Evidence for the alkaline nature of parental carbonatite melts at Oka complex in Canada.

abstract：:The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibr...

journal_title：Nature communications

authors： Cazet AS,Hui MN,Elsworth BL,Wu SZ,Roden D,Chan CL,Skhinas JN,Collot R,Yang J,Harvey K,Johan MZ,Cooper C,Nair R,Herrmann D,McFarland A,Deng N,Ruiz-Borrego M,Rojo F,Trigo JM,Bezares S,Caballero R,Lim E,Timpson P

更新日期：2018-07-24 00:00:00

abstract：:Silicon dioxide is one of the most abundant natural compounds. Polymorphs of SiO₂ and their phase transitions have long been a focus of great interest and intense theoretical and experimental pursuits. Here, compressing single-crystal coesite SiO₂ under hydrostatic pressures of 26-53 GPa at room temperature, we discov...

journal_title：Nature communications

authors： Hu QY,Shu JF,Cadien A,Meng Y,Yang WG,Sheng HW,Mao HK

更新日期：2015-03-20 00:00:00

abstract：:In 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane's insight that new beneficial alleles are lost...

journal_title：Nature communications

authors： Chelo IM,Nédli J,Gordo I,Teotónio H

更新日期：2013-01-01 00:00:00

abstract：:Van Allen radiation belts are typically two zones of energetic particles encircling the Earth separated by the slot region. How the outer radiation belt electrons are accelerated to relativistic energies remains an unanswered question. Recent studies have presented compelling evidence for the local acceleration by ver...

journal_title：Nature communications

authors： Su Z,Zhu H,Xiao F,Zong QG,Zhou XZ,Zheng H,Wang Y,Wang S,Hao YX,Gao Z,He Z,Baker DN,Spence HE,Reeves GD,Blake JB,Wygant JR

更新日期：2015-12-22 00:00:00

abstract：:D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independent of the hexosamine pathway, extends Caenorhabditis elegans life span by impairing glucose metabolism that a...

journal_title：Nature communications

authors： Weimer S,Priebs J,Kuhlow D,Groth M,Priebe S,Mansfeld J,Merry TL,Dubuis S,Laube B,Pfeiffer AF,Schulz TJ,Guthke R,Platzer M,Zamboni N,Zarse K,Ristow M

更新日期：2014-04-08 00:00:00

abstract：:Secret communication over public channels is one of the central pillars of a modern information society. Using quantum key distribution this is achieved without relying on the hardness of mathematical problems, which might be compromised by improved algorithms or by future quantum computers. State-of-the-art quantum k...

journal_title：Nature communications

authors： Gehring T,Händchen V,Duhme J,Furrer F,Franz T,Pacher C,Werner RF,Schnabel R

更新日期：2015-10-30 00:00:00

abstract：:Sorting nexins (SNX) are a family of PX domain-containing proteins with pivotal roles in trafficking and signaling. SNX-BARs, which also have a curvature-generating Bin/Amphiphysin/Rvs (BAR) domain, have membrane-remodeling functions, particularly at the endosome. The minimal PX-BAR module is a dimer mediated by BAR-B...

journal_title：Nature communications

authors： Sun D,Varlakhanova NV,Tornabene BA,Ramachandran R,Zhang P,Ford MGJ

更新日期：2020-03-20 00:00:00

abstract：:When pressure is applied, the molecules inside a crystal undergo significant changes of their stereoelectronic properties. The most interesting are those enhancing the reactivity of systems that would be otherwise rather inert at ambient conditions. Before a reaction can occur, however, a molecule must be activated, w...

journal_title：Nature communications

authors： Casati N,Kleppe A,Jephcoat AP,Macchi P

更新日期：2016-03-16 00:00:00

abstract：:Each skeletal muscle acquires its unique size before birth, when terminally differentiating myocytes fuse to form a defined number of multinucleated myofibres. Although mice in which the transcription factor Myogenin is mutated lack most myogenesis and die perinatally, a specific cell biological role for Myogenin has ...

journal_title：Nature communications

authors： Ganassi M,Badodi S,Ortuste Quiroga HP,Zammit PS,Hinits Y,Hughes SM

更新日期：2018-10-12 00:00:00

abstract：:The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR st...

journal_title：Nature communications

authors： Chakravarty D,Sboner A,Nair SS,Giannopoulou E,Li R,Hennig S,Mosquera JM,Pauwels J,Park K,Kossai M,MacDonald TY,Fontugne J,Erho N,Vergara IA,Ghadessi M,Davicioni E,Jenkins RB,Palanisamy N,Chen Z,Nakagawa S,Hirose T

更新日期：2014-11-21 00:00:00

abstract：:Soft particulate media include a wide range of systems involving athermal dissipative particles both in non-living and biological materials. Characterization of flows of particulate media is of great practical and theoretical importance. A fascinating feature of these systems is the existence of a critical rigidity tr...

journal_title：Nature communications

authors： Rahbari SHE,Saberi AA,Park H,Vollmer J

更新日期：2017-04-10 00:00:00

abstract：:Interfacial issues commonly exist in solid-state batteries, and the microstructural complexity combines with the chemical heterogeneity to govern the local interfacial chemistry. The conventional wisdom suggests that "point-to-point" ion diffusion at the interface determines the ion transport kinetics. Here, we show t...

journal_title：Nature communications

authors： Lou S,Liu Q,Zhang F,Liu Q,Yu Z,Mu T,Zhao Y,Borovilas J,Chen Y,Ge M,Xiao X,Lee WK,Yin G,Yang Y,Sun X,Wang J

更新日期：2020-11-11 00:00:00

abstract：:Potassium-ion batteries are a compelling technology for large scale energy storage due to their low-cost and good rate performance. However, the development of potassium-ion batteries remains in its infancy, mainly hindered by the lack of suitable cathode materials. Here we show that a previously known frustrated magn...

journal_title：Nature communications

authors： Ji B,Yao W,Zheng Y,Kidkhunthod P,Zhou X,Tunmee S,Sattayaporn S,Cheng HM,He H,Tang Y

更新日期：2020-03-06 00:00:00

abstract：:Research on surface plasmon resonance coupling of metallic nanostructures is an important area in the field of plasmonics because distinctive collective optical properties can be realized that are different from the individual constituents. Here we report the localized surface plasmon resonance of hybrid metal-organic...

journal_title：Nature communications

authors： Jung I,Kim M,Kwak M,Kim G,Jang M,Kim SM,Park DJ,Park S

更新日期：2018-03-08 00:00:00

abstract：:Melanoma cells use different migratory strategies to exit the primary tumor mass and invade surrounding and subsequently distant tissues. We reported previously that ADAR1 expression is downregulated in metastatic melanoma, thereby facilitating proliferation. Here we show that ADAR1 silencing enhances melanoma cell in...

journal_title：Nature communications

authors： Nemlich Y,Baruch EN,Besser MJ,Shoshan E,Bar-Eli M,Anafi L,Barshack I,Schachter J,Ortenberg R,Markel G

更新日期：2018-05-31 00:00:00

abstract：:Graphite dual-ion batteries represent a potential battery concept for large-scale stationary storage of electricity, especially when constructed free of lithium and other chemical elements with limited natural reserves. Owing to their non-rocking-chair operation mechanism, however, the practical deployment of graphite...

journal_title：Nature communications

authors： Kravchyk KV,Bhauriyal P,Piveteau L,Guntlin CP,Pathak B,Kovalenko MV

更新日期：2018-10-26 00:00:00

abstract：:Base editing tools with diversified editing scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editors (ABEs) with minimized RNA off-target activities display constrained editing scopes with efficient editing...

journal_title：Nature communications

authors： Li S,Yuan B,Cao J,Chen J,Chen J,Qiu J,Zhao XM,Wang X,Qiu Z,Cheng TL

更新日期：2020-11-17 00:00:00

abstract：:Electron spins of diamond nitrogen-vacancy (NV) centres are important quantum resources for nanoscale sensing and quantum information. Combining NV spins with levitated optomechanical resonators will provide a hybrid quantum system for novel applications. Here we optically levitate a nanodiamond and demonstrate electr...

journal_title：Nature communications

authors： Hoang TM,Ahn J,Bang J,Li T

更新日期：2016-07-19 00:00:00

abstract：:Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive cancer types and the leading cause of cancer-associated deaths. The EMT-inducing transcriptional repressor ZEB1 is a crucial stimulator of these processes, particularly by coupling the activation of cellular motility with stemne...

journal_title：Nature communications

authors： Lehmann W,Mossmann D,Kleemann J,Mock K,Meisinger C,Brummer T,Herr R,Brabletz S,Stemmler MP,Brabletz T

更新日期：2016-02-15 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms15732. ...

journal_title：Nature communications

authors： Liang J,Lyu J,Zhao M,Li D,Zheng M,Fang Y,Zhao F,Lou J,Guo C,Wang L,Wang D,Liu W,Lu L

更新日期：2018-03-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Hart Y,Goldberg H,Striem-Amit E,Mayo AE,Noy L,Alon U

更新日期：2020-02-24 00:00:00

abstract：:Chronic cranial window (CCW) is an essential tool in enabling longitudinal imaging and manipulation of various brain activities in live animals. However, an active CCW capable of sensing the concealed in vivo environment while simultaneously providing longitudinal optical access to the brain is not currently available...

journal_title：Nature communications

authors： Li H,Dong B,Zhang X,Shu X,Chen X,Hai R,Czaplewski DA,Zhang HF,Sun C

更新日期：2019-09-19 00:00:00

abstract：:Large-scale genomic analyses of human cancers have cataloged somatic point mutations thought to initiate tumor development and sustain cancer growth. However, determining the functional significance of specific alterations remains a major bottleneck in our understanding of the genetic determinants of cancer. Here, we ...

journal_title：Nature communications

authors： Winters IP,Chiou SH,Paulk NK,McFarland CD,Lalgudi PV,Ma RK,Lisowski L,Connolly AJ,Petrov DA,Kay MA,Winslow MM

更新日期：2017-12-12 00:00:00

abstract：:Peridotite carbonation represents a critical step within the long-term carbon cycle by sequestering volatile CO2 in solid carbonate. This has been proposed as one potential pathway to mitigate the effects of greenhouse gas release. Most of our current understanding of reaction mechanisms is based on hand specimen and ...

journal_title：Nature communications

authors： Tominaga M,Beinlich A,Lima EA,Tivey MA,Hampton BA,Weiss B,Harigane Y

更新日期：2017-11-30 00:00:00

abstract：:Controlling the transmission of electrical current using a quantum point contact constriction paved a way to a large variety of experiments in mesoscopic physics. The increasing interest in heat transfer in such systems fosters questions about possible manipulations of quantum heat modes that do not carry net charge (...

journal_title：Nature communications

authors： Rosenblatt A,Lafont F,Levkivskyi I,Sabo R,Gurman I,Banitt D,Heiblum M,Umansky V

更新日期：2017-12-21 00:00:00

abstract：:Efficient organic light-emitting diodes have been developed using emitters containing rare metals, such as platinum and iridium complexes. However, there is an urgent need to develop emitters composed of more abundant materials. Here we show a thermally activated delayed fluorescence material for organic light-emittin...

journal_title：Nature communications

authors： Kaji H,Suzuki H,Fukushima T,Shizu K,Suzuki K,Kubo S,Komino T,Oiwa H,Suzuki F,Wakamiya A,Murata Y,Adachi C

更新日期：2015-10-19 00:00:00

abstract：:Water is a complex liquid that displays a surprising array of unusual properties, the most famous being the density maximum at about 4 °C. The origin of these anomalies is still a matter of debate, and so far a quantitative description of water's phase behaviour starting from the molecular arrangements is still missin...

journal_title：Nature communications

authors： Russo J,Tanaka H

更新日期：2014-04-02 00:00:00

abstract：:Multiple myeloma (MM) is characterized by an uninhibited, clonal growth of plasma cells. While first-degree relatives of patients with MM show an increased risk of MM, the genetic basis of inherited MM susceptibility is incompletely understood. Here we report a genome-wide association study in the Nordic region identi...

journal_title：Nature communications

authors： Swaminathan B,Thorleifsson G,Jöud M,Ali M,Johnsson E,Ajore R,Sulem P,Halvarsson BM,Eyjolfsson G,Haraldsdottir V,Hultman C,Ingelsson E,Kristinsson SY,Kähler AK,Lenhoff S,Masson G,Mellqvist UH,Månsson R,Nelander S,Ola

更新日期：2015-05-26 00:00:00

abstract：:MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with hi...

journal_title：Nature communications

authors： Meng L,Liu C,Lü J,Zhao Q,Deng S,Wang G,Qiao J,Zhang C,Zhen L,Lu Y,Li W,Zhang Y,Pestell RG,Fan H,Chen YH,Liu Z,Yu Z

更新日期：2017-01-03 00:00:00

abstract：:Human mesenchymal stromal cells (hMSCs) are a promising source for engineered cell-based therapies in which genetic engineering could enhance therapeutic efficacy and install novel cellular functions. Here, we describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutagenesis and integrat...

journal_title：Nature communications

authors： Srifa W,Kosaric N,Amorin A,Jadi O,Park Y,Mantri S,Camarena J,Gurtner GC,Porteus M

更新日期：2020-05-18 00:00:00