当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum.

Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum.

Abstract：

:Neurodegenerative lesions induce sprouting of new collaterals from surviving axons, but the extent to which this form of axonal remodelling alters brain functional structure remains unclear. To understand how collateral sprouting proceeds in the adult brain, we imaged post-lesion sprouting of cerebellar climbing fibres (CFs) in mice using in vivo time-lapse microscopy. Here we show that newly sprouted CF collaterals innervate multiple Purkinje cells (PCs) over several months, with most innervations emerging at 3-4 weeks post lesion. Simultaneous imaging of cerebellar functional structure reveals that surviving CFs similarly innervate functionally relevant and non-relevant PCs, but have more synaptic area on PCs near the collateral origin than on distant PCs. These results suggest that newly sprouted axon collaterals do not preferentially innervate functionally relevant postsynaptic targets. Nonetheless, the spatial gradient of collateral innervation might help to loosely maintain functional synaptic circuits if functionally relevant neurons are clustered in the lesioned area.

journal_name

Nat Commun

journal_title

Nature communications

authors

Dhar M,Brenner JM,Sakimura K,Kano M,Nishiyama H

doi

10.1038/ncomms12938

subject

Has Abstract

pub_date

2016-09-21 00:00:00

pages

12938

issn

2041-1723

pii

ncomms12938

journal_volume

7

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.

    abstract：:Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key regulators of immune cell functions, but their roles in macrophage's fibrogenesis have not been characterized. Here we show that IL-4 and IL-13 induce miR-142-5p a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9523

    authors： Su S,Zhao Q,He C,Huang D,Liu J,Chen F,Chen J,Liao JY,Cui X,Zeng Y,Yao H,Su F,Liu Q,Jiang S,Song E

    更新日期：2015-10-05 00:00:00

  • Cytosolic targeting factor AKR2A captures chloroplast outer membrane-localized client proteins at the ribosome during translation.

    abstract：:In eukaryotic cells, organellar proteome biogenesis is pivotal for cellular function. Chloroplasts contain a complex proteome, the biogenesis of which includes post-translational import of nuclear-encoded proteins. However, the mechanisms determining when and how nascent chloroplast-targeted proteins are sorted in the...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7843

    authors： Kim DH,Lee JE,Xu ZY,Geem KR,Kwon Y,Park JW,Hwang I

    更新日期：2015-04-16 00:00:00

  • Excess forest mortality is consistently linked to drought across Europe.

    abstract：:Pulses of tree mortality caused by drought have been reported recently in forests around the globe, but large-scale quantitative evidence is lacking for Europe. Analyzing high-resolution annual satellite-based canopy mortality maps from 1987 to 2016 we here show that excess forest mortality (i.e., canopy mortality exc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19924-1

    authors： Senf C,Buras A,Zang CS,Rammig A,Seidl R

    更新日期：2020-12-03 00:00:00

  • FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA.

    abstract：:N(6)-methyladenosine is a prevalent internal modification in messenger RNA and non-coding RNA affecting various cellular pathways. Here we report the discovery of two additional modifications, N(6)-hydroxymethyladenosine (hm(6)A) and N(6)-formyladenosine (f(6)A), in mammalian messenger RNA. We show that Fe(II)- and α-...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2822

    authors： Fu Y,Jia G,Pang X,Wang RN,Wang X,Li CJ,Smemo S,Dai Q,Bailey KA,Nobrega MA,Han KL,Cui Q,He C

    更新日期：2013-01-01 00:00:00

  • Millimetre-long transport of photogenerated carriers in topological insulators.

    abstract：:Excitons are spin integer particles that are predicted to condense into a coherent quantum state at sufficiently low temperature. Here by using photocurrent imaging we report experimental evidence of formation and efficient transport of non-equilibrium excitons in Bi2-xSbxSe3 nanoribbons. The photocurrent distribution...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13711-3

    authors： Hou Y,Wang R,Xiao R,McClintock L,Clark Travaglini H,Paulus Francia J,Fetsch H,Erten O,Savrasov SY,Wang B,Rossi A,Vishik I,Rotenberg E,Yu D

    更新日期：2019-12-16 00:00:00

  • Graphene chiral liquid crystals and macroscopic assembled fibres.

    abstract：:Chirality and liquid crystals are both widely expressed in nature and biology. Helical assembly of mesophasic molecules and colloids may produce intriguing chiral liquid crystals. To date, chiral liquid crystals of 2D colloids have not been explored. As a typical 2D colloid, graphene is now receiving unprecedented att...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1583

    authors： Xu Z,Gao C

    更新日期：2011-12-06 00:00:00

  • A novel thiol-reductase activity of Arabidopsis YUC6 confers drought tolerance independently of auxin biosynthesis.

    abstract：:YUCCA (YUC) proteins constitute a family of flavin monooxygenases (FMOs), with an important role in auxin (IAA) biosynthesis. Here we report that Arabidopsis plants overexpressing YUC6 display enhanced IAA-related phenotypes and exhibit improved drought stress tolerance, low rate of water loss and controlled ROS accum...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9041

    authors： Cha JY,Kim WY,Kang SB,Kim JI,Baek D,Jung IJ,Kim MR,Li N,Kim HJ,Nakajima M,Asami T,Sabir JS,Park HC,Lee SY,Bohnert HJ,Bressan RA,Pardo JM,Yun DJ

    更新日期：2015-08-28 00:00:00

  • A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.

    abstract：:Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, electrolyte abnormalities and metabolic waste accumulation- manifesting as acute kidney injury (A...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15638-6

    authors： Kim JY,Bai Y,Jayne LA,Hector RD,Persaud AK,Ong SS,Rojesh S,Raj R,Feng MJHH,Chung S,Cianciolo RE,Christman JW,Campbell MJ,Gardner DS,Baker SD,Sparreboom A,Govindarajan R,Singh H,Chen T,Poi M,Susztak K,Cobb SR,P

    更新日期：2020-04-21 00:00:00

  • Structure and substrate selectivity of the 750-kDa α6β6 holoenzyme of geranyl-CoA carboxylase.

    abstract：:Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudomonas organisms with geranic acid as the sole carbon source. GCC has the same domain organization and shares strong sequence conservation with the related biotin-dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and propionyl-CoA carboxylas...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9986

    authors： Jurado AR,Huang CS,Zhang X,Zhou ZH,Tong L

    更新日期：2015-11-23 00:00:00

  • Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility.

    abstract：:Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is ge...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13855-2

    authors： Kachuri L,Johansson M,Rashkin SR,Graff RE,Bossé Y,Manem V,Caporaso NE,Landi MT,Christiani DC,Vineis P,Liu G,Scelo G,Zaridze D,Shete SS,Albanes D,Aldrich MC,Tardón A,Rennert G,Chen C,Goodman GE,Doherty JA,Bickebö

    更新日期：2020-01-07 00:00:00

  • T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells.

    abstract：:Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06090-8

    authors： Kim HR,Mun Y,Lee KS,Park YJ,Park JS,Park JH,Jeon BN,Kim CH,Jun Y,Hyun YM,Kim M,Lee SM,Park CS,Im SH,Jun CD

    更新日期：2018-09-07 00:00:00

  • Superconducting metamaterials for waveguide quantum electrodynamics.

    abstract：:Embedding tunable quantum emitters in a photonic bandgap structure enables control of dissipative and dispersive interactions between emitters and their photonic bath. Operation in the transmission band, outside the gap, allows for studying waveguide quantum electrodynamics in the slow-light regime. Alternatively, tun...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06142-z

    authors： Mirhosseini M,Kim E,Ferreira VS,Kalaee M,Sipahigil A,Keller AJ,Painter O

    更新日期：2018-09-12 00:00:00

  • Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes.

    abstract：:Transition metal catalyzed Sonogashira cross-coupling of terminal alkynes with aryl(vinyl) (pseudo)halides has been successfully extended to alkyl halides for the synthesis of functionalized internal alkynes. The direct alkynylation of remote unfunctionalized sp3 carbon by terminal alkynes remains difficult to realize...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14292-2

    authors： Li Z,Torres-Ochoa RO,Wang Q,Zhu J

    更新日期：2020-01-21 00:00:00

  • Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival.

    abstract：:Genomic instability pathways in colorectal cancer (CRC) have been extensively studied, but the role of retrotransposition in colorectal carcinogenesis remains poorly understood. Although retrotransposons are usually repressed, they become active in several human cancers, in particular those of the gastrointestinal tra...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11770-0

    authors： Cajuso T,Sulo P,Tanskanen T,Katainen R,Taira A,Hänninen UA,Kondelin J,Forsström L,Välimäki N,Aavikko M,Kaasinen E,Ristimäki A,Koskensalo S,Lepistö A,Renkonen-Sinisalo L,Seppälä T,Kuopio T,Böhm J,Mecklin JP,Kilpivaar

    更新日期：2019-09-06 00:00:00

  • Stretching fibronectin fibres disrupts binding of bacterial adhesins by physically destroying an epitope.

    abstract：:Although soluble inhibitors are frequently used to block cell binding to the extracellular matrix (ECM), mechanical stretching of a protein fibre alone can physically destroy a cell-binding site. Here, we show using binding assays and steered molecular dynamics that mechanical tension along fibronectin (Fn) fibres cau...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1135

    authors： Chabria M,Hertig S,Smith ML,Vogel V

    更新日期：2010-01-01 00:00:00

  • Greenhouse conditions induce mineralogical changes and dolomite accumulation in coralline algae on tropical reefs.

    abstract：:Human-induced ocean acidification and warming alter seawater carbonate chemistry reducing the calcification of reef-building crustose coralline algae (CCA), which has implications for reef stability. However, due to the presence of multiple carbonate minerals with different solubilities in seawater, the algal mineralo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4310

    authors： Diaz-Pulido G,Nash MC,Anthony KR,Bender D,Opdyke BN,Reyes-Nivia C,Troitzsch U

    更新日期：2014-01-01 00:00:00

  • Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome.

    abstract：:Enlarged vestibular aqueduct (EVA) is one of the most commonly identified inner ear malformations in hearing loss patients including Pendred syndrome. While biallelic mutations of the SLC26A4 gene, encoding pendrin, causes non-syndromic hearing loss with EVA or Pendred syndrome, a considerable number of patients appea...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15198-9

    authors： Li M,Nishio SY,Naruse C,Riddell M,Sapski S,Katsuno T,Hikita T,Mizapourshafiyi F,Smith FM,Cooper LT,Lee MG,Asano M,Boettger T,Krueger M,Wietelmann A,Graumann J,Day BW,Boyd AW,Offermanns S,Kitajiri SI,Usami SI,Nak

    更新日期：2020-03-12 00:00:00

  • Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies.

    abstract：:The indisputable role of epigenetics in cancer and the fact that epigenetic alterations can be reversed have favoured development of epigenetic drugs. In this study, we design and synthesize potent novel, selective and reversible chemical probes that simultaneously inhibit the G9a and DNMTs methyltransferase activity....

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15424

    authors： San José-Enériz E,Agirre X,Rabal O,Vilas-Zornoza A,Sanchez-Arias JA,Miranda E,Ugarte A,Roa S,Paiva B,Estella-Hermoso de Mendoza A,Alvarez RM,Casares N,Segura V,Martín-Subero JI,Ogi FX,Soule P,Santiveri CM,Campos-Olivas

    更新日期：2017-05-26 00:00:00

  • Social networks and risk of delayed hospital arrival after acute stroke.

    abstract：:Arriving rapidly to the hospital after a heart attack or stroke is critical for patients to be within time windows for treatment. Prior research in heart attacks has suggested a paradoxical role of the social environment: those who arrive early are surrounded by nonrelatives, while those who arrive late are surrounded...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09073-5

    authors： Dhand A,Luke D,Lang C,Tsiaklides M,Feske S,Lee JM

    更新日期：2019-03-14 00:00:00

  • Host suppression of quorum sensing during catheter-associated urinary tract infections.

    abstract：:Chronic bacterial infections on medical devices, including catheter-associated urinary tract infections (CAUTI), are associated with bacterial biofilm communities that are refractory to antibiotic therapy and resistant to host immunity. Previously, we have shown that Pseudomonas aeruginosa can cause CAUTI by forming a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06882-y

    authors： Cole SJ,Hall CL,Schniederberend M,Farrow Iii JM,Goodson JR,Pesci EC,Kazmierczak BI,Lee VT

    更新日期：2018-10-25 00:00:00

  • Publisher Correction: Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-019-13138-w

    authors： Weinert LA,Chaudhuri RR,Wang J,Peters SE,Corander J,Jombart T,Baig A,Howell KJ,Vehkala M,Välimäki N,Harris D,Chieu TTB,Van Vinh Chau N,Campbell J,Schultsz C,Parkhill J,Bentley SD,Langford PR,Rycroft AN,Wren BW,Far

    更新日期：2019-11-22 00:00:00

  • Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration.

    abstract：:The availability of multiple datasets comprising genome-scale RNAi viability screens in hundreds of diverse cancer cell lines presents new opportunities for understanding cancer vulnerabilities. Integrated analyses of these data to assess differential dependency across genes and cell lines are challenging due to confo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06916-5

    authors： McFarland JM,Ho ZV,Kugener G,Dempster JM,Montgomery PG,Bryan JG,Krill-Burger JM,Green TM,Vazquez F,Boehm JS,Golub TR,Hahn WC,Root DE,Tsherniak A

    更新日期：2018-11-02 00:00:00

  • Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells.

    abstract：:Injury and loss of oligodendrocytes can cause demyelinating diseases such as multiple sclerosis. To improve our understanding of human oligodendrocyte development, which could facilitate development of remyelination-based treatment strategies, here we describe time-course single-cell-transcriptomic analysis of develop...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-021-20892-3

    authors： Chamling X,Kallman A,Fang W,Berlinicke CA,Mertz JL,Devkota P,Pantoja IEM,Smith MD,Ji Z,Chang C,Kaushik A,Chen L,Whartenby KA,Calabresi PA,Mao HQ,Ji H,Wang TH,Zack DJ

    更新日期：2021-01-28 00:00:00

  • Using the president's tweets to understand political diversion in the age of social media.

    abstract：:Social media has arguably shifted political agenda-setting power away from mainstream media onto politicians. Current U.S. President Trump's reliance on Twitter is unprecedented, but the underlying implications for agenda setting are poorly understood. Using the president as a case study, we present evidence suggestin...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19644-6

    authors： Lewandowsky S,Jetter M,Ecker UKH

    更新日期：2020-11-10 00:00:00

  • Examining charitable giving in real-world online donations.

    abstract：:The current study uses big data to study prosocial behavior by analyzing donations made on the GoFundMe platform. In a dataset of more than $44 million in online donations, we find that 21% were made while opting to be anonymous to the public, with survey results indicating that 11% of these anonymous donations (2.3% ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11852-z

    authors： Sisco MR,Weber EU

    更新日期：2019-09-03 00:00:00

  • Microscopic origins of the terahertz carrier relaxation and cooling dynamics in graphene.

    abstract：:The ultrafast dynamics of hot carriers in graphene are key to both understanding of fundamental carrier-carrier interactions and carrier-phonon relaxation processes in two-dimensional materials, and understanding of the physics underlying novel high-speed electronic and optoelectronic devices. Many recent experiments ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11617

    authors： Mihnev MT,Kadi F,Divin CJ,Winzer T,Lee S,Liu CH,Zhong Z,Berger C,de Heer WA,Malic E,Knorr A,Norris TB

    更新日期：2016-05-25 00:00:00

  • Enhanced acoustic sensing through wave compression and pressure amplification in anisotropic metamaterials.

    abstract：:Acoustic sensors play an important role in many areas, such as homeland security, navigation, communication, health care and industry. However, the fundamental pressure detection limit hinders the performance of current acoustic sensing technologies. Here, through analytical, numerical and experimental studies, we sho...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6247

    authors： Chen Y,Liu H,Reilly M,Bae H,Yu M

    更新日期：2014-10-15 00:00:00

  • Shaping polymersomes into predictable morphologies via out-of-equilibrium self-assembly.

    abstract：:Polymersomes are bilayer vesicles, self-assembled from amphiphilic block copolymers. They are versatile nanocapsules with adjustable properties, such as flexibility, permeability, size and functionality. However, so far no methodological approach to control their shape exists. Here we demonstrate a mechanistically ful...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12606

    authors： Rikken RS,Engelkamp H,Nolte RJ,Maan JC,van Hest JC,Wilson DA,Christianen PC

    更新日期：2016-08-25 00:00:00

  • Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning.

    abstract：:Neurons can activate pathways that destroy the whole cell via apoptosis or selectively degenerate only the axon (pruning). Both apoptosis and axon degeneration require Bax and caspases. Here we demonstrate that despite this overlap, the pathways mediating axon degeneration during apoptosis versus axon pruning are dist...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2910

    authors： Cusack CL,Swahari V,Hampton Henley W,Michael Ramsey J,Deshmukh M

    更新日期：2013-01-01 00:00:00

  • Dawn-dusk asymmetry in the Kelvin-Helmholtz instability at Mercury.

    abstract：:The NASA MErcury Surface, Space ENvironment, GEochemistry and Ranging (MESSENGER) spacecraft entered orbital phase around Mercury on 18 March 2011. A surprising consistent feature in the data returned is large-scale vortices that form exclusively on the dusk side of the magnetosphere. Here we present global kinetic hy...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2676

    authors： Paral J,Rankin R

    更新日期：2013-01-01 00:00:00