Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET.

abstract：:The analysis of whole-genome sequencing studies is challenging due to the large number of noncoding rare variants, our limited understanding of their functional effects, and the lack of natural units for testing. Here we propose a scan statistic framework, WGScan, to simultaneously detect the existence, and estimate t...

journal_title：Nature communications

authors： He Z,Xu B,Buxbaum J,Ionita-Laza I

更新日期：2019-07-09 00:00:00

abstract：:Maintaining DNA integrity is vital for all cells and organisms. Defective DNA repair may contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced levels of BRCA1, but not of other DNA repair factors, in the brains of AD patients and human amyloid precursor protein (hAPP) transgenic mi...

journal_title：Nature communications

authors： Suberbielle E,Djukic B,Evans M,Kim DH,Taneja P,Wang X,Finucane M,Knox J,Ho K,Devidze N,Masliah E,Mucke L

更新日期：2015-11-30 00:00:00

abstract：:Cytidine base editors (CBEs) and adenine base editors (ABEs), composed of a cytidine deaminase or an evolved adenine deaminase fused to Cas9 nickase, enable the conversion of C·G to T·A or A·T to G·C base pair in organisms, respectively. Here, we show that BE3 and ABE7.10 systems can achieve a targeted mutation effici...

journal_title：Nature communications

authors： Liu Z,Chen M,Chen S,Deng J,Song Y,Lai L,Li Z

更新日期：2018-07-13 00:00:00

abstract：:Efficient charge separation is of crucial importance for the improvement of photocatalytic activity for solar hydrogen evolution. Here we report efficient photo-generated charge separation by twin-induced one-dimensional homojunctions with type-II staggered band alignment, using a ternary chalcogenate, i.e. Cd0.5Zn0.5...

journal_title：Nature communications

authors： Liu M,Jing D,Zhou Z,Guo L

更新日期：2013-01-01 00:00:00

abstract：:How the stressosome, the epicenter of the stress response in bacteria, transmits stress signals from the environment has remained elusive. The stressosome consists of multiple copies of three proteins RsbR, RsbS and RsbT, a kinase that is important for its activation. Using cryo-electron microscopy, we determined the ...

journal_title：Nature communications

authors： Williams AH,Redzej A,Rolhion N,Costa TRD,Rifflet A,Waksman G,Cossart P

更新日期：2019-07-08 00:00:00

abstract：:Intentional doping is the core of semiconductor technologies to tune electrical and optical properties of semiconductors for electronic devices, however, it has shown to be a grand challenge for halide perovskites. Here, we show that some metal ions, such as silver, strontium, cerium ions, which exist in the precursor...

journal_title：Nature communications

authors： Lin Y,Shao Y,Dai J,Li T,Liu Y,Dai X,Xiao X,Deng Y,Gruverman A,Zeng XC,Huang J

更新日期：2021-01-04 00:00:00

abstract：:The insulator-to-metal transition continues to be a challenging subject, especially when electronic correlations are strong. In layered compounds, such as La2-xSrxNiO4 and La2-xBaxCuO4, the doped charge carriers can segregate into periodically spaced charge stripes separating narrow domains of antiferromagnetic order....

journal_title：Nature communications

authors： Anissimova S,Parshall D,Gu GD,Marty K,Lumsden MD,Chi S,Fernandez-Baca JA,Abernathy DL,Lamago D,Tranquada JM,Reznik D

更新日期：2014-03-17 00:00:00

abstract：:The realization that mitigation efforts to reduce carbon dioxide emissions have, until now, been relatively ineffective has led to an increasing interest in climate engineering as a possible means of preventing the potentially catastrophic consequences of climate change. While many studies have addressed the potential...

journal_title：Nature communications

authors： Keller DP,Feng EY,Oschlies A

更新日期：2014-02-25 00:00:00

abstract：:Regional differences in health-related phenotypes have been detected between and within countries. In Scotland, regions differ for a variety of health-related traits and display differences in mean lifespan of up to 7.5 years. Both genetics and lifestyle differences are potential causes of this variation. Using data o...

journal_title：Nature communications

authors： Amador C,Xia C,Nagy R,Campbell A,Porteous D,Smith BH,Hastie N,Vitart V,Hayward C,Navarro P,Haley CS

更新日期：2017-10-06 00:00:00

abstract：:Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting stratified associa...

journal_title：Nature communications

authors： Arnold M,Nho K,Kueider-Paisley A,Massaro T,Huynh K,Brauner B,MahmoudianDehkordi S,Louie G,Moseley MA,Thompson JW,John-Williams LS,Tenenbaum JD,Blach C,Chang R,Brinton RD,Baillie R,Han X,Trojanowski JQ,Shaw LM,Martin

更新日期：2020-03-02 00:00:00

abstract：:Materials hosting magnetic skyrmions at room temperature could enable compact and energetically-efficient storage such as racetrack memories, where information is coded by the presence/absence of skyrmions forming a moving chain through the device. The skyrmion Hall effect leading to their annihilation at the racetrac...

journal_title：Nature communications

authors： Mandru AO,Yıldırım O,Tomasello R,Heistracher P,Penedo M,Giordano A,Suess D,Finocchio G,Hug HJ

更新日期：2020-12-11 00:00:00

abstract：:Emerging evidence suggests associations between the vaginal microbiota (VMB) composition, human papillomavirus (HPV) infection, and cervical intraepithelial neoplasia (CIN); however, causal inference remains uncertain. Here, we use bacterial DNA sequencing from serially collected vaginal samples from a cohort of 87 ad...

journal_title：Nature communications

authors： Mitra A,MacIntyre DA,Ntritsos G,Smith A,Tsilidis KK,Marchesi JR,Bennett PR,Moscicki AB,Kyrgiou M

更新日期：2020-04-24 00:00:00

abstract：:In response to virus infection, RIG-I-like receptors (RLRs) sense virus RNA and induce MAVS to form prion-like aggregates to further propagate antiviral signalling. Although monomeric MAVS recombinant protein can assemble into prion-like filaments spontaneously in vitro, endogenous MAVS in cells is prevented from aggr...

journal_title：Nature communications

authors： Qi N,Shi Y,Zhang R,Zhu W,Yuan B,Li X,Wang C,Zhang X,Hou F

更新日期：2017-06-13 00:00:00

abstract：:The Fc region of HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) is required for suppressing viraemia, through mechanisms which remain poorly understood. Here, we identify bNAbs that exert antibody-dependent cellular cytotoxicity (ADCC) in cell culture and kill HIV-1-infected lymphocytes through natural kil...

journal_title：Nature communications

authors： Bruel T,Guivel-Benhassine F,Amraoui S,Malbec M,Richard L,Bourdic K,Donahue DA,Lorin V,Casartelli N,Noël N,Lambotte O,Mouquet H,Schwartz O

更新日期：2016-03-03 00:00:00

abstract：:Printed electronics offer a breakthrough in the penetration of information technology into everyday life. The possibility of printing electronic circuits will further promote the spread of the Internet of Things applications. Inks based on graphene have a chance to dominate this technology, as they potentially can be ...

journal_title：Nature communications

authors： Pan K,Fan Y,Leng T,Li J,Xin Z,Zhang J,Hao L,Gallop J,Novoselov KS,Hu Z

更新日期：2018-12-05 00:00:00

abstract：:Reduced-dimensional perovskites are attractive light-emitting materials due to their efficient luminescence, color purity, tunable bandgap, and structural diversity. A major limitation in perovskite light-emitting diodes is their limited operational stability. Here we demonstrate that rapid photodegradation arises fro...

journal_title：Nature communications

authors： Na Quan L,Ma D,Zhao Y,Voznyy O,Yuan H,Bladt E,Pan J,García de Arquer FP,Sabatini R,Piontkowski Z,Emwas AH,Todorović P,Quintero-Bermudez R,Walters G,Fan JZ,Liu M,Tan H,Saidaminov MI,Gao L,Li Y,Anjum DH,Wei N,Ta

更新日期：2020-01-10 00:00:00

abstract：:Cellular senescence has been perceived as a barrier against carcinogenesis. However, the senescence-associated secretory phenotype (SASP) of senescent cells can promote tumorigenesis. Here, we show senescent tumour cells are frequently present in the front region of collective invasion of papillary thyroid carcinoma (...

journal_title：Nature communications

authors： Kim YH,Choi YW,Lee J,Soh EY,Kim JH,Park TJ

更新日期：2017-05-10 00:00:00

abstract：:In areas where malaria epidemiology is spatially and temporally heterogeneous, human-mediated parasite importation can result in non-locally acquired clinical cases and outbreaks in low-transmission areas. Using mobility estimates derived from the mobile phone data and spatial malaria prevalence data, we identify trav...

journal_title：Nature communications

authors： Ihantamalala FA,Herbreteau V,Rakotoarimanana FMJ,Rakotondramanga JM,Cauchemez S,Rahoilijaona B,Pennober G,Buckee CO,Rogier C,Metcalf CJE,Wesolowski A

更新日期：2018-09-25 00:00:00

abstract：:From intracellular protein trafficking to large-scale motion of animal groups, the physical concepts driving the self-organization of living systems are still largely unraveled. Self-organization of active entities, leading to novel phases and emergent macroscopic properties, recently shed new light on these complex d...

journal_title：Nature communications

authors： Vincenti B,Ramos G,Cordero ML,Douarche C,Soto R,Clement E

更新日期：2019-11-08 00:00:00

abstract：:Electron spins of diamond nitrogen-vacancy (NV) centres are important quantum resources for nanoscale sensing and quantum information. Combining NV spins with levitated optomechanical resonators will provide a hybrid quantum system for novel applications. Here we optically levitate a nanodiamond and demonstrate electr...

journal_title：Nature communications

authors： Hoang TM,Ahn J,Bang J,Li T

更新日期：2016-07-19 00:00:00

abstract：:The removal of dying neurons by microglia has a key role during both development and in several diseases. To date, little is known about the cellular and molecular processes underlying neuronal engulfment in the brain. Here we took a live imaging approach to quantify neuronal cell death progression in embryonic zebraf...

journal_title：Nature communications

authors： Mazaheri F,Breus O,Durdu S,Haas P,Wittbrodt J,Gilmour D,Peri F

更新日期：2014-06-05 00:00:00

abstract：:Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axi...

journal_title：Nature communications

authors： Miyake M,Yamashiro K,Tabara Y,Suda K,Morooka S,Nakanishi H,Khor CC,Chen P,Qiao F,Nakata I,Akagi-Kurashige Y,Gotoh N,Tsujikawa A,Meguro A,Kusuhara S,Polasek O,Hayward C,Wright AF,Campbell H,Richardson AJ,Schache M

更新日期：2015-03-31 00:00:00

abstract：:Nitric oxide (NO) has important functions in biology and atmospheric chemistry as a toxin, signaling molecule, ozone depleting agent and the precursor of the greenhouse gas nitrous oxide (N2O). Although NO is a potent oxidant, and was available on Earth earlier than oxygen, it is unclear whether NO can be used by micr...

journal_title：Nature communications

authors： Hu Z,Wessels HJCT,van Alen T,Jetten MSM,Kartal B

更新日期：2019-03-20 00:00:00

abstract：:Three-dimensional topological Dirac semimetals (TDSs) are a new kind of Dirac materials that exhibit linear energy dispersion in the bulk and can be viewed as three-dimensional graphene. It has been proposed that TDSs can be driven to other exotic phases like Weyl semimetals, topological insulators and topological sup...

journal_title：Nature communications

authors： Cao J,Liang S,Zhang C,Liu Y,Huang J,Jin Z,Chen ZG,Wang Z,Wang Q,Zhao J,Li S,Dai X,Zou J,Xia Z,Li L,Xiu F

更新日期：2015-07-13 00:00:00

abstract：:CRISPR/Cas9 technology offers novel approaches for the development of new therapies for many unmet clinical needs, including a significant number of inherited monogenic diseases. However, in vivo correction of disease-causing genes is still inefficient, especially for those diseases without selective advantage for cor...

journal_title：Nature communications

authors： Zabaleta N,Barberia M,Martin-Higueras C,Zapata-Linares N,Betancor I,Rodriguez S,Martinez-Turrillas R,Torella L,Vales A,Olagüe C,Vilas-Zornoza A,Castro-Labrador L,Lara-Astiaso D,Prosper F,Salido E,Gonzalez-Aseguinolaza G,R

更新日期：2018-12-21 00:00:00

abstract：:Central insulin is thought to act at the neural interface between metabolic and hedonic drives to eat. Here, using pharmacological fMRI, we show that intranasal insulin (INI) changes the value of food cues through modulation of mesolimbic pathways. Overnight fasted participants rated the palatability of food pictures ...

journal_title：Nature communications

authors： Tiedemann LJ,Schmid SM,Hettel J,Giesen K,Francke P,Büchel C,Brassen S

更新日期：2017-07-18 00:00:00

abstract：:CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs systemically. Here, we report a generalizable methodology that allows en...

journal_title：Nature communications

authors： Wei T,Cheng Q,Min YL,Olson EN,Siegwart DJ

更新日期：2020-06-26 00:00:00

abstract：:Owing to the significant difference in the numbers of simulated and experimentally feasible zeolite structures, several alternative strategies have been developed for zeolite synthesis. Despite their rationality and originality, most of these techniques are based on trial-and-error, which makes it difficult to predict...

journal_title：Nature communications

authors： Kasneryk V,Shamzhy M,Zhou J,Yue Q,Mazur M,Mayoral A,Luo Z,Morris RE,Čejka J,Opanasenko M

更新日期：2019-11-12 00:00:00

abstract：:Between the land and ocean, diverse coastal ecosystems transform, store, and transport material. Across these interfaces, the dynamic exchange of energy and matter is driven by hydrological and hydrodynamic processes such as river and groundwater discharge, tides, waves, and storms. These dynamics regulate ecosystem f...

journal_title：Nature communications

authors： Ward ND,Megonigal JP,Bond-Lamberty B,Bailey VL,Butman D,Canuel EA,Diefenderfer H,Ganju NK,Goñi MA,Graham EB,Hopkinson CS,Khangaonkar T,Langley JA,McDowell NG,Myers-Pigg AN,Neumann RB,Osburn CL,Price RM,Rowland J,Sen

更新日期：2020-05-18 00:00:00

abstract：:Co-expression analysis is widely used to predict gene function and to identify functionally related gene sets. However, co-expression analysis using human cancer transcriptomic data is confounded by somatic copy number alterations (SCNA), which produce co-expression signatures based on physical proximity rather than b...

journal_title：Nature communications

authors： Cai L,Li Q,Du Y,Yun J,Xie Y,DeBerardinis RJ,Xiao G

更新日期：2017-12-19 00:00:00