Abstract:
:Cortical neurons are often functionally heterogeneous even for molecularly defined subtypes. In sensory cortices, physiological responses to natural stimuli can be sparse and vary widely even for neighboring neurons. It is thus difficult to parse out circuits that encode specific stimuli for further experimentation. Here, we report the development of a Cre-reporter mouse that allows recombination for cellular labeling and genetic manipulation, and use it with an activity-dependent Fos-CreERT2 driver to identify functionally active circuits in the auditory cortex. In vivo targeted patch recordings validate our method for neurons responding to physiologically relevant natural sounds such as pup wriggling calls and ultrasonic vocalizations (USVs). Using this system to investigate cortical responses in postpartum mothers, we find a transient recruitment of neurons highly responsive to USVs. This subpopulation of neurons has distinct physiological properties that improve the coding efficiency for pup USV calls, implicating it as a unique signature in parental plasticity.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Tasaka GI,Guenthner CJ,Shalev A,Gilday O,Luo L,Mizrahi Adoi
10.1038/s41467-018-03183-2subject
Has Abstractpub_date
2018-02-28 00:00:00pages
871issue
1issn
2041-1723pii
10.1038/s41467-018-03183-2journal_volume
9pub_type
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