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Single-breath-hold photoacoustic computed tomography of the breast.

Abstract：

:We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts. SBH-PACT features a deep penetration depth (4 cm in vivo) with high spatial and temporal resolutions (255 µm in-plane resolution and a 10 Hz 2D frame rate). By scanning the entire breast within a single breath hold (~15 s), a volumetric image can be acquired and subsequently reconstructed utilizing 3D back-projection with negligible breathing-induced motion artifacts. SBH-PACT clearly reveals tumors by observing higher blood vessel densities associated with tumors at high spatial resolution, showing early promise for high sensitivity in radiographically dense breasts. In addition to blood vessel imaging, the high imaging speed enables dynamic studies, such as photoacoustic elastography, which identifies tumors by showing less compliance. We imaged breast cancer patients with breast sizes ranging from B cup to DD cup, and skin pigmentations ranging from light to dark. SBH-PACT identified all the tumors without resorting to ionizing radiation or exogenous contrast, posing no health risks.

journal_name

Nat Commun

journal_title

Nature communications

authors

Lin L,Hu P,Shi J,Appleton CM,Maslov K,Li L,Zhang R,Wang LV

doi

10.1038/s41467-018-04576-z

subject

Has Abstract

pub_date

2018-06-15 00:00:00

pages

2352

issue

1

issn

2041-1723

pii

10.1038/s41467-018-04576-z

journal_volume

9

pub_type

杂志文章

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