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Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization.

Abstract：

:Bone tissue, by definition, is an organic-inorganic nanocomposite, where metabolically active cells are embedded within a matrix that is heavily calcified on the nanoscale. Currently, there are no strategies that replicate these definitive characteristics of bone tissue. Here we describe a biomimetic approach where a supersaturated calcium and phosphate medium is used in combination with a non-collagenous protein analog to direct the deposition of nanoscale apatite, both in the intra- and extrafibrillar spaces of collagen embedded with osteoprogenitor, vascular, and neural cells. This process enables engineering of bone models replicating the key hallmarks of the bone cellular and extracellular microenvironment, including its protein-guided biomineralization, nanostructure, vasculature, innervation, inherent osteoinductive properties (without exogenous supplements), and cell-homing effects on bone-targeting diseases, such as prostate cancer. Ultimately, this approach enables fabrication of bone-like tissue models with high levels of biomimicry that may have broad implications for disease modeling, drug discovery, and regenerative engineering.

journal_name

Nat Commun

journal_title

Nature communications

authors

Thrivikraman G,Athirasala A,Gordon R,Zhang L,Bergan R,Keene DR,Jones JM,Xie H,Chen Z,Tao J,Wingender B,Gower L,Ferracane JL,Bertassoni LE

doi

10.1038/s41467-019-11455-8

subject

Has Abstract

pub_date

2019-08-06 00:00:00

pages

3520

issue

1

issn

2041-1723

pii

10.1038/s41467-019-11455-8

journal_volume

10

pub_type

杂志文章

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