Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.

abstract：:Hematopoietic stem cells (HSCs) are maintained in a hypoxic niche to limit oxidative stress. Although iron elicits oxidative stress, the importance of iron homeostasis in HSCs has been unknown. Here we show that iron regulation by the F-box protein FBXL5 is required for HSC self-renewal. Conditional deletion of Fbxl5 ...

journal_title：Nature communications

authors： Muto Y,Nishiyama M,Nita A,Moroishi T,Nakayama KI

更新日期：2017-07-17 00:00:00

abstract：:Topological defects in matter behave collectively to form highly non-trivial structures called topological textures that are characterised by conserved quantities such as the winding number. Here we show that an epitaxial ferroelectric square nanoplate of bismuth ferrite subjected to a large strain gradient (as much a...

journal_title：Nature communications

authors： Kim KE,Jeong S,Chu K,Lee JH,Kim GY,Xue F,Koo TY,Chen LQ,Choi SY,Ramesh R,Yang CH

更新日期：2018-01-26 00:00:00

abstract：:Mesostriatal dopaminergic neurons possess extensively branched axonal arbours. Whether action potentials are converted to dopamine output in the striatum will be influenced dynamically and critically by axonal properties and mechanisms that are poorly understood. Here, we address the roles for mechanisms governing rel...

journal_title：Nature communications

authors： Condon MD,Platt NJ,Zhang YF,Roberts BM,Clements MA,Vietti-Michelina S,Tseu MY,Brimblecombe KR,Threlfell S,Mann EO,Cragg SJ

更新日期：2019-09-19 00:00:00

abstract：:Perceptual decisions are accompanied by feelings of confidence that reflect the likelihood that the decision was correct. Here we aim to clarify the relationship between perception and confidence by studying the same perceptual task across three different confidence contexts. Human observers were asked to categorize t...

journal_title：Nature communications

authors： Balsdon T,Wyart V,Mamassian P

更新日期：2020-04-09 00:00:00

abstract：:For COVID-19, it is vital to understand if quarantines shorter than 14 days can be equally effective with judiciously deployed testing. Here, we develop a mathematical model that quantifies the probability of post-quarantine transmission incorporating testing into travel quarantine, quarantine of traced contacts with ...

journal_title：Nature communications

authors： Wells CR,Townsend JP,Pandey A,Moghadas SM,Krieger G,Singer B,McDonald RH,Fitzpatrick MC,Galvani AP

更新日期：2021-01-07 00:00:00

abstract：:Actin-based vesicular trafficking of Cdc42, leading to a polarized concentration of the GTPase, has been implicated in cell polarization, but it was recently debated whether this mechanism allows stable maintenance of cell polarity. Here we show that endocytosis and exocytosis are spatially segregated in the polar pla...

journal_title：Nature communications

authors： Slaughter BD,Unruh JR,Das A,Smith SE,Rubinstein B,Li R

更新日期：2013-01-01 00:00:00

abstract：:Quantum technologies promise a variety of exciting applications. Even though impressive progress has been achieved recently, a major bottleneck currently is the lack of practical certification techniques. The challenge consists of ensuring that classically intractable quantum devices perform as expected. Here we prese...

journal_title：Nature communications

authors： Aolita L,Gogolin C,Kliesch M,Eisert J

更新日期：2015-11-18 00:00:00

abstract：:The intrinsically disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core components of the super elongation complex required for HIV-1 proviral transcription. Here we report the 2.0-Å resolution crystal structure of the human ELL2 C-terminal domain bound to its 50-residue binding ...

journal_title：Nature communications

authors： Qi S,Li Z,Schulze-Gahmen U,Stjepanovic G,Zhou Q,Hurley JH

更新日期：2017-01-30 00:00:00

abstract：:The Mid-Cayman spreading centre is an ultraslow-spreading ridge in the Caribbean Sea. Its extreme depth and geographic isolation from other mid-ocean ridges offer insights into the effects of pressure on hydrothermal venting, and the biogeography of vent fauna. Here we report the discovery of two hydrothermal vent fie...

journal_title：Nature communications

authors： Connelly DP,Copley JT,Murton BJ,Stansfield K,Tyler PA,German CR,Van Dover CL,Amon D,Furlong M,Grindlay N,Hayman N,Hühnerbach V,Judge M,Le Bas T,McPhail S,Meier A,Nakamura K,Nye V,Pebody M,Pedersen RB,Plouviez S,

更新日期：2012-01-10 00:00:00

abstract：:Seeded propagation of amyloid-beta (Aβ) pathology is suggested to contribute to the progression of Alzheimer's disease. Local overproduction of aggregation-prone Aβ variants could explain the focal initiation of a seeding cascade that subsequently triggers widespread pathology. Several animal models support this seedi...

journal_title：Nature communications

authors： Sowade RF,Jahn TR

更新日期：2017-09-11 00:00:00

abstract：:The original version of this Article contained an error in the spelling of the author Woochul Song, which was incorrectly given as Woochul C. Song. This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Shen YX,Song W,Barden DR,Ren T,Lang C,Feroz H,Henderson CB,Saboe PO,Tsai D,Yan H,Butler PJ,Bazan GC,Phillip WA,Hickey RJ,Cremer PS,Vashisth H,Kumar M

更新日期：2018-08-14 00:00:00

abstract：:In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS, possibly suggesting a unique oncogenic activity mediated by KRAS-specific interaction partners, which might be targeted. Here, we determine the spec...

journal_title：Nature communications

authors： Adhikari H,Counter CM

更新日期：2018-09-07 00:00:00

abstract：:Solution-processable perovskites show highly emissive and good charge transport, making them attractive for low-cost light-emitting diodes (LEDs) with high energy conversion efficiencies. Despite recent advances in device efficiency, the stability of perovskite LEDs is still a major obstacle. Here, we demonstrate stab...

journal_title：Nature communications

authors： Miao Y,Ke Y,Wang N,Zou W,Xu M,Cao Y,Sun Y,Yang R,Wang Y,Tong Y,Xu W,Zhang L,Li R,Li J,He H,Jin Y,Gao F,Huang W,Wang J

更新日期：2019-08-09 00:00:00

abstract：:Transcription initiation involves the coordinated activities of large multimeric complexes, but little is known about their biogenesis. Here we report several principles underlying the assembly and topological organization of the highly conserved SAGA and NuA4 co-activator complexes, which share the Tra1 subunit. We s...

journal_title：Nature communications

authors： Elías-Villalobos A,Toullec D,Faux C,Séveno M,Helmlinger D

更新日期：2019-11-20 00:00:00

abstract：:Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that the human microcephaly protein, RTTN, is recruited to the proximal end of the procentriole at early S phase, and is located at the inner luminal walls of centrioles. Further stud...

journal_title：Nature communications

authors： Chen HY,Wu CT,Tang CC,Lin YN,Wang WJ,Tang TK

更新日期：2017-08-15 00:00:00

abstract：:The survival of viruses partly relies on their ability to self-assemble inside host cells. Although coarse-grained simulations have identified different pathways leading to assembled virions from their components, experimental evidence is severely lacking. Here, we use time-resolved small-angle X-ray scattering to unc...

journal_title：Nature communications

authors： Chevreuil M,Law-Hine D,Chen J,Bressanelli S,Combet S,Constantin D,Degrouard J,Möller J,Zeghal M,Tresset G

更新日期：2018-08-06 00:00:00

abstract：:Lithium metal batteries have been considerably limited by the problems of uncontrolled dendritic lithium formation and the highly reactive nature of lithium with electrolytes. Herein, we have developed functional porous bilayer composite separators by simply blade-coating polyacrylamide-grafted graphene oxide molecula...

journal_title：Nature communications

authors： Li C,Liu S,Shi C,Liang G,Lu Z,Fu R,Wu D

更新日期：2019-03-25 00:00:00

abstract：:Pineoblastoma is a rare pediatric cancer induced by germline mutations in the tumor suppressors RB1 or DICER1. Presence of leptomeningeal metastases is indicative of poor prognosis. Here we report that inactivation of Rb plus p53 via a WAP-Cre transgene, commonly used to target the mammary gland during pregnancy, indu...

journal_title：Nature communications

authors： Chung PED,Gendoo DMA,Ghanbari-Azarnier R,Liu JC,Jiang Z,Tsui J,Wang DY,Xiao X,Li B,Dubuc A,Shih D,Remke M,Ho B,Garzia L,Ben-David Y,Kang SG,Croul S,Haibe-Kains B,Huang A,Taylor MD,Zacksenhaus E

更新日期：2020-04-14 00:00:00

abstract：:Targeting of immunoglobulin E (IgE) represents an interesting approach for the treatment of allergic disorders. A high-affinity monoclonal anti-IgE antibody, ligelizumab, has recently been developed to overcome some of the limitations associated with the clinical use of the therapeutic anti-IgE antibody, omalizumab. H...

journal_title：Nature communications

authors： Gasser P,Tarchevskaya SS,Guntern P,Brigger D,Ruppli R,Zbären N,Kleinboelting S,Heusser C,Jardetzky TS,Eggel A

更新日期：2020-01-08 00:00:00

abstract：:Interactions between proteins play an essential role in metabolic and signaling pathways, cellular processes and organismal systems. We report the development of splitFAST, a fluorescence complementation system for the visualization of transient protein-protein interactions in living cells. Engineered from the fluorog...

journal_title：Nature communications

authors： Tebo AG,Gautier A

更新日期：2019-06-27 00:00:00

abstract：:Marine reserves are viewed as flagship tools to protect exploited species and to contribute to the effective management of coastal fisheries. Yet, the extent to which marine reserves are globally interconnected and able to effectively seed areas, where fisheries are most critical for food and livelihood security is la...

journal_title：Nature communications

authors： Andrello M,Guilhaumon F,Albouy C,Parravicini V,Scholtens J,Verley P,Barange M,Sumaila UR,Manel S,Mouillot D

更新日期：2017-07-10 00:00:00

abstract：:Dysfunction of CD8+ T cells can lead to the development of chronic viral infection. Identifying mechanisms responsible for such T cell dysfunction is therefore of great importance to understand how to prevent persistent viral infection. Here we show using lymphocytic choriomeningitis virus (LCMV) infection that carcin...

journal_title：Nature communications

authors： Khairnar V,Duhan V,Patil AM,Zhou F,Bhat H,Thoens C,Sharma P,Adomati T,Friendrich SK,Bezgovsek J,Dreesen JD,Wennemuth G,Westendorf AM,Zelinskyy G,Dittmer U,Hardt C,Timm J,Göthert JR,Lang PA,Singer BB,Lang KS

更新日期：2018-07-02 00:00:00

abstract：:Crustal fluids exist near fault zones, but their relation to the processes that generate earthquakes, including slow-slip events, is unclear. Fault-zone fluids are characterized by low electrical resistivity. Here we investigate the time-dependent crustal resistivity in the rupture area of the 1999 Mw 7.6 Izmit earthq...

journal_title：Nature communications

authors： Honkura Y,Oshiman N,Matsushima M,Barış S,Kemal Tunçer M,Bülent Tank S,Celik C,Ciftçi ET

更新日期：2013-01-01 00:00:00

abstract：:The field of optical metrology with its high precision position, rotation and wavefront sensors represents the basis for lithography and high resolution microscopy. However, the on-chip integration-a task highly relevant for future nanotechnological devices-necessitates the reduction of the spatial footprint of sensin...

journal_title：Nature communications

authors： Bag A,Neugebauer M,Mick U,Christiansen S,Schulz SA,Banzer P

更新日期：2020-06-09 00:00:00

abstract：:Prolonged cell survival occurs through the expression of specific protein isoforms generated by alternate splicing of mRNA precursors in cancer cells. How alternate splicing regulates tumor development and resistance to targeted therapies in cancer remain poorly understood. Here we show that RNF113A, whose loss-of-fun...

journal_title：Nature communications

authors： Shostak K,Jiang Z,Charloteaux B,Mayer A,Habraken Y,Tharun L,Klein S,Xu X,Duong HQ,Vislovukh A,Close P,Florin A,Rambow F,Marine JC,Büttner R,Chariot A

更新日期：2020-03-09 00:00:00

abstract：:A topological insulator is the state of quantum matter possessing gapless spin-locking surface states across the bulk band gap, which has created new opportunities from novel electronics to energy conversion. However, the large concentration of bulk residual carriers has been a major challenge for revealing the proper...

journal_title：Nature communications

authors： Hong SS,Cha JJ,Kong D,Cui Y

更新日期：2012-03-27 00:00:00

abstract：:The exploration of chemical space for new reactivity, reactions and molecules is limited by the need for separate work-up-separation steps searching for molecules rather than reactivity. Herein we present a system that can autonomously evaluate chemical reactivity within a network of 64 possible reaction combinations ...

journal_title：Nature communications

authors： Dragone V,Sans V,Henson AB,Granda JM,Cronin L

更新日期：2017-06-09 00:00:00

abstract：:Irreversible phase transformation of layered structure into spinel structure is considered detrimental for most of the layered structure cathode materials. Here we report that this presumably irreversible phase transformation can be rendered to be reversible in sodium birnessite (NaxMnO2·yH2O) as a basic structural un...

journal_title：Nature communications

authors： Jo MR,Kim Y,Yang J,Jeong M,Song K,Kim YI,Lim JM,Cho M,Shim JH,Kim YM,Yoon WS,Kang YM

更新日期：2019-09-02 00:00:00

abstract：:HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case-control samples to investigate mutational signatures and the role of human APOBEC3-induced mutations in viral clearance and cervical carcinogen...

journal_title：Nature communications

authors： Zhu B,Xiao Y,Yeager M,Clifford G,Wentzensen N,Cullen M,Boland JF,Bass S,Steinberg MK,Raine-Bennett T,Lee D,Burk RD,Pinheiro M,Song L,Dean M,Nelson CW,Burdett L,Yu K,Roberson D,Lorey T,Franceschi S,Castle PE,Wa

更新日期：2020-02-14 00:00:00

abstract：:As in human speech acquisition, songbird vocal learning depends on early auditory experience. During development, juvenile songbirds listen to and form auditory memories of adult tutor songs, which they use to shape their own vocalizations in later sensorimotor learning. The higher-level auditory cortex, called the ca...

journal_title：Nature communications

authors： Yanagihara S,Yazaki-Sugiyama Y

更新日期：2016-06-21 00:00:00