A novel thiol-reductase activity of Arabidopsis YUC6 confers drought tolerance independently of auxin biosynthesis.

Abstract:

:YUCCA (YUC) proteins constitute a family of flavin monooxygenases (FMOs), with an important role in auxin (IAA) biosynthesis. Here we report that Arabidopsis plants overexpressing YUC6 display enhanced IAA-related phenotypes and exhibit improved drought stress tolerance, low rate of water loss and controlled ROS accumulation under drought and oxidative stresses. Co-overexpression of an IAA-conjugating enzyme reduces IAA levels but drought stress tolerance is unaffected, indicating that the stress-related phenotype is not based on IAA overproduction. YUC6 contains a previously unrecognized FAD- and NADPH-dependent thiol-reductase activity (TR) that overlaps with the FMO domain involved in IAA biosynthesis. Mutation of a conserved cysteine residue (Cys-85) preserves FMO but suppresses TR activity and stress tolerance, whereas mutating the FAD- and NADPH-binding sites, that are common to TR and FMO domains, abolishes all outputs. We provide a paradigm for a single protein playing a dual role, regulating plant development and conveying stress defence responses.

journal_name

Nat Commun

journal_title

Nature communications

authors

Cha JY,Kim WY,Kang SB,Kim JI,Baek D,Jung IJ,Kim MR,Li N,Kim HJ,Nakajima M,Asami T,Sabir JS,Park HC,Lee SY,Bohnert HJ,Bressan RA,Pardo JM,Yun DJ

doi

10.1038/ncomms9041

subject

Has Abstract

pub_date

2015-08-28 00:00:00

pages

8041

issn

2041-1723

pii

ncomms9041

journal_volume

6

pub_type

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