Abstract：
:Variation in the geographic spread of fossil localities strongly biases inferences about the evolution of biodiversity, due to the ubiquitous scaling of species richness with area. This obscures answers to key questions, such as how tetrapods attained their tremendous extant diversity. Here, we address this problem by applying sampling standardization methods to spatial regions of equal size, within a global Mesozoic-early Palaeogene data set of non-flying terrestrial tetrapods. We recover no significant increase in species richness between the Late Triassic and the Cretaceous/Palaeogene (K/Pg) boundary, strongly supporting bounded diversification in Mesozoic tetrapods. An abrupt tripling of richness in the earliest Palaeogene suggests that this diversity equilibrium was reset following the K/Pg extinction. Spatial heterogeneity in sampling is among the most important biases of fossil data, but has often been overlooked. Our results indicate that controlling for variance in geographic spread in the fossil record significantly impacts inferred patterns of diversity through time.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Close RA,Benson RBJ,Upchurch P,Butler RJdoi
10.1038/ncomms15381subject
Has Abstractpub_date
2017-05-22 00:00:00pages
15381issn
2041-1723pii
ncomms15381journal_volume
8pub_type
杂志文章abstract：:Hypoxia is a main driver of sprouting angiogenesis, but how tip endothelial cells are directed to hypoxic regions remains poorly understood. Here, we show that an endothelial MST1-FOXO1 cascade is essential for directional migration of tip cells towards hypoxic regions. In mice, endothelial-specific deletion of either...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-08773-2
更新日期：2019-02-19 00:00:00
abstract：:Brain-inspired parallel computing, which is typically performed using a hardware neural-network platform consisting of numerous artificial synapses, is a promising technology for effectively handling large amounts of informational data. However, the reported nonlinear and asymmetric conductance-update characteristics ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-17849-3
更新日期：2020-08-07 00:00:00
abstract：:Benzoxaboroles are effective against bacterial, fungal and protozoan pathogens. We report potent activity of the benzoxaborole AN3661 against Plasmodium falciparum laboratory-adapted strains (mean IC50 32 nM), Ugandan field isolates (mean ex vivo IC50 64 nM), and murine P. berghei and P. falciparum infections (day 4 E...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms14574
更新日期：2017-03-06 00:00:00
abstract：:Use of aromatase inhibitors (AIs), exemestane, letrozole and anastrozole, for breast cancer therapy is associated with severe pain symptoms, the underlying mechanism of which is unknown. The electrophilic nature of AIs suggests that they may target the transient receptor potential ankyrin 1 (TRPA1) channel, a major pa...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6736
更新日期：2014-12-08 00:00:00
abstract：:Closed timelike curves are striking predictions of general relativity allowing for time-travel. They are afflicted by notorious causality issues (e.g. grandfather's paradox). Quantum models where a qubit travels back in time solve these problems, at the cost of violating quantum theory's linearity-leading e.g. to univ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-08100-1
更新日期：2019-01-14 00:00:00
abstract：:The 'phonon-glass electron-crystal' concept has triggered most of the progress that has been achieved in inorganic thermoelectrics in the past two decades. Organic thermoelectric materials, unlike their inorganic counterparts, exhibit molecular diversity, flexible mechanical properties and easy fabrication, and are mo...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19537-8
更新日期：2020-11-10 00:00:00
abstract：:A high-sugar diet has been associated with reduced lifespan in organisms ranging from worms to mammals. However, the mechanisms underlying the harmful effects of glucose are poorly understood. Here we establish a causative relationship between endogenous glucose storage in the form of glycogen, resistance to oxidative...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15868
更新日期：2017-06-19 00:00:00
abstract：:Significant advances have been made towards fault-tolerant operation of silicon spin qubits, with single qubit fidelities exceeding 99.9%, several demonstrations of two-qubit gates based on exchange coupling, and the achievement of coherent single spin-photon coupling. Coupling arbitrary pairs of spatially separated q...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-08970-z
更新日期：2019-03-05 00:00:00
abstract：:New microbial genomes are constantly being sequenced, and it is crucial to accurately determine their taxonomic identities and evolutionary relationships. Here we report PhyloPhlAn, a new method to assign microbial phylogeny and putative taxonomy using >400 proteins optimized from among 3,737 genomes. This method meas...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms3304
更新日期：2013-01-01 00:00:00
abstract：:Formation of domain walls in ferroelectrics is not energetically favourable in low-dimensional systems. Instead, vortex-type structures are formed that are driven by depolarization fields occurring in such systems. Consequently, polarization vortices have only been experimentally found in systems in which these fields...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms13484
更新日期：2016-11-16 00:00:00
abstract：:Understanding the fundamental alterations in brain functioning that lead to psychotic disorders remains a major challenge in clinical neuroscience. In particular, it is unknown whether any state-independent biomarkers can potentially predict the onset of psychosis and distinguish patients from healthy controls, regard...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06350-7
更新日期：2018-09-21 00:00:00
abstract：:The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology, but how proteins localize differentially to these structures within a shared cytoplasm remains unclear. Here, we show that the actin-binding domains of accessory proteins can be sensitive to filament conform...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19768-9
更新日期：2020-11-25 00:00:00
abstract：:Metastasis is the main cause of cancer-related death and thus understanding the molecular and cellular mechanisms underlying this process is critical. Here, our data demonstrate, contrary to established dogma, that loss of haematopoietic-derived focal adhesion kinase (FAK) is sufficient to enhance tumour metastasis. U...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6054
更新日期：2014-10-01 00:00:00
abstract：:Soil microorganisms dominate terrestrial biogeochemical cycles; however, we know very little about their spatial distribution and how changes in the distributions of specific groups of microbes translate into landscape and global patterns of biogeochemical processes. In this paper, we use a nested sampling scheme at s...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1055
更新日期：2010-08-10 00:00:00
abstract：:Reliable quantum information processing in the face of errors is a major fundamental and technological challenge. Quantum error correction protects quantum states by encoding a logical quantum bit (qubit) in multiple physical qubits. To be compatible with universal fault-tolerant computations, it is essential that sta...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms11526
更新日期：2016-05-05 00:00:00
abstract：:Single-photon counters are single-pixel binary devices that click upon the absorption of a photon but obscure its spectral information, whereas resolving the color of detected photons has been in critical demand for frontier astronomical observation, spectroscopic imaging and wavelength division multiplexed quantum co...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12149-x
更新日期：2019-09-10 00:00:00
abstract：:Writing artificial logic and dynamic function into complex cellular background to achieve desired phenotypes or improved outputs calls for the development of new genetic tools as well as their innovative use. In this study, we present a sensor-regulator and RNAi-based bifunctional dynamic control network that can prov...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05466-0
更新日期：2018-08-02 00:00:00
abstract：:Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs expressing fibroblast activation protein alpha (FAP) and haem oxygenase-1 (HO-1), which are also fou...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05346-7
更新日期：2018-07-27 00:00:00
abstract：:The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of proliferation of peripherally-derived inflammatory macrophages under physiological conditions. Here we show that proliferation of both bone marrow-derived infl...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2877
更新日期：2013-01-01 00:00:00
abstract：:Pseudomonas aeruginosa, an opportunistic pathogen of humans, uses quorum sensing (QS) to regulate the production of extracellular products that can benefit all members of the population. P. aeruginosa can police QS-deficient cheaters by producing hydrogen cyanide, which is also QS regulated; however, the mechanism by ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13013-8
更新日期：2019-11-01 00:00:00
abstract：:Preterm birth places infants in an adverse environment that leads to abnormal brain development and cerebral injury through a poorly understood mechanism known to involve neuroinflammation. In this study, we integrate human and mouse molecular and neuroimaging data to investigate the role of microglia in preterm white...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-00422-w
更新日期：2017-09-05 00:00:00
abstract：:APOBEC3A is a cytidine deaminase driving mutagenesis, DNA replication stress and DNA damage in cancer cells. While the APOBEC3A-induced vulnerability of cancers offers an opportunity for therapy, APOBEC3A protein and mRNA are difficult to quantify in tumors due to their low abundance. Here, we describe a quantitative ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16802-8
更新日期：2020-06-12 00:00:00
abstract：:Heterostructures formed by stacking layered materials require atomically clean interfaces. However, contaminants are usually trapped between the layers, aggregating into randomly located blisters, incompatible with scalable fabrication processes. Here we report a process to remove blisters from fully formed heterostru...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07558-3
更新日期：2018-12-19 00:00:00
abstract：:Biogenic furans are currently discussed as highly attractive alternative feedstock in a post-fossil society; thus, also the creation of sustainable furan valorization pathways appears of great importance. Here an artificial Achmatowicz monooxygenase activity for the aerobic ring expansion of furans is achieved by the ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6278
更新日期：2014-10-22 00:00:00
abstract：:Recently, surface-enhanced Raman scattering nanoprobes have shown tremendous potential in oncological imaging owing to the high sensitivity and specificity of their fingerprint-like spectra. As current Raman scanners rely on a slow, point-by-point spectrum acquisition, there is an unmet need for faster imaging to cove...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09173-2
更新日期：2019-04-26 00:00:00
abstract：:The human pathogen Helicobacter pylori displays extensive genetic diversity. While H. pylori is known to evolve during infection, population dynamics inside the gastric environment have not been extensively investigated. Here we obtained gastric biopsies from multiple stomach regions of 16 H. pylori-infected adults, a...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-10050-1
更新日期：2019-05-22 00:00:00
abstract：:The emergence of antibiotic resistant bacteria is a major threat to the practice of modern medicine. Photobactericidal agents have obtained significant attention as promising candidates to kill bacteria, and they have been extensively studied. However, to obtain photobactericidal activity, an intense white light sourc...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15004-6
更新日期：2020-03-05 00:00:00
abstract：:Aerosol-cloud interactions constitute the largest source of uncertainty in global radiative forcing estimates, hampering our understanding of climate evolution. Recent empirical evidence suggests surface tension depression by organic aerosol to significantly influence the formation of cloud droplets, and hence cloud o...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12982-0
更新日期：2019-11-18 00:00:00
abstract：:The deployment of next-generation renewable biofuels can be enhanced by improving their compatibility with the current infrastructure for transportation, storage and utilization. Propane, the bulk component of liquid petroleum gas, is an appealing target as it already has a global market. In addition, it is a gas unde...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5731
更新日期：2014-09-02 00:00:00
abstract：:Elevated plasma cholesterol and type 2 diabetes (T2D) are associated with coronary artery disease (CAD). Individuals treated with cholesterol-lowering statins have increased T2D risk, while individuals with hypercholesterolemia have reduced T2D risk. We explore the relationship between lipid and glucose control by con...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20750-8
更新日期：2021-01-22 00:00:00
