Overcurvature describes the buckling and folding of rings from curved origami to foldable tents.

abstract：:The isolation of the two-dimensional semiconductor molybdenum disulphide introduced a new optically active material possessing a band gap that can be facilely tuned via elastic strain. As an atomically thin membrane with exceptional strength, monolayer molybdenum disulphide subjected to biaxial strain can embed wide b...

journal_title：Nature communications

authors： Li H,Contryman AW,Qian X,Ardakani SM,Gong Y,Wang X,Weisse JM,Lee CH,Zhao J,Ajayan PM,Li J,Manoharan HC,Zheng X

更新日期：2015-06-19 00:00:00

abstract：:How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of th...

journal_title：Nature communications

authors： Helfrich RF,Lendner JD,Mander BA,Guillen H,Paff M,Mnatsakanyan L,Vadera S,Walker MP,Lin JJ,Knight RT

更新日期：2019-08-08 00:00:00

abstract：:Free-electron lasers providing ultra-short high-brightness pulses of X-ray radiation have great potential for a wide impact on science, and are a critical element for unravelling the structural dynamics of matter. To fully harness this potential, we must accurately know the X-ray properties: intensity, spectrum and te...

journal_title：Nature communications

authors： Sanchez-Gonzalez A,Micaelli P,Olivier C,Barillot TR,Ilchen M,Lutman AA,Marinelli A,Maxwell T,Achner A,Agåker M,Berrah N,Bostedt C,Bozek JD,Buck J,Bucksbaum PH,Montero SC,Cooper B,Cryan JP,Dong M,Feifel R,Frasinski

更新日期：2017-06-05 00:00:00

abstract：:Genetic screens are powerful tools to identify the genes required for a given biological process. However, for technical reasons, comprehensive screens have been restricted to very few model organisms. Therefore, although deep sequencing is revealing the genes of ever more insect species, the functional studies predom...

journal_title：Nature communications

authors： Schmitt-Engel C,Schultheis D,Schwirz J,Ströhlein N,Troelenberg N,Majumdar U,Dao VA,Grossmann D,Richter T,Tech M,Dönitz J,Gerischer L,Theis M,Schild I,Trauner J,Koniszewski ND,Küster E,Kittelmann S,Hu Y,Lehmann S,S

更新日期：2015-07-28 00:00:00

abstract：:Generating a comprehensive map of molecular interactions in living cells is difficult and great efforts are undertaken to infer molecular interactions from large-scale perturbation experiments. Here, we develop the analytical and numerical tools to quantify the fundamental limits for inferring transcriptional networks...

journal_title：Nature communications

authors： Blum CF,Heramvand N,Khonsari AS,Kollmann M

更新日期：2018-01-09 00:00:00

abstract：:SecB chaperones assist protein export by binding both unfolded proteins and the SecA motor. Certain SecB homologs can also control toxin-antitoxin (TA) systems known to modulate bacterial growth in response to stress. In such TA-chaperone (TAC) systems, SecB assists the folding and prevents degradation of the antitoxi...

journal_title：Nature communications

authors： Guillet V,Bordes P,Bon C,Marcoux J,Gervais V,Sala AJ,Dos Reis S,Slama N,Mares-Mejía I,Cirinesi AM,Maveyraud L,Genevaux P,Mourey L

更新日期：2019-02-15 00:00:00

abstract：:Bacterial contamination of biological channels, catheters or water resources is a major threat to public health, which can be amplified by the ability of bacteria to swim upstream. The mechanisms of this 'rheotaxis', the reorientation with respect to flow gradients, are still poorly understood. Here, we follow individ...

journal_title：Nature communications

authors： Mathijssen AJTM,Figueroa-Morales N,Junot G,Clément É,Lindner A,Zöttl A

更新日期：2019-07-31 00:00:00

abstract：:We lack an understanding of how the full range of genetic variants that occur in individuals can interact. To address this shortcoming, here we combine diverse mutations between genes in a model regulatory network, the galactose (GAL) switch of budding yeast. The effects of thousands of pairs of mutations fall into a ...

journal_title：Nature communications

authors： New AM,Lehner B

更新日期：2019-08-14 00:00:00

abstract：:Knots are natural topologies of chains. Yet, little is known about spontaneous knot formation in a polypeptide chain-an event that can potentially impair its folding-and about the effect of a knot on the stability and folding kinetics of a protein. Here we used optical tweezers to show that the free energy cost to for...

journal_title：Nature communications

authors： Bustamante A,Sotelo-Campos J,Guerra DG,Floor M,Wilson CAM,Bustamante C,Báez M

更新日期：2017-11-17 00:00:00

abstract：:In response to brain injury, microglia rapidly extend processes that isolate lesion sites and protect the brain from further injury. Here we report that microglia carrying a pathogenic mutation in the Parkinson's disease (PD)-associated gene, G2019S-LRRK2 (GS-Tg microglia), show retarded ADP-induced motility and delay...

journal_title：Nature communications

authors： Choi I,Kim B,Byun JW,Baik SH,Huh YH,Kim JH,Mook-Jung I,Song WK,Shin JH,Seo H,Suh YH,Jou I,Park SM,Kang HC,Joe EH

更新日期：2015-09-14 00:00:00

abstract：:The preparation of α-functionalized organic acids can be greatly simplified by adopting a protocol involving the catalytic assembly of achiral building blocks. However, the enzymatic assembly of small amino acids and aldehydes to form numerous α-functionalized organic acids is highly desired and remains a significant ...

journal_title：Nature communications

authors： Song W,Wang JH,Wu J,Liu J,Chen XL,Liu LM

更新日期：2018-09-19 00:00:00

abstract：:Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptors. Receptors with t...

journal_title：Nature communications

authors： Cai W,Sakaguchi M,Kleinridders A,Gonzalez-Del Pino G,Dreyfuss JM,O'Neill BT,Ramirez AK,Pan H,Winnay JN,Boucher J,Eck MJ,Kahn CR

更新日期：2017-03-27 00:00:00

abstract：:AML1-ETO (AE) is a fusion transcription factor, generated by the t(8;21) translocation, that functions as a leukemia promoting oncogene. Here, we demonstrate that TATA-Box Binding Protein Associated Factor 1 (TAF1) associates with K43 acetylated AE and this association plays a pivotal role in the proliferation of AE-e...

journal_title：Nature communications

authors： Xu Y,Man N,Karl D,Martinez C,Liu F,Sun J,Martinez CJ,Martin GM,Beckedorff F,Lai F,Yue J,Roisman A,Greenblatt S,Duffort S,Wang L,Sun X,Figueroa M,Shiekhattar R,Nimer S

更新日期：2019-10-29 00:00:00

abstract：:Scintillation based X-ray detection has received great attention for its application in a wide range of areas from security to healthcare. Here, we report highly efficient X-ray scintillators with state-of-the-art performance based on an organic metal halide, ethylenebis-triphenylphosphonium manganese (II) bromide ((C...

journal_title：Nature communications

authors： Xu LJ,Lin X,He Q,Worku M,Ma B

更新日期：2020-08-28 00:00:00

abstract：:The recent discovery of high-temperature superconductivity in iron-based compounds has attracted much attention. How to further increase the superconducting transition temperature (T(c)) and how to understand the superconductivity mechanism are two prominent issues facing the current study of iron-based superconductor...

journal_title：Nature communications

authors： Liu D,Zhang W,Mou D,He J,Ou YB,Wang QY,Li Z,Wang L,Zhao L,He S,Peng Y,Liu X,Chen C,Yu L,Liu G,Dong X,Zhang J,Chen C,Xu Z,Hu J,Chen X,Ma X,Xue Q,Zhou XJ

更新日期：2012-07-03 00:00:00

abstract：:Cell-to-cell variability (noise) is an important feature of gene expression that impacts cell fitness and development. The regulatory mechanism of this variability is not fully understood. Here we investigate the effect on gene expression noise in divergent gene pairs (DGPs). We generated reporters driven by divergent...

journal_title：Nature communications

authors： Yan C,Wu S,Pocetti C,Bai L

更新日期：2016-03-24 00:00:00

abstract：:Recent advances in nonlinear optics have revolutionized integrated photonics, providing on-chip solutions to a wide range of new applications. Currently, state of the art integrated nonlinear photonic devices are mainly based on dielectric material platforms, such as Si3N4 and SiO2. While semiconductor materials featu...

journal_title：Nature communications

authors： Chang L,Xie W,Shu H,Yang QF,Shen B,Boes A,Peters JD,Jin W,Xiang C,Liu S,Moille G,Yu SP,Wang X,Srinivasan K,Papp SB,Vahala K,Bowers JE

更新日期：2020-03-12 00:00:00

abstract：:Understanding human mobility is crucial for applications such as forecasting epidemic spreading, planning transport infrastructure and urbanism in general. While, traditionally, mobility information has been collected via surveys, the pervasive adoption of mobile technologies has brought a wealth of (real time) data. ...

journal_title：Nature communications

authors： Mazzoli M,Molas A,Bassolas A,Lenormand M,Colet P,Ramasco JJ

更新日期：2019-08-29 00:00:00

abstract：:Intracellular trafficking of organelles, driven by kinesin-1 stepping along microtubules, underpins essential cellular processes. In absence of other proteins on the microtubule surface, kinesin-1 performs micron-long runs. Under crowding conditions, however, kinesin-1 motility is drastically impeded. It is thus uncle...

journal_title：Nature communications

authors： Henrichs V,Grycova L,Barinka C,Nahacka Z,Neuzil J,Diez S,Rohlena J,Braun M,Lansky Z

更新日期：2020-06-19 00:00:00

abstract：:In response to virus infection, RIG-I-like receptors (RLRs) sense virus RNA and induce MAVS to form prion-like aggregates to further propagate antiviral signalling. Although monomeric MAVS recombinant protein can assemble into prion-like filaments spontaneously in vitro, endogenous MAVS in cells is prevented from aggr...

journal_title：Nature communications

authors： Qi N,Shi Y,Zhang R,Zhu W,Yuan B,Li X,Wang C,Zhang X,Hou F

更新日期：2017-06-13 00:00:00

abstract：:The energy band alignment in solar cell devices is critically important because it largely governs elementary photovoltaic processes, such as the generation, separation, transport, recombination and collection of charge carriers. Despite the expenditure of considerable effort, the measurement of energy band depth prof...

journal_title：Nature communications

authors： Chen Q,Mao L,Li Y,Kong T,Wu N,Ma C,Bai S,Jin Y,Wu D,Lu W,Wang B,Chen L

更新日期：2015-07-13 00:00:00

abstract：:Monolayer transition metal dichalcogenides integrated in optical microcavities host exciton-polaritons as a hallmark of the strong light-matter coupling regime. Analogous concepts for hybrid light-matter systems employing spatially indirect excitons with a permanent electric dipole moment in heterobilayer crystals pro...

journal_title：Nature communications

authors： Förg M,Colombier L,Patel RK,Lindlau J,Mohite AD,Yamaguchi H,Glazov MM,Hunger D,Högele A

更新日期：2019-08-16 00:00:00

abstract：:Proactive, that is, unsolicited, prosociality is a key component of our hyper-cooperation, which in turn has enabled the emergence of various uniquely human traits, including complex cognition, morality and cumulative culture and technology. However, the evolutionary foundation of the human prosocial sentiment remains...

journal_title：Nature communications

authors： Burkart JM,Allon O,Amici F,Fichtel C,Finkenwirth C,Heschl A,Huber J,Isler K,Kosonen ZK,Martins E,Meulman EJ,Richiger R,Rueth K,Spillmann B,Wiesendanger S,van Schaik CP

更新日期：2014-08-27 00:00:00

abstract：:Base editing tools with diversified editing scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editors (ABEs) with minimized RNA off-target activities display constrained editing scopes with efficient editing...

journal_title：Nature communications

authors： Li S,Yuan B,Cao J,Chen J,Chen J,Qiu J,Zhao XM,Wang X,Qiu Z,Cheng TL

更新日期：2020-11-17 00:00:00

abstract：:Microglia and peripheral monocytes contribute to hypersensitivity in rodent models of neuropathic pain. However, the precise respective function of microglia and peripheral monocytes has not been investigated in these models. To address this question, here we combined transgenic mice and pharmacological tools to speci...

journal_title：Nature communications

authors： Peng J,Gu N,Zhou L,B Eyo U,Murugan M,Gan WB,Wu LJ

更新日期：2016-06-28 00:00:00

abstract：:Conventional epitaxy of semiconductor films requires a compatible single crystalline substrate and precisely controlled growth conditions, which limit the price competitiveness and versatility of the process. We demonstrate substrate-tolerant nano-heteroepitaxy (NHE) of high-quality formamidinium-lead-tri-iodide (FAPb...

journal_title：Nature communications

authors： Lee JW,Tan S,Han TH,Wang R,Zhang L,Park C,Yoon M,Choi C,Xu M,Liao ME,Lee SJ,Nuryyeva S,Zhu C,Huynh K,Goorsky MS,Huang Y,Pan X,Yang Y

更新日期：2020-11-02 00:00:00

abstract：:The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 strains in animal models. However, NAb responses are relatively weak and narrow in specificity. Displaying antigens in a multivalent fashion on n...

journal_title：Nature communications

authors： Brouwer PJM,Antanasijevic A,Berndsen Z,Yasmeen A,Fiala B,Bijl TPL,Bontjer I,Bale JB,Sheffler W,Allen JD,Schorcht A,Burger JA,Camacho M,Ellis D,Cottrell CA,Behrens AJ,Catalano M,Del Moral-Sánchez I,Ketas TJ,LaBranche

更新日期：2019-09-19 00:00:00

abstract：:Subglacial lakes are widespread beneath the Antarctic Ice Sheet but their control on ice-sheet dynamics and their ability to harbour life remain poorly characterized. Here we present evidence for a palaeo-subglacial lake on the Antarctic continental shelf. A distinct sediment facies recovered from a bedrock basin in P...

journal_title：Nature communications

authors： Kuhn G,Hillenbrand CD,Kasten S,Smith JA,Nitsche FO,Frederichs T,Wiers S,Ehrmann W,Klages JP,Mogollón JM

更新日期：2017-06-01 00:00:00

abstract：:In the evolutionary arms race between microbes, their parasites, and their neighbours, the capacity for rapid protein diversification is a potent weapon. Diversity-generating retroelements (DGRs) use mutagenic reverse transcription and retrohoming to generate myriad variants of a target gene. Originally discovered in ...

journal_title：Nature communications

authors： Paul BG,Bagby SC,Czornyj E,Arambula D,Handa S,Sczyrba A,Ghosh P,Miller JF,Valentine DL

更新日期：2015-03-23 00:00:00

abstract：:Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed osteoblastic bone formation is mostly unknown. Here, we show that increased osteoclastic miR-214-...

journal_title：Nature communications

authors： Li D,Liu J,Guo B,Liang C,Dang L,Lu C,He X,Cheung HY,Xu L,Lu C,He B,Liu B,Shaikh AB,Li F,Wang L,Yang Z,Au DW,Peng S,Zhang Z,Zhang BT,Pan X,Qian A,Shang P,Xiao L,Jiang B,Wong CK,Xu J,Bian Z,Liang Z,

更新日期：2016-03-07 00:00:00