Quantifying the polygenic contribution to variable expressivity in eleven rare genetic disorders.

abstract：:Cas9/gRNA-mediated gene-drive systems have advanced development of genetic technologies for controlling vector-borne pathogen transmission. These technologies include population suppression approaches, genetic analogs of insecticidal techniques that reduce the number of insect vectors, and population modification (rep...

journal_title：Nature communications

authors： Adolfi A,Gantz VM,Jasinskiene N,Lee HF,Hwang K,Terradas G,Bulger EA,Ramaiah A,Bennett JB,Emerson JJ,Marshall JM,Bier E,James AA

更新日期：2020-11-03 00:00:00

abstract：:The low-energy elementary excitations in frustrated quantum magnets have fascinated researchers for decades. In frustrated Ising magnets on a pyrochlore lattice possessing macroscopically degenerate spin-ice ground states, the excitations have been discussed in terms of classical magnetic monopoles, which do not conta...

journal_title：Nature communications

authors： Tokiwa Y,Yamashita T,Udagawa M,Kittaka S,Sakakibara T,Terazawa D,Shimoyama Y,Terashima T,Yasui Y,Shibauchi T,Matsuda Y

更新日期：2016-02-25 00:00:00

abstract：:It is generally believed that the remarkable sensitivity and frequency selectivity of mammalian hearing depend on outer hair cell-generated force, which amplifies sound-induced vibrations inside the cochlea. This 'reverse transduction' force production has never been demonstrated experimentally, however, in the living...

journal_title：Nature communications

authors： Ren T,He W,Barr-Gillespie PG

更新日期：2016-01-06 00:00:00

abstract：:Comparisons of climate model hindcasts with independent proxy data are essential for assessing model performance in non-analogue situations. However, standardized palaeoclimate data sets for assessing the spatial pattern of past climatic change across continents are lacking for some of the most dynamic episodes of Ear...

journal_title：Nature communications

authors： Heiri O,Brooks SJ,Renssen H,Bedford A,Hazekamp M,Ilyashuk B,Jeffers ES,Lang B,Kirilova E,Kuiper S,Millet L,Samartin S,Toth M,Verbruggen F,Watson JE,van Asch N,Lammertsma E,Amon L,Birks HH,Birks HJ,Mortensen MF,H

更新日期：2014-09-11 00:00:00

abstract：:Discharge from sliding outlet glaciers controls uncertainty in projections for future sea level. Remarkably, over 90% of glacial area is subject to gravitational driving stresses below 150 kPa (median ∼70 kPa). Longstanding explanations that appeal to the shear-thinning rheology of ice tend to overpredict driving stre...

journal_title：Nature communications

authors： Meyer CR,Downey AS,Rempel AW

更新日期：2018-08-13 00:00:00

abstract：:The process of crystallization is difficult to observe for transported, out-of-equilibrium systems, as the continuous energy injection increases activity and competes with ordering. In emerging fields such as microfluidics and active matter, the formation of long-range order is often frustrated by the presence of hydr...

journal_title：Nature communications

authors： Massana-Cid H,Meng F,Matsunaga D,Golestanian R,Tierno P

更新日期：2019-06-04 00:00:00

abstract：:Cavity quantum electrodynamics describes the fundamental interactions between light and matter, and how they can be controlled by shaping the local environment. For example, optical microcavities allow high-efficiency detection and manipulation of single atoms. In this regime, fluctuations of atom number are on the or...

journal_title：Nature communications

authors： Goldwin J,Trupke M,Kenner J,Ratnapala A,Hinds EA

更新日期：2011-08-09 00:00:00

abstract：:Linking microbial metabolomics and carbon sequestration in the ocean via refractory organic molecules has been hampered by the chemical complexity of dissolved organic matter (DOM). Here, using bioassay experiments and ultra-high resolution metabolic profiling, we demonstrate that marine bacteria rapidly utilize simpl...

journal_title：Nature communications

authors： Lechtenfeld OJ,Hertkorn N,Shen Y,Witt M,Benner R

更新日期：2015-03-31 00:00:00

abstract：:Low-light-level imaging techniques have application in many diverse fields, ranging from biological sciences to security. A high-quality digital camera based on a multi-megapixel array will typically record an image by collecting of order 10(5) photons per pixel, but by how much could this photon flux be reduced? In t...

journal_title：Nature communications

authors： Morris PA,Aspden RS,Bell JE,Boyd RW,Padgett MJ

更新日期：2015-01-05 00:00:00

abstract：:Instant curing adhesives typically fall within three categories, being activated by either light (photocuring), heat (thermocuring) or chemical means. These curing strategies limit applications to specific substrates and can only be activated under certain conditions. Here we present the development of an instant curi...

journal_title：Nature communications

authors： Ping J,Gao F,Chen JL,Webster RD,Steele TW

更新日期：2015-08-18 00:00:00

abstract：:Amazon forests have experienced frequent and severe droughts in the past two decades. However, little is known about the large-scale legacy of droughts on carbon stocks and dynamics of forests. Using systematic sampling of forest structure measured by LiDAR waveforms from 2003 to 2008, here we show a significant loss ...

journal_title：Nature communications

authors： Yang Y,Saatchi SS,Xu L,Yu Y,Choi S,Phillips N,Kennedy R,Keller M,Knyazikhin Y,Myneni RB

更新日期：2018-08-09 00:00:00

abstract：:The realization of low-cost photodetectors with high sensitivity, high quantum efficiency, high gain and fast photoresponse in the visible and short-wave infrared remains one of the challenges in optoelectronics. Two classes of photodetectors that have been developed are photodiodes and phototransistors, each of them ...

journal_title：Nature communications

authors： Nikitskiy I,Goossens S,Kufer D,Lasanta T,Navickaite G,Koppens FH,Konstantatos G

更新日期：2016-06-17 00:00:00

abstract：:Here, to overcome many limitations accompanying current available methods to detect protein-protein interactions (PPIs), we develop a live cell method called Split Intein-Mediated Protein Ligation (SIMPL). In this approach, bait and prey proteins are respectively fused to an intein N-terminal fragment (IN) and C-termi...

journal_title：Nature communications

authors： Yao Z,Aboualizadeh F,Kroll J,Akula I,Snider J,Lyakisheva A,Tang P,Kotlyar M,Jurisica I,Boxem M,Stagljar I

更新日期：2020-05-15 00:00:00

abstract：:The pyridine ring is a potent pharmacophore in alkaloid natural products. Nonetheless, its biosynthetic pathways are poorly understood. Rubrolones A and B are tropolone alkaloid natural products possessing a unique tetra-substituted pyridine moiety. Here, we report the gene cluster and propose a biosynthetic pathway f...

journal_title：Nature communications

authors： Yan Y,Yang J,Yu Z,Yu M,Ma YT,Wang L,Su C,Luo J,Horsman GP,Huang SX

更新日期：2016-10-07 00:00:00

abstract：:Competing interactions in the so-called spin-ice compounds stabilize a frustrated ground state with finite zero-point entropy and, interestingly, emergent magnetic monopole excitations. The properties of these monopoles are at the focus of recent research with particular emphasis on their quantum dynamics. It is predi...

journal_title：Nature communications

authors： Grams CP,Valldor M,Garst M,Hemberger J

更新日期：2014-09-04 00:00:00

abstract：:Streptomycetes are notable for their complex life cycle and production of most clinically important antibiotics. A key factor that controls entry into development and the onset of antibiotic production is the 68-residue protein, BldC. BldC is a putative DNA-binding protein related to MerR regulators, but lacks coiled-...

journal_title：Nature communications

authors： Schumacher MA,den Hengst CD,Bush MJ,Le TBK,Tran NT,Chandra G,Zeng W,Travis B,Brennan RG,Buttner MJ

更新日期：2018-03-19 00:00:00

abstract：:Adaptive optics by direct imaging of the wavefront distortions of a laser-induced guide star has long been used in astronomy, and more recently in microscopy to compensate for aberrations in transparent specimens. Here we extend this approach to tissues that strongly scatter visible light by exploiting the reduced sca...

journal_title：Nature communications

authors： Wang K,Sun W,Richie CT,Harvey BK,Betzig E,Ji N

更新日期：2015-06-15 00:00:00

abstract：:The Mott metal-insulator transition-a manifestation of Coulomb interactions among electrons-is known as a discontinuous transition. Recent theoretical studies, however, suggest that the transition is continuous if the Mott insulator carries a spin liquid with a spinon Fermi surface. Here, we demonstrate the case of a ...

journal_title：Nature communications

authors： Furukawa T,Kobashi K,Kurosaki Y,Miyagawa K,Kanoda K

更新日期：2018-01-22 00:00:00

abstract：:The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter-patient and intra-patient het...

journal_title：Nature communications

authors： Desai N,Neyaz A,Szabolcs A,Shih AR,Chen JH,Thapar V,Nieman LT,Solovyov A,Mehta A,Lieb DJ,Kulkarni AS,Jaicks C,Xu KH,Raabe MJ,Pinto CJ,Juric D,Chebib I,Colvin RB,Kim AY,Monroe R,Warren SE,Danaher P,Reeves JW,

更新日期：2020-12-09 00:00:00

abstract：:The bio-integrated electronics industry is booming and becoming more integrated with biological tissues. To successfully integrate with the soft tissues of the body (eg. skin), the material must possess many of the same properties including compliance, toughness, elasticity, and tear resistance. In this work, we prepa...

journal_title：Nature communications

authors： Chen S,Sun L,Zhou X,Guo Y,Song J,Qian S,Liu Z,Guan Q,Meade Jeffries E,Liu W,Wang Y,He C,You Z

更新日期：2020-02-27 00:00:00

abstract：:Knowledge of key drivers and therapeutic targets in mucosal melanoma is limited due to the paucity of comprehensive mutation data on this rare tumor type. To better understand the genomic landscape of mucosal melanoma, here we describe whole genome sequencing analysis of 67 tumors and validation of driver gene mutatio...

journal_title：Nature communications

authors： Newell F,Kong Y,Wilmott JS,Johansson PA,Ferguson PM,Cui C,Li Z,Kazakoff SH,Burke H,Dodds TJ,Patch AM,Nones K,Tembe V,Shang P,van der Weyden L,Wong K,Holmes O,Lo S,Leonard C,Wood S,Xu Q,Rawson RV,Mukhopadhyay P

更新日期：2019-07-18 00:00:00

abstract：:Non-linear interactions in coherent gases are not only at the origin of bright and dark solitons and superfluids; they also give rise to phenomena such as multistability, which hold great promise for the development of advanced photonic and spintronic devices. In particular, spinor multistability in strongly coupled s...

journal_title：Nature communications

authors： Cerna R,Léger Y,Paraïso TK,Wouters M,Morier-Genoud F,Portella-Oberli MT,Deveaud B

更新日期：2013-01-01 00:00:00

abstract：:Some two-dimensional liquid systems are theoretically predicted to have an anomalous phase transition due to unique intermolecular interactions, for example the first-order transition between two-dimensional high-density water and low-density amorphous ice. However, it has never been experimentally observed, to the be...

journal_title：Nature communications

authors： Li W,Kong L,Feng B,Fu H,Li H,Zeng XC,Wu K,Chen L

更新日期：2018-01-15 00:00:00

abstract：:Vesicular photothermal therapy agents (PTAs) are highly desirable in photothermal therapy (PTT) for their excellent light-harvesting ability and versatile hollow compartments. However, up to now, the reported vesicular PTAs are generally self-assembled from small molecules like liposomes, and polymer vesicles have sel...

journal_title：Nature communications

authors： Liu Y,Wang H,Li S,Chen C,Xu L,Huang P,Liu F,Su Y,Qi M,Yu C,Zhou Y

更新日期：2020-04-07 00:00:00

abstract：:Multi-partite entangled states are important for developing studies of quantum networking and quantum computation. To date, the largest number of particles that have been successfully manipulated is 14 trapped ions. Yet in quantum information science, photons have partic...

journal_title：Nature communications

authors： Huang YF,Liu BH,Peng L,Li YH,Li L,Li CF,Guo GC

更新日期：2011-11-22 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Temko D,Tomlinson IPM,Severini S,Schuster-Böckler B,Graham TA

更新日期：2020-04-20 00:00:00

abstract：:Metagenomic sequencing provides a window into microbial community structure and metabolic potential; however, linking these data to exogenous metabolites that microorganisms process and produce (the exometabolome) remains challenging. Previously, we observed strong exometabolite niche partitioning among bacterial isol...

journal_title：Nature communications

authors： Swenson TL,Karaoz U,Swenson JM,Bowen BP,Northen TR

更新日期：2018-01-02 00:00:00

abstract：:Single impurities with nonzero spin and multiple ground states offer a degree of freedom that can be utilized to store the quantum information. However, Fe(2+) dopant is known for having a single nondegenerate ground state in the bulk host semiconductors and thus is of little use for spintronic applications. Here we s...

journal_title：Nature communications

authors： Smoleński T,Kazimierczuk T,Kobak J,Goryca M,Golnik A,Kossacki P,Pacuski W

更新日期：2016-01-28 00:00:00

abstract：:Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers. While we previously identified KRAS mutations as molecular culprits of MPE formation, the underlying mechanism remained unknown. Here, we determine that non-canonical IKKα-RelB pathway activation of KRAS-mutant tumor cells mediat...

journal_title：Nature communications

authors： Marazioti A,Lilis I,Vreka M,Apostolopoulou H,Kalogeropoulou A,Giopanou I,Giotopoulou GA,Krontira AC,Iliopoulou M,Kanellakis NI,Agalioti T,Giannou AD,Jones-Paris C,Iwakura Y,Kardamakis D,Blackwell TS,Taraviras S,Spella M

更新日期：2018-02-14 00:00:00

abstract：:Transcription of eukaryotic protein-coding genes requires passage of RNA polymerase II (Pol II) through nucleosomes, but it is unclear how this is achieved. Here we report the cryo-EM structure of transcribing Saccharomyces cerevisiae Pol II engaged with a downstream nucleosome core particle at an overall resolution o...

journal_title：Nature communications

authors： Farnung L,Vos SM,Cramer P

更新日期：2018-12-21 00:00:00