Abstract:
:Priming of the mucosal immune system during the postnatal period substantially influences host-microbial interaction and susceptibility to immune-mediated diseases in adult life. The underlying mechanisms are ill defined. Here we show that shortly after birth, CD4 T cells populate preformed lymphoid structures in the small intestine and quickly acquire a distinct transcriptional profile. T-cell recruitment is independent of microbial colonization and innate or adaptive immune stimulation but requires β7 integrin expression. Surprisingly, neonatal CD4 T cells remain immature throughout the postnatal period under homeostatic conditions but undergo maturation and gain effector function on barrier disruption. Maternal SIgA and regulatory T cells act in concert to prevent immune stimulation and maintain the immature phenotype of CD4 T cells in the postnatal intestine during homeostasis. Active suppression of CD4 T-cell maturation during the postnatal period might contribute to prevent auto-reactivity, sustain a broad TCR repertoire and establish life-long immune homeostasis.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Torow N,Yu K,Hassani K,Freitag J,Schulz O,Basic M,Brennecke A,Sparwasser T,Wagner N,Bleich A,Lochner M,Weiss S,Förster R,Pabst O,Hornef MWdoi
10.1038/ncomms8725subject
Has Abstractpub_date
2015-07-21 00:00:00pages
7725issn
2041-1723pii
ncomms8725journal_volume
6pub_type
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