Abstract:
:The physical nature of the bacterial chromosome has important implications for its function. Using high-resolution dynamic tracking, we observe the existence of rare but ubiquitous 'rapid movements' of chromosomal loci exhibiting near-ballistic dynamics. This suggests that these movements are either driven by an active machinery or part of stress-relaxation mechanisms. Comparison with a null physical model for subdiffusive chromosomal dynamics shows that rapid movements are excursions from a basal subdiffusive dynamics, likely due to driven and/or stress-relaxation motion. Additionally, rapid movements are in some cases coupled with known transitions of chromosomal segregation. They do not co-occur strictly with replication, their frequency varies with growth condition and chromosomal coordinate, and they show a preference for longitudinal motion. These findings support an emerging picture of the bacterial chromosome as off-equilibrium active matter and help developing a correct physical model of its in vivo dynamic structure.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Javer A,Kuwada NJ,Long Z,Benza VG,Dorfman KD,Wiggins PA,Cicuta P,Lagomarsino MCdoi
10.1038/ncomms4854subject
Has Abstractpub_date
2014-05-30 00:00:00pages
3854issn
2041-1723pii
ncomms4854journal_volume
5pub_type
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