Imaging enzyme-triggered self-assembly of small molecules inside live cells.

abstract：:Electric fields at interfaces exhibit useful phenomena, such as switching functions in transistors, through electron accumulations and/or electric dipole inductions. We find one potentially unique situation in a metal-dielectric interface in which the electric field is atomically inhomogeneous because of the strong el...

journal_title：Nature communications

authors： Miwa S,Suzuki M,Tsujikawa M,Matsuda K,Nozaki T,Tanaka K,Tsukahara T,Nawaoka K,Goto M,Kotani Y,Ohkubo T,Bonell F,Tamura E,Hono K,Nakamura T,Shirai M,Yuasa S,Suzuki Y

更新日期：2017-06-23 00:00:00

abstract：:The rapid spread of Zika virus (ZIKV), which causes microcephaly and Guillain-Barré syndrome, signals an urgency to identify therapeutics. Recent efforts to rescreen dengue virus human antibodies for ZIKV cross-neutralization activity showed antibody C10 as one of the most potent. To investigate the ability of the ant...

journal_title：Nature communications

authors： Zhang S,Kostyuchenko VA,Ng TS,Lim XN,Ooi JSG,Lambert S,Tan TY,Widman DG,Shi J,Baric RS,Lok SM

更新日期：2016-11-24 00:00:00

abstract：:Nitric oxide (NO) has important functions in biology and atmospheric chemistry as a toxin, signaling molecule, ozone depleting agent and the precursor of the greenhouse gas nitrous oxide (N2O). Although NO is a potent oxidant, and was available on Earth earlier than oxygen, it is unclear whether NO can be used by micr...

journal_title：Nature communications

authors： Hu Z,Wessels HJCT,van Alen T,Jetten MSM,Kartal B

更新日期：2019-03-20 00:00:00

abstract：:Cellular microRNAs (miRNAs) have been shown to regulate hepatitis C virus (HCV) replication, yet a systematic interrogation of the repertoire of miRNAs impacting HCV life cycle is lacking. Here we apply integrative functional genomics strategies to elucidate global HCV-miRNA interactions. Through genome-wide miRNA mim...

journal_title：Nature communications

authors： Li Q,Lowey B,Sodroski C,Krishnamurthy S,Alao H,Cha H,Chiu S,El-Diwany R,Ghany MG,Liang TJ

更新日期：2017-11-27 00:00:00

abstract：:Large single-crystal graphene is highly desired and important for the applications of graphene in electronics, as grain boundaries between graphene grains markedly degrade its quality and properties. Here we report the growth of millimetre-sized hexagonal single-crystal graphene and graphene films joined from such gra...

journal_title：Nature communications

authors： Gao L,Ren W,Xu H,Jin L,Wang Z,Ma T,Ma LP,Zhang Z,Fu Q,Peng LM,Bao X,Cheng HM

更新日期：2012-02-28 00:00:00

abstract：:Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the ability to select appropriate responses from a vast behavioral repertoire. Modulation by the prefrontal cortex (PFC) is thought to be key for both processes, but the precise role of specific circuits remains unclear. We examined th...

journal_title：Nature communications

authors： Huda R,Sipe GO,Breton-Provencher V,Cruz KG,Pho GN,Adam E,Gunter LM,Sullins A,Wickersham IR,Sur M

更新日期：2020-11-26 00:00:00

abstract：:The growth of atomically dispersed metal catalysts (ADMCs) remains a great challenge owing to the thermodynamically driven atom aggregation. Here we report a surface-limited electrodeposition technique that uses site-specific substrates for the rapid and room-temperature synthesis of ADMCs. We obtained ADMCs by the un...

journal_title：Nature communications

authors： Shi Y,Huang WM,Li J,Zhou Y,Li ZQ,Yin YC,Xia XH

更新日期：2020-09-11 00:00:00

abstract：:Liquid sensors composed of ionic liquids are rising as alternatives to solid semiconductors for flexible and self-healing electronics. However, the fluidic nature may give rise to leakage problems in cases of accidental damages. Here, we proposed a liquid sensor based on a binary ionic liquid system, in which a flowin...

journal_title：Nature communications

authors： Gao N,He Y,Tao X,Xu XQ,Wu X,Wang Y

更新日期：2019-02-01 00:00:00

abstract：:In vitro fabrication of functional vascularized three-dimensional tissues has been a long-standing objective in the field of tissue engineering. Here we report a technique to engineer cardiac tissues with perfusable blood vessels in vitro. Using resected tissue with a connectable artery and vein as a vascular bed, we ...

journal_title：Nature communications

authors： Sekine H,Shimizu T,Sakaguchi K,Dobashi I,Wada M,Yamato M,Kobayashi E,Umezu M,Okano T

更新日期：2013-01-01 00:00:00

abstract：:The emergence of antimicrobial-resistant bacteria is an increasingly serious threat to global health, necessitating the development of innovative antimicrobials. Here we report the development of a series of CRISPR-Cas13a-based antibacterial nucleocapsids, termed CapsidCas13a(s), capable of sequence-specific killing o...

journal_title：Nature communications

authors： Kiga K,Tan XE,Ibarra-Chávez R,Watanabe S,Aiba Y,Sato'o Y,Li FY,Sasahara T,Cui B,Kawauchi M,Boonsiri T,Thitiananpakorn K,Taki Y,Azam AH,Suzuki M,Penadés JR,Cui L

更新日期：2020-06-10 00:00:00

abstract：:Lysosomes are the major degradative compartments within cells, harbouring a wide variety of hydrolytic enzymes within their lumen. Release of lysosomal hydrolases from lysosomes into the cell cytoplasm results in cell death. Here we report that damaged lysosomes undergo autophagic turnover. Using a light-induced lysos...

journal_title：Nature communications

authors： Hung YH,Chen LM,Yang JY,Yang WY

更新日期：2013-01-01 00:00:00

abstract：:Cancer cells often display altered cell-surface glycans compared to their nontransformed counterparts. However, functional contributions of glycans to cancer initiation and progression remain poorly understood. Here, from expression-based analyses across cancer lineages, we found that melanomas exhibit significant tra...

journal_title：Nature communications

authors： Sweeney JG,Liang J,Antonopoulos A,Giovannone N,Kang S,Mondala TS,Head SR,King SL,Tani Y,Brackett D,Dell A,Murphy GF,Haslam SM,Widlund HR,Dimitroff CJ

更新日期：2018-08-22 00:00:00

abstract：:There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of ris...

journal_title：Nature communications

authors： Taylor JL,Debost JPG,Morton SU,Wigdor EM,Heyne HO,Lal D,Howrigan DP,Bloemendal A,Larsen JT,Kosmicki JA,Weiner DJ,Homsy J,Seidman JG,Seidman CE,Agerbo E,McGrath JJ,Mortensen PB,Petersen L,Daly MJ,Robinson EB

更新日期：2019-07-10 00:00:00

abstract：:Strategies to harness photosynthesis from living organisms to generate electrical power have long been considered, yet efficiency remains low. Here, we aimed to reroute photosynthetic electron flow in photosynthetic organisms without compromising their phototrophic properties. We show that 2,6-dimethyl-p-benzoquinone ...

journal_title：Nature communications

authors： Fu HY,Picot D,Choquet Y,Longatte G,Sayegh A,Delacotte J,Guille-Collignon M,Lemaître F,Rappaport F,Wollman FA

更新日期：2017-05-03 00:00:00

abstract：:The original version of this article contained an error in the spelling of Juan Pedro Martinez-Barbera, which was incorrectly given as Juan Pedro Martinez Barbera. This error has now been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Bowling S,Di Gregorio A,Sancho M,Pozzi S,Aarts M,Signore M,Schneider MD,Martinez-Barbera JP,Gil J,Rodríguez TA

更新日期：2018-08-02 00:00:00

abstract：:DNA methylation plays important roles in prokaryotes, and their genomic landscapes-prokaryotic epigenomes-have recently begun to be disclosed. However, our knowledge of prokaryotic methylation systems is focused on those of culturable microbes, which are rare in nature. Here, we used single-molecule real-time and circ...

journal_title：Nature communications

authors： Hiraoka S,Okazaki Y,Anda M,Toyoda A,Nakano SI,Iwasaki W

更新日期：2019-01-11 00:00:00

abstract：:Short DNA linkers are increasingly being exploited for driving-specific self-assembly of Brownian objects. DNA-functionalized colloids can assemble into ordered or amorphous materials with tailored morphology. Recently, the same approach has been applied to compliant units, including emulsion droplets and lipid vesicl...

journal_title：Nature communications

authors： Parolini L,Mognetti BM,Kotar J,Eiser E,Cicuta P,Di Michele L

更新日期：2015-01-07 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi) are approved for treating certain haematological malignancies, however, recent evidence also illustrates they are modulators of the immune system. In experimental models, HDACi are particularly potent against malignancies originating from the B-lymphocyte lineage. Here we examine...

journal_title：Nature communications

authors： Waibel M,Christiansen AJ,Hibbs ML,Shortt J,Jones SA,Simpson I,Light A,O'Donnell K,Morand EF,Tarlinton DM,Johnstone RW,Hawkins ED

更新日期：2015-04-27 00:00:00

abstract：:Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer. Although the control of Gli transcription factors by SuFu is critical in Hh signalling, our understanding of the mechanism regulating this key e...

journal_title：Nature communications

authors： Infante P,Faedda R,Bernardi F,Bufalieri F,Lospinoso Severini L,Alfonsi R,Mazzà D,Siler M,Coni S,Po A,Petroni M,Ferretti E,Mori M,De Smaele E,Canettieri G,Capalbo C,Maroder M,Screpanti I,Kool M,Pfister SM,Guardavac

更新日期：2018-03-07 00:00:00

abstract：:Vortices in quantum condensates exist owing to a macroscopic phase coherence. Here we show, both experimentally and theoretically, that a quantum vortex with a well-defined core can exist in a rather thick normal metal, proximized with a superconductor. Using scanning tunneling spectroscopy we reveal a proximity vorte...

journal_title：Nature communications

authors： Stolyarov VS,Cren T,Brun C,Golovchanskiy IA,Skryabina OV,Kasatonov DI,Khapaev MM,Kupriyanov MY,Golubov AA,Roditchev D

更新日期：2018-06-11 00:00:00

abstract：:The hypothalamic suprachiasmatic (SCN) clock contains several neurochemically defined cell groups that contribute to the genesis of circadian rhythms. Using cell-specific and genetically targeted approaches we have confirmed an indispensable role for vasoactive intestinal polypeptide-expressing SCN (SCNVIP) neurons, i...

journal_title：Nature communications

authors： Todd WD,Venner A,Anaclet C,Broadhurst RY,De Luca R,Bandaru SS,Issokson L,Hablitz LM,Cravetchi O,Arrigoni E,Campbell JN,Allen CN,Olson DP,Fuller PM

更新日期：2020-09-02 00:00:00

abstract：:Understanding the formation chemistry of metal halide perovskites is key to optimizing processing conditions and realizing enhanced optoelectronic properties. Here, we reveal the structure of the crystalline precursor in the formation of methylammonium lead iodide (MAPbI3) from the single-step deposition of lead chlor...

journal_title：Nature communications

authors： Stone KH,Gold-Parker A,Pool VL,Unger EL,Bowring AR,McGehee MD,Toney MF,Tassone CJ

更新日期：2018-08-27 00:00:00

abstract：:A detailed understanding of the human infectious reservoir is essential for improving malaria transmission-reducing interventions. Here we report a multi-regional assessment of population-wide malaria transmission potential based on 1209 mosquito feeding assays in endemic areas of Burkina Faso and Kenya. Across both s...

journal_title：Nature communications

authors： Gonçalves BP,Kapulu MC,Sawa P,Guelbéogo WM,Tiono AB,Grignard L,Stone W,Hellewell J,Lanke K,Bastiaens GJH,Bradley J,Nébié I,Ngoi JM,Oriango R,Mkabili D,Nyaurah M,Midega J,Wirth DF,Marsh K,Churcher TS,Bejon P,Siri

更新日期：2017-10-26 00:00:00

abstract：:The study of multicellular development is grounded in two complementary domains: cell biomechanics, which examines how physical forces shape the embryo, and genetic regulation and molecular signalling, which concern how cells determine their states and behaviours. Integrating both sides into a unified framework is cru...

journal_title：Nature communications

authors： Delile J,Herrmann M,Peyriéras N,Doursat R

更新日期：2017-01-23 00:00:00

abstract：:Circuit reactivations involve a stereotyped sequence of neuronal firing and have been behaviourally linked to memory consolidation. Here we use multiphoton imaging and patch-clamp recording, and observe sparse and stereotyped circuit reactivations that correspond to UP states within active neurons. To evaluate the eff...

journal_title：Nature communications

authors： Kruskal PB,Li L,MacLean JN

更新日期：2013-01-01 00:00:00

abstract：:Of the many challenges in building a wireless network at terahertz frequencies, link discovery remains one of the most critical and least explored. In a network of mobile receivers using narrow directional beams, how do the nodes rapidly locate each other? This direction information is crucial for beam forming and ste...

journal_title：Nature communications

authors： Ghasempour Y,Shrestha R,Charous A,Knightly E,Mittleman DM

更新日期：2020-04-24 00:00:00

abstract：:Many cities globally are seeking strategies to counter the consequences of both a hotter and drier climate. While urban heat mitigation strategies have been shown to have beneficial effects on health, energy consumption, and greenhouse gas emissions, their implications for water conservation have not been widely exami...

journal_title：Nature communications

authors： Vahmani P,Jones AD

更新日期：2017-10-20 00:00:00

abstract：:Identification of the optimal quantum metrological protocols in realistic many particle quantum models is in general a challenge that cannot be efficiently addressed by the state-of-the-art numerical and analytical methods. Here we provide a comprehensive framework exploiting matrix product operators (MPO) type tensor...

journal_title：Nature communications

authors： Chabuda K,Dziarmaga J,Osborne TJ,Demkowicz-Dobrzański R

更新日期：2020-01-14 00:00:00

abstract：:Electrically pumped organic lasing is one of the most challenging issues in organic optoelectronics. We present a systematic theoretical investigation to screen out electrical pumping lasing molecules over a wide range of organic materials. With the electronic structure information obtained from time-dependent density...

journal_title：Nature communications

authors： Ou Q,Peng Q,Shuai Z

更新日期：2020-09-08 00:00:00

abstract：:Compounds with incommensurate structural modulations have been extensively studied in last several decades. However, the relationship between structurally incommensurate/commensurate phases and associated electronic states remains enigmatic. Here we report the coexisting of complex incommensurate structures and highly...

journal_title：Nature communications

authors： Li Q,Lin W,Yan J,Chen X,Gianfrancesco AG,Singh DJ,Mandrus D,Kalinin SV,Pan M

更新日期：2014-11-07 00:00:00