Selective inhibition of the kinase DYRK1A by targeting its folding process.

abstract：:A key challenge in the field of molecular spintronics, and for the design of single-molecule magnet-based devices in particular, is the understanding and control of the molecular coupling at the electrode interfaces. It was demonstrated for the field of molecular electronics that the characterization of the molecule-m...

journal_title：Nature communications

authors： Schwöbel J,Fu Y,Brede J,Dilullo A,Hoffmann G,Klyatskaya S,Ruben M,Wiesendanger R

更新日期：2012-07-17 00:00:00

abstract：:Generating a comprehensive map of molecular interactions in living cells is difficult and great efforts are undertaken to infer molecular interactions from large-scale perturbation experiments. Here, we develop the analytical and numerical tools to quantify the fundamental limits for inferring transcriptional networks...

journal_title：Nature communications

authors： Blum CF,Heramvand N,Khonsari AS,Kollmann M

更新日期：2018-01-09 00:00:00

abstract：:Superlubricity of graphite and graphene has aroused increasing interest in recent years. Yet how to obtain a long-lasting superlubricity between graphene layers, under high applied normal load in ambient atmosphere still remains a challenge but is highly desirable. Here, we report a direct measurement of sliding frict...

journal_title：Nature communications

authors： Liu SW,Wang HP,Xu Q,Ma TB,Yu G,Zhang C,Geng D,Yu Z,Zhang S,Wang W,Hu YZ,Wang H,Luo J

更新日期：2017-02-14 00:00:00

abstract：:Sustainable food production in the context of climate change necessitates diversification of agriculture and a more efficient utilization of plant genetic resources. Fonio millet (Digitaria exilis) is an orphan African cereal crop with a great potential for dryland agriculture. Here, we establish high-quality genomic ...

journal_title：Nature communications

authors： Abrouk M,Ahmed HI,Cubry P,Šimoníková D,Cauet S,Pailles Y,Bettgenhaeuser J,Gapa L,Scarcelli N,Couderc M,Zekraoui L,Kathiresan N,Čížková J,Hřibová E,Doležel J,Arribat S,Bergès H,Wieringa JJ,Gueye M,Kane NA,Leclerc C

更新日期：2020-09-08 00:00:00

abstract：:Pulmonary disease increases the risk of developing abdominal aortic aneurysms (AAA). However, the mechanism underlying the pathological dialogue between the lungs and aorta is undefined. Here, we find that inflicting acute lung injury (ALI) to mice doubles their incidence of AAA and accelerates macrophage-driven prote...

journal_title：Nature communications

authors： Boytard L,Hadi T,Silvestro M,Qu H,Kumpfbeck A,Sleiman R,Fils KH,Alebrahim D,Boccalatte F,Kugler M,Corsica A,Gelb BE,Jacobowitz G,Miller G,Bellini C,Oakes J,Silvestre JS,Zangi L,Ramkhelawon B

更新日期：2020-08-27 00:00:00

abstract：:Complex polyketides are typically associated with microbial metabolism. Here, we report that animals also make complex, microbe-like polyketides. We show there is a widespread branch of fatty acid synthase- (FAS)-like polyketide synthase (PKS) proteins, which sacoglossan animals use to synthesize complex products. The...

journal_title：Nature communications

authors： Torres JP,Lin Z,Winter JM,Krug PJ,Schmidt EW

更新日期：2020-06-08 00:00:00

abstract：:Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (SNP) content of genome-wide arrays. The UK10K Cohorts project has generated a data set of 3,781 whole genomes sequenced at low depth (average 7x), aimi...

journal_title：Nature communications

authors： Huang J,Howie B,McCarthy S,Memari Y,Walter K,Min JL,Danecek P,Malerba G,Trabetti E,Zheng HF,UK10K Consortium.,Gambaro G,Richards JB,Durbin R,Timpson NJ,Marchini J,Soranzo N

更新日期：2015-09-14 00:00:00

abstract：:A number of modes of oscillations of particles and fields can exist in space plasmas. Since the early 1970s, space missions have observed noise-like plasma waves near the geomagnetic equator known as 'equatorial noise'. Several theories were suggested, but clear observational evidence supported by realistic modelling ...

journal_title：Nature communications

authors： Balikhin MA,Shprits YY,Walker SN,Chen L,Cornilleau-Wehrlin N,Dandouras I,Santolik O,Carr C,Yearby KH,Weiss B

更新日期：2015-07-14 00:00:00

abstract：:Combining vapour sensors into arrays is an accepted compromise to mitigate poor selectivity of conventional sensors. Here we show individual nanofabricated sensors that not only selectively detect separate vapours in pristine conditions but also quantify these vapours in mixtures, and when blended with a variable mois...

journal_title：Nature communications

authors： Potyrailo RA,Bonam RK,Hartley JG,Starkey TA,Vukusic P,Vasudev M,Bunning T,Naik RR,Tang Z,Palacios MA,Larsen M,Le Tarte LA,Grande JC,Zhong S,Deng T

更新日期：2015-09-01 00:00:00

abstract：:Many photosynthetic organisms globally, including crops, forests and algae, must grow in environments where the availability of light energy fluctuates dramatically. How photosynthesis maintains high efficiency despite such fluctuations in its energy source remains poorly understood. Here we show that Arabidopsis thal...

journal_title：Nature communications

authors： Armbruster U,Carrillo LR,Venema K,Pavlovic L,Schmidtmann E,Kornfeld A,Jahns P,Berry JA,Kramer DM,Jonikas MC

更新日期：2014-11-13 00:00:00

abstract：:Herbivore-induced volatile organic compounds prime non-attacked plant tissues to respond more strongly to subsequent attacks. However, the key volatiles that trigger this primed state remain largely unidentified. In maize, the release of the aromatic compound indole is herbivore-specific and occurs earlier than other ...

journal_title：Nature communications

authors： Erb M,Veyrat N,Robert CA,Xu H,Frey M,Ton J,Turlings TC

更新日期：2015-02-16 00:00:00

abstract：:Molecules containing multiple bonds between atoms-most often in the form of olefins-are ubiquitous in nature, commerce, and science, and as such have a huge impact on everyday life. Given their prominence, over the last few decades, frequent attempts have been made to perturb the structure and reactivity of multiply-b...

journal_title：Nature communications

authors： Böhnke J,Dellermann T,Celik MA,Krummenacher I,Dewhurst RD,Demeshko S,Ewing WC,Hammond K,Heß M,Bill E,Welz E,Röhr MIS,Mitrić R,Engels B,Meyer F,Braunschweig H

更新日期：2018-03-22 00:00:00

abstract：:Exploitation of the oxidation behaviour in an environmentally sensitive semiconductor is significant to modulate its electronic properties and develop unique applications. Here, we demonstrate a native oxidation-inspired InSe field-effect transistor as an artificial synapse in device level that benefits from the boost...

journal_title：Nature communications

authors： Yang FS,Li M,Lee MP,Ho IY,Chen JY,Ling H,Li Y,Chang JK,Yang SH,Chang YM,Lee KC,Chou YC,Ho CH,Li W,Lien CH,Lin YF

更新日期：2020-06-12 00:00:00

abstract：:All-inorganic perovskites have a special place in halide perovskite family because of their potential for better stability. However, the representative cesium lead iodide (CsPbI3) is metastable and spontaneously converts to the non-perovskite structure at room temperature. Here, we demonstrate that what appears to be ...

journal_title：Nature communications

authors： Ke W,Spanopoulos I,Stoumpos CC,Kanatzidis MG

更新日期：2018-11-14 00:00:00

abstract：:Nuclear magnetic resonance (NMR) spectroscopy is a powerful method for analyzing the chemical composition and molecular structure of materials. At the nanometer scale, NMR has the prospect of mapping the atomic-scale structure of individual molecules, provided a method that can sensitively detect single nuclei and mea...

journal_title：Nature communications

authors： Zopes J,Cujia KS,Sasaki K,Boss JM,Itoh KM,Degen CL

更新日期：2018-11-08 00:00:00

abstract：:Diagnosis of disease outside of sophisticated laboratories urgently requires low-cost, user-friendly devices. Disposable, instrument-free testing devices are used for home and physician office testing, but are limited in applicability to a small class of highly abundant analytes. Direct, unambiguous visual read-out is...

journal_title：Nature communications

authors： Besant JD,Das J,Burgess IB,Liu W,Sargent EH,Kelley SO

更新日期：2015-04-22 00:00:00

abstract：:Genome replication is highly regulated in time and space, but the rules governing the remodeling of these programs during evolution remain largely unknown. We generated genome-wide replication timing profiles for ten Lachancea yeasts, covering a continuous evolutionary range from closely related to more divergent spec...

journal_title：Nature communications

authors： Agier N,Delmas S,Zhang Q,Fleiss A,Jaszczyszyn Y,van Dijk E,Thermes C,Weigt M,Cosentino-Lagomarsino M,Fischer G

更新日期：2018-06-06 00:00:00

abstract：:Multiciliated ependymal (E1) cells line the brain ventricles and are essential for brain homeostasis. We previously identified in the lateral ventricles a rare ependymal subpopulation (E2) with only two cilia and unique basal bodies. Here we show that E2 cells form a distinct biciliated epithelium extending along the ...

journal_title：Nature communications

authors： Mirzadeh Z,Kusne Y,Duran-Moreno M,Cabrales E,Gil-Perotin S,Ortiz C,Chen B,Garcia-Verdugo JM,Sanai N,Alvarez-Buylla A

更新日期：2017-01-09 00:00:00

abstract：:The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural variations in SD and m...

journal_title：Nature communications

authors： Ding J,Chen K,Liu H,Huang L,Chen Y,Lv Y,Yang Q,Guo Q,Han Z,Lambon Ralph MA

更新日期：2020-05-22 00:00:00

abstract：:Graphyne allotropes of carbon are fascinating materials, and their electronic properties are predicted to rival those of the "wonder material" graphene. One allotrope of graphyne, having rectangular symmetry rather than hexagonal, stands out as particularly attractive, namely 6,6,12-graphyne. It is currently an insurm...

journal_title：Nature communications

authors： Kilde MD,Murray AH,Andersen CL,Storm FE,Schmidt K,Kadziola A,Mikkelsen KV,Hampel F,Hammerich O,Tykwinski RR,Nielsen MB

更新日期：2019-08-16 00:00:00

abstract：:Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic lesions, homology donors and the endogenous DNA repair machinery. Here we engineered programmable cytidine deaminases and test if we could introduce site-specific...

journal_title：Nature communications

authors： Yang L,Briggs AW,Chew WL,Mali P,Guell M,Aach J,Goodman DB,Cox D,Kan Y,Lesha E,Soundararajan V,Zhang F,Church G

更新日期：2016-11-02 00:00:00

abstract：:Normal epithelial cells are stably connected to each other via the apical junctional complex (AJC). AJCs, however, tend to be disrupted during tumor progression, and this process is implicated in cancer dissemination. Here, using colon carcinoma cells that fail to form AJCs, we investigated molecular defects behind th...

journal_title：Nature communications

authors： Ito S,Okuda S,Abe M,Fujimoto M,Onuki T,Nishimura T,Takeichi M

更新日期：2017-11-28 00:00:00

abstract：:The costs for solar photovoltaics, wind, and battery storage have dropped markedly since 2010, however, many recent studies and reports around the world have not adequately captured such dramatic decrease. Those costs are projected to decline further in the near future, bringing new prospects for the widespread penetr...

journal_title：Nature communications

authors： He G,Lin J,Sifuentes F,Liu X,Abhyankar N,Phadke A

更新日期：2020-05-19 00:00:00

abstract：:Layered materials embrace rich intercalation reactions to accommodate high concentrations of foreign species within their structures, and find many applications spanning from energy storage, ion exchange to secondary batteries. Light alkali metals are generally most easily intercalated due to their light mass, high ch...

journal_title：Nature communications

authors： Yajima T,Koshiko M,Zhang Y,Oguchi T,Yu W,Kato D,Kobayashi Y,Orikasa Y,Yamamoto T,Uchimoto Y,Green MA,Kageyama H

更新日期：2016-12-14 00:00:00

abstract：:Circulating CCR2+ monocytes are crucial for maintaining the adult tissue-resident F4/80hiMHCIIhi macrophage pool in the intestinal lamina propria. Here we show that a subpopulation of CCR2-independent F4/80hiMHCIIlow macrophages, which are the most abundant F4/80hi cells in neonates, gradually decline in number in adu...

journal_title：Nature communications

authors： Soncin I,Sheng J,Chen Q,Foo S,Duan K,Lum J,Poidinger M,Zolezzi F,Karjalainen K,Ruedl C

更新日期：2018-02-08 00:00:00

abstract：:Mutations in patatin-like phospholipase domain-containing 1 (PNPLA1) cause autosomal recessive congenital ichthyosis, but the mechanism involved remains unclear. Here we show that PNPLA1, an enzyme expressed in differentiated keratinocytes, plays a crucial role in the biosynthesis of ω-O-acylceramide, a lipid componen...

journal_title：Nature communications

authors： Hirabayashi T,Anjo T,Kaneko A,Senoo Y,Shibata A,Takama H,Yokoyama K,Nishito Y,Ono T,Taya C,Muramatsu K,Fukami K,Muñoz-Garcia A,Brash AR,Ikeda K,Arita M,Akiyama M,Murakami M

更新日期：2017-03-01 00:00:00

abstract：:Control over interactions with biomolecules holds the key to applications of graphene in biotechnology. One such application is nanopore sequencing, where a DNA molecule is electrophoretically driven through a graphene nanopore. Here we investigate how interactions of single-stranded DNA and a graphene membrane can be...

journal_title：Nature communications

authors： Shankla M,Aksimentiev A

更新日期：2014-10-09 00:00:00

abstract：:Homozygosity mapping is a powerful method for identifying mutations in patients with recessive conditions, especially in consanguineous families or isolated populations. Historically, it has been used in conjunction with genotypes from highly polymorphic markers, such as DNA microsatellites or common SNPs. Traditional...

journal_title：Nature communications

authors： Quinodoz M,Peter VG,Bedoni N,Royer Bertrand B,Cisarova K,Salmaninejad A,Sepahi N,Rodrigues R,Piran M,Mojarrad M,Pasdar A,Ghanbari Asad A,Sousa AB,Coutinho Santos L,Superti-Furga A,Rivolta C

更新日期：2021-01-22 00:00:00

abstract：:Use of aromatase inhibitors (AIs), exemestane, letrozole and anastrozole, for breast cancer therapy is associated with severe pain symptoms, the underlying mechanism of which is unknown. The electrophilic nature of AIs suggests that they may target the transient receptor potential ankyrin 1 (TRPA1) channel, a major pa...

journal_title：Nature communications

authors： Fusi C,Materazzi S,Benemei S,Coppi E,Trevisan G,Marone IM,Minocci D,De Logu F,Tuccinardi T,Di Tommaso MR,Susini T,Moneti G,Pieraccini G,Geppetti P,Nassini R

更新日期：2014-12-08 00:00:00

abstract：:Transport of nanoscale energy in the form of excitons is at the core of photosynthesis and the operation of a wide range of nanostructured optoelectronic devices such as solar cells, light-emitting diodes and excitonic transistors. Of particular importance is the relationship between exciton transport and nanoscale di...

journal_title：Nature communications

authors： Akselrod GM,Deotare PB,Thompson NJ,Lee J,Tisdale WA,Baldo MA,Menon VM,Bulović V

更新日期：2014-04-16 00:00:00