The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer.

abstract：:Transition metal-catalyzed enantioselective Sonogashira-type oxidative C(sp3)-C(sp) coupling of unactivated C(sp3)-H bonds with terminal alkynes has remained a prominent challenge. The difficulties mainly stem from the regiocontrol in unactivated C(sp3)-H bond functionalization and the inhibition of readily occurring ...

journal_title：Nature communications

authors： Zhang ZH,Dong XY,Du XY,Gu QS,Li ZL,Liu XY

更新日期：2019-12-12 00:00:00

abstract：:In addition to acting as a cellular energy source, ATP can also act as a damage-associated molecular pattern in both animals and plants. Stomata are leaf pores that control gas exchange and, therefore, impact critical functions such as photosynthesis, drought tolerance, and also are the preferred entry point for patho...

journal_title：Nature communications

authors： Chen D,Cao Y,Li H,Kim D,Ahsan N,Thelen J,Stacey G

更新日期：2017-12-22 00:00:00

abstract：:Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult population. Proteolytic turnover of tumour suppressors by the ubiquitin-proteasome system is a mechanism that tumour cells can adopt to sustain their growth and invasiveness. However, the identity of ubiquitin-proteasome targets a...

journal_title：Nature communications

authors： Lignitto L,Arcella A,Sepe M,Rinaldi L,Delle Donne R,Gallo A,Stefan E,Bachmann VA,Oliva MA,Tiziana Storlazzi C,L'Abbate A,Brunetti A,Gargiulo S,Gramanzini M,Insabato L,Garbi C,Gottesman ME,Feliciello A

更新日期：2013-01-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer deaths, and effective treatments are urgently needed. Loss-of-function mutations in the DNA damage response kinase ATM are common in lung adenocarcinoma but directly targeting these with drugs remains challenging. Here we report that ATM loss-of-function is synthetic lethal w...

journal_title：Nature communications

authors： Smida M,Fece de la Cruz F,Kerzendorfer C,Uras IZ,Mair B,Mazouzi A,Suchankova T,Konopka T,Katz AM,Paz K,Nagy-Bojarszky K,Muellner MK,Bago-Horvath Z,Haura EB,Loizou JI,Nijman SM

更新日期：2016-12-06 00:00:00

abstract：:Dense ceramic materials can form in nature under mild temperatures in water. By contrast, man-made ceramics often require sintering temperatures in excess of 1,400 °C for densification. Chemical strategies inspired by biomineralization processes have been demonstrated but remain limited to the fabrication of thin film...

journal_title：Nature communications

authors： Bouville F,Studart AR

更新日期：2017-03-06 00:00:00

abstract：:Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engineered blood vessels (TEBVs) by plastic compression. TEBVs maintain mechanical strength, vasoactivity, and nitric oxide...

journal_title：Nature communications

authors： Zhang X,Bishawi M,Zhang G,Prasad V,Salmon E,Breithaupt JJ,Zhang Q,Truskey GA

更新日期：2020-10-27 00:00:00

abstract：:Both basal ganglia (BG) and orbitofrontal cortex (OFC) have been widely implicated in social and non-social decision-making. However, unlike OFC damage, BG pathology is not typically associated with disturbances in social functioning. Here we studied the behavior of patients with focal lesions to either BG or OFC in a...

journal_title：Nature communications

authors： Zhu L,Jiang Y,Scabini D,Knight RT,Hsu M

更新日期：2019-02-18 00:00:00

abstract：:Explaining trait differences between individuals is a core and challenging aim of life sciences. Here, we introduce a powerful framework for complete decomposition of trait variation into its underlying genetic causes in diploid model organisms. We sequence and systematically pair the recombinant gametes of two interc...

journal_title：Nature communications

authors： Hallin J,Märtens K,Young AI,Zackrisson M,Salinas F,Parts L,Warringer J,Liti G

更新日期：2016-11-02 00:00:00

abstract：:A reliable description of any spatial pattern in species richness requires accurate knowledge about species geographical distribution. However, sampling bias may generate artefactual absences within species range and compromise our capacity to describe biodiversity patterns. Here, we analysed the spatial distribution ...

journal_title：Nature communications

authors： Menegotto A,Rangel TF

更新日期：2018-11-09 00:00:00

abstract：:Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise gene...

journal_title：Nature communications

authors： Jiang X,Finucane HK,Schumacher FR,Schmit SL,Tyrer JP,Han Y,Michailidou K,Lesseur C,Kuchenbaecker KB,Dennis J,Conti DV,Casey G,Gaudet MM,Huyghe JR,Albanes D,Aldrich MC,Andrew AS,Andrulis IL,Anton-Culver H,Antoniou AC

更新日期：2019-01-25 00:00:00

abstract：:Nature has developed striking light-powered proteins such as bacteriorhodopsin, which can convert light energy into conformational changes for biological functions. Such natural machines are a great source of inspiration for creation of their synthetic analogues. However, synthetic molecular machines typically operate...

journal_title：Nature communications

authors： Kuzyk A,Yang Y,Duan X,Stoll S,Govorov AO,Sugiyama H,Endo M,Liu N

更新日期：2016-02-02 00:00:00

abstract：:Autophagy perturbation represents an emerging therapeutic strategy in cancer. Although LATS1 and LATS2 kinases, core components of the mammalian Hippo pathway, have been shown to exert tumor suppressive activities, here we report a pro-survival role of LATS1 but not LATS2 in hepatocellular carcinoma (HCC) cells. Speci...

journal_title：Nature communications

authors： Tang F,Gao R,Jeevan-Raj B,Wyss CB,Kalathur RKR,Piscuoglio S,Ng CKY,Hindupur SK,Nuciforo S,Dazert E,Bock T,Song S,Buechel D,Morini MF,Hergovich A,Matthias P,Lim DS,Terracciano LM,Heim MH,Hall MN,Christofori G

更新日期：2019-12-17 00:00:00

abstract：:Colloidal quantum dots have emerged as a material platform for low-cost high-performance optoelectronics. At the heart of optoelectronic devices lies the formation of a junction, which requires the intimate contact of n-type and p-type semiconductors. Doping in bulk semiconductors has been largely deployed for many de...

journal_title：Nature communications

authors： Stavrinadis A,Rath AK,de Arquer FP,Diedenhofen SL,Magén C,Martinez L,So D,Konstantatos G

更新日期：2013-01-01 00:00:00

abstract：:Time-resolved photoelectron spectroscopy (TRPES) is a useful approach to elucidate the coupled electronic-nuclear quantum dynamics underlying chemical processes, but has remained limited by the use of low photon energies. Here, we demonstrate the general advantages of XUV-TRPES through an application to NO2, one of th...

journal_title：Nature communications

authors： von Conta A,Tehlar A,Schletter A,Arasaki Y,Takatsuka K,Wörner HJ

更新日期：2018-08-08 00:00:00

abstract：:Direct reciprocity is a mechanism for cooperation among humans. Many of our daily interactions are repeated. We interact repeatedly with our family, friends, colleagues, members of the local and even global community. In the theory of repeated games, it is a tacit assumption that the various games that a person plays ...

journal_title：Nature communications

authors： Reiter JG,Hilbe C,Rand DG,Chatterjee K,Nowak MA

更新日期：2018-02-07 00:00:00

abstract：:The Hippo pathway is an evolutionarily conserved regulator of organ size and tumorigenesis that negatively regulates cell growth and survival. Here we report that Yes-associated protein (YAP), the terminal effector of the Hippo pathway, interacts with FoxO1 in the nucleus of cardiomyocytes, thereby promoting survival....

journal_title：Nature communications

authors： Shao D,Zhai P,Del Re DP,Sciarretta S,Yabuta N,Nojima H,Lim DS,Pan D,Sadoshima J

更新日期：2014-01-01 00:00:00

abstract：:Oceanic mesoscale eddies contribute important horizontal heat and salt transports on a global scale. Here we show that eddy transports are mainly due to individual eddy movements. Theoretical and observational analyses indicate that cyclonic and anticyclonic eddies move westwards, and they also move polewards and equa...

journal_title：Nature communications

authors： Dong C,McWilliams JC,Liu Y,Chen D

更新日期：2014-01-01 00:00:00

abstract：:Flexible, wearable sensing devices can yield important information about the underlying physiology of a human subject for applications in real-time health and fitness monitoring. Despite significant progress in the fabrication of flexible biosensors that naturally comply with the epidermis, most designs measure only a...

journal_title：Nature communications

authors： Imani S,Bandodkar AJ,Mohan AM,Kumar R,Yu S,Wang J,Mercier PP

更新日期：2016-05-23 00:00:00

abstract：:DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single-stranded (ss) 5'-flaps one nucleotide into duplex (ds) DNA. Yet, how FEN1 selects for but does not incise the ss 5'-flap was enigmatic. Here we combine...

journal_title：Nature communications

authors： Tsutakawa SE,Thompson MJ,Arvai AS,Neil AJ,Shaw SJ,Algasaier SI,Kim JC,Finger LD,Jardine E,Gotham VJB,Sarker AH,Her MZ,Rashid F,Hamdan SM,Mirkin SM,Grasby JA,Tainer JA

更新日期：2017-06-27 00:00:00

abstract：:Loss of gut mucosal integrity and an aberrant gut microbiota are proposed mechanisms contributing to chronic inflammation and increased morbidity and mortality during antiretroviral-treated HIV disease. Sexual practice has recently been uncovered as a major source of microbiota variation, potentially confounding prior...

journal_title：Nature communications

authors： Vujkovic-Cvijin I,Sortino O,Verheij E,Sklar J,Wit FW,Kootstra NA,Sellers B,Brenchley JM,Ananworanich J,Loeff MSV,Belkaid Y,Reiss P,Sereti I

更新日期：2020-05-15 00:00:00

abstract：:Type I interferon (IFN) is a key driver of immunity to infections and cancer. Plasmacytoid dendritic cells (pDCs) are uniquely equipped to produce large quantities of type I IFN but the mechanisms that control this process are poorly understood. Here we report on a droplet-based microfluidic platform to investigate ty...

journal_title：Nature communications

authors： Wimmers F,Subedi N,van Buuringen N,Heister D,Vivié J,Beeren-Reinieren I,Woestenenk R,Dolstra H,Piruska A,Jacobs JFM,van Oudenaarden A,Figdor CG,Huck WTS,de Vries IJM,Tel J

更新日期：2018-08-20 00:00:00

abstract：:The ontogeny of haematopoietic niches in vertebrates is essentially unknown. Here we show that the stromal cells of the caudal haematopoietic tissue (CHT), the first niche where definitive haematopoietic stem/progenitor cells (HSPCs) home in zebrafish development, derive from the caudal somites through an epithelial-m...

journal_title：Nature communications

authors： Murayama E,Sarris M,Redd M,Le Guyader D,Vivier C,Horsley W,Trede N,Herbomel P

更新日期：2015-09-28 00:00:00

abstract：:In the original version of this Article, the four structural depictions of orbital distributions were inadvertently omitted from Figure 5. This has now been corrected in both the HTML and PDF versions of the Article. ...

journal_title：Nature communications

authors： Zhao J,Peng Q,Wang Z,Xu W,Xiao H,Wu Q,Sun HL,Ma F,Zhao J,Sun CJ,Zhao J,Li J

更新日期：2019-06-21 00:00:00

abstract：:The striking diversity of bird beak shapes is an outcome of natural selection, yet the relative importance of the limitations imposed by the process of beak development on generating such variation is unclear. Untangling these factors requires mapping developmental mechanisms over a phylogeny far exceeding model syste...

journal_title：Nature communications

authors： Fritz JA,Brancale J,Tokita M,Burns KJ,Hawkins MB,Abzhanov A,Brenner MP

更新日期：2014-04-16 00:00:00

abstract：:Antiaromatic and open-shell molecules are attractive because of their distinct electronic and magnetic behaviour. However, their increased reactivity creates a challenge for probing their properties. Here, we describe the on-surface and in-solution generation and characterisation of a highly reactive antiaromatic mole...

journal_title：Nature communications

authors： Majzik Z,Pavliček N,Vilas-Varela M,Pérez D,Moll N,Guitián E,Meyer G,Peña D,Gross L

更新日期：2018-03-22 00:00:00

abstract：:Three-dimensional topological Dirac semimetals (TDSs) are a new kind of Dirac materials that exhibit linear energy dispersion in the bulk and can be viewed as three-dimensional graphene. It has been proposed that TDSs can be driven to other exotic phases like Weyl semimetals, topological insulators and topological sup...

journal_title：Nature communications

authors： Cao J,Liang S,Zhang C,Liu Y,Huang J,Jin Z,Chen ZG,Wang Z,Wang Q,Zhao J,Li S,Dai X,Zou J,Xia Z,Li L,Xiu F

更新日期：2015-07-13 00:00:00

abstract：:Autophosphorylation of amino-acid residues is part of the folding process of various protein kinases. Conventional chemical screening of mature kinases has missed inhibitors that selectively interfere with the folding process. Here we report a cell-based assay that evaluates inhibition of a kinase at a transitional st...

journal_title：Nature communications

authors： Kii I,Sumida Y,Goto T,Sonamoto R,Okuno Y,Yoshida S,Kato-Sumida T,Koike Y,Abe M,Nonaka Y,Ikura T,Ito N,Shibuya H,Hosoya T,Hagiwara M

更新日期：2016-04-22 00:00:00

abstract：:Signaling molecules that regulate neurodevelopmental processes in the early postnatal subventricular zone (SVZ) are critical for proper brain development yet remain poorly characterized. Here, we report that Endothelin-1 (ET-1), a molecular component of the postnatal SVZ, promotes radial glial cell maintenance and pro...

journal_title：Nature communications

authors： Adams KL,Riparini G,Banerjee P,Breur M,Bugiani M,Gallo V

更新日期：2020-05-01 00:00:00

abstract：:Melanoma cells use different migratory strategies to exit the primary tumor mass and invade surrounding and subsequently distant tissues. We reported previously that ADAR1 expression is downregulated in metastatic melanoma, thereby facilitating proliferation. Here we show that ADAR1 silencing enhances melanoma cell in...

journal_title：Nature communications

authors： Nemlich Y,Baruch EN,Besser MJ,Shoshan E,Bar-Eli M,Anafi L,Barshack I,Schachter J,Ortenberg R,Markel G

更新日期：2018-05-31 00:00:00

abstract：:The worldwide biodiversity crisis has intensified the need to better understand how biodiversity and human disturbance are related. The 'intermediate disturbance hypothesis' suggests that disturbance regimes generate predictable non-linear patterns in species richness. Evidence often contradicts intermediate disturban...

journal_title：Nature communications

authors： Mayor SJ,Cahill JF Jr,He F,Sólymos P,Boutin S

更新日期：2012-01-01 00:00:00