Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.

abstract：:Variability in dense shelf water formation can potentially impact Antarctic Bottom Water (AABW) production, a vital component of the global climate system. In East Antarctica, the George V Land polynya system (142-150°E) is structured by the local 'icescape', promoting sea ice formation that is driven by the offshore ...

journal_title：Nature communications

authors： Tamura T,Williams GD,Fraser AD,Ohshima KI

更新日期：2012-05-08 00:00:00

abstract：:Coherence in light-matter interaction is a necessary ingredient if light is used to control the quantum state of a material system. Coherent effects are firmly associated with isolated systems kept at low temperature. The exceedingly fast dephasing in condensed matter environments, in particular at elevated temperatur...

journal_title：Nature communications

authors： Kolarczik M,Owschimikow N,Korn J,Lingnau B,Kaptan Y,Bimberg D,Schöll E,Lüdge K,Woggon U

更新日期：2013-01-01 00:00:00

abstract：:In the bottom-up synthesis of graphene nanoribbons (GNRs) from self-assembled linear polymer intermediates, surface-assisted cyclodehydrogenations usually take place on catalytic metal surfaces. Here we demonstrate the formation of GNRs from quasi-freestanding polymers assisted by hole injections from a scanning tunne...

journal_title：Nature communications

authors： Ma C,Xiao Z,Zhang H,Liang L,Huang J,Lu W,Sumpter BG,Hong K,Bernholc J,Li AP

更新日期：2017-03-13 00:00:00

abstract：:How the stressosome, the epicenter of the stress response in bacteria, transmits stress signals from the environment has remained elusive. The stressosome consists of multiple copies of three proteins RsbR, RsbS and RsbT, a kinase that is important for its activation. Using cryo-electron microscopy, we determined the ...

journal_title：Nature communications

authors： Williams AH,Redzej A,Rolhion N,Costa TRD,Rifflet A,Waksman G,Cossart P

更新日期：2019-07-08 00:00:00

abstract：:Trypanosoma brucei is a protozoan parasite that evades its host's adaptive immune response by repeatedly replacing its dense variant surface glycoprotein (VSG) coat from its large genomic VSG repertoire. While the mechanisms regulating VSG gene expression and diversification have been examined extensively, the dynamic...

journal_title：Nature communications

authors： Pinger J,Chowdhury S,Papavasiliou FN

更新日期：2017-10-10 00:00:00

abstract：:Rising demand for ruminant meat and dairy products in developing countries is expected to double anthropogenic greenhouse gas and ammonia emissions from livestock by 2050. Mitigation strategies are urgently needed to meet demand while minimizing environmental impacts. Here, we develop scenarios for mitigating emission...

journal_title：Nature communications

authors： Du Y,Ge Y,Ren Y,Fan X,Pan K,Lin L,Wu X,Min Y,Meyerson LA,Heino M,Chang SX,Liu X,Mao F,Yang G,Peng C,Qu Z,Chang J,Didham RK

更新日期：2018-10-08 00:00:00

abstract：:The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for these are available. Here we report cyclic peptide inhibitors of the KDM4A-C with selectivity over other KDMs/2OG oxygenases, including closely related KDM4D/E ...

journal_title：Nature communications

authors： Kawamura A,Münzel M,Kojima T,Yapp C,Bhushan B,Goto Y,Tumber A,Katoh T,King ON,Passioura T,Walport LJ,Hatch SB,Madden S,Müller S,Brennan PE,Chowdhury R,Hopkinson RJ,Suga H,Schofield CJ

更新日期：2017-04-06 00:00:00

abstract：:The social intelligence hypothesis (SIH) posits that within-group interactions drive cognitive evolution, but it has received equivocal support. We argue the SIH overlooks a major component of social life: interactions with conspecific outsiders. Competition for vital resources means conspecific outsiders present myri...

journal_title：Nature communications

authors： Ashton BJ,Kennedy P,Radford AN

更新日期：2020-10-06 00:00:00

abstract：:The experimental investigation of quantum devices incorporating mechanical resonators has opened up new frontiers in the study of quantum mechanics at a macroscopic level. It has recently been shown that surface acoustic waves (SAWs) can be piezoelectrically coupled to superconducting qubits, and confined in high-qual...

journal_title：Nature communications

authors： Manenti R,Kockum AF,Patterson A,Behrle T,Rahamim J,Tancredi G,Nori F,Leek PJ

更新日期：2017-10-17 00:00:00

abstract：:Monomeric near-infrared (NIR) fluorescent proteins (FPs) are in high demand as protein tags and components of biosensors for deep-tissue imaging and multicolour microscopy. We report three bright and spectrally distinct monomeric NIR FPs, termed miRFPs, engineered from bacterial phytochrome, which can be used as easil...

journal_title：Nature communications

authors： Shcherbakova DM,Baloban M,Emelyanov AV,Brenowitz M,Guo P,Verkhusha VV

更新日期：2016-08-19 00:00:00

abstract：:The design and assembly of artificial protocell consortia displaying dynamical behaviours and systems-based properties are emerging challenges in bottom-up synthetic biology. Cellular processes such as morphogenesis and differentiation rely in part on reaction-diffusion gradients, and the ability to mimic rudimentary ...

journal_title：Nature communications

authors： Tian L,Li M,Patil AJ,Drinkwater BW,Mann S

更新日期：2019-07-25 00:00:00

abstract：:The proliferative and functional heterogeneity among seemingly uniform cells is a universal phenomenon. Identifying the underlying factors requires single-cell analysis of function and proliferation. Here we show that the pancreatic beta-cells in zebrafish exhibit different growth-promoting and functional properties, ...

journal_title：Nature communications

authors： Singh SP,Janjuha S,Hartmann T,Kayisoglu Ö,Konantz J,Birke S,Murawala P,Alfar EA,Murata K,Eugster A,Tsuji N,Morrissey ER,Brand M,Ninov N

更新日期：2017-09-22 00:00:00

abstract：:Artificial particle ices are model systems of constrained, interacting particles. They have been introduced theoretically to study ice-manifolds emergent from frustration, along with domain wall and grain boundary dynamics, doping, pinning-depinning, controlled transport of topological defects, avalanches, and memory ...

journal_title：Nature communications

authors： Libál A,Lee DY,Ortiz-Ambriz A,Reichhardt C,Reichhardt CJO,Tierno P,Nisoli C

更新日期：2018-10-08 00:00:00

abstract：:Two voltage-gated calcium channel subtypes-CaV1.2 and CaV1.3-underlie the major L-type Ca(2+) currents in the mammalian central nervous system. Owing to their high sequence homology, the two channel subtypes share similar pharmacological properties, and at high doses classic calcium channel blockers, such as dihydropy...

journal_title：Nature communications

authors： Huang H,Ng CY,Yu D,Zhai J,Lam Y,Soong TW

更新日期：2014-07-24 00:00:00

abstract：:The exceptional interest in improving the limitations of data storage, molecular electronics and optoelectronics has promoted the development of an ever increasing number of techniques used to pattern polymers at micro and nanoscale. Most of them rely on atomic force microscopy to thermally or electrostatically induce...

journal_title：Nature communications

authors： Farina M,Ye T,Lanzani G,di Donato A,Venanzoni G,Mencarelli D,Pietrangelo T,Morini A,Keivanidis PE

更新日期：2013-01-01 00:00:00

abstract：:The yeast Saccharomyces cerevisiae has been an essential component of human civilization because of its long global history of use in food and beverage fermentation. However, the diversity and evolutionary history of the domesticated populations of the yeast remain elusive. We show here that China/Far East Asia is lik...

journal_title：Nature communications

authors： Duan SF,Han PJ,Wang QM,Liu WQ,Shi JY,Li K,Zhang XL,Bai FY

更新日期：2018-07-12 00:00:00

abstract：:Hidden hearing loss (HHL) is a recently described auditory neuropathy believed to contribute to speech discrimination and intelligibility deficits in people with normal audiological tests. Animals and humans with HHL have normal auditory thresholds but defective cochlear neurotransmission, that is, reduced suprathresh...

journal_title：Nature communications

authors： Wan G,Corfas G

更新日期：2017-02-17 00:00:00

abstract：:Sensors using nitrogen-vacancy centers in diamond are a promising tool for small-volume nuclear magnetic resonance (NMR) spectroscopy, but the limited sensitivity remains a challenge. Here we show nearly two orders of magnitude improvement in concentration sensitivity over previous nitrogen-vacancy and picoliter NMR s...

journal_title：Nature communications

authors： Kehayias P,Jarmola A,Mosavian N,Fescenko I,Benito FM,Laraoui A,Smits J,Bougas L,Budker D,Neumann A,Brueck SRJ,Acosta VM

更新日期：2017-08-04 00:00:00

abstract：:Nanoparticles attached just above a flat metallic surface can trap optical fields in the nanoscale gap. This enables local spectroscopy of a few molecules within each coupled plasmonic hotspot, with near thousand-fold enhancement of the incident fields. As a result of non-radiative relaxation pathways, the plasmons in...

journal_title：Nature communications

authors： de Nijs B,Benz F,Barrow SJ,Sigle DO,Chikkaraddy R,Palma A,Carnegie C,Kamp M,Sundararaman R,Narang P,Scherman OA,Baumberg JJ

更新日期：2017-10-20 00:00:00

abstract：:Even as the study of plant genomics rapidly develops through the use of high-throughput sequencing techniques, traditional plant phenotyping lags far behind. Here we develop a high-throughput rice phenotyping facility (HRPF) to monitor 13 traditional agronomic traits and 2 newly defined traits during the rice growth p...

journal_title：Nature communications

authors： Yang W,Guo Z,Huang C,Duan L,Chen G,Jiang N,Fang W,Feng H,Xie W,Lian X,Wang G,Luo Q,Zhang Q,Liu Q,Xiong L

更新日期：2014-10-08 00:00:00

abstract：:Purely organic room temperature phosphorescence (RTP) has attracted wide attention recently due to its various application potentials. However, ultralong RTP (URTP) with high efficiency is still rarely achieved. Herein, by dissolving 1,8-naphthalic anhydride in certain organic solid hosts, URTP with a lifetime of over...

journal_title：Nature communications

authors： Zhang X,Du L,Zhao W,Zhao Z,Xiong Y,He X,Gao PF,Alam P,Wang C,Li Z,Leng J,Liu J,Zhou C,Lam JWY,Phillips DL,Zhang G,Tang BZ

更新日期：2019-11-14 00:00:00

abstract：:Controlling the biodistribution of nanoparticles upon intravenous injection is the key to achieving target specificity. One of the impediments in nanoparticle-based tumor targeting is the inability to limit the trafficking of nanoparticles to liver and other organs leading to smaller accumulated amounts in tumor tissu...

journal_title：Nature communications

authors： Chen F,Ma K,Madajewski B,Zhuang L,Zhang L,Rickert K,Marelli M,Yoo B,Turker MZ,Overholtzer M,Quinn TP,Gonen M,Zanzonico P,Tuesca A,Bowen MA,Norton L,Subramony JA,Wiesner U,Bradbury MS

更新日期：2018-10-08 00:00:00

abstract：:Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key regulators of immune cell functions, but their roles in macrophage's fibrogenesis have not been characterized. Here we show that IL-4 and IL-13 induce miR-142-5p a...

journal_title：Nature communications

authors： Su S,Zhao Q,He C,Huang D,Liu J,Chen F,Chen J,Liao JY,Cui X,Zeng Y,Yao H,Su F,Liu Q,Jiang S,Song E

更新日期：2015-10-05 00:00:00

abstract：:Many regulatory and signaling proteins have multiple modification sites. In bacterial chemotaxis, each chemoreceptor has multiple methylation sites that are responsible for adaptation. However, whether the ordering of the multisite methylation process affects adaptation remains unclear. Furthermore, the benefit of hav...

journal_title：Nature communications

authors： Mello BA,Beserra AB,Tu Y

更新日期：2020-06-08 00:00:00

abstract：:An invisibility cloak should completely hide an object from an observer, ideally across the visible spectrum and for all angles of incidence and polarizations of light, in three dimensions. However, until now, all such devices have been limited to either small bandwidths or have disregarded the phase of the impinging ...

journal_title：Nature communications

authors： Tsakmakidis KL,Reshef O,Almpanis E,Zouros GP,Mohammadi E,Saadat D,Sohrabi F,Fahimi-Kashani N,Etezadi D,Boyd RW,Altug H

更新日期：2019-10-24 00:00:00

abstract：:The costs for solar photovoltaics, wind, and battery storage have dropped markedly since 2010, however, many recent studies and reports around the world have not adequately captured such dramatic decrease. Those costs are projected to decline further in the near future, bringing new prospects for the widespread penetr...

journal_title：Nature communications

authors： He G,Lin J,Sifuentes F,Liu X,Abhyankar N,Phadke A

更新日期：2020-05-19 00:00:00

abstract：:The need for active and stable oxidation catalysts is driven by the demands in production of valuable chemicals, remediation of hydrocarbon pollutants and energy sustainability. Traditional approaches focus on oxygen-activating oxides as support which provides the oxygen activation at the catalyst-support peripheral i...

journal_title：Nature communications

authors： Shan S,Li J,Maswadeh Y,O'Brien C,Kareem H,Tran DT,Lee IC,Wu ZP,Wang S,Yan S,Cronk H,Mott D,Yang L,Luo J,Petkov V,Zhong CJ

更新日期：2020-08-21 00:00:00

abstract：:Imaging the atomic structure of a single biomolecule is an important challenge in the physical biosciences. Whilst existing techniques all rely on averaging over large ensembles of molecules, the single-molecule realm remains unsolved. Here we present a protocol for 3D magnetic resonance imaging of a single molecule u...

journal_title：Nature communications

authors： Perunicic VS,Hill CD,Hall LT,Hollenberg LC

更新日期：2016-10-11 00:00:00

abstract：:Liquid-liquid phase separation is increasingly recognized as a process involved in cellular organization. Thus far, a detailed structural characterization of this intrinsically heterogeneous process has been challenging. Here we combine solid- and solution-state NMR spectroscopy to obtain atomic-level insights into th...

journal_title：Nature communications

authors： Damman R,Schütz S,Luo Y,Weingarth M,Sprangers R,Baldus M

更新日期：2019-10-04 00:00:00

abstract：:According to the clonal evolution model, tumour growth is driven by competing subclones in somatically evolving cancer cell populations, which gives rise to genetically heterogeneous tumours. Here we present a comparative targeted deep-sequencing approach combined with a customised statistical algorithm, called deepSN...

journal_title：Nature communications

authors： Gerstung M,Beisel C,Rechsteiner M,Wild P,Schraml P,Moch H,Beerenwinkel N

更新日期：2012-05-01 00:00:00