Abstract:
:Central nervous system (CNS) injuries persist for years, and currently there are no therapeutics that can address the complex injury cascade that develops over this time-scale. 17β-estradiol (E2) has broad tropism within the CNS, targeting and inducing beneficial phenotypic changes in myriad cells following injury. To address the unmet need for vastly prolonged E2 release, we report first-generation poly(pro-E2) biomaterial scaffolds that release E2 at nanomolar concentrations over the course of 1-10 years via slow hydrolysis in vitro. As a result of their finely tuned properties, these scaffolds demonstrate the ability to promote and guide neurite extension ex vivo and protect neurons from oxidative stress in vitro. The design and testing of these materials reported herein demonstrate the first step towards next-generation implantable biomaterials with prolonged release and excellent regenerative potential.
journal_name
Nat Communjournal_title
Nature communicationsauthors
D'Amato AR,Puhl DL,Ellman SAT,Balouch B,Gilbert RJ,Palermo EFdoi
10.1038/s41467-019-12835-wsubject
Has Abstractpub_date
2019-10-23 00:00:00pages
4830issue
1issn
2041-1723pii
10.1038/s41467-019-12835-wjournal_volume
10pub_type
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