Abstract:
:Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that γδ T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is impaired in IL-17A-deficient mice due to a defect in osteoblastic bone formation. IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor cells. This study identifies a novel role for IL-17-producing γδ T cells in skeletal tissue regeneration.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Ono T,Okamoto K,Nakashima T,Nitta T,Hori S,Iwakura Y,Takayanagi Hdoi
10.1038/ncomms10928subject
Has Abstractpub_date
2016-03-11 00:00:00pages
10928issn
2041-1723pii
ncomms10928journal_volume
7pub_type
杂志文章abstract::Quantum computers promise to solve certain problems more efficiently than their digital counterparts. A major challenge towards practically useful quantum computing is characterizing and reducing the various errors that accumulate during an algorithm running on large-scale processors. Current characterization techniqu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13068-7
更新日期:2019-11-25 00:00:00
abstract::High-resolution structural information on RNA and its functionally important complexes with proteins is dramatically underrepresented compared with proteins but is urgently needed for understanding cellular processes at the molecular and atomic level. Here we present an EPR-based protocol to help solving large RNA and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4669
更新日期:2014-05-14 00:00:00
abstract::Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project d...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/ncomms9559
更新日期:2015-10-01 00:00:00
abstract::Fas induces apoptosis in activated T cell to maintain immune homeostasis, but the effects of non-apoptotic Fas signaling on T cells remain unclear. Here we show that Fas promotes TH9 cell differentiation by activating NF-κB via Ca2+-dependent PKC-β activation. In addition, PKC-β also phosphorylates p38 to inactivate N...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10889-4
更新日期:2019-07-02 00:00:00
abstract::Protein homeostasis (proteostasis) is a potential mechanism that contributes to cancer cell survival and drug resistance. Constitutively active androgen receptor (AR) variants confer anti-androgen resistance in advanced prostate cancer. However, the role of proteostasis involved in next generation anti-androgen resist...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07178-x
更新日期:2018-11-16 00:00:00
abstract::Considerable progress in the fabrication of quasicrystals demonstrates that they can be realized in a broad range of materials. However, the development of chemistries enabling direct experimental observation of early quasicrystal growth pathways remains challenging. Here, we report the synthesis of four surfactant-di...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00351-8
更新日期:2017-08-15 00:00:00
abstract::Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterized by the genetic translocation t(9;22)(q34;q11.2) encoding for the BCR-ABL fusion oncogene. However, many molecular mechanisms of the disease progression still remain poorly understood. A growing body of evidence suggests that the epigenetic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8091
更新日期:2015-05-22 00:00:00
abstract::Invariant natural killer T cells have a distinct developmental pathway from conventional αβ T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2580
更新日期:2013-01-01 00:00:00
abstract::Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective, transient or lack specificity. Here we report that neutrophil...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16596-9
更新日期:2020-06-02 00:00:00
abstract::HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide ("Man9-V3") for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage ("DH270"), to visualize the epitope...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03565-6
更新日期:2018-03-16 00:00:00
abstract::During stress, prompt export of stress-inducible transcripts is critical for cell survival. Here, we characterize a function of the SAGA (Spt-Ada-Gcn5 acetyltransferase) deubiquitylating module (DUBm) in monitoring messenger ribonucleoprotein (mRNP) biogenesis to regulate non-canonical mRNA export of stress-inducible ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10350-6
更新日期:2019-06-05 00:00:00
abstract::Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contusion. The viability of such neuropreservative strategies depends on the degree to which initially injured axons can reco...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6683
更新日期:2014-12-16 00:00:00
abstract::To function, biomolecules require sufficient specificity of interaction as well as stability to live in the cell while still being able to move. Thermodynamic stability of only a limited number of specific structures is important so as to prevent promiscuous interactions. The individual interactions in proteins, there...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19560-9
更新日期:2020-11-23 00:00:00
abstract::Despite their energy-efficient merits as promising light-weight structural materials, magnesium (Mg) based alloys suffer from inadequate corrosion resistance. One primary reason is that the native surface film on Mg formed in air mainly consists of Mg(OH)2 and MgO, which is porous and unprotective, especially in humid...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06433-5
更新日期:2018-10-03 00:00:00
abstract::The complex transport processes contributing to sintering are not yet fully understood, partially because in-situ observations of sintering in three dimensions (3D) are very difficult. Here we report a novel experiment in which monocrystalline copper spheres are first marked with microscopic boreholes drilled using a ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1300
更新日期:2011-01-01 00:00:00
abstract::It is a relatively new insight of classical statistics that empirical data can contain information about causation rather than mere correlation. First algorithms have been proposed that are capable of testing whether a presumed causal relationship is compatible with an observed distribution. However, no systematic met...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6766
更新日期:2015-01-06 00:00:00
abstract::The mammalian pseudokinase SgK223, and its structurally related homologue SgK269, are oncogenic scaffolds that nucleate the assembly of specific signalling complexes and regulate tyrosine kinase signalling. Both SgK223 and SgK269 form homo- and hetero-oligomers, a mechanism that underpins a diversity of signalling out...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01279-9
更新日期:2017-10-27 00:00:00
abstract::Scattering-type scanning near-field optical microscopy (s-SNOM) allows spectroscopic imaging with spatial resolution below the diffraction limit. With suitable light sources, s-SNOM is instrumental in numerous discoveries at the nanoscale. So far, the light sources have been limited to continuous wave or high-repetiti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13212
更新日期:2016-10-17 00:00:00
abstract::Hypoxia is a main driver of sprouting angiogenesis, but how tip endothelial cells are directed to hypoxic regions remains poorly understood. Here, we show that an endothelial MST1-FOXO1 cascade is essential for directional migration of tip cells towards hypoxic regions. In mice, endothelial-specific deletion of either...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08773-2
更新日期:2019-02-19 00:00:00
abstract::NaK and other non-selective channels are able to conduct both sodium (Na+) and potassium (K+) with equally high efficiency. In contrast to previous crystallographic results, we show that the selectivity filter (SF) of NaK in native-like lipid membranes adopts two distinct conformations that are stabilized by either Na...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03179-y
更新日期:2018-02-19 00:00:00
abstract::Solid-state quantum acoustodynamic (QAD) systems provide a compact platform for quantum information storage and processing by coupling acoustic phonon sources with superconducting or spin qubits. The multi-mode composite high-overtone bulk acoustic wave resonator (HBAR) is a popular phonon source well suited for QAD. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15472-w
更新日期:2020-05-08 00:00:00
abstract::Magnetic resonance imaging is an important technique for identifying different types of tissues in a body or spatial information about composite materials. Because temperature is a fundamental parameter reflecting the biological status of the body and individual tissues, it would be helpful to have temperature maps su...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12415
更新日期:2016-08-09 00:00:00
abstract::Molecularly targeted therapies for advanced prostate cancer include castration modalities that suppress ligand-dependent transcriptional activity of the androgen receptor (AR). However, persistent AR signalling undermines therapeutic efficacy and promotes progression to lethal castration-resistant prostate cancer (CRP...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13668
更新日期:2016-11-29 00:00:00
abstract::Epithelial-to-mesenchymal transition-like (EMT-like) is a critical process allowing initiation of metastases during tumour progression. Here, to investigate its role in intestinal cancer, we combine computational network-based and experimental approaches to create a mouse model with high metastatic potential. Construc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6005
更新日期:2014-10-08 00:00:00
abstract::Materials with a negative Poisson's ratio, also known as auxetic materials, exhibit unusual and counterintuitive mechanical behaviour-becoming fatter in cross-section when stretched. Such behaviour is mostly attributed to some special re-entrant or hinged geometric structures regardless of the chemical composition and...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15224
更新日期:2017-05-25 00:00:00
abstract::Synthesis of ethanol from non-petroleum carbon resources via syngas (a mixture of H2 and CO) is an important but challenging research target. The current conversion of syngas to ethanol suffers from low selectivity or multiple processes with high energy consumption. Here, we report a high-selective conversion of synga...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14672-8
更新日期:2020-02-11 00:00:00
abstract::We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a consequence of misdirected AID in the partner oncogenes of IGH translocations, which are activating and associated with impaired clinical outcome. An APOBEC mutat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7997
更新日期:2015-04-23 00:00:00
abstract::A widely appreciated aspect of developmental robustness is pattern formation in proportion to size. But how such scaling features emerge dynamically remains poorly understood. Here we generate a data set of the expression profiles of six gap genes in Drosophila melanogaster embryos that differ significantly in size. E...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10031
更新日期:2015-12-08 00:00:00
abstract::The original version of this Article contained an error in the third sentence of the penultimate paragraph of the 'Definition of the harmonic phase' section of the Results, which incorrectly read 'In the Coulomb phase the tensor S αβ (q) has one zero and two degenerate eigenvalues and it may be represented by an infin...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-03815-7
更新日期:2018-04-16 00:00:00
abstract::Extremely metal-poor galaxies with metallicity below 10% of the solar value in the local universe are the best analogues to investigating the interstellar medium at a quasi-primitive environment in the early universe. In spite of the ongoing formation of stars in these galaxies, the presence of molecular gas (which is...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13789
更新日期:2016-12-09 00:00:00