MeCP2 regulates gene expression through recognition of H3K27me3.

abstract：:Prostate development depends on balanced cell proliferation and differentiation, and acetylated KLF5 is known to alter epithelial proliferation. It remains elusive whether post-translational modifications of transcription factors can differentially determine adult stem/progenitor cell fate. Here we report that, in hum...

journal_title：Nature communications

authors： Zhang B,Ci X,Tao R,Ni JJ,Xuan X,King JL,Xia S,Li Y,Frierson HF,Lee DK,Xu J,Osunkoya AO,Dong JT

更新日期：2020-02-21 00:00:00

abstract：:Neuropeptides have central roles in the regulation of homoeostatic behaviours such as sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. Here we show that the neuropeptide ...

journal_title：Nature communications

authors： Nelson MD,Trojanowski NF,George-Raizen JB,Smith CJ,Yu CC,Fang-Yen C,Raizen DM

更新日期：2013-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Weinert LA,Chaudhuri RR,Wang J,Peters SE,Corander J,Jombart T,Baig A,Howell KJ,Vehkala M,Välimäki N,Harris D,Chieu TTB,Van Vinh Chau N,Campbell J,Schultsz C,Parkhill J,Bentley SD,Langford PR,Rycroft AN,Wren BW,Far

更新日期：2019-11-22 00:00:00

abstract：:Many decisions are based on an internal model of the world. Yet, how such a model is constructed from experience and represented in memory remains unknown. We test the hypothesis that reward shapes memory for sequences of events by retroactively prioritizing memory for objects as a function of their distance from rewa...

journal_title：Nature communications

authors： Braun EK,Wimmer GE,Shohamy D

更新日期：2018-11-20 00:00:00

abstract：:Transition metal dichalcogenides have attracted research interest over the last few decades due to their interesting structural chemistry, unusual electronic properties, rich intercalation chemistry and wide spectrum of potential applications. Despite the fact that the majority of related research focuses on semicondu...

journal_title：Nature communications

authors： Qi Y,Naumov PG,Ali MN,Rajamathi CR,Schnelle W,Barkalov O,Hanfland M,Wu SC,Shekhar C,Sun Y,Süß V,Schmidt M,Schwarz U,Pippel E,Werner P,Hillebrand R,Förster T,Kampert E,Parkin S,Cava RJ,Felser C,Yan B,Medvedev S

更新日期：2016-03-14 00:00:00

abstract：:The complexity embedded in condensed matter fertilizes the discovery of new states of matter, enriched by ingredients like frustration. Illustrating examples in magnetic systems are Kitaev spin liquids, skyrmions phases, or spin ices. These unconventional ground states support exotic excitations, for example the magne...

journal_title：Nature communications

authors： Lefrançois E,Cathelin V,Lhotel E,Robert J,Lejay P,Colin CV,Canals B,Damay F,Ollivier J,Fåk B,Chapon LC,Ballou R,Simonet V

更新日期：2017-08-08 00:00:00

abstract：:Starting from the gas phase, small clusters can be produced and deposited with huge flexibility with regard to composition, materials choice and cluster size. Despite many advances in experimental characterization, a detailed morphology of such clusters is still lacking. Here we present an atomic scale observation as ...

journal_title：Nature communications

authors： Bals S,Van Aert S,Romero CP,Lauwaet K,Van Bael MJ,Schoeters B,Partoens B,Yücelen E,Lievens P,Van Tendeloo G

更新日期：2012-06-12 00:00:00

abstract：:SMC (structural maintenance of chromosomes) family members play essential roles in chromosome condensation, sister chromatid cohesion and DNA repair. It remains unclear how SMCs structure chromosomes and how their mechanochemical cycle regulates their interactions with DNA. Here we used single-molecule fluorescence mi...

journal_title：Nature communications

authors： Kim H,Loparo JJ

更新日期：2016-01-04 00:00:00

abstract：:Device performance and in particular device stability for blue perovskite light-emitting diodes (PeLEDs) remain considerable challenges for the whole community. In this manuscript, we conceive an approach by tuning the 'A-site' cation composition of perovskites to develop blue-emitters. We herein report a Rubidium-Ces...

journal_title：Nature communications

authors： Jiang Y,Qin C,Cui M,He T,Liu K,Huang Y,Luo M,Zhang L,Xu H,Li S,Wei J,Liu Z,Wang H,Kim GH,Yuan M,Chen J

更新日期：2019-04-23 00:00:00

abstract：:Magnetic reconnection is a fundamental process in magnetized plasma where magnetic energy is converted to plasma energy. Despite huge differences in the physical size of the reconnection layer, remarkably similar characteristics are observed in both laboratory and magnetosphere plasmas. Here we present the comparative...

journal_title：Nature communications

authors： Yamada M,Chen LJ,Yoo J,Wang S,Fox W,Jara-Almonte J,Ji H,Daughton W,Le A,Burch J,Giles B,Hesse M,Moore T,Torbert R

更新日期：2018-12-06 00:00:00

abstract：:Circadian clock mechanisms have been extensively investigated but the main rate-limiting step that determines circadian period remains unclear. Formation of a stable complex between clock proteins and CK1 is a conserved feature in eukaryotic circadian mechanisms. Here we show that the FRQ-CK1 interaction, but not FRQ ...

journal_title：Nature communications

authors： Liu X,Chen A,Caicedo-Casso A,Cui G,Du M,He Q,Lim S,Kim HJ,Hong CI,Liu Y

更新日期：2019-09-25 00:00:00

abstract：:Time-resolved photoelectron spectroscopy (TRPES) is a useful approach to elucidate the coupled electronic-nuclear quantum dynamics underlying chemical processes, but has remained limited by the use of low photon energies. Here, we demonstrate the general advantages of XUV-TRPES through an application to NO2, one of th...

journal_title：Nature communications

authors： von Conta A,Tehlar A,Schletter A,Arasaki Y,Takatsuka K,Wörner HJ

更新日期：2018-08-08 00:00:00

abstract：:The work content of non-equilibrium systems in relation to a heat bath is often analysed in terms of expectation values of an underlying random work variable. However, when optimizing the expectation value of the extracted work, the resulting extraction process is subject to intrinsic fluctuations, uniquely determined...

journal_title：Nature communications

authors： Aberg J

更新日期：2013-01-01 00:00:00

abstract：:Steels belong to one of the best established materials, however, the mechanisms of various phase transformations down to the nano length scale are still not fully clear. In this work, high-resolution transmission electron microscopy is combined with atomistic simulations to study the nanoscale carbide precipitation in...

journal_title：Nature communications

authors： Wang H,Zhang X,Yan D,Somsen C,Eggeler G

更新日期：2018-10-01 00:00:00

abstract：:Bacterial CRISPR-Cas systems comprise diverse effector endonucleases with different targeting ranges, specificities and enzymatic properties, but many of them are inactive in mammalian cells and are thus precluded from genome-editing applications. Here we show that the type II-B FnCas9 from Francisella novicida posses...

journal_title：Nature communications

authors： Chen F,Ding X,Feng Y,Seebeck T,Jiang Y,Davis GD

更新日期：2017-04-07 00:00:00

abstract：:Intermolecular halogen bonds are ideally suited for designing new molecular assemblies because of their strong directionality and the possibility of tuning the interactions by using different types of halogens or molecular moieties. Due to these unique properties of the halogen bonds, numerous areas of application hav...

journal_title：Nature communications

authors： Tschakert J,Zhong Q,Martin-Jimenez D,Carracedo-Cosme J,Romero-Muñiz C,Henkel P,Schlöder T,Ahles S,Mollenhauer D,Wegner HA,Pou P,Pérez R,Schirmeisen A,Ebeling D

更新日期：2020-11-06 00:00:00

abstract：:Alike materials in the solid state, the phase diagram of type-II superconductors exhibit crystalline, amorphous, liquid and spatially inhomogeneous phases. The multitude of different phases of vortex matter has thence proven to act as almost ideal model system for the study of both the underlying properties of superco...

journal_title：Nature communications

authors： Reimann T,Mühlbauer S,Schulz M,Betz B,Kaestner A,Pipich V,Böni P,Grünzweig C

更新日期：2015-11-02 00:00:00

abstract：:Although chemically very simple, Fe2O3 is known to undergo a series of enigmatic structural, electronic and magnetic transformations at high pressures and high temperatures. So far, these transformations have neither been correctly described nor understood because of the lack of structural data. Here we report a syste...

journal_title：Nature communications

authors： Bykova E,Dubrovinsky L,Dubrovinskaia N,Bykov M,McCammon C,Ovsyannikov SV,Liermann HP,Kupenko I,Chumakov AI,Rüffer R,Hanfland M,Prakapenka V

更新日期：2016-02-11 00:00:00

abstract：:The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the question about the underlying cellular and molecular mechanism of CT action. Here we show that either ubiquitous or osteoclas...

journal_title：Nature communications

authors： Keller J,Catala-Lehnen P,Huebner AK,Jeschke A,Heckt T,Lueth A,Krause M,Koehne T,Albers J,Schulze J,Schilling S,Haberland M,Denninger H,Neven M,Hermans-Borgmeyer I,Streichert T,Breer S,Barvencik F,Levkau B,Rathkolb B

更新日期：2014-10-21 00:00:00

abstract：:Despite the success of current therapies for acute myocardial infarction (MI), many patients still develop adverse cardiac remodeling and heart failure. With the growing prevalence of heart failure, a new therapy is needed that can prevent remodeling and support tissue repair. Herein, we report on injectable recombina...

journal_title：Nature communications

authors： McLaughlin S,McNeill B,Podrebarac J,Hosoyama K,Sedlakova V,Cron G,Smyth D,Seymour R,Goel K,Liang W,Rayner KJ,Ruel M,Suuronen EJ,Alarcon EI

更新日期：2019-10-25 00:00:00

abstract：:Activation of the NLRP3 inflammasome and subsequent maturation of IL-1β have been implicated in acute lung injury (ALI), resulting in inflammation and fibrosis. We investigated the role of vimentin, a type III intermediate filament, in this process using three well-characterized murine models of ALI known to require N...

journal_title：Nature communications

authors： dos Santos G,Rogel MR,Baker MA,Troken JR,Urich D,Morales-Nebreda L,Sennello JA,Kutuzov MA,Sitikov A,Davis JM,Lam AP,Cheresh P,Kamp D,Shumaker DK,Budinger GR,Ridge KM

更新日期：2015-03-12 00:00:00

abstract：:MicroRNAs play important roles in regulating tumour development, progression and metastasis. Here we show that one of the miR-200 family members, miR-141, is under-expressed in several prostate cancer (PCa) stem/progenitor cell populations in both xenograft and primary patient tumours. Enforced expression of miR-141 i...

journal_title：Nature communications

authors： Liu C,Liu R,Zhang D,Deng Q,Liu B,Chao HP,Rycaj K,Takata Y,Lin K,Lu Y,Zhong Y,Krolewski J,Shen J,Tang DG

更新日期：2017-01-23 00:00:00

abstract：:Transition metal-catalyzed enantioselective Sonogashira-type oxidative C(sp3)-C(sp) coupling of unactivated C(sp3)-H bonds with terminal alkynes has remained a prominent challenge. The difficulties mainly stem from the regiocontrol in unactivated C(sp3)-H bond functionalization and the inhibition of readily occurring ...

journal_title：Nature communications

authors： Zhang ZH,Dong XY,Du XY,Gu QS,Li ZL,Liu XY

更新日期：2019-12-12 00:00:00

abstract：:Piezo proteins are transmembrane ion channels which transduce many forms of mechanical stimuli into electrochemical signals. Their pore, formed by the assembly of three identical subunits, opens by an unknown mechanism. Here, to probe this mechanism, we investigate the interaction of Piezo1 with the small molecule ago...

journal_title：Nature communications

authors： Lacroix JJ,Botello-Smith WM,Luo Y

更新日期：2018-05-23 00:00:00

abstract：:Band-inverted electron-hole bilayers support quantum spin Hall insulator and exciton condensate phases. Interest in quantum spin Hall effect in these systems has recently put them in the spotlight. We investigate such a bilayer in an external magnetic field. We show that the interlayer correlations lead to formation o...

journal_title：Nature communications

authors： Pikulin DI,Silvestrov PG,Hyart T

更新日期：2016-01-25 00:00:00

abstract：:Spectrally-selective monitoring of ultraviolet radiations (UVR) is of paramount importance across diverse fields, including effective monitoring of excessive solar exposure. Current UV sensors cannot differentiate between UVA, B, and C, each of which has a remarkably different impact on human health. Here we show spec...

journal_title：Nature communications

authors： Zou W,González A,Jampaiah D,Ramanathan R,Taha M,Walia S,Sriram S,Bhaskaran M,Dominguez-Vera JM,Bansal V

更新日期：2018-09-25 00:00:00

abstract：:RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral fitness is not well characterized. Here we report the X-ray crystal structure of the receptor-binding domain (RBD) of the human coronavirus, HCoV-229E, in comple...

journal_title：Nature communications

authors： Wong AHM,Tomlinson ACA,Zhou D,Satkunarajah M,Chen K,Sharon C,Desforges M,Talbot PJ,Rini JM

更新日期：2017-11-23 00:00:00

abstract：:Efficient engulfment of apoptotic cells is critical for maintaining tissue homoeostasis. When phagocytes recognize 'eat me' signals presented on the surface of apoptotic cells, this subsequently induces cytoskeletal rearrangement of phagocytes for the engulfment through Rac1 activation. However, the intracellular sign...

journal_title：Nature communications

authors： Nakaya M,Tajima M,Kosako H,Nakaya T,Hashimoto A,Watari K,Nishihara H,Ohba M,Komiya S,Tani N,Nishida M,Taniguchi H,Sato Y,Matsumoto M,Tsuda M,Kuroda M,Inoue K,Kurose H

更新日期：2013-01-01 00:00:00

abstract：:Pentacyclic triterpenoids (PTs) constitute one of the biggest families of natural products, many with higher oxidation state at the D/E rings possess a wide spectrum of biological activties but are poorly accessible. Here we report a site-selective C-H hydroxylation at the D/E rings of PTs paving a way toward these im...

journal_title：Nature communications

authors： Mu T,Wei B,Zhu D,Yu B

更新日期：2020-09-01 00:00:00

abstract：:Drugs of abuse, including alcohol, ablate the expression of specific forms of long-term synaptic depression (LTD) at glutamatergic synapses in dorsal striatum (DS), a brain region involved in goal-directed and habitual behaviors. This loss of LTD is associated with altered DS-dependent behavior. Given the role of the ...

journal_title：Nature communications

authors： Muñoz B,Fritz BM,Yin F,Atwood BK

更新日期：2018-04-03 00:00:00