Abstract:
:In the enteric pathogen Salmonella enterica serovar Typhimurium, invasion and motility are coordinated by the master regulator HilD, which induces expression of the type III secretion system 1 (T3SS1) and motility genes. Methyl-accepting chemotaxis proteins (MCPs) detect specific ligands and control the direction of the flagellar motor, promoting tumbling and changes in direction (if a repellent is detected) or smooth swimming (in the presence of an attractant). Here, we show that HilD induces smooth swimming by upregulating an uncharacterized MCP (McpC), and this is important for invasion of epithelial cells. Remarkably, in vitro assays show that McpC can suppress tumbling and increase smooth swimming in the absence of exogenous ligands. Expression of mcpC is repressed by the universal regulator H-NS, which can be displaced by HilD. Our results highlight the importance of smooth swimming for Salmonella Typhimurium invasiveness and indicate that McpC can act via a ligand-independent mechanism when incorporated into the chemotactic receptor array.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Cooper KG,Chong A,Kari L,Jeffrey B,Starr T,Martens C,McClurg M,Posada VR,Laughlin RC,Whitfield-Cargile C,Garry Adams L,Bryan LK,Little SV,Krath M,Lawhon SD,Steele-Mortimer Odoi
10.1038/s41467-020-20558-6subject
Has Abstractpub_date
2021-01-13 00:00:00pages
348issue
1issn
2041-1723pii
10.1038/s41467-020-20558-6journal_volume
12pub_type
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