoli F

    更新日期:2016-12-21 00:00:00

  • Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.

    abstract::Precise frequency discrimination is a hallmark of auditory function in birds and mammals and is required for distinguishing similar sounding words, like 'bat,' 'cat' and 'hat.' In the cochlea, tuning and spectral separation result from longitudinal differences in basilar membrane stiffness and numerous individual grad...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Thiede BR,Mann ZF,Chang W,Ku YC,Son YK,Lovett M,Kelley MW,Corwin JT

    更新日期:2014-05-20 00:00:00

  • Long-range exciton transport and slow annihilation in two-dimensional hybrid perovskites.

    abstract::Two-dimensional hybrid organic-inorganic perovskites with strongly bound excitons and tunable structures are desirable for optoelectronic applications. Exciton transport and annihilation are two key processes in determining device efficiencies; however, a thorough understanding of these processes is hindered by that a...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Deng S,Shi E,Yuan L,Jin L,Dou L,Huang L

    更新日期:2020-01-31 00:00:00

  • Global pattern for the effect of climate and land cover on water yield.

    abstract::Research results on the effects of land cover change on water resources vary greatly and the topic remains controversial. Here we use published data worldwide to examine the validity of Fuh's equation, which relates annual water yield (R) to a wetness index (precipitation/potential evapotranspiration; P/PET) and water...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Zhou G,Wei X,Chen X,Zhou P,Liu X,Xiao Y,Sun G,Scott DF,Zhou S,Han L,Su Y

    更新日期:2015-01-09 00:00:00

  • Unique behaviour of dinitrogen-bridged dimolybdenum complexes bearing pincer ligand towards catalytic formation of ammonia.

    abstract::It is vital to design effective nitrogen fixation systems that operate under mild conditions, and to this end we recently reported an example of the catalytic formation of ammonia using a dinitrogen-bridged dimolybdenum complex bearing a pincer ligand, where up to twenty three equivalents of ammonia were produced base...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Tanaka H,Arashiba K,Kuriyama S,Sasada A,Nakajima K,Yoshizawa K,Nishibayashi Y

    更新日期:2014-04-28 00:00:00

  • Frustration-driven C 4 symmetric order in a naturally-heterostructured superconductor Sr2VO3FeAs.

    abstract::A subtle balance between competing interactions in iron-based superconductors (FeSCs) can be tipped by additional interfacial interactions in a heterostructure, often inducing exotic phases with unprecedented properties. Particularly when the proximity-coupled layer is magnetically active, rich phase diagrams are expe...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Ok JM,Baek SH,Hoch C,Kremer RK,Park SY,Ji S,Büchner B,Park JH,Hyun SI,Shim JH,Bang Y,Moon EG,Mazin II,Kim JS

    更新日期:2017-12-18 00:00:00

  • Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation.

    abstract::The presence and absence of RNA modifications regulates RNA metabolism by modulating the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m5C) however, it is largely unknown how it recruits or repels RNA-binding proteins. Here, we decipher the consequences of m5C deposition into the abundant non-c...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Sajini AA,Choudhury NR,Wagner RE,Bornelöv S,Selmi T,Spanos C,Dietmann S,Rappsilber J,Michlewski G,Frye M

    更新日期:2019-06-11 00:00:00

  • The genome of broomcorn millet.

    abstract::Broomcorn millet (Panicum miliaceum L.) is the most water-efficient cereal and one of the earliest domesticated plants. Here we report its high-quality, chromosome-scale genome assembly using a combination of short-read sequencing, single-molecule real-time sequencing, Hi-C, and a high-density genetic map. Phylogeneti...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Zou C,Li L,Miki D,Li D,Tang Q,Xiao L,Rajput S,Deng P,Peng L,Jia W,Huang R,Zhang M,Sun Y,Hu J,Fu X,Schnable PS,Chang Y,Li F,Zhang H,Feng B,Zhu X,Liu R,Schnable JC,Zhu JK,Zhang H

    更新日期:2019-01-25 00:00:00

  • Carbon-doped SnS2 nanostructure as a high-efficiency solar fuel catalyst under visible light.

    abstract::Photocatalytic formation of hydrocarbons using solar energy via artificial photosynthesis is a highly desirable renewable-energy source for replacing conventional fossil fuels. Using an L-cysteine-based hydrothermal process, here we synthesize a carbon-doped SnS2 (SnS2-C) metal dichalcogenide nanostructure, which exhi...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Shown I,Samireddi S,Chang YC,Putikam R,Chang PH,Sabbah A,Fu FY,Chen WF,Wu CI,Yu TY,Chung PW,Lin MC,Chen LC,Chen KH

    更新日期:2018-01-12 00:00:00

  • Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway.

    abstract::Antibiotic biosynthetic gene clusters (BGCs) produce bioactive metabolites that impart a fitness advantage to their producer, providing a mechanism for natural selection. This selection drives antibiotic evolution and adapts BGCs for expression in different organisms, potentially providing clues to improve heterologou...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Johnston CW,Badran AH,Collins JJ

    更新日期:2020-08-21 00:00:00

  • Primed histone demethylation regulates shoot regenerative competency.

    abstract::Acquisition of pluripotency by somatic cells is a striking process that enables multicellular organisms to regenerate organs. This process includes silencing of genes to erase original tissue memory and priming of additional cell type specification genes, which are then poised for activation by external signal inputs....

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Ishihara H,Sugimoto K,Tarr PT,Temman H,Kadokura S,Inui Y,Sakamoto T,Sasaki T,Aida M,Suzuki T,Inagaki S,Morohashi K,Seki M,Kakutani T,Meyerowitz EM,Matsunaga S

    更新日期:2019-04-16 00:00:00

  • SPA70 is a potent antagonist of human pregnane X receptor.

    abstract::Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-metabolizing enzymes, resulting in decreased drug efficacy and increased resistance. This suggests that hPXR antagonists have therapeutic value. Here we report that SPA70 is a potent and selective hPXR antagonist. SPA70 inhibits hPXR i...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Lin W,Wang YM,Chai SC,Lv L,Zheng J,Wu J,Zhang Q,Wang YD,Griffin PR,Chen T

    更新日期:2017-09-29 00:00:00

  • An in vivo platform to select and evolve aggregation-resistant proteins.

    abstract::Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic stability, prediction of poorly-behaving biologics is di...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Ebo JS,Saunders JC,Devine PWA,Gordon AM,Warwick AS,Schiffrin B,Chin SE,England E,Button JD,Lloyd C,Bond NJ,Ashcroft AE,Radford SE,Lowe DC,Brockwell DJ

    更新日期:2020-04-14 00:00:00

  • Genetic tagging of active neurons in auditory cortex reveals maternal plasticity of coding ultrasonic vocalizations.

    abstract::Cortical neurons are often functionally heterogeneous even for molecularly defined subtypes. In sensory cortices, physiological responses to natural stimuli can be sparse and vary widely even for neighboring neurons. It is thus difficult to parse out circuits that encode specific stimuli for further experimentation. H...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Tasaka GI,Guenthner CJ,Shalev A,Gilday O,Luo L,Mizrahi A

    更新日期:2018-02-28 00:00:00

  • Highly atroposelective synthesis of nonbiaryl naphthalene-1,2-diamine N-C atropisomers through direct enantioselective C-H amination.

    abstract::Nonbiaryl N-C atropisomer is an important structural scaffold, which is present in natural products, medicines and chiral ligands. However the direct enantioselective C-H amination to access optically pure N-C atropisomer is still difficult and rare. Here we report a π-π interaction and dual H-bond concerted control s...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Bai HY,Tan FX,Liu TQ,Zhu GD,Tian JM,Ding TM,Chen ZM,Zhang SY

    更新日期:2019-07-11 00:00:00

  • Publisher Correction: Orbital bistatic radar observations of asteroid Vesta by the Dawn mission.

    abstract::An incorrect version of the Supplementary Information was inadvertently published with this Article. The HTML has now been updated to include the correct version of the Supplementary Information. ...

    journal_title:Nature communications

    pub_type: 杂志文章,已发布勘误


    authors: Palmer EM,Heggy E,Kofman W

    更新日期:2017-11-23 00:00:00

  • Influence of atomic site-specific strain on catalytic activity of supported nanoparticles.

    abstract::Heterogeneous catalysis is an enabling technology that utilises transition metal nanoparticles (NPs) supported on oxides to promote chemical reactions. Structural mismatch at the NP-support interface generates lattice strain that could affect catalytic properties. However, detailed knowledge about strain in supported ...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Nilsson Pingel T,Jørgensen M,Yankovich AB,Grönbeck H,Olsson E

    更新日期:2018-07-13 00:00:00

  • Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma.

    abstract::Gluconeogenesis is a fundamental feature of hepatocytes. Whether this gluconeogenic activity is also present in malignant hepatocytes remains unexplored. A better understanding of this biological process may lead to novel therapeutic strategies. Here we show that gluconeogenesis is not present in mouse or human malign...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Ma R,Zhang W,Tang K,Zhang H,Zhang Y,Li D,Li Y,Xu P,Luo S,Cai W,Ji T,Katirai F,Ye D,Huang B

    更新日期:2013-01-01 00:00:00

  • mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis.

    abstract::Regulatory T (Treg) cells derived from the thymus (tTreg) and periphery (pTreg) have central and distinct functions in immunosuppression, but mechanisms for the generation and activation of Treg subsets in vivo are unclear. Here, we show that mechanistic target of rapamycin (mTOR) unexpectedly supports the homeostasis...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Chapman NM,Zeng H,Nguyen TM,Wang Y,Vogel P,Dhungana Y,Liu X,Neale G,Locasale JW,Chi H

    更新日期:2018-05-29 00:00:00

  • Bio-inspired sensitive and reversible mechanochromisms via strain-dependent cracks and folds.

    abstract::A number of marine organisms use muscle-controlled surface structures to achieve rapid changes in colour and transparency with outstanding reversibility. Inspired by these display tactics, we develop analogous deformation-controlled surface-engineering approaches via strain-dependent cracks and folds to realize the fo...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Zeng S,Zhang D,Huang W,Wang Z,Freire SG,Yu X,Smith AT,Huang EY,Nguon H,Sun L

    更新日期:2016-07-08 00:00:00

  • MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity.

    abstract::The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein synthesis and widespread activation of muscle-spec...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Moretti I,Ciciliot S,Dyar KA,Abraham R,Murgia M,Agatea L,Akimoto T,Bicciato S,Forcato M,Pierre P,Uhlenhaut NH,Rigby PW,Carvajal JJ,Blaauw B,Calabria E,Schiaffino S

    更新日期:2016-08-03 00:00:00

  • MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB.

    abstract::Autophagy is the major cellular pathway by which macromolecules are degraded, and amino acid depletion powerfully activates autophagy. MAP4K3, or germinal-center kinase-like kinase, is required for robust cell growth in response to amino acids, but the basis for MAP4K3 regulation of cellular metabolic disposition rema...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Hsu CL,Lee EX,Gordon KL,Paz EA,Shen WC,Ohnishi K,Meisenhelder J,Hunter T,La Spada AR

    更新日期:2018-03-05 00:00:00