Abstract:
:The original version of this Article contained errors in Figures 1 and 3. In Fig. 1b, the label 'IP-PBP3' above the second of the three blots incorrectly read 'IP-PBP1B'. In Fig. 3b, the label 'PBP1B' under the first bar of each chart incorrectly read 'PBP1A'. These errors have been corrected in both the PDF and HTML versions of the Article.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Pazos M,Peters K,Casanova M,Palacios P,VanNieuwenhze M,Breukink E,Vicente M,Vollmer Wdoi
10.1038/s41467-019-08410-ysubject
Has Abstractpub_date
2019-01-30 00:00:00pages
591issue
1issn
2041-1723pii
10.1038/s41467-019-08410-yjournal_volume
10pub_type
杂志文章,已发布勘误abstract::Cystic fibrosis (CF) is a genetic disorder caused by defective CF Transmembrane Conductance Regulator (CFTR) function. Insulin producing pancreatic islets are located in close proximity to the pancreatic duct and there is a possibility of impaired cell-cell signaling between pancreatic ductal epithelial cells (PDECs) ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11178-w
更新日期:2019-07-16 00:00:00
abstract::The HIRA histone chaperone complex deposits the histone variant H3.3 onto chromatin in a DNA synthesis-independent manner. It comprises three identified subunits, HIRA, UBN1 and CABIN1, however the functional oligomerization state of the complex has not been investigated. Here we use biochemical and crystallographic a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05581-y
更新日期:2018-08-06 00:00:00
abstract::Blood vessel expansion is driven by sprouting angiogenesis of endothelial cells, and is essential for development, wound healing and disease. Membrane-localized vascular endothelial growth factor receptor-1 (mVEGFR1) is an endothelial cell-intrinsic decoy receptor that negatively modulates blood vessel morphogenesis. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15699
更新日期:2017-06-07 00:00:00
abstract::Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new therapeutic strategy for the in vivo delivery of nucleotides and chemical drugs. Here we describe a new tool for...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12277
更新日期:2016-07-22 00:00:00
abstract::Nanostructured materials premise to revolutionize the label-free biosensing of analytes for clinical applications, leveraging the deeper interaction between materials and analytes with comparable size. However, when the characteristic dimension of the materials reduces to the nanoscale, the surface functionalization f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07723-8
更新日期:2018-12-10 00:00:00
abstract::Invariant natural killer T cells have a distinct developmental pathway from conventional αβ T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2580
更新日期:2013-01-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-13715-z
更新日期:2019-12-06 00:00:00
abstract::There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of ris...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11039-6
更新日期:2019-07-10 00:00:00
abstract::In vivo electronic monitoring systems are promising technology to obtain biosignals with high spatiotemporal resolution and sensitivity. Here we demonstrate the fabrication of a biocompatible highly conductive gel composite comprising multi-walled carbon nanotube-dispersed sheet with an aqueous hydrogel. This gel comp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11425
更新日期:2016-04-29 00:00:00
abstract::Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03001-9
更新日期:2018-02-12 00:00:00
abstract::China has enacted a series of policies since 2015 to substitute electricity for in-home combustion for rural residential heating. The Electric Heating Policy (EHP) has contributed to significant improvements in air quality, benefiting hundreds of millions of people. This shift, however, has resulted in a sharp increas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19854-y
更新日期:2020-11-27 00:00:00
abstract::The flexibility in structural design of organic semiconductors endows organic solar cells (OSCs) not only great function-tunabilities, but also high potential toward practical application. In this work, simple non-fused-ring electron acceptors are developed through two-step synthesis from single aromatic units for con...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10098-z
更新日期:2019-05-14 00:00:00
abstract::Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing strain. We demonstrate that TeA is synthesize...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9758
更新日期:2015-10-27 00:00:00
abstract::Inferring neural mechanisms from functional magnetic resonance imaging (fMRI) is challenging because the fMRI signal integrates over millions of neurons. One approach is to compare computational models that map neural activity to fMRI responses, to see which best predicts fMRI data. We use this approach to compare fou...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05957-0
更新日期:2018-09-21 00:00:00
abstract::Genomic instability pathways in colorectal cancer (CRC) have been extensively studied, but the role of retrotransposition in colorectal carcinogenesis remains poorly understood. Although retrotransposons are usually repressed, they become active in several human cancers, in particular those of the gastrointestinal tra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11770-0
更新日期:2019-09-06 00:00:00
abstract::In adult skin epidermis and the epithelium lining the esophagus cells are constantly shed from the tissue surface and replaced by cell division. Tracking genetically labelled cells in transgenic mice has given insight into cell behavior, but conflicting models appear consistent with the results. Here, we use an additi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15258-0
更新日期:2020-03-18 00:00:00
abstract::Coordination of outer membrane constriction with septation is critical to faithful division in Gram-negative bacteria and vital to the barrier function of the membrane. This coordination requires the recruitment of the peptidoglycan-binding outer-membrane lipoprotein Pal at division sites by the Tol system. Here, we s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15083-5
更新日期:2020-03-11 00:00:00
abstract::Dynamic processes have many implications in functional molecules, including catalysts, enzymes, host-guest complexes, and molecular machines. Here, we demonstrate via deuterium NMR relaxation experiments how halogen bonding directly impacts the dynamics in solid 2,3,5,6-tetramethylpyrazine cocrystals, catalyzing the m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08878-8
更新日期:2019-02-22 00:00:00
abstract::Telomere maintenance is a universal hallmark of cancer. Most tumors including low-grade oligodendrogliomas use telomerase reverse transcriptase (TERT) expression for telomere maintenance while astrocytomas use the alternative lengthening of telomeres (ALT) pathway. Although TERT and ALT are hallmarks of tumor prolifer...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20312-y
更新日期:2021-01-04 00:00:00
abstract::In chronic lymphocytic leukemia (CLL), the non-hematopoietic stromal microenvironment plays a critical role in promoting tumor cell recruitment, activation, survival, and expansion. However, the nature of the stromal cells and molecular pathways involved remain largely unknown. Here, we demonstrate that leukemic B lym...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04150-7
更新日期:2018-05-03 00:00:00
abstract::Following microbial pathogen invasion, one of the main challenges for the host is to rapidly control pathogen spreading to avoid vital tissue damage. Here we report that an effector CD8(+) T-cell population that expresses the marker NK1.1 undergoes delayed contraction and sustains early anti-microbial protection. NK1....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6150
更新日期:2014-10-06 00:00:00
abstract::Differences in white adipose tissue (WAT) lipid turnover between the visceral (vWAT) and subcutaneous (sWAT) depots may cause metabolic complications in obesity. Here we compare triglyceride age and, thereby, triglyceride turnover in vWAT and sWAT biopsies from 346 individuals and find that subcutaneous triglyceride a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15253
更新日期:2017-05-23 00:00:00
abstract::Species-specific gamete recognition is a key premise to ensure reproductive success and the maintenance of species boundaries. During plant pollen tube (PT) reception, gametophyte interactions likely allow the species-specific recognition of signals from the PT (male gametophyte) by the embryo sac (female gametophyte)...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10826
更新日期:2016-03-11 00:00:00
abstract::Mutations in fused in sarcoma (FUS) lead to amyotrophic lateral sclerosis (ALS) with varying ages of onset, progression and severity. This suggests that unknown genetic factors contribute to disease pathogenesis. Here we show the identification of muscleblind as a novel modifier of FUS-mediated neurodegeneration in vi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13383-z
更新日期:2019-12-06 00:00:00
abstract::Range expansions are central to two ecological issues reshaping patterns of global biodiversity: biological invasions and climate change. Traditional theory considers range expansion as the outcome of the demographic processes of birth, death and dispersal, while ignoring the evolutionary implications of such processe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14303
更新日期:2017-01-27 00:00:00
abstract::Spontaneous molecular oscillations are ubiquitous in biology. But to our knowledge, periodic cell migratory patterns have not been observed. Here we report the highly regular, periodic migration of cells along rectilinear tracks generated inside three-dimensional matrices, with each excursion encompassing several cell...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1711
更新日期:2012-03-06 00:00:00
abstract::Many applications proposed for graphene require multiple sheets be assembled into a monolithic structure. The ability to maintain structural integrity upon large deformation is essential to ensure a macroscopic material which functions reliably. However, it has remained a great challenge to achieve high elasticity in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2251
更新日期:2012-01-01 00:00:00
abstract::Legionella pneumophila is a bacterial pathogen that utilises a Type IV secretion (T4S) system to inject effector proteins into human macrophages. Essential to the recruitment and delivery of effectors to the T4S machinery is the membrane-embedded T4 coupling complex (T4CC). Here, we purify an intact T4CC from the Legi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16681-z
更新日期:2020-06-08 00:00:00
abstract::The liver integrates multiple metabolic pathways to warrant systemic energy homeostasis. An excessive lipogenic flux due to chronic dietary stimulation contributes to the development of hepatic steatosis, dyslipidemia and hyperglycemia. Here we show that the oxidoreductase retinol saturase (RetSat) is involved in the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00430-w
更新日期:2017-08-30 00:00:00
abstract::The role of microglia in spinal cord injury (SCI) remains poorly understood and is often confused with the response of macrophages. Here, we use specific transgenic mouse lines and depleting agents to understand the response of microglia after SCI. We find that microglia are highly dynamic and proliferate extensively ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08446-0
更新日期:2019-01-31 00:00:00