Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks.

abstract：:Maintaining DNA integrity is vital for all cells and organisms. Defective DNA repair may contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced levels of BRCA1, but not of other DNA repair factors, in the brains of AD patients and human amyloid precursor protein (hAPP) transgenic mi...

journal_title：Nature communications

authors： Suberbielle E,Djukic B,Evans M,Kim DH,Taneja P,Wang X,Finucane M,Knox J,Ho K,Devidze N,Masliah E,Mucke L

更新日期：2015-11-30 00:00:00

abstract：:The word 'holography' means a drawing that contains all of the information for light-both amplitude and wavefront. However, because of the insufficient bandwidth of current electronics, the direct measurement of the wavefront of light has not yet been achieved. Though reference-field-assisted interferometric methods h...

journal_title：Nature communications

authors： Lee K,Park Y

更新日期：2016-10-31 00:00:00

abstract：:A key question of theoretical ecology is which properties of ecosystems favour their stability and help maintaining biodiversity. This question recently reconsidered mutualistic systems, generating intense controversy about the role of mutualistic interactions and their network architecture. Here we show analytically ...

journal_title：Nature communications

authors： Pascual-García A,Bastolla U

更新日期：2017-02-24 00:00:00

abstract：:Antibiotic resistance poses rapidly increasing global problems in combatting multidrug-resistant (MDR) infectious diseases like MDR tuberculosis, prompting for novel approaches including host-directed therapies (HDT). Intracellular pathogens like Salmonellae and Mycobacterium tuberculosis (Mtb) exploit host pathways t...

journal_title：Nature communications

authors： Korbee CJ,Heemskerk MT,Kocev D,van Strijen E,Rabiee O,Franken KLMC,Wilson L,Savage NDL,Džeroski S,Haks MC,Ottenhoff THM

更新日期：2018-01-24 00:00:00

abstract：:Stable benzotriazinyl radicals (Blatter's radicals) recently attracted considerable interest as building blocks for functional materials. The existing strategies to derivatize Blatter's radicals are limited, however, and synthetic routes are complex. Here, we report that an inexpensive, commercially available, analyti...

journal_title：Nature communications

authors： Grant JA,Lu Z,Tucker DE,Hockin BM,Yufit DS,Fox MA,Kataky R,Chechik V,O'Donoghue AC

更新日期：2017-05-15 00:00:00

abstract：:Nanocrystallization is a well-known strategy to dramatically tune the properties of materials; however, the grain-size effect of graphene at the nanometer scale remains unknown experimentally because of the lack of nanocrystalline samples. Here we report an ultrafast growth of graphene films within a few seconds by qu...

journal_title：Nature communications

authors： Zhao T,Xu C,Ma W,Liu Z,Zhou T,Liu Z,Feng S,Zhu M,Kang N,Sun DM,Cheng HM,Ren W

更新日期：2019-10-24 00:00:00

abstract：:Considerable interest has been devoted to converting mechanical energy into electricity using polymer nanofibres. In particular, piezoelectric nanofibres produced by electrospinning have shown remarkable mechanical energy-to-electricity conversion ability. However, there is little data for the acoustic-to-electric con...

journal_title：Nature communications

authors： Lang C,Fang J,Shao H,Ding X,Lin T

更新日期：2016-03-23 00:00:00

abstract：:Controlling the properties of quantum dots at the atomic scale, such as dangling bonds, is a general motivation as they allow studying various nanoscale processes including atomic switches, charge storage, or low binding energy state interactions. Adjusting the coupling of individual silicon dangling bonds to form a 2...

journal_title：Nature communications

authors： Yengui M,Duverger E,Sonnet P,Riedel D

更新日期：2017-12-20 00:00:00

abstract：:Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells, and map the chromatin accessibility an...

journal_title：Nature communications

authors： Liu L,Leng L,Liu C,Lu C,Yuan Y,Wu L,Gong F,Zhang S,Wei X,Wang M,Zhao L,Hu L,Wang J,Yang H,Zhu S,Chen F,Lu G,Shang Z,Lin G

更新日期：2019-01-21 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms15587. ...

journal_title：Nature communications

authors： Yu T,Zhou YJ,Wenning L,Liu Q,Krivoruchko A,Siewers V,Nielsen J,David F

更新日期：2018-07-13 00:00:00

abstract：:An evolutionary account of human language as a neurobiological system must distinguish between human-unique neurocognitive processes supporting language and evolutionarily conserved, domain-general processes that can be traced back to our primate ancestors. Neuroimaging studies across species may determine whether can...

journal_title：Nature communications

authors： Wilson B,Kikuchi Y,Sun L,Hunter D,Dick F,Smith K,Thiele A,Griffiths TD,Marslen-Wilson WD,Petkov CI

更新日期：2015-11-17 00:00:00

abstract：:Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers....

journal_title：Nature communications

authors： Seki R,Li C,Fang Q,Hayashi S,Egawa S,Hu J,Xu L,Pan H,Kondo M,Sato T,Matsubara H,Kamiyama N,Kitajima K,Saito D,Liu Y,Gilbert MT,Zhou Q,Xu X,Shiroishi T,Irie N,Tamura K,Zhang G

更新日期：2017-02-06 00:00:00

abstract：:The original version of this Article contained errors in the units of concentration of three reagents listed in the Methods. These errors have all been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Stepanauskas R,Fergusson EA,Brown J,Poulton NJ,Tupper B,Labonté JM,Becraft ED,Brown JM,Pachiadaki MG,Povilaitis T,Thompson BP,Mascena CJ,Bellows WK,Lubys A

更新日期：2017-12-12 00:00:00

abstract：:In response to intracellular signals in Gram--negative bacteria, translational riboswitches--commonly embedded in messenger RNAs (mRNAs)-regulate gene expression through inhibition of translation initiation. It is generally thought that this regulation originates from occlusion of the Shine-Dalgarno (SD) sequence upon...

journal_title：Nature communications

authors： Rinaldi AJ,Lund PE,Blanco MR,Walter NG

更新日期：2016-01-19 00:00:00

abstract：:Intracellular trafficking of organelles, driven by kinesin-1 stepping along microtubules, underpins essential cellular processes. In absence of other proteins on the microtubule surface, kinesin-1 performs micron-long runs. Under crowding conditions, however, kinesin-1 motility is drastically impeded. It is thus uncle...

journal_title：Nature communications

authors： Henrichs V,Grycova L,Barinka C,Nahacka Z,Neuzil J,Diez S,Rohlena J,Braun M,Lansky Z

更新日期：2020-06-19 00:00:00

abstract：:Non-collinear spin transport is at the heart of spin or magnetization control in spintronics devices. The use of nanoscale conductors exhibiting quantum effects in transport could provide new paths for that purpose. Here we study non-collinear spin transport in a quantum dot. We use a device made out of a single-wall ...

journal_title：Nature communications

authors： Crisan AD,Datta S,Viennot JJ,Delbecq MR,Cottet A,Kontos T

更新日期：2016-01-27 00:00:00

abstract：:MAVS and MITA are essential adaptor proteins mediating innate antiviral immune responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays dual roles in response to RNA or DNA virus infections by catalyzing distinct types of ubiquitination of MAVS and MITA at different phases of viral infection...

journal_title：Nature communications

authors： Zhang ZD,Xiong TC,Yao SQ,Wei MC,Chen M,Lin D,Zhong B

更新日期：2020-11-02 00:00:00

abstract：:Different symmetry breaking ways determine various magnetization switching modes driven by spin-orbit torques (SOT). For instance, an applied or effective field parallel to applied current is indispensable to switch magnetization with perpendicular anisotropy by SOT. Besides of this mode, here we experimentally demons...

journal_title：Nature communications

authors： Kong WJ,Wan CH,Wang X,Tao BS,Huang L,Fang C,Guo CY,Guang Y,Irfan M,Han XF

更新日期：2019-01-16 00:00:00

abstract：:Despite the pursuit of quantum advantages in various applications, the power of quantum computers in executing neural network has mostly remained unknown, primarily due to a missing tool that effectively designs a neural network suitable for quantum circuit. Here, we present a neural network and quantum circuit co-des...

journal_title：Nature communications

authors： Jiang W,Xiong J,Shi Y

更新日期：2021-01-25 00:00:00

abstract：:Embedding tunable quantum emitters in a photonic bandgap structure enables control of dissipative and dispersive interactions between emitters and their photonic bath. Operation in the transmission band, outside the gap, allows for studying waveguide quantum electrodynamics in the slow-light regime. Alternatively, tun...

journal_title：Nature communications

authors： Mirhosseini M,Kim E,Ferreira VS,Kalaee M,Sipahigil A,Keller AJ,Painter O

更新日期：2018-09-12 00:00:00

abstract：:Numerous examples of biosynthetic gene clusters (BGCs), including for compounds of agricultural and medicinal importance, have now been discovered in plant genomes. However, little is known about how these complex traits are assembled and diversified. Here, we examine a large number of variants within and between spec...

journal_title：Nature communications

authors： Liu Z,Cheema J,Vigouroux M,Hill L,Reed J,Paajanen P,Yant L,Osbourn A

更新日期：2020-10-23 00:00:00

abstract：:It is commonly assumed that neural systems efficiently process natural sensory input. However, the mechanisms by which such efficient processing is achieved, and the consequences for perception and behaviour remain poorly understood. Here we show that small conductance calcium-activated potassium (SK) channels enable ...

journal_title：Nature communications

authors： Huang CG,Zhang ZD,Chacron MJ

更新日期：2016-04-18 00:00:00

abstract：:The originally published version of this Article contained errors in Figure 4. In panel b, the square and diamond labels associated with the uppermost survival curve were incorrectly displayed as 'n' and 'u', respectively. These errors have now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Wang P,Li X,Wang J,Gao D,Li Y,Li H,Chu Y,Zhang Z,Liu H,Jiang G,Cheng Z,Wang S,Dong J,Feng B,Chard LS,Lemoine NR,Wang Y

更新日期：2018-01-10 00:00:00

abstract：:The flexibility in structural design of organic semiconductors endows organic solar cells (OSCs) not only great function-tunabilities, but also high potential toward practical application. In this work, simple non-fused-ring electron acceptors are developed through two-step synthesis from single aromatic units for con...

journal_title：Nature communications

authors： Yu ZP,Liu ZX,Chen FX,Qin R,Lau TK,Yin JL,Kong X,Lu X,Shi M,Li CZ,Chen H

更新日期：2019-05-14 00:00:00

abstract：:Creatine kinase (CK) and lactate dehydrogenase (LDH) are widely used markers of tissue damage. To search for sequence variants influencing serum levels of CK and LDH, 28.3 million sequence variants identified through whole-genome sequencing of 2,636 Icelanders were imputed into 63,159 and 98,585 people with CK and LDH...

journal_title：Nature communications

authors： Kristjansson RP,Oddsson A,Helgason H,Sveinbjornsson G,Arnadottir GA,Jensson BO,Jonasdottir A,Jonasdottir A,Bragi Walters G,Sulem G,Oskarsdottir A,Benonisdottir S,Davidsson OB,Masson G,Magnusson OT,Holm H,Sigurdardottir O

更新日期：2016-02-03 00:00:00

abstract：:In the originally published version of this Article, the affiliation details for Eric E. Schadt and Radoslav Savic incorrectly omitted 'Sema4, a Mount Sinai venture, Stamford, Connecticut, USA'. This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Readhead B,Hartley BJ,Eastwood BJ,Collier DA,Evans D,Farias R,He C,Hoffman G,Sklar P,Dudley JT,Schadt EE,Savić R,Brennand KJ

更新日期：2018-11-19 00:00:00

abstract：:Photoluminescence phenomena normally obey Stokes' law of luminescence according to which the emitted photon energy is typically lower than its excitation counterparts. Here we show that carbon nanotubes break this rule under one-photon excitation conditions. We found that the carbon nanotubes exhibit efficient near-in...

journal_title：Nature communications

authors： Akizuki N,Aota S,Mouri S,Matsuda K,Miyauchi Y

更新日期：2015-11-16 00:00:00

abstract：:Ferroelectric materials exhibit a phase transition to a paraelectric state driven by temperature - called the Curie transition. In conventional ferroelectrics, the Curie transition is caused by a change in crystal symmetry, while the material itself remains a continuous three-dimensional solid crystal. However, ferroe...

journal_title：Nature communications

authors： Hafner J,Benaglia S,Richheimer F,Teuschel M,Maier FJ,Werner A,Wood S,Platz D,Schneider M,Hradil K,Castro FA,Garcia R,Schmid U

更新日期：2021-01-08 00:00:00

abstract：:The formation of the HIV-1 core is the final step in the viral maturation pathway, resulting in the formation of infectious virus. Most current models for HIV-1 core formation suggest that, upon proteolytic cleavage from the immature Gag, capsid (CA) dissociates into the viral interior before reforming into the core. ...

journal_title：Nature communications

authors： Frank GA,Narayan K,Bess JW Jr,Del Prete GQ,Wu X,Moran A,Hartnell LM,Earl LA,Lifson JD,Subramaniam S

更新日期：2015-01-08 00:00:00

abstract：:Nematode neurons generally produce graded potentials instead of action potentials. It is unclear how the graded potentials control postsynaptic cells under physiological conditions. Here we show that postsynaptic currents frequently occur in bursts at the neuromuscular junction of Caenorhabditis elegans. Cholinergic b...

journal_title：Nature communications

authors： Liu P,Chen B,Wang ZW

更新日期：2013-01-01 00:00:00