Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Abbey-Lee RN,Dingemanse NJdoi
10.1038/s41467-019-13715-zsubject
Has Abstractpub_date
2019-12-06 00:00:00pages
5667issue
1issn
2041-1723pii
10.1038/s41467-019-13715-zjournal_volume
10pub_type
已发布勘误abstract::Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time 13C MRI. The type of applications is however limited by the relatively fast decay time of the hyperpolarized spin state together wit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15757
更新日期:2017-06-01 00:00:00
abstract::Biologists have long been fascinated by the amazing diversity of animal colour patterns. Despite much interest, the underlying evolutionary and developmental mechanisms contributing to their rich variety remain largely unknown, especially the vivid and complex colour patterns seen in vertebrates. Here, we show that co...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1071
更新日期:2010-09-07 00:00:00
abstract::The genome of the thermophilic bacterium, Aeribacillus pallidus 8, encodes the bacteriocin pallidocin. It belongs to the small class of glycocins and is posttranslationally modified, containing an S-linked glucose on a specific Cys residue. In this study, the pallidocin biosynthetic machinery is cloned and expressed i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09065-5
更新日期:2019-03-07 00:00:00
abstract::Post-transcriptional RNA modifications play a critical role in the pathogenesis of human mitochondrial disorders, but the mechanisms by which specific modifications affect mitochondrial protein synthesis remain poorly understood. Here we used a quantitative RNA sequencing approach to investigate, at nucleotide resolut...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06471-z
更新日期:2018-09-27 00:00:00
abstract::The core of a ferromagnetic vortex domain creates a strong, localized magnetic field, which can be manipulated on nanosecond timescales, providing a platform for addressing and controlling individual nitrogen-vacancy centre spins in diamond at room temperature, with nanometre-scale resolution. Here, we show that the f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11584
更新日期:2016-06-14 00:00:00
abstract::The advent and growth of synthetic biology has demonstrated its potential as a promising avenue of research to address many societal needs. However, plant synthetic biology efforts have been hampered by a dearth of DNA part libraries, versatile transformation vectors and efficient assembly strategies. Here, we describ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13215
更新日期:2016-10-26 00:00:00
abstract::The complexity embedded in condensed matter fertilizes the discovery of new states of matter, enriched by ingredients like frustration. Illustrating examples in magnetic systems are Kitaev spin liquids, skyrmions phases, or spin ices. These unconventional ground states support exotic excitations, for example the magne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00277-1
更新日期:2017-08-08 00:00:00
abstract::Solitary chemosensory cells (SCCs) are epithelial sentinels that utilize bitter Tas2r receptors and coupled taste transduction elements to detect pathogenic bacterial metabolites, triggering host defenses to control the infection. Here we report that SCCs are present in mouse gingival junctional epithelium, where they...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12505-x
更新日期:2019-10-03 00:00:00
abstract::Single-nucleotide substitutions are a defining characteristic of cancer genomes. Many single-nucleotide substitutions in cancer genomes arise because of errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA replication patterns help shape the mutational landscapes of normal and can...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2502
更新日期:2013-01-01 00:00:00
abstract::Storage of anthropogenic CO2 in geological formations relies on a caprock as the primary seal preventing buoyant super-critical CO2 escaping. Although natural CO2 reservoirs demonstrate that CO2 may be stored safely for millions of years, uncertainty remains in predicting how caprocks will react with CO2-bearing brine...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12268
更新日期:2016-07-28 00:00:00
abstract::Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive cancer types and the leading cause of cancer-associated deaths. The EMT-inducing transcriptional repressor ZEB1 is a crucial stimulator of these processes, particularly by coupling the activation of cellular motility with stemne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10498
更新日期:2016-02-15 00:00:00
abstract::The Spitzenkörper (SPK) constitutes a collection of secretory vesicles and polarity-related proteins intimately associated with polarized growth of fungal hyphae. Many SPK-localized proteins are known, but their assembly and dynamics remain poorly understood. Here, we identify protein-protein interaction cascades lead...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16712-9
更新日期:2020-06-05 00:00:00
abstract::Despite the success of current therapies for acute myocardial infarction (MI), many patients still develop adverse cardiac remodeling and heart failure. With the growing prevalence of heart failure, a new therapy is needed that can prevent remodeling and support tissue repair. Herein, we report on injectable recombina...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12748-8
更新日期:2019-10-25 00:00:00
abstract::ADAM17, a prominent member of the 'Disintegrin and Metalloproteinase' (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates. Here we present evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert sheddase activity. PS exposure is tightly coupled...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11523
更新日期:2016-05-10 00:00:00
abstract::To balance immunity and tolerance, the endogenous pool of Foxp3+ regulatory T (Treg) cells is tightly controlled, but the underlying mechanisms of this control remain poorly understood. Here we show that the number of Treg cells is negatively regulated by the kinase Lkb1 in dendritic cells (DCs). Conditional knockout ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07545-8
更新日期:2018-12-13 00:00:00
abstract::The interface between LaAlO(3) and SrTiO(3) possesses a range of intriguing properties, notably a proposed connection between the surface state of the LaAlO(3) and the conductivity buried in the SrTiO(3). Here we study the effect of the surface adsorption of a variety of common laboratory solvents on the conductivity ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1501
更新日期:2011-10-11 00:00:00
abstract::Homologous recombination deficiency (HRD) is a defining characteristic in BRCA-deficient breast tumors caused by genetic or epigenetic alterations in key pathway genes. We investigated the frequency of BRCA1 promoter hypermethylation in 237 triple-negative breast cancers (TNBCs) from a population-based study using rep...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17537-2
更新日期:2020-07-27 00:00:00
abstract::A key feature of meiosis is the step-wise removal of cohesin, the protein complex holding sister chromatids together, first from arms in meiosis I and then from the centromere region in meiosis II. Centromeric cohesin is protected by Sgo2 from Separase-mediated cleavage, in order to maintain sister chromatids together...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00774-3
更新日期:2017-09-25 00:00:00
abstract::Spinal motor neurons (MNs) control diverse motor tasks including respiration, posture and locomotion that are disrupted by neurodegenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy. Methods directing MN differentiation from stem cells have been developed to enable disease modelling i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7778
更新日期:2015-04-14 00:00:00
abstract::Nanoscale correlation of structural information acquisition with specific-molecule identification provides new insight for studying rare subcellular events. To achieve this correlation, scanning electron microscopy has been combined with super-resolution fluorescent microscopy, despite its destructivity when acquiring...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13748
更新日期:2016-12-09 00:00:00
abstract::Molecular crystals can be bent elastically by expansion or plastically by delamination into slabs that glide along slip planes. Here we report that upon bending, terephthalic acid crystals can undergo a mechanically induced phase transition without delamination and their overall crystal integrity is retained. Such pla...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11612-z
更新日期:2019-08-19 00:00:00
abstract::Temporal lobe epilepsy (TLE) is the most common focal seizure disorder in adults. In many patients, transient brain insults, including status epilepticus (SE), are followed by a latent period of epileptogenesis, preceding the emergence of clinical seizures. In experimental animals, transcriptional upregulation of CaV3...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9688
更新日期:2015-10-26 00:00:00
abstract::The superconducting gap structure in iron-based high-temperature superconductors (Fe-HTSs) is non-universal. In contrast to other unconventional superconductors, in the Fe-HTSs both d-wave and extended s-wave pairing symmetries are close in energy. Probing the proximity between these very different superconducting sta...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9863
更新日期:2015-11-09 00:00:00
abstract::Single-atom catalysts have recently been applied in many applications such as CO oxidation. Experimental in situ investigations into this reaction, however, are limited. Hereby, we present a suite of operando/in situ spectroscopic experiments for structurally well-defined atomically dispersed Rh on phosphotungstic aci...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09188-9
更新日期:2019-03-22 00:00:00
abstract::The widespread use of fuel cells is currently limited by the lack of efficient and cost-effective catalysts for the oxygen reduction reaction. Iron-based non-precious metal catalysts exhibit promising activity and stability, as an alternative to state-of-the-art platinum catalysts. However, the identity of the active ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12582
更新日期:2016-08-19 00:00:00
abstract::Connection of tubules into larger networks is the key process for the development of circulatory systems. In Drosophila development, tip cells of the tracheal system lead the migration of each branch and connect tubules by adhering to each other and simultaneously changing into a torus-shape. We show that as adhesion ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11141
更新日期:2016-04-12 00:00:00
abstract::Covalent functionalization tailors carbon nanotubes for a wide range of applications in varying environments. Its strength and stability of attachment come at the price of degrading the carbon nanotubes sp2 network and destroying the tubes electronic and optoelectronic features. Here we present a non-destructive, cova...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14281
更新日期:2017-01-30 00:00:00
abstract::Hydroarylation is an environmentally attractive strategy which incorporates all of the atoms contained in the substrates into the desired products. Almost all the hydroarylations of norbornene reported to date involve an exo-selective reaction. Here we show the endo-selective hydroarylation of norbornene in the Rh(I)-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01531-2
更新日期:2017-11-13 00:00:00
abstract::The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. By combining highly purified, fully active bovine F-ATP synthase with preformed liposomes we show that Ca2+ dissipates the H+ gradient generated by ATP hydrolysis. Afte...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12331-1
更新日期:2019-09-25 00:00:00
abstract::Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin αMβ2, or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbα is required for injury responses in diverse disease models. However, the role of Mac-1 i...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15559
更新日期:2017-05-30 00:00:00