Abstract：
:Acoustical tweezers open major prospects in microbiology for cells and microorganisms contactless manipulation, organization and mechanical properties testing since they are biocompatible, label-free and have the potential to exert forces several orders of magnitude larger than their optical counterpart at equivalent power. Yet, these perspectives have so far been hindered by the absence of spatial selectivity of existing acoustical tweezers - i.e., the ability to select and move objects individually - and/or their limited resolution restricting their use to large particle manipulation only and/or finally the limited forces that they could apply. Here, we report precise selective manipulation and positioning of individual human cells in a standard microscopy environment with trapping forces up to ~200 pN without altering their viability. These results are obtained with miniaturized acoustical tweezers combining holography with active materials to synthesize specific wavefields called focused acoustical vortices designed to produce stiff localized traps with reduced acoustic power.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Baudoin M,Thomas JL,Sahely RA,Gerbedoen JC,Gong Z,Sivery A,Matar OB,Smagin N,Favreau P,Vlandas Adoi
10.1038/s41467-020-18000-ysubject
Has Abstractpub_date
2020-08-25 00:00:00pages
4244issue
1issn
2041-1723pii
10.1038/s41467-020-18000-yjournal_volume
11pub_type
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