Observation of topological transport quantization by dissipation in fast Thouless pumps.

abstract：:The complex transport processes contributing to sintering are not yet fully understood, partially because in-situ observations of sintering in three dimensions (3D) are very difficult. Here we report a novel experiment in which monocrystalline copper spheres are first marked with microscopic boreholes drilled using a ...

journal_title：Nature communications

authors： Grupp R,Nöthe M,Kieback B,Banhart J

更新日期：2011-01-01 00:00:00

abstract：:Ryanodine receptors (RyRs) form calcium release channels located in the membranes of the sarcoplasmic and endoplasmic reticulum. RyRs play a major role in excitation-contraction coupling and other Ca(2+)-dependent signalling events, and consist of several globular domains that together form a large assembly. Here we d...

journal_title：Nature communications

authors： Yuchi Z,Yuen SM,Lau K,Underhill AQ,Cornea RL,Fessenden JD,Van Petegem F

更新日期：2015-08-06 00:00:00

abstract：:Somatic mutations in the RNase IIIb domain of DICER1 arise in cancer and disrupt the cleavage of 5' pre-miRNA arms. Here, we characterize an unstudied, recurrent, mutation (S1344L) in the DICER1 RNase IIIa domain in tumors from The Cancer Genome Atlas (TCGA) project and MSK-IMPACT profiling. RNase IIIa/b hotspots are ...

journal_title：Nature communications

authors： Vedanayagam J,Chatila WK,Aksoy BA,Majumdar S,Skanderup AJ,Demir E,Schultz N,Sander C,Lai EC

更新日期：2019-08-15 00:00:00

abstract：:Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecular signatures of ageing reflect this phenomenon. Here we report on the identification of a conserved transcri...

journal_title：Nature communications

authors： Aramillo Irizar P,Schäuble S,Esser D,Groth M,Frahm C,Priebe S,Baumgart M,Hartmann N,Marthandan S,Menzel U,Müller J,Schmidt S,Ast V,Caliebe A,König R,Krawczak M,Ristow M,Schuster S,Cellerino A,Diekmann S,Englert C

更新日期：2018-01-30 00:00:00

abstract：:One of the primary contributors to forgetting is interference from overlapping memories. Intuitively, this suggests-and prominent theoretical models argue-that memory interference is best avoided by encoding overlapping memories as if they were unrelated. It is therefore surprising that reactivation of older memories ...

journal_title：Nature communications

authors： Chanales AJH,Dudukovic NM,Richter FR,Kuhl BA

更新日期：2019-11-25 00:00:00

abstract：:Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53's invasive/migratory gain-of-function by incre...

journal_title：Nature communications

authors： Novo D,Heath N,Mitchell L,Caligiuri G,MacFarlane A,Reijmer D,Charlton L,Knight J,Calka M,McGhee E,Dornier E,Sumpton D,Mason S,Echard A,Klinkert K,Secklehner J,Kruiswijk F,Vousden K,Macpherson IR,Blyth K,Bailey P,

更新日期：2018-11-29 00:00:00

abstract：:Since the formulation of the geometric phase by Berry, its relevance has been demonstrated in a large variety of physical systems. However, a geometric phase of the most fundamental spin-1/2 system, the electron spin, has not been observed directly and controlled independently from dynamical phases. Here we report exp...

journal_title：Nature communications

authors： Nagasawa F,Frustaglia D,Saarikoski H,Richter K,Nitta J

更新日期：2013-01-01 00:00:00

abstract：:The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly impacts physical autonomy and survival. Here, we compare genome-wide transcriptional changes of sarcopen...

journal_title：Nature communications

authors： Migliavacca E,Tay SKH,Patel HP,Sonntag T,Civiletto G,McFarlane C,Forrester T,Barton SJ,Leow MK,Antoun E,Charpagne A,Seng Chong Y,Descombes P,Feng L,Francis-Emmanuel P,Garratt ES,Giner MP,Green CO,Karaz S,Kothandaram

更新日期：2019-12-20 00:00:00

abstract：:Superionic ice is a special group of ice phases at high temperature and pressure, which may exist in ice-rich planets and exoplanets. In superionic ice liquid hydrogen coexists with a crystalline oxygen sublattice. At high pressures, the properties of superionic ice are largely unknown. Here we report evidence that fr...

journal_title：Nature communications

authors： Sun J,Clark BK,Torquato S,Car R

更新日期：2015-08-28 00:00:00

abstract：:Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease are largely unknown. As the HLA-A*68:01 allele can be linked to severe pandemic 2009-H1N1 disease, we investigate a potential impairment of HLA-A*68:01-restricted CD8+ T cells to mount robust...

journal_title：Nature communications

authors： van de Sandt CE,Clemens EB,Grant EJ,Rowntree LC,Sant S,Halim H,Crowe J,Cheng AC,Kotsimbos TC,Richards M,Miller A,Tong SYC,Rossjohn J,Nguyen THO,Gras S,Chen W,Kedzierska K

更新日期：2019-12-06 00:00:00

abstract：:Chiral metal complexes show promise as asymmetric catalysts and optical materials. Chiral-at-metal complexes composed of achiral ligands have expanded the versatility and applicability of chiral metal complexes, especially for octahedral and half-sandwich complexes. However, Werner-type tetrahedral complexes with a st...

journal_title：Nature communications

authors： Endo K,Liu Y,Ube H,Nagata K,Shionoya M

更新日期：2020-12-09 00:00:00

abstract：:Dimensionality reduction is often used to visualize complex expression profiling data. Here, we use the Uniform Manifold Approximation and Projection (UMAP) method on published transcript profiles of 1484 single gene deletions of Saccharomyces cerevisiae. Proximity in low-dimensional UMAP space identifies groups of ge...

journal_title：Nature communications

authors： Dorrity MW,Saunders LM,Queitsch C,Fields S,Trapnell C

更新日期：2020-03-24 00:00:00

abstract：:CRISPR-Cas immunity is at the forefront of antivirus defense in bacteria and archaea and specifically targets viruses carrying protospacers matching the spacers catalogued in the CRISPR arrays. Here, we perform deep sequencing of the CRISPRome-all spacers contained in a microbiome-associated with hyperthermophilic arc...

journal_title：Nature communications

authors： Medvedeva S,Liu Y,Koonin EV,Severinov K,Prangishvili D,Krupovic M

更新日期：2019-11-15 00:00:00

abstract：:Blood vessels in the central nervous system (CNS) develop unique features, but the contribution of CNS neurons to regulating those features is not fully understood. We report that inhibiting spontaneous cholinergic activity or reducing starburst amacrine cell numbers prevents invasion of endothelial cells into the dee...

journal_title：Nature communications

authors： Weiner GA,Shah SH,Angelopoulos CM,Bartakova AB,Pulido RS,Murphy A,Nudleman E,Daneman R,Goldberg JL

更新日期：2019-06-06 00:00:00

abstract：:Quantum Hall edge channels offer an efficient and controllable platform to study quantum transport in one dimension. Such channels are a prospective tool for the efficient transfer of quantum information at the nanoscale, and play a vital role in exposing intriguing physics. Electric current along the edge carries ene...

journal_title：Nature communications

authors： Krähenmann T,Fischer SG,Röösli M,Ihn T,Reichl C,Wegscheider W,Ensslin K,Gefen Y,Meir Y

更新日期：2019-09-02 00:00:00

abstract：:Intercellular signaling is indispensable for single cells to form complex biological structures, such as biofilms, tissues and organs. The genetic tools available for engineering intercellular signaling, however, are quite limited. Here we exploit the chemical diversity of biological small molecules to de novo design ...

journal_title：Nature communications

authors： Du P,Zhao H,Zhang H,Wang R,Huang J,Tian Y,Luo X,Luo X,Wang M,Xiang Y,Qian L,Chen Y,Tao Y,Lou C

更新日期：2020-08-24 00:00:00

abstract：:Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin α transgenic mice exhibit an emphysema phenotype, but the pathophysiological role of prothymosin α in emphysema remains unclear. Here we show that prothymosin α contributes to the pathogenesis of emphysema by in...

journal_title：Nature communications

authors： Su BH,Tseng YL,Shieh GS,Chen YC,Shiang YC,Wu P,Li KJ,Yen TH,Shiau AL,Wu CL

更新日期：2013-01-01 00:00:00

abstract：:Theory predicts a trade-off between investments in precopulatory (ornaments and armaments) and postcopulatory (testes and ejaculates) sexual traits due to the costs associated with their growth and maintenance within the finite energy resources available. Empirical studies, however, have revealed considerable inconsis...

journal_title：Nature communications

authors： Lüpold S,Tomkins JL,Simmons LW,Fitzpatrick JL

更新日期：2014-01-01 00:00:00

abstract：:Understanding marine environmental change and associated biological turnover across the Palaeocene-Eocene Thermal Maximum (PETM; ~56 Ma)-the most pronounced Cenozoic short-term global warming event-is important because of the potential role of the ocean in atmospheric CO2 drawdown, yet proxies for tracing marine produ...

journal_title：Nature communications

authors： Chang L,Harrison RJ,Zeng F,Berndt TA,Roberts AP,Heslop D,Zhao X

更新日期：2018-10-01 00:00:00

abstract：:The preparation of α-functionalized organic acids can be greatly simplified by adopting a protocol involving the catalytic assembly of achiral building blocks. However, the enzymatic assembly of small amino acids and aldehydes to form numerous α-functionalized organic acids is highly desired and remains a significant ...

journal_title：Nature communications

authors： Song W,Wang JH,Wu J,Liu J,Chen XL,Liu LM

更新日期：2018-09-19 00:00:00

abstract：:Materials genomics represents a research mode for materials development, for which reliable methods for efficient materials construction are essential. Here we present a methodology for high-throughput construction of covalent organic frameworks (COFs) based on materials genomics strategy, in which a gene partition me...

journal_title：Nature communications

authors： Lan Y,Han X,Tong M,Huang H,Yang Q,Liu D,Zhao X,Zhong C

更新日期：2018-12-10 00:00:00

abstract：:Time-resolved photoelectron spectroscopy (TRPES) is a useful approach to elucidate the coupled electronic-nuclear quantum dynamics underlying chemical processes, but has remained limited by the use of low photon energies. Here, we demonstrate the general advantages of XUV-TRPES through an application to NO2, one of th...

journal_title：Nature communications

authors： von Conta A,Tehlar A,Schletter A,Arasaki Y,Takatsuka K,Wörner HJ

更新日期：2018-08-08 00:00:00

abstract：:Covalent functionalization tailors carbon nanotubes for a wide range of applications in varying environments. Its strength and stability of attachment come at the price of degrading the carbon nanotubes sp2 network and destroying the tubes electronic and optoelectronic features. Here we present a non-destructive, cova...

journal_title：Nature communications

authors： Setaro A,Adeli M,Glaeske M,Przyrembel D,Bisswanger T,Gordeev G,Maschietto F,Faghani A,Paulus B,Weinelt M,Arenal R,Haag R,Reich S

更新日期：2017-01-30 00:00:00

abstract：:Akin to single-site homogeneous catalysis, a long sought-after goal is to achieve reaction site precision in heterogeneous catalysis for chemical control over patterns of activity, selectivity and stability. Herein, we report on metal phosphides as a class of material capable of realizing these attributes and unlock t...

journal_title：Nature communications

authors： Xu YF,Duchesne PN,Wang L,Tavasoli A,Jelle AA,Xia M,Liao JF,Kuang DB,Ozin GA

更新日期：2020-10-13 00:00:00

abstract：:The original version of this article contained an error in the spelling of the author Christian A.M. Wilson, which was incorrectly given as Christian M.A. Wilson. This has now been corrected in both the PDF and HTML versions of the article. ...

journal_title：Nature communications

authors： Bustamante A,Sotelo-Campos J,Guerra DG,Floor M,Wilson CAM,Bustamante C,Báez M

更新日期：2017-12-14 00:00:00

abstract：:The complex of yeast cytochrome c peroxidase and cytochrome c is a paradigm of the biological electron transfer (ET). Building on seven decades of research, two different models have been proposed to explain its functional redox activity. One postulates that the intermolecular ET occurs only in the dominant, high-affi...

journal_title：Nature communications

authors： Van de Water K,Sterckx YG,Volkov AN

更新日期：2015-05-06 00:00:00

abstract：:Cortical neurons are often functionally heterogeneous even for molecularly defined subtypes. In sensory cortices, physiological responses to natural stimuli can be sparse and vary widely even for neighboring neurons. It is thus difficult to parse out circuits that encode specific stimuli for further experimentation. H...

journal_title：Nature communications

authors： Tasaka GI,Guenthner CJ,Shalev A,Gilday O,Luo L,Mizrahi A

更新日期：2018-02-28 00:00:00

abstract：:As a key variance partitioning tool, linear mixed models (LMMs) using genome-based restricted maximum likelihood (GREML) allow both fixed and random effects. Classic LMMs assume independence between random effects, which can be violated, causing bias. Here we introduce a generalized GREML, named CORE GREML, that expli...

journal_title：Nature communications

authors： Zhou X,Im HK,Lee SH

更新日期：2020-08-21 00:00:00

abstract：:Conventional epitaxy of semiconductor films requires a compatible single crystalline substrate and precisely controlled growth conditions, which limit the price competitiveness and versatility of the process. We demonstrate substrate-tolerant nano-heteroepitaxy (NHE) of high-quality formamidinium-lead-tri-iodide (FAPb...

journal_title：Nature communications

authors： Lee JW,Tan S,Han TH,Wang R,Zhang L,Park C,Yoon M,Choi C,Xu M,Liao ME,Lee SJ,Nuryyeva S,Zhu C,Huynh K,Goorsky MS,Huang Y,Pan X,Yang Y

更新日期：2020-11-02 00:00:00

abstract：:Human immunoglobulin G (IgG) agonistic antibodies targeting costimulatory immunoreceptors represent promising cancer immunotherapies yet to be developed. Whether, and how, human IgG hinge and Fc impact on their agonistic functions have been disputed. Here, we show that different natural human IgGs confer divergent ago...

journal_title：Nature communications

authors： Liu X,Zhao Y,Shi H,Zhang Y,Yin X,Liu M,Zhang H,He Y,Lu B,Jin T,Li F

更新日期：2019-09-27 00:00:00