Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats.

abstract：:Scalable quantum networking requires quantum systems with quantum processing capabilities. Solid state spin systems with reliable spin-optical interfaces are a leading hardware in this regard. However, available systems suffer from large electron-phonon interaction or fast spin dephasing. Here, we demonstrate that the...

journal_title：Nature communications

authors： Nagy R,Niethammer M,Widmann M,Chen YC,Udvarhelyi P,Bonato C,Hassan JU,Karhu R,Ivanov IG,Son NT,Maze JR,Ohshima T,Soykal ÖO,Gali Á,Lee SY,Kaiser F,Wrachtrup J

更新日期：2019-04-26 00:00:00

abstract：:Forests are of major importance to human society, contributing several crucial ecosystem services. Biodiversity is suggested to positively influence multiple services but evidence from natural systems at scales relevant to management is scarce. Here, across a scale of 400,000 km(2), we report that tree species richnes...

journal_title：Nature communications

authors： Gamfeldt L,Snäll T,Bagchi R,Jonsson M,Gustafsson L,Kjellander P,Ruiz-Jaen MC,Fröberg M,Stendahl J,Philipson CD,Mikusiński G,Andersson E,Westerlund B,Andrén H,Moberg F,Moen J,Bengtsson J

更新日期：2013-01-01 00:00:00

abstract：:Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank), we here show that ...

journal_title：Nature communications

authors： Joshi PK,Fischer K,Schraut KE,Campbell H,Esko T,Wilson JF

更新日期：2016-03-31 00:00:00

abstract：:The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation of self-anchored, K63-linked ubiquitin chains by the heterodimeric E2 enzyme Ube2N/Ube2V2....

journal_title：Nature communications

authors： Kiss L,Zeng J,Dickson CF,Mallery DL,Yang JC,McLaughlin SH,Boland A,Neuhaus D,James LC

更新日期：2019-10-03 00:00:00

abstract：:In order to control and eradicate epidemic cholera, we need to understand how epidemics begin, how they spread, and how they decline and eventually end. This requires extensive sampling of epidemic disease over time, alongside the background of endemic disease that may exist concurrently with the epidemic. The unique ...

journal_title：Nature communications

authors： Dorman MJ,Domman D,Poklepovich T,Tolley C,Zolezzi G,Kane L,Viñas MR,Panagópulo M,Moroni M,Binsztein N,Caffer MI,Clare S,Dougan G,Salmond GPC,Parkhill J,Campos J,Thomson NR

更新日期：2020-10-01 00:00:00

abstract：:Human pressures on the ocean are thought to be increasing globally, yet we know little about their patterns of cumulative change, which pressures are most responsible for change, and which places are experiencing the greatest increases. Managers and policymakers require such information to make strategic decisions and...

journal_title：Nature communications

authors： Halpern BS,Frazier M,Potapenko J,Casey KS,Koenig K,Longo C,Lowndes JS,Rockwood RC,Selig ER,Selkoe KA,Walbridge S

更新日期：2015-07-14 00:00:00

abstract：:To colonise their host, pathogens must counter local environmental and immunological challenges. Here, we reveal that the fungal pathogen Candida albicans exploits diverse host-associated signals to promote immune evasion by masking of a major pathogen-associated molecular pattern (PAMP), β-glucan. Certain nutrients, ...

journal_title：Nature communications

authors： Pradhan A,Avelar GM,Bain JM,Childers D,Pelletier C,Larcombe DE,Shekhova E,Netea MG,Brown GD,Erwig L,Gow NAR,Brown AJP

更新日期：2019-11-22 00:00:00

abstract：:Understanding how cellular functions emerge from the underlying molecular mechanisms is a key challenge in biology. This will require computational models, whose predictive power is expected to increase with coverage and precision of formulation. Genome-scale models revolutionised the metabolic field and made the firs...

journal_title：Nature communications

authors： Münzner U,Klipp E,Krantz M

更新日期：2019-03-21 00:00:00

abstract：:Proper regulation of energy storage in adipose tissue is crucial for maintaining insulin sensitivity and molecules contributing to this process have not been fully revealed. Here we show that type II transmembrane protein tenomodulin (TNMD) is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive...

journal_title：Nature communications

authors： Senol-Cosar O,Flach RJ,DiStefano M,Chawla A,Nicoloro S,Straubhaar J,Hardy OT,Noh HL,Kim JK,Wabitsch M,Scherer PE,Czech MP

更新日期：2016-02-16 00:00:00

abstract：:Stimuli-responsive behaviors of flexible metal-organic frameworks (MOFs) make these materials promising in a wide variety of applications such as gas separation, drug delivery, and molecular sensing. Considerable efforts have been made over the last decade to understand the structural changes of flexible MOFs in respo...

journal_title：Nature communications

authors： Zhao P,Fang H,Mukhopadhyay S,Li A,Rudić S,McPherson IJ,Tang CC,Fairen-Jimenez D,Tsang SCE,Redfern SAT

更新日期：2019-03-01 00:00:00

abstract：:Cellular events that occur across the seminiferous epithelium in the mammalian testis during spermatogenesis are tightly coordinated by biologically active peptides released from laminin chains. Laminin-γ3 domain IV is released at the apical ectoplasmic specialization during spermiation and mediates restructuring of t...

journal_title：Nature communications

authors： Su L,Mruk DD,Lie PP,Silvestrini B,Cheng CY

更新日期：2012-01-01 00:00:00

abstract：:Despite extensive studies on transcription mechanisms, it is unknown how termination complexes are disassembled, especially in what order the essential components dissociate. Our single-molecule fluorescence study unveils that RNA transcript release precedes RNA polymerase (RNAP) dissociation from the DNA template muc...

journal_title：Nature communications

authors： Kang W,Ha KS,Uhm H,Park K,Lee JY,Hohng S,Kang C

更新日期：2020-01-23 00:00:00

abstract：:High-harmonic generation (HHG) in gases has been the main enabling technology of attosecond science since its discovery. Recently, HHG from solids has been demonstrated, opening a lively area of research. In contrast, harmonic generation from liquids has so far remained restricted to low harmonics in the visible regim...

journal_title：Nature communications

authors： Luu TT,Yin Z,Jain A,Gaumnitz T,Pertot Y,Ma J,Wörner HJ

更新日期：2018-09-13 00:00:00

abstract：:The principles governing the recruitment of interneurons during acceleration in vertebrate locomotion are unknown. In the mouse, the V2a spinal interneurons are dispensable for left-right coordination at low locomotor frequencies, but their function is essential for maintaining left-right coordination at high frequenc...

journal_title：Nature communications

authors： Zhong G,Sharma K,Harris-Warrick RM

更新日期：2011-01-01 00:00:00

abstract：:Genomic imprinting is a phenomenon that restricts transcription to predominantly one parental allele. How this transcriptional duality is regulated is poorly understood. Here we perform an RNA interference screen for epigenetic factors involved in paternal allelic silencing at the Kcnq1ot1 imprinted domain in mouse ex...

journal_title：Nature communications

authors： Sachani SS,Landschoot LS,Zhang L,White CR,MacDonald WA,Golding MC,Mann MRW

更新日期：2018-07-18 00:00:00

abstract：:An effective way to improve polymer solar cell efficiency is to use a tandem structure, as a broader part of the spectrum of solar radiation is used and the thermalization loss of photon energy is minimized. In the past, the lack of high-performance low-bandgap polymers was the major limiting factor for achieving high...

journal_title：Nature communications

authors： You J,Dou L,Yoshimura K,Kato T,Ohya K,Moriarty T,Emery K,Chen CC,Gao J,Li G,Yang Y

更新日期：2013-01-01 00:00:00

abstract：:The human Immunodeficiency Centromeric Instability Facial Anomalies (ICF) 4 syndrome is a severe disease with increased mortality caused by mutation in the LSH gene. Although LSH belongs to a family of chromatin remodeling proteins, it remains unknown how LSH mediates its function on chromatin in vivo. Here, we use ch...

journal_title：Nature communications

authors： Ni K,Ren J,Xu X,He Y,Finney R,Braun SMG,Hathaway NA,Crabtree GR,Muegge K

更新日期：2020-11-06 00:00:00

abstract：:Underlying cellular responses is a transcriptional regulatory network (TRN) that modulates gene expression. A useful description of the TRN would decompose the transcriptome into targeted effects of individual transcriptional regulators. Here, we apply unsupervised machine learning to a diverse compendium of over 250 ...

journal_title：Nature communications

authors： Sastry AV,Gao Y,Szubin R,Hefner Y,Xu S,Kim D,Choudhary KS,Yang L,King ZA,Palsson BO

更新日期：2019-12-04 00:00:00

abstract：:Graphene and hexagonal boron nitride are typical conductor and insulator, respectively, while their hybrids hexagonal boron carbonitride are promising as a semiconductor. Here we demonstrate a direct chemical conversion reaction, which systematically converts the hexagonal carbon lattice of graphene to boron nitride, ...

journal_title：Nature communications

authors： Gong Y,Shi G,Zhang Z,Zhou W,Jung J,Gao W,Ma L,Yang Y,Yang S,You G,Vajtai R,Xu Q,MacDonald AH,Yakobson BI,Lou J,Liu Z,Ajayan PM

更新日期：2014-01-01 00:00:00

abstract：:In order to model realistic quantum devices it is necessary to simulate quantum systems strongly coupled to their environment. To date, most understanding of open quantum systems is restricted either to weak system-bath couplings or to special cases where specific numerical techniques become effective. Here we present...

journal_title：Nature communications

authors： Strathearn A,Kirton P,Kilda D,Keeling J,Lovett BW

更新日期：2018-08-20 00:00:00

abstract：:The practices of synthetic biology are being integrated into 'multiscale' designs enabling two-way communication across organic and inorganic information substrates in biological, digital and cyber-physical system integrations. Novel applications of 'bio-informational' engineering will arise in environmental monitorin...

journal_title：Nature communications

authors： Dixon TA,Williams TC,Pretorius IS

更新日期：2021-01-15 00:00:00

abstract：:The quiescent centre (QC) in the Arabidopsis root apical meristem is essential for stem cell organization. Here we show that the loss of REPRESSOR OF WUSCHEL1 (ROW1), a PHD domain-containing protein, leads to QC failure, defects in cell differentiation and ectopic expression of WUSCHEL-RELATED HOMEOBOX 5 (WOX5) in cel...

journal_title：Nature communications

authors： Zhang Y,Jiao Y,Liu Z,Zhu YX

更新日期：2015-01-29 00:00:00

abstract：:Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (~35,000 samples) with the population-specific reference panel created by the Genome of T...

journal_title：Nature communications

authors： van Leeuwen EM,Karssen LC,Deelen J,Isaacs A,Medina-Gomez C,Mbarek H,Kanterakis A,Trompet S,Postmus I,Verweij N,van Enckevort DJ,Huffman JE,White CC,Feitosa MF,Bartz TM,Manichaikul A,Joshi PK,Peloso GM,Deelen P,van D

更新日期：2015-03-09 00:00:00

abstract：:The emergence of artificial intelligence (AI) and its progressively wider impact on many sectors requires an assessment of its effect on the achievement of the Sustainable Development Goals. Using a consensus-based expert elicitation process, we find that AI can enable the accomplishment of 134 targets across all the ...

journal_title：Nature communications

authors： Vinuesa R,Azizpour H,Leite I,Balaam M,Dignum V,Domisch S,Felländer A,Langhans SD,Tegmark M,Fuso Nerini F

更新日期：2020-01-13 00:00:00

abstract：:Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic loca...

journal_title：Nature communications

authors： Lin WY,Fordham SE,Sunter N,Elstob C,Rahman T,Willmore E,Shepherd C,Strathdee G,Mainou-Fowler T,Piddock R,Mearns H,Barrow T,Houlston RS,Marr H,Wallis J,Summerfield G,Marshall S,Pettitt A,Pepper C,Fegan C,Forconi F

更新日期：2021-01-28 00:00:00

abstract：:Generally, a homogeneous catalyst exhibits good activity and defined active sites but it is difficult to recycle. Meanwhile, a heterogeneous catalyst can easily be reused but its active site is difficult to reveal. It is interesting to bridge the gap between homogeneous and heterogeneous catalysis via controllable con...

journal_title：Nature communications

authors： Zhang Y,Pang S,Wei Z,Jiao H,Dai X,Wang H,Shi F

更新日期：2018-04-13 00:00:00

abstract：:The molecular mechanisms that couple glycolysis to cancer drug resistance remain unclear. Here we identify an ATP-binding motif within the NADPH oxidase isoform, NOX4, and show that ATP directly binds and negatively regulates NOX4 activity. We find that NOX4 localizes to the inner mitochondria membrane and that subcel...

journal_title：Nature communications

authors： Shanmugasundaram K,Nayak BK,Friedrichs WE,Kaushik D,Rodriguez R,Block K

更新日期：2017-10-19 00:00:00

abstract：:Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and obesity on pubertal timing are unknown. Here, we identify Sirtuin 1 (SIRT1), a fuel-sensing deacetylase, as a molecule that restrains female p...

journal_title：Nature communications

authors： Vazquez MJ,Toro CA,Castellano JM,Ruiz-Pino F,Roa J,Beiroa D,Heras V,Velasco I,Dieguez C,Pinilla L,Gaytan F,Nogueiras R,Bosch MA,Rønnekleiv OK,Lomniczi A,Ojeda SR,Tena-Sempere M

更新日期：2018-10-10 00:00:00

abstract：:The social intelligence hypothesis (SIH) posits that within-group interactions drive cognitive evolution, but it has received equivocal support. We argue the SIH overlooks a major component of social life: interactions with conspecific outsiders. Competition for vital resources means conspecific outsiders present myri...

journal_title：Nature communications

authors： Ashton BJ,Kennedy P,Radford AN

更新日期：2020-10-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Luo Y,Teng X,Zhang L,Chen J,Liu Z,Chen X,Zhao S,Yang S,Feng J,Yan X

更新日期：2019-09-05 00:00:00