Abstract:
:One of the primary efforts in influenza vaccine strain recommendation is to monitor through gene sequencing the viral surface protein haemagglutinin (HA) variants that lead to viral antigenic changes. Here we have developed a computational method, denoted as PREDAC, to predict antigenic clusters of influenza A (H3N2) viruses with high accuracy from viral HA sequences. Application of PREDAC to large-scale HA sequence data of H3N2 viruses isolated from diverse regions of Mainland China identified 17 antigenic clusters that have dominated for at least one season between 1968 and 2010. By tracking the dynamics of the dominant antigenic clusters, we not only find that dominant antigenic clusters change more frequently in China than in the United States/Europe, but also characterize the antigenic patterns of seasonal H3N2 viruses within China. Furthermore, we demonstrate that the coupling of large-scale HA sequencing with PREDAC can significantly improve vaccine strain recommendation for China.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Du X,Dong L,Lan Y,Peng Y,Wu A,Zhang Y,Huang W,Wang D,Wang M,Guo Y,Shu Y,Jiang Tdoi
10.1038/ncomms1710subject
Has Abstractpub_date
2012-02-28 00:00:00pages
709issn
2041-1723pii
ncomms1710journal_volume
3pub_type
杂志文章abstract::Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). It remains controversial how RFC and RLCs cooperate to regulate PCNA loading and unloading. Here, we show the distinct PCNA loading or unloading activity of each clamp loader. ATAD5-R...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10376-w
更新日期:2019-06-03 00:00:00
abstract::Despite extensive studies on transcription mechanisms, it is unknown how termination complexes are disassembled, especially in what order the essential components dissociate. Our single-molecule fluorescence study unveils that RNA transcript release precedes RNA polymerase (RNAP) dissociation from the DNA template muc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-14200-3
更新日期:2020-01-23 00:00:00
abstract::It is commonly assumed that neural systems efficiently process natural sensory input. However, the mechanisms by which such efficient processing is achieved, and the consequences for perception and behaviour remain poorly understood. Here we show that small conductance calcium-activated potassium (SK) channels enable ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11353
更新日期:2016-04-18 00:00:00
abstract::Neuronal reward valuations provide the physiological basis for economic behaviour. Yet, how such valuations are converted to economic decisions remains unclear. Here we show that the dorsolateral prefrontal cortex (DLPFC) implements a flexible value code based on object-specific valuations by single neurons. As monkey...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12554
更新日期:2016-09-13 00:00:00
abstract::Mechanically flexible mobile phones have been long anticipated due to the rapid development of thin-film electronics in the last couple of decades. However, to date, no such phone has been developed, largely due to a lack of flexible electronic components that are fast enough for the required wireless communications, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8561
更新日期:2015-07-03 00:00:00
abstract::Compounds with incommensurate structural modulations have been extensively studied in last several decades. However, the relationship between structurally incommensurate/commensurate phases and associated electronic states remains enigmatic. Here we report the coexisting of complex incommensurate structures and highly...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6358
更新日期:2014-11-07 00:00:00
abstract::We characterized the population-level neural coding of ensemble representations in visual working memory from human electroencephalography. Ensemble representations provide a unique opportunity to investigate structured representations of working memory because the visual system encodes high-order summary statistics a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13592-6
更新日期:2019-12-11 00:00:00
abstract::Abnormal cancer antioxidant capacity is considered as a potential mechanism of tumor malignancy. Modulation of oxidative stress status is emerging as an anti-cancer treatment. Our previous studies have found that Nestin-knockdown cells were more sensitive to oxidative stress in non-small cell lung cancer (NSCLC). Howe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12925-9
更新日期:2019-11-06 00:00:00
abstract::Band-inverted electron-hole bilayers support quantum spin Hall insulator and exciton condensate phases. Interest in quantum spin Hall effect in these systems has recently put them in the spotlight. We investigate such a bilayer in an external magnetic field. We show that the interlayer correlations lead to formation o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10462
更新日期:2016-01-25 00:00:00
abstract::Moonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been no large-scale method to identify them, nor any effort to characterize them as a group. Here, we propose the first method for the identification of 'extreme mu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8412
更新日期:2015-06-09 00:00:00
abstract::Mineralisation of calcium phosphates in bone has been proposed to proceed via an initial amorphous precursor phase which transforms into nanocrystalline, carbonated hydroxyapatite. While calcium phosphates have been under intense investigation, the exact steps during the crystallisation of spherical amorphous particle...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06570-x
更新日期:2018-10-09 00:00:00
abstract::The physical nature of the bacterial chromosome has important implications for its function. Using high-resolution dynamic tracking, we observe the existence of rare but ubiquitous 'rapid movements' of chromosomal loci exhibiting near-ballistic dynamics. This suggests that these movements are either driven by an activ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4854
更新日期:2014-05-30 00:00:00
abstract::Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank), we here show that ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11174
更新日期:2016-03-31 00:00:00
abstract::Corona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins. Herein we develop a variant of a CoPhMoRe screening procedure of single-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10241
更新日期:2016-01-08 00:00:00
abstract::Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptors. Receptors with t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14892
更新日期:2017-03-27 00:00:00
abstract::Sclerosing stromal tumor (SST) of the ovary is a rare type of sex cord-stromal tumor (SCST), whose genetic underpinning is currently unknown. Here, using whole-exome, targeted capture and RNA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs and other GLI2 rearrangements in additional 15% (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13806-x
更新日期:2020-01-02 00:00:00
abstract::Base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG) is essential for removal of aberrantly methylated DNA bases. Genome instability and accumulation of aberrant bases accompany multiple diseases, including cancer and neurological disorders. While BER is well studied on naked DNA, it remains uncl...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13394-w
更新日期:2019-11-29 00:00:00
abstract::How electronic charge is distributed over a molecule determines to a large extent its chemical properties. Here, we demonstrate how the electrostatic force field, originating from the inhomogeneous charge distribution in a molecule, can be measured with submolecular resolution. We exploit the fact that distortions typ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11560
更新日期:2016-05-27 00:00:00
abstract::Transposable elements constitute a substantial portion of eukaryotic genomes and contribute to genomic variation, function, and evolution. Miniature inverted-repeat transposable elements (MITEs), as DNA transposons, are widely distributed in plant and animal genomes. Previous studies have suggested that retrotransposo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14651
更新日期:2017-03-03 00:00:00
abstract::Coordination between osteoblasts and osteoclasts is required for bone health and homeostasis. Here we show that mice deficient in SMURF2 have severe osteoporosis in vivo. This low bone mass phenotype is accompanied by a pronounced increase in osteoclast numbers, although Smurf2-deficient osteoclasts have no intrinsic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14570
更新日期:2017-02-20 00:00:00
abstract::The prefrontal cortex and striatum form a recurrent network whose spiking activity encodes multiple types of learning-relevant information. This spike-encoded information is evident in average firing rates, but finer temporal coding might allow multiplexing and enhanced readout across the connected network. We tested ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18435-3
更新日期:2020-09-16 00:00:00
abstract::The study of the high pressure phase diagram of hydrogen has continued with renewed effort for about one century as it remains a fundamental challenge for experimental and theoretical techniques. Here we employ an efficient molecular dynamics based on the quantum Monte Carlo method, which can describe accurately the e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4487
更新日期:2014-03-19 00:00:00
abstract::Quantifying chemical compositions around nanovoids is a fundamental task for research and development of various materials. Atom probe tomography (APT) and scanning transmission electron microscopy (STEM) are currently the most suitable tools because of their ability to probe materials at the nanoscale. Both technique...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14832-w
更新日期:2020-02-24 00:00:00
abstract::Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by tracking individual tubular cells in conditional Pax8/Confetti mice that kidney function is recovered after AKI despite substantial t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03753-4
更新日期:2018-04-09 00:00:00
abstract::DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates with c-Myc and p300 acetyltransferase to epigenetically activate epithelial-mesenchymal transition (EMT) regulators in breast cancer progress...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8821
更新日期:2015-07-22 00:00:00
abstract::The original version of this Article contained errors in Figs. 1a, 2a, 3a, and 4b, in which the units on the scale bars incorrectly read 'µm' rather than the correct 'nm.' This has been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-03634-w
更新日期:2018-03-14 00:00:00
abstract::CD4(+) Th17 are heterogeneous in terms of cytokine production and capacity to initiate autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE). Here we demonstrate that experimental priming of encephalitogenic Th cells expressing RORγt and T-bet and producing IL-17A, IFN-γ and GM-CSF but not IL-10...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11541
更新日期:2016-05-18 00:00:00
abstract::Regional differences in health-related phenotypes have been detected between and within countries. In Scotland, regions differ for a variety of health-related traits and display differences in mean lifespan of up to 7.5 years. Both genetics and lifestyle differences are potential causes of this variation. Using data o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00497-5
更新日期:2017-10-06 00:00:00
abstract::Neisseria meningitidis (meningococcus) is an invasive bacterial pathogen that colonizes human vessels, causing thrombotic lesions and meningitis. Establishment of tight interactions with endothelial cells is crucial for meningococci to resist haemodynamic forces. Two endothelial receptors, CD147 and the β2-adrenergic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15764
更新日期:2017-06-01 00:00:00
abstract::The emergence of antibiotic resistant bacteria is a major threat to the practice of modern medicine. Photobactericidal agents have obtained significant attention as promising candidates to kill bacteria, and they have been extensively studied. However, to obtain photobactericidal activity, an intense white light sourc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15004-6
更新日期:2020-03-05 00:00:00