Abstract:
:N(6)-methyladenosine is a prevalent internal modification in messenger RNA and non-coding RNA affecting various cellular pathways. Here we report the discovery of two additional modifications, N(6)-hydroxymethyladenosine (hm(6)A) and N(6)-formyladenosine (f(6)A), in mammalian messenger RNA. We show that Fe(II)- and α-ketoglutarate-dependent fat mass and obesity-associated (FTO) protein oxidize N(6)-methyladenosine to generate N(6)-hydroxymethyladenosine as an intermediate modification, and N(6)-formyladenosine as a further oxidized product. N(6)-hydroxymethyladenosine and N(6)-formyladenosine have half-life times of ~3 h in aqueous solution under physiological relevant conditions, and are present in isolated messenger RNA from human cells as well as mouse tissues. These previously unknown modifications derived from the prevalent N(6)-methyladenosine in messenger RNA, formed through oxidative RNA demethylation, may dynamically modulate RNA-protein interactions to affect gene expression regulation.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Fu Y,Jia G,Pang X,Wang RN,Wang X,Li CJ,Smemo S,Dai Q,Bailey KA,Nobrega MA,Han KL,Cui Q,He Cdoi
10.1038/ncomms2822subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1798issn
2041-1723pii
ncomms2822journal_volume
4pub_type
杂志文章abstract::This corrects the article DOI: 10.1038/ncomms6053. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/ncomms16201
更新日期:2018-04-10 00:00:00
abstract::Three-dimensional (3D) assemblies based on carbon nanomaterials still lag behind their individual one-dimensional building blocks in terms of mechanical and electrical properties. Here we demonstrate a simple strategy for the fabrication of an open porous 3D self-organized double-hierarchical carbon nanotube tube stru...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01324-7
更新日期:2017-10-31 00:00:00
abstract::The primary productivity of the Southern Ocean ecosystem is limited by iron availability. Away from benthic and aeolian sources, iron reaches phytoplankton primarily when iron-rich subsurface waters enter the euphotic zone. Here, eddy-resolving physical/biogeochemical simulations of a seasonally-forced, open-Southern-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14955-0
更新日期:2020-02-28 00:00:00
abstract::In life sciences, the material properties of suspended cells have attained significance close to that of fluorescent markers but with the advantage of label-free and unbiased sample characterization. Until recently, cell rheological measurements were either limited by acquisition throughput, excessive post processing,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08370-3
更新日期:2019-01-24 00:00:00
abstract::Even a single-component liquid may have more than two liquid states. The transition between them is called a 'liquid-liquid transition' (LLT). Such LLTs have recently attracted considerable attention mainly because of the fundamental interest in the physical origin of this counter-intuitive phenomenon. In this study, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1015
更新日期:2010-05-04 00:00:00
abstract::Breaking time-reversal symmetry enables the realization of non-reciprocal devices, such as isolators and circulators, of fundamental importance in microwave and photonic communication systems. This effect is almost exclusively achieved today through magneto-optical phenomena, which are incompatible with integrated tec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3407
更新日期:2013-01-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-11859-6
更新日期:2019-08-21 00:00:00
abstract::China has enacted a series of policies since 2015 to substitute electricity for in-home combustion for rural residential heating. The Electric Heating Policy (EHP) has contributed to significant improvements in air quality, benefiting hundreds of millions of people. This shift, however, has resulted in a sharp increas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19854-y
更新日期:2020-11-27 00:00:00
abstract::The original version of this Article incorrectly omitted an affiliation of Hongming Weng: "Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, 100190, Beijing, China"This has been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-06643-x
更新日期:2018-10-08 00:00:00
abstract::Amongst the many spectacular properties of hybrid lead halide perovskites, their defect tolerance is regarded as the key enabler for a spectrum of high-performance optoelectronic devices that propel perovskites to prominence. However, the plateauing efficiency enhancement of perovskite devices calls into question the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16463-7
更新日期:2020-06-01 00:00:00
abstract::Scenarios that limit global warming to below 2 °C by 2100 assume significant land-use change to support large-scale carbon dioxide (CO2) removal from the atmosphere by afforestation/reforestation, avoided deforestation, and Biomass Energy with Carbon Capture and Storage (BECCS). The more ambitious mitigation scenarios...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05340-z
更新日期:2018-08-07 00:00:00
abstract::Accumulating evidence suggests that transcriptional regulation is required for maintenance of long-term memories (LTMs). Here we characterize global transcriptional and epigenetic changes that occur during LTM storage in the Drosophila mushroom bodies (MBs), structures important for memory. Although LTM formation requ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13471
更新日期:2016-11-14 00:00:00
abstract::Polaritons are widely investigated quasiparticles with fundamental and technological significance due to their unique properties. They have been studied most extensively in semiconductors when photons interact with various elementary excitations. However, other strongly coupled excitations demonstrate similar dynamics...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10545-x
更新日期:2019-06-14 00:00:00
abstract::Biodiversity loss can alter ecosystem functioning; however, it remains unclear how it alters decomposition-a critical component of biogeochemical cycles in the biosphere. Here, we provide a global-scale meta-analysis to quantify how changes in the diversity of organic matter derived from plants (i.e. litter) affect ra...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/s41467-020-18296-w
更新日期:2020-09-11 00:00:00
abstract::Influenza virus can escape most antibodies with single mutations. However, rare antibodies broadly neutralize many viral strains. It is unclear how easily influenza virus might escape such antibodies if there was strong pressure to do so. Here, we map all single amino-acid mutations that increase resistance to broad a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03665-3
更新日期:2018-04-11 00:00:00
abstract::Weyl points, as monopoles of Berry curvature in momentum space, have captured much attention recently in various branches of physics. Realizing topological materials that exhibit such nodal points is challenging and indeed, Weyl points have been found experimentally in transition metal arsenide and phosphide and gyroi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13038
更新日期:2016-10-05 00:00:00
abstract::Groups of people or even robots often face problems they need to solve together. Examples include collectively searching for resources, choosing when and where to invest time and effort, and many more. Although a hierarchical ordering of the relevance of the group members' inputs during collective decision making is a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3484
更新日期:2013-01-01 00:00:00
abstract::Base editors (BEs) are RNA-guided CRISPR-Cas-derived genome editing tools that induce single-nucleotide changes. The limitations of current BEs lie in their low precision (especially when multiple target nucleotides of the deaminase are present within the activity window) and their restriction to targets that are in p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14465-z
更新日期:2020-01-31 00:00:00
abstract::Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the developing mammalian brain. However, little is known about how metabolic signals instruct gene expression to control NPC homeostasis. Here, we show that methylglyoxa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15941-2
更新日期:2020-04-24 00:00:00
abstract::Organic semiconductors enable the fabrication of a range of lightweight and mechanically flexible optoelectronic devices. Most organic semiconductor lasers, however, have remained rigid until now, predominantly due to the need for a support substrate. Here, we use a simple fabrication process to make membrane-based, s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03874-w
更新日期:2018-05-01 00:00:00
abstract::Compounds with incommensurate structural modulations have been extensively studied in last several decades. However, the relationship between structurally incommensurate/commensurate phases and associated electronic states remains enigmatic. Here we report the coexisting of complex incommensurate structures and highly...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6358
更新日期:2014-11-07 00:00:00
abstract::Doping is a primary tool for the modification of the properties of materials. Occlusion of guest molecules in crystals generally reduces their symmetry by the creation of polar domains, which engender polarization and pyroelectricity in the doped crystals. Here we describe a molecular-level determination of the struct...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13351
更新日期:2016-11-08 00:00:00
abstract::Vortices play a crucial role in determining the properties of superconductors as well as their applications. Therefore, characterization and manipulation of vortices, especially at the single-vortex level, is of great importance. Among many techniques to study single vortices, scanning tunnelling microscopy (STM) stan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13880
更新日期:2016-12-09 00:00:00
abstract::A 'pseudogap' was introduced by Mott to describe a state of matter that has a minimum in the density of states at the Fermi level, deep enough for states to become localized. It can arise either from Coulomb repulsion between electrons, and/or incipient charge or spin order. Here we employ ultrafast spectroscopy to st...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7958
更新日期:2015-04-20 00:00:00
abstract::Glycans from microbial pathogens are well known pathogen-associated molecular patterns that are recognized by the host immunity; however, little is known about whether and how mammalian self-glycans activate the host immune response, especially in the context of autoimmune disease. Using biochemical fractionation and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10319-5
更新日期:2019-05-30 00:00:00
abstract::Metagenomic sequencing has greatly improved our ability to profile the composition of environmental and host-associated microbial communities. However, the dependency of most methods on reference genomes, which are currently unavailable for a substantial fraction of microbial species, introduces estimation biases. We ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08844-4
更新日期:2019-03-04 00:00:00
abstract::Mitochondria and peroxisomes proliferate by division. During division, a part of their membrane is pinched off by constriction of the ring-shaped mitochondrial division (MD) and peroxisome-dividing (POD) machinery. This constriction is mediated by a dynamin-like GTPase Dnm1 that requires a large amount of GTP as an en...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07009-z
更新日期:2018-11-06 00:00:00
abstract::Nanocrystallization is a well-known strategy to dramatically tune the properties of materials; however, the grain-size effect of graphene at the nanometer scale remains unknown experimentally because of the lack of nanocrystalline samples. Here we report an ultrafast growth of graphene films within a few seconds by qu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12662-z
更新日期:2019-10-24 00:00:00
abstract::Transition metal oxides host a wealth of exotic phenomena ranging from charge, orbital and magnetic order to nontrivial topological phases and superconductivity. In order to translate these unique materials properties into device functionalities these materials must be doped; however, the nature of carriers and their ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15769
更新日期:2017-06-08 00:00:00
abstract::In vitro fabrication of functional vascularized three-dimensional tissues has been a long-standing objective in the field of tissue engineering. Here we report a technique to engineer cardiac tissues with perfusable blood vessels in vitro. Using resected tissue with a connectable artery and vein as a vascular bed, we ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2406
更新日期:2013-01-01 00:00:00