Abstract:
:In the originally published version of this Article, the affiliation details for Eric E. Schadt and Radoslav Savic incorrectly omitted 'Sema4, a Mount Sinai venture, Stamford, Connecticut, USA'. This has been corrected in both the PDF and HTML versions of the Article.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Readhead B,Hartley BJ,Eastwood BJ,Collier DA,Evans D,Farias R,He C,Hoffman G,Sklar P,Dudley JT,Schadt EE,Savić R,Brennand KJdoi
10.1038/s41467-018-07326-3subject
Has Abstractpub_date
2018-11-19 00:00:00pages
4926issue
1issn
2041-1723pii
10.1038/s41467-018-07326-3journal_volume
9pub_type
杂志文章,已发布勘误abstract::The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11471
更新日期:2016-05-10 00:00:00
abstract::Defensins are cationic antimicrobial peptides expressed throughout the plant and animal kingdoms as a first line of defense against pathogens. Membrane targeting and disruption is a crucial function of many defensins, however the precise mechanism remains unclear. Certain plant defensins form dimers that specifically ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04434-y
更新日期:2018-05-17 00:00:00
abstract::The metazoan TREX complex is recruited to mRNA during nuclear RNA processing and functions in exporting mRNA to the cytoplasm. Nxf1 is an mRNA export receptor, which binds processed mRNA and transports it through the nuclear pore complex. At present, the relationship between TREX and Nxf1 is not understood. Here we sh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2005
更新日期:2012-01-01 00:00:00
abstract::CD36 transmembrane proteins have diverse roles in lipid uptake, cell adhesion and pathogen sensing. Despite numerous in vitro studies, how they act in native cellular contexts is poorly understood. A Drosophila CD36 homologue, sensory neuron membrane protein 1 (SNMP1), was previously shown to facilitate detection of l...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11866
更新日期:2016-06-15 00:00:00
abstract::Peptide macrocycles are promising therapeutic molecules because they are protease resistant, structurally rigid, membrane permeable, and capable of modulating protein-protein interactions. Here, we report the characterization of the dual function macrocyclase-peptidase enzyme involved in the biosynthesis of the highly...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00862-4
更新日期:2017-10-19 00:00:00
abstract::The equilibrium volume of a thermoresponsive polymer gel changes dramatically across a temperature due to the coil-globule transitions of the polymers. When cofacially oriented nanosheets are embedded in such a gel, the composite gel deforms at the temperature, without changing the volume, and the response time is con...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04533-w
更新日期:2018-05-25 00:00:00
abstract::The mitochondrial respiratory chain is essential for oxidative phosphorylation and comprises multiple complexes, including cytochrome c oxidase, assembled in macromolecular supercomplexes. Little is known about factors that contribute to supercomplex organization. Here we identify COX7RP as a factor that promotes supe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3147
更新日期:2013-01-01 00:00:00
abstract::The indisputable role of epigenetics in cancer and the fact that epigenetic alterations can be reversed have favoured development of epigenetic drugs. In this study, we design and synthesize potent novel, selective and reversible chemical probes that simultaneously inhibit the G9a and DNMTs methyltransferase activity....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15424
更新日期:2017-05-26 00:00:00
abstract::Human APOBEC3A (A3A) cytidine deaminase is a host enzyme that can introduce mutations into chromosomal DNA. As APOBEC3B (A3B) encodes a C-terminal catalytic domain ~91% identical to A3A, we examined its genotoxic potential as well as that of a highly prevalent chimaeric A3A-A3B deletion allele (ΔA3B), which is linked ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6129
更新日期:2014-10-09 00:00:00
abstract::Southern Africa is characterised by unusually elevated topography and abnormal heat flow. This can be explained by thermal perturbation of the mantle, but the origin of this is unclear. Geophysics has not detected a thermal anomaly in the upper mantle and there is no geochemical evidence of an asthenosphere mantle con...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12944-6
更新日期:2019-11-05 00:00:00
abstract::Development of on-chip integrated carbon-based optoelectronic nanocircuits requires fast and non-invasive structural characterization of their building blocks. Recent advances in synthesis of single wall carbon nanotubes and graphene nanoribbons allow for their use as atomically precise building blocks. However, while...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13728-8
更新日期:2020-01-03 00:00:00
abstract::Within all physical disciplines, it is accepted that wave transport is predetermined by the existence of disorder. In this vein, it is known that ballistic transport is possible only when a structure is ordered, and that disorder is crucial for diffusion or (Anderson-)localization to occur. As this commonly accepted p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3533
更新日期:2013-01-01 00:00:00
abstract::Methane cold seep systems typically exhibit extensive buildups of authigenic carbonate minerals, resulting from local increases in alkalinity driven by methane oxidation. Here, we demonstrate that modern seep authigenic carbonates exhibit anomalously low clumped isotope values (Δ47), as much as ∼0.2‰ lower than expect...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12274
更新日期:2016-07-22 00:00:00
abstract::The biological pump transports organic carbon produced by photosynthesis to the meso- and bathypelagic zones, the latter removing carbon from exchanging with the atmosphere over centennial time scales. Organisms living in both zones are supported by a passive flux of particles, and carbon transported to the deep-sea t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19875-7
更新日期:2020-11-27 00:00:00
abstract::Variation in the geographic spread of fossil localities strongly biases inferences about the evolution of biodiversity, due to the ubiquitous scaling of species richness with area. This obscures answers to key questions, such as how tetrapods attained their tremendous extant diversity. Here, we address this problem by...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15381
更新日期:2017-05-22 00:00:00
abstract::The ability to modulate light at high speeds is of paramount importance for telecommunications, information processing and medical imaging technologies. This has stimulated intense efforts to master optoelectronic switching at visible and near-infrared frequencies, although coping with current computer speeds in integ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4548
更新日期:2014-03-27 00:00:00
abstract::Stackable select devices such as the oxide p-n junction diode and the Schottky diode (one-way switch) have been proposed for non-volatile unipolar resistive switching devices; however, bidirectional select devices (or two-way switch) need to be developed for bipolar resistive switching devices. Here we report on a ful...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3629
更新日期:2013-01-01 00:00:00
abstract::Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, electrolyte abnormalities and metabolic waste accumulation- manifesting as acute kidney injury (A...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15638-6
更新日期:2020-04-21 00:00:00
abstract::The original version of this Article contained an error in the third sentence of the penultimate paragraph of the 'Definition of the harmonic phase' section of the Results, which incorrectly read 'In the Coulomb phase the tensor S αβ (q) has one zero and two degenerate eigenvalues and it may be represented by an infin...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-03815-7
更新日期:2018-04-16 00:00:00
abstract::Cosmic rays interact with the Earth's atmosphere to produce 14C, which can be absorbed by trees. Therefore, rapid increases of 14C in tree rings can be used to probe previous cosmic-ray events. By this method, three 14C rapidly increasing events have been found. Plausible causes of these events include large solar pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01698-8
更新日期:2017-11-14 00:00:00
abstract::The use of graphene in electronic devices requires a band gap, which can be achieved by creating nanostructures such as graphene nanoribbons. A wide variety of atomically precise graphene nanoribbons can be prepared through on-surface synthesis, bringing the concept of graphene nanoribbon electronics closer to reality...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00195-2
更新日期:2017-07-25 00:00:00
abstract::Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12295-2
更新日期:2019-09-20 00:00:00
abstract::Sequencing of a single-cell genome requires DNA amplification, a process prone to introducing bias and errors into the amplified genome. Here we introduce a novel multiple displacement amplification (MDA) method based on the unique DNA primase features of Thermus thermophilus (Tth) PrimPol. TthPrimPol displays a poten...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13296
更新日期:2016-11-29 00:00:00
abstract::The superconducting state is formed by the condensation of Cooper pairs and protected by the superconducting gap. The pairing interaction between the two electrons of a Cooper pair determines the gap function. Thus, it is pivotal to detect the gap structure for understanding the mechanism of superconductivity. In cupr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09340-5
更新日期:2019-04-08 00:00:00
abstract::The role of the histamine H3 receptor (H3R) in cerebral ischaemia/reperfusion (I/R) injury remains unknown. Here we show that H3R expression is upregulated after I/R in two mouse models. H3R antagonists and H3R knockout attenuate I/R injury, which is reversed by an H3R-selective agonist. Interestingly, H1R and H2R ant...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4334
更新日期:2014-02-25 00:00:00
abstract::The temporal resolution of ultrafast electron diffraction and microscopy experiments is currently limited by the available experimental techniques for the generation and characterization of electron bunches with single femtosecond or attosecond durations. Here, we present proof of principle experiments of an optical g...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14342
更新日期:2017-01-25 00:00:00
abstract::Hollow-core fibre (HCF) is a powerful technology platform offering breakthrough performance improvements in sensing, communications, higher-power pulse delivery and other applications. Free from the usual constraints on what materials can guide light, it promises qualitatively new and ideal operating regimes: precisio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6085
更新日期:2014-10-28 00:00:00
abstract::Strain engineering is widely used in material science to tune the (opto-)electronic properties of materials and enhance the performance of devices. Two-dimensional atomic crystals are a versatile playground to study the influence of strain, as they can sustain very large deformations without breaking. Various optical ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02830-y
更新日期:2018-02-06 00:00:00
abstract::The degradation of intrinsic properties of graphene during the transfer process constitutes a major challenge in graphene device fabrication, stimulating the need for direct growth of graphene on dielectric substrates. Previous attempts of metal-induced transformation of diamond and silicon carbide into graphene suffe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12099
更新日期:2016-07-04 00:00:00
abstract::Oxygenic photosynthetic organisms perform solar energy conversion of water and CO2 to O2 and sugar at a broad range of wavelengths and light intensities. These cells also metabolize sugars using a respiratory system that functionally overlaps the photosynthetic apparatus. In this study, we describe the harvesting of p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04613-x
更新日期:2018-06-04 00:00:00