当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Molecular structure of promoter-bound yeast TFIID.

Molecular structure of promoter-bound yeast TFIID.

Abstract：

:Transcription preinitiation complex assembly on the promoters of protein encoding genes is nucleated in vivo by TFIID composed of the TATA-box Binding Protein (TBP) and 13 TBP-associate factors (Tafs) providing regulatory and chromatin binding functions. Here we present the cryo-electron microscopy structure of promoter-bound yeast TFIID at a resolution better than 5 Å, except for a flexible domain. We position the crystal structures of several subunits and, in combination with cross-linking studies, describe the quaternary organization of TFIID. The compact tri lobed architecture is stabilized by a topologically closed Taf5-Taf6 tetramer. We confirm the unique subunit stoichiometry prevailing in TFIID and uncover a hexameric arrangement of Tafs containing a histone fold domain in the Twin lobe.

journal_name

Nat Commun

journal_title

Nature communications

authors

Kolesnikova O,Ben-Shem A,Luo J,Ranish J,Schultz P,Papai G

doi

10.1038/s41467-018-07096-y

subject

Has Abstract

pub_date

2018-11-07 00:00:00

pages

4666

issue

1

issn

2041-1723

pii

10.1038/s41467-018-07096-y

journal_volume

9

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Single-digit-micrometer thickness wood speaker.

    abstract：:Thin films of several microns in thickness are ubiquitously used in packaging, electronics, and acoustic sensors. Here we demonstrate that natural wood can be directly converted into an ultrathin film with a record-small thickness of less than 10 μm through partial delignification followed by densification. Benefiting...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13053-0

    authors： Gan W,Chen C,Kim HT,Lin Z,Dai J,Dong Z,Zhou Z,Ping W,He S,Xiao S,Yu M,Hu L

    更新日期：2019-11-08 00:00:00

  • Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility.

    abstract：:Single-nucleotide variants that underlie phenotypic variation can affect chromatin occupancy of transcription factors (TFs). To delineate determinants of in vivo TF binding and chromatin accessibility, we introduce an approach that compares ChIP-seq and DNase-seq data sets from genetically divergent murine erythroid c...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03082-6

    authors： Behera V,Evans P,Face CJ,Hamagami N,Sankaranarayanan L,Keller CA,Giardine B,Tan K,Hardison RC,Shi J,Blobel GA

    更新日期：2018-02-22 00:00:00

  • Nutrients cause grassland biomass to outpace herbivory.

    abstract：:Human activities are transforming grassland biomass via changing climate, elemental nutrients, and herbivory. Theory predicts that food-limited herbivores will consume any additional biomass stimulated by nutrient inputs ('consumer-controlled'). Alternatively, nutrient supply is predicted to increase biomass where her...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19870-y

    authors： Borer ET,Harpole WS,Adler PB,Arnillas CA,Bugalho MN,Cadotte MW,Caldeira MC,Campana S,Dickman CR,Dickson TL,Donohue I,Eskelinen A,Firn JL,Graff P,Gruner DS,Heckman RW,Koltz AM,Komatsu KJ,Lannes LS,MacDougall AS,Mar

    更新日期：2020-11-27 00:00:00

  • Structure of the processive human Pol δ holoenzyme.

    abstract：:In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. We present the high-resolution cryo-EM structure of the human processive Pol δ-DNA-PCNA comple...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14898-6

    authors： Lancey C,Tehseen M,Raducanu VS,Rashid F,Merino N,Ragan TJ,Savva CG,Zaher MS,Shirbini A,Blanco FJ,Hamdan SM,De Biasio A

    更新日期：2020-02-28 00:00:00

  • Nonreciprocal reconfigurable microwave optomechanical circuit.

    abstract：:Nonreciprocal microwave devices are ubiquitous in radar and radio communication and indispensable in the readout chains of superconducting quantum circuits. Since they commonly rely on ferrite materials requiring large magnetic fields that make them bulky and lossy, there has been significant interest in magnetic-fiel...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00447-1

    authors： Bernier NR,Tóth LD,Koottandavida A,Ioannou MA,Malz D,Nunnenkamp A,Feofanov AK,Kippenberg TJ

    更新日期：2017-09-19 00:00:00

  • Dual loss of human POLQ and LIG4 abolishes random integration.

    abstract：:Homologous recombination-mediated gene targeting has greatly contributed to genetic analysis in a wide range of species, but is highly inefficient in human cells because of overwhelmingly frequent random integration events, whose molecular mechanism remains elusive. Here we show that DNA polymerase θ, despite its mino...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms16112

    authors： Saito S,Maeda R,Adachi N

    更新日期：2017-07-11 00:00:00

  • Electrochemical mechanism of ion current rectification of polyelectrolyte gel diodes.

    abstract：:Polyelectrolyte gel diodes that are double layers of two oppositely charged polyelectrolyte gels, sandwiched by two symmetric electrodes, are emergent ionic devices. These diodes are designed to rectify ion currents with a physical mechanism that is analogous to conventional semiconductor diodes-the asymmetry in the p...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5162

    authors： Yamamoto T,Doi M

    更新日期：2014-06-17 00:00:00

  • Somatodendritic consistency check for temporal feature segmentation.

    abstract：:The brain identifies potentially salient features within continuous information streams to process hierarchical temporal events. This requires the compression of information streams, for which effective computational principles are yet to be explored. Backpropagating action potentials can induce synaptic plasticity in...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15367-w

    authors： Asabuki T,Fukai T

    更新日期：2020-03-25 00:00:00

  • Author Correction: The effects of mutational processes and selection on driver mutations across cancer types.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-020-15800-0

    authors： Temko D,Tomlinson IPM,Severini S,Schuster-Böckler B,Graham TA

    更新日期：2020-04-20 00:00:00

  • Meta-analysis of gut microbiome studies identifies disease-specific and shared responses.

    abstract：:Hundreds of clinical studies have demonstrated associations between the human microbiome and disease, yet fundamental questions remain on how we can generalize this knowledge. Results from individual studies can be inconsistent, and comparing published data is further complicated by a lack of standard processing and a...

    journal_title：Nature communications

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41467-017-01973-8

    authors： Duvallet C,Gibbons SM,Gurry T,Irizarry RA,Alm EJ

    更新日期：2017-12-05 00:00:00

  • The Escherichia coli transcriptome mostly consists of independently regulated modules.

    abstract：:Underlying cellular responses is a transcriptional regulatory network (TRN) that modulates gene expression. A useful description of the TRN would decompose the transcriptome into targeted effects of individual transcriptional regulators. Here, we apply unsupervised machine learning to a diverse compendium of over 250 ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13483-w

    authors： Sastry AV,Gao Y,Szubin R,Hefner Y,Xu S,Kim D,Choudhary KS,Yang L,King ZA,Palsson BO

    更新日期：2019-12-04 00:00:00

  • Midwinter Arctic leads form and dissipate low clouds.

    abstract：:Leads are a key feature of the Arctic ice pack during the winter owing to their substantial contribution to the surface energy balance. According to the present understanding, enhanced heat and moisture fluxes from high lead concentrations tend to produce more boundary layer clouds. However, described here in our comp...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-14074-5

    authors： Li X,Krueger SK,Strong C,Mace GG,Benson S

    更新日期：2020-01-10 00:00:00

  • All-optical polariton transistor.

    abstract：:Although optical technology provides the best solution for the transmission of information, all-optical devices must satisfy several qualitative criteria to be used as logic elements. In particular, cascadability is difficult to obtain in optical systems, and it is assured only if the output of one stage is in the cor...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2734

    authors： Ballarini D,De Giorgi M,Cancellieri E,Houdré R,Giacobino E,Cingolani R,Bramati A,Gigli G,Sanvitto D

    更新日期：2013-01-01 00:00:00

  • Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency.

    abstract：:Clusters of enhancers, referred as to super-enhancers (SEs), control the expression of cell identity genes. The organisation of these clusters, and how they are remodelled upon developmental transitions remain poorly understood. Here, we report the existence of two types of enhancer units within SEs typified by distin...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14916-7

    authors： Bell E,Curry EW,Megchelenbrink W,Jouneau L,Brochard V,Tomaz RA,Mau KHT,Atlasi Y,de Souza RA,Marks H,Stunnenberg HG,Jouneau A,Azuara V

    更新日期：2020-02-28 00:00:00

  • The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution.

    abstract：:The dynamic incorporation of histone variants influences chromatin structure and many biological processes. In Arabidopsis, the canonical variant H3.1 differs from H3.3 in four residues, one of which (H3.1Phe41) is unique and conserved in plants. However, its evolutionary significance remains unclear. Here, we show th...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-02976-9

    authors： Lu L,Chen X,Qian S,Zhong X

    更新日期：2018-02-12 00:00:00

  • In vivo imaging of specific drug-target binding at subcellular resolution.

    abstract：:The possibility of measuring binding of small-molecule drugs to desired targets in live cells could provide a better understanding of drug action. However, current approaches mostly yield static data, require lysis or rely on indirect assays and thus often provide an incomplete understanding of drug action. Here, we p...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4946

    authors： Dubach JM,Vinegoni C,Mazitschek R,Fumene Feruglio P,Cameron LA,Weissleder R

    更新日期：2014-05-28 00:00:00

  • Metal-induced rapid transformation of diamond into single and multilayer graphene on wafer scale.

    abstract：:The degradation of intrinsic properties of graphene during the transfer process constitutes a major challenge in graphene device fabrication, stimulating the need for direct growth of graphene on dielectric substrates. Previous attempts of metal-induced transformation of diamond and silicon carbide into graphene suffe...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12099

    authors： Berman D,Deshmukh SA,Narayanan B,Sankaranarayanan SK,Yan Z,Balandin AA,Zinovev A,Rosenmann D,Sumant AV

    更新日期：2016-07-04 00:00:00

  • Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.

    abstract：:The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for these are available. Here we report cyclic peptide inhibitors of the KDM4A-C with selectivity over other KDMs/2OG oxygenases, including closely related KDM4D/E ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14773

    authors： Kawamura A,Münzel M,Kojima T,Yapp C,Bhushan B,Goto Y,Tumber A,Katoh T,King ON,Passioura T,Walport LJ,Hatch SB,Madden S,Müller S,Brennan PE,Chowdhury R,Hopkinson RJ,Suga H,Schofield CJ

    更新日期：2017-04-06 00:00:00

  • Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets.

    abstract：:Controlling nanocarrier interactions with the immune system requires a thorough understanding of the surface properties that modulate protein adsorption in biological fluids, since the resulting protein corona redefines cellular interactions with nanocarrier surfaces. Albumin is initially one of the dominant proteins ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20886-7

    authors： Vincent MP,Bobbala S,Karabin NB,Frey M,Liu Y,Navidzadeh JO,Stack T,Scott EA

    更新日期：2021-01-28 00:00:00

  • Intertwined topological phases induced by emergent symmetry protection.

    abstract：:The dual role played by symmetry in many-body physics manifests itself through two fundamental mechanisms: spontaneous symmetry breaking and topological symmetry protection. These two concepts, ubiquitous in both condensed matter and high energy physics, have been applied successfully in the last decades to unravel a ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10796-8

    authors： González-Cuadra D,Bermudez A,Grzybowski PR,Lewenstein M,Dauphin A

    更新日期：2019-06-19 00:00:00

  • A universal and independent synthetic DNA ladder for the quantitative measurement of genomic features.

    abstract：:Standard units of measurement are required for the quantitative description of nature; however, few standard units have been established for genomics to date. Here, we have developed a synthetic DNA ladder that defines a quantitative standard unit that can measure DNA sequence abundance within a next-generation sequen...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17445-5

    authors： Reis ALM,Deveson IW,Wong T,Madala BS,Barker C,Blackburn J,Marcellin E,Mercer TR

    更新日期：2020-07-17 00:00:00

  • Dynamics of soliton self-injection locking in optical microresonators.

    abstract：:Soliton microcombs constitute chip-scale optical frequency combs, and have the potential to impact a myriad of applications from frequency synthesis and telecommunications to astronomy. The demonstration of soliton formation via self-injection locking of the pump laser to the microresonator has significantly relaxed t...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20196-y

    authors： Voloshin AS,Kondratiev NM,Lihachev GV,Liu J,Lobanov VE,Dmitriev NY,Weng W,Kippenberg TJ,Bilenko IA

    更新日期：2021-01-11 00:00:00

  • Using controlled disorder to probe the interplay between charge order and superconductivity in NbSe2.

    abstract：:The interplay between superconductivity and charge-density wave (CDW) in 2H-NbSe2 is not fully understood despite decades of study. Artificially introduced disorder can tip the delicate balance between two competing long-range orders, and reveal the underlying interactions that give rise to them. Here we introduce dis...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05153-0

    authors： Cho K,Kończykowski M,Teknowijoyo S,Tanatar MA,Guss J,Gartin PB,Wilde JM,Kreyssig A,McQueeney RJ,Goldman AI,Mishra V,Hirschfeld PJ,Prozorov R

    更新日期：2018-07-18 00:00:00

  • Author Correction: GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

    abstract：:We have been alerted that in our recent Article the calculations used to transform the heritability from the observed scale to the liability scale did not take into account the individuals in category 2 of the baldness scale, who were removed in our original analysis. This led to an overestimation of the heritability ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-018-04857-7

    authors： Pirastu N,Joshi PK,de Vries PS,Cornelis MC,McKeigue PM,Keum N,Franceschini N,Colombo M,Giovannucci EL,Spiliopoulou A,Franke L,North KE,Kraft P,Morrison AC,Esko T,Wilson JF

    更新日期：2018-06-29 00:00:00

  • Evolutionary signals of selection on cognition from the great tit genome and methylome.

    abstract：:For over 50 years, the great tit (Parus major) has been a model species for research in evolutionary, ecological and behavioural research; in particular, learning and cognition have been intensively studied. Here, to provide further insight into the molecular mechanisms behind these important traits, we de novo assemb...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10474

    authors： Laine VN,Gossmann TI,Schachtschneider KM,Garroway CJ,Madsen O,Verhoeven KJ,de Jager V,Megens HJ,Warren WC,Minx P,Crooijmans RP,Corcoran P,Great Tit HapMap Consortium.,Sheldon BC,Slate J,Zeng K,van Oers K,Visser ME,Gro

    更新日期：2016-01-25 00:00:00

  • Evidence for the alkaline nature of parental carbonatite melts at Oka complex in Canada.

    abstract：:The Earth's sole active carbonatite volcano, Oldoinyo Lengai (Tanzania), is presently erupting unique natrocarbonatite lavas that are characterized by Na- and K-bearing magmatic carbonates of nyerereite [Na2Ca(CO3)2] and gregoryite [(Na2,K2,Ca)CO3]. Contrarily, the vast majority of older, plutonic carbonatite occurren...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3687

    authors： Chen W,Kamenetsky VS,Simonetti A

    更新日期：2013-01-01 00:00:00

  • Dynamic structure of active nematic shells.

    abstract：:When a thin film of active, nematic microtubules and kinesin motor clusters is confined on the surface of a vesicle, four +1/2 topological defects oscillate in a periodic manner between tetrahedral and planar arrangements. Here a theoretical description of nematics, coupled to the relevant hydrodynamic equations, is p...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13483

    authors： Zhang R,Zhou Y,Rahimi M,de Pablo JJ

    更新日期：2016-11-21 00:00:00

  • MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.

    abstract：:The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and show a distinct distribution of MNK1 and MNK2 in germinal ce...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6413

    authors： Landon AL,Muniandy PA,Shetty AC,Lehrmann E,Volpon L,Houng S,Zhang Y,Dai B,Peroutka R,Mazan-Mamczarz K,Steinhardt J,Mahurkar A,Becker KG,Borden KL,Gartenhaus RB

    更新日期：2014-11-18 00:00:00

  • Author Correction: Metal-coordinated sub-10 nm membranes for water purification.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-020-14339-4

    authors： You X,Wu H,Zhang R,Su Y,Cao L,Yu Q,Yuan J,Xiao K,He M,Jiang Z

    更新日期：2020-01-24 00:00:00

  • PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity.

    abstract：:Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung inflammation. As the programmed cell death protein-1 (PD-1) inhibitory axis regulates a variety of immune responses...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17813-1

    authors： Helou DG,Shafiei-Jahani P,Lo R,Howard E,Hurrell BP,Galle-Treger L,Painter JD,Lewis G,Soroosh P,Sharpe AH,Akbari O

    更新日期：2020-08-10 00:00:00